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Analysis and design of a versatile synthetic network for inducible gene expression in mammalian systems 哺乳动物系统中诱导基因表达的多功能合成网络的分析与设计
2010 Biomedical Circuits and Systems Conference (BioCAS) Pub Date : 2010-11-01 DOI: 10.1109/BIOCAS.2010.5709601
A. Polynikis, G. Cuccato, S. Criscuolo, S. Hogan, M. di Bernardo, D. di Bernardo
{"title":"Analysis and design of a versatile synthetic network for inducible gene expression in mammalian systems","authors":"A. Polynikis, G. Cuccato, S. Criscuolo, S. Hogan, M. di Bernardo, D. di Bernardo","doi":"10.1109/BIOCAS.2010.5709601","DOIUrl":"https://doi.org/10.1109/BIOCAS.2010.5709601","url":null,"abstract":"This paper presents a mathematical model for a novel synthetic gene regulatory network. The aim of this circuit is to behave as a bistable switch for in vivo delivery of short hairpin RNA (shRNA) which can induce RNA interference (RNAi) of a target mRNA. Through the mathematical analysis performed here, it will be shown how the circuit can be controlled to induce sustained expression of a shRNA, with a transient input of two different inducer molecules.","PeriodicalId":440499,"journal":{"name":"2010 Biomedical Circuits and Systems Conference (BioCAS)","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123600673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A 200Mbps, 0.66nJ/b DTR UWB receiver for high data rate wireless biotelemetry applications 200Mbps, 0.66nJ/b DTR UWB接收机，用于高数据速率无线生物遥测应用
2010 Biomedical Circuits and Systems Conference (BioCAS) Pub Date : 2010-11-01 DOI: 10.1109/BIOCAS.2010.5709561
Chul Kim, S. Nooshabadi
{"title":"A 200Mbps, 0.66nJ/b DTR UWB receiver for high data rate wireless biotelemetry applications","authors":"Chul Kim, S. Nooshabadi","doi":"10.1109/BIOCAS.2010.5709561","DOIUrl":"https://doi.org/10.1109/BIOCAS.2010.5709561","url":null,"abstract":"This paper introduces a CMOS design of differential transmit-reference (DTR) ultra-wideband (UWB) receiver in 90nm RF CMOS process for high data rate wireless biotelemetry applications with the operation range of 0.5m and receiver sensitivity of −70dBm. From the simulation results the receiver achieves a data rate of 200Mbps, the highest reported in biotelemetry systems, with a low power consumption of 0.66nJ/bit during the data detection, consuming a small silicon area of 1.17mm2, making it most suitable for the high data rate in-vivo wireless biotelemetry applications.","PeriodicalId":440499,"journal":{"name":"2010 Biomedical Circuits and Systems Conference (BioCAS)","volume":"105 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123633466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
A CMOS frequency-mixing transimpedance amplifier with 5nArms input noise for frequency-domain near-infrared spectroscopy 用于频域近红外光谱的输入噪声为5nArms的CMOS混频透阻放大器
2010 Biomedical Circuits and Systems Conference (BioCAS) Pub Date : 2010-11-01 DOI: 10.1109/BIOCAS.2010.5709615
Ruida Yun, V. Joyner
{"title":"A CMOS frequency-mixing transimpedance amplifier with 5nArms input noise for frequency-domain near-infrared spectroscopy","authors":"Ruida Yun, V. Joyner","doi":"10.1109/BIOCAS.2010.5709615","DOIUrl":"https://doi.org/10.1109/BIOCAS.2010.5709615","url":null,"abstract":"A novel frequency mixing transimpedance amplifier (FM-TIA) is proposed and implemented in 0.18μm CMOS for low-noise detection of sinusoidally-modulated optical signals in frequency-domain near infrared (NIR) spectroscopy instrumentation. The FM-TIA topology employs a T-feedback resistor network incorporating gate-controlled transistors for resistance modulation, enabling operation in both wideband and frequency-mixing mode. In wideband mode, the TIA achieves a transimpedance gain of 110 (dBΩ, 263 MHz bandwidth, 230 nArms total integrated input current noise and 1 dB compression point of 1.65 μA for 4pF photodiode capacitance. In frequency-mixing mode, the amplifier is capable of directly downcon-verting and amplifying photocurrent signals generated by near-infrared excitation light modulated at 100 MHz. The FM-TIA obtains 5 nArms input noise, current-to-voltage conversion gain of 93dBQ, and ldB compression point of 1.1 μA with up to 47 dB dynamic range. The amplifier consumes only 22 mW of power from a 1.8 V supply.","PeriodicalId":440499,"journal":{"name":"2010 Biomedical Circuits and Systems Conference (BioCAS)","volume":"79 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124833614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
A low-power implantable device for epileptic seizure detection and neurostimulation 一种用于癫痫发作检测和神经刺激的低功率植入式装置
2010 Biomedical Circuits and Systems Conference (BioCAS) Pub Date : 2010-11-01 DOI: 10.1109/BIOCAS.2010.5709594
M. T. Salam, D. Nguyen, M. Sawan
{"title":"A low-power implantable device for epileptic seizure detection and neurostimulation","authors":"M. T. Salam, D. Nguyen, M. Sawan","doi":"10.1109/BIOCAS.2010.5709594","DOIUrl":"https://doi.org/10.1109/BIOCAS.2010.5709594","url":null,"abstract":"In this paper, we present the design of a low-power closed-loop neurostimulator (CLNS) as an adjunctive treatment for patients with refractory partial epilepsy. The CLNS combines epileptic seizure detection with simultaneous electrical stimulation feedback. The system amplifies the neural signal with adjustable gain, detects epileptic low-voltage fast-activity, and generates programmable stimulation currents. The implemented seizure detector is based on a detection algorithm validated in Matlab tools and was tested using intracerebral electroencephalographic (iEEG) recordings from a patient with drug-resistant epilepsy. The amplifier, epileptic-seizure detector and electric stimulator were implemented using CMOS 0.18-μm process. The iEEG were assessed by the proposed CMOS building blocks and the predefined seizure suppression biphasic electrical stimulations were administrated at 2 to 3 sec after electrographical seizure onsets. The simulated power consumption of the CLNS has showed that the system could run on a button cell battery for more than 8 years.","PeriodicalId":440499,"journal":{"name":"2010 Biomedical Circuits and Systems Conference (BioCAS)","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125201234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 18
Compressive sampling of ECG bio-signals: Quantization noise and sparsity considerations 心电生物信号的压缩采样:量化噪声和稀疏性考虑
2010 Biomedical Circuits and Systems Conference (BioCAS) Pub Date : 2010-11-01 DOI: 10.1109/BIOCAS.2010.5709566
Emily G. Allstot, Andrew Y. Chen, Anna M. R. Dixon, Daibashish Gangopadhyay, D. Allstot
{"title":"Compressive sampling of ECG bio-signals: Quantization noise and sparsity considerations","authors":"Emily G. Allstot, Andrew Y. Chen, Anna M. R. Dixon, Daibashish Gangopadhyay, D. Allstot","doi":"10.1109/BIOCAS.2010.5709566","DOIUrl":"https://doi.org/10.1109/BIOCAS.2010.5709566","url":null,"abstract":"Compressed sensing (CS) is an emerging signal processing paradigm that enables the sub-Nyquist processing of sparse signals; i.e., signals with significant redundancy. Electrocardiogram (ECG) signals show significant time-domain sparsity that can be exploited using CS techniques to reduce energy consumption in an adaptive data acquisition scheme. A measurement matrix of random values is central to CS computation. Signal-to-quantization noise ratio (SQNR) results with ECG signals show that 5- and 6-bit Gaussian random coefficients are sufficient for compression factors up to 6X and from 8X-16X, respectively, whereas 6-bit uniform random coefficients are needed for 2X-16X compression ratios.","PeriodicalId":440499,"journal":{"name":"2010 Biomedical Circuits and Systems Conference (BioCAS)","volume":"87 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123118305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 44
A least-voltage drop high output resistance current source for neural stimulation 一种用于神经刺激的小电压降高输出电阻电流源
2010 Biomedical Circuits and Systems Conference (BioCAS) Pub Date : 2010-11-01 DOI: 10.1109/BIOCAS.2010.5709583
C. Sawigun, W. Ngamkham, Marijn van Dongen, A. Wouter
{"title":"A least-voltage drop high output resistance current source for neural stimulation","authors":"C. Sawigun, W. Ngamkham, Marijn van Dongen, A. Wouter","doi":"10.1109/BIOCAS.2010.5709583","DOIUrl":"https://doi.org/10.1109/BIOCAS.2010.5709583","url":null,"abstract":"This paper presents a feedback technique to increase the output resistance of a MOS current mirror circuit that requires only one effective drain-source voltage drop. The proposed circuit requires a few additional current braches to form two feedback loops. With its compact structure, the proposed circuit is suitable as a current generator for neural stimulation. Simulation results, using 0.35 μm AMIS I3T25 technology, show that the proposed current generator, applied for bi-phasic stimulation, can convey more charge to a series resistive-capacitive load compared to the widely use low-voltage cascode current source.","PeriodicalId":440499,"journal":{"name":"2010 Biomedical Circuits and Systems Conference (BioCAS)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130152264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Amperometric instrumentation system with on-chip electrode array for biosensor application 应用于生物传感器的片上电极阵列安培仪表系统
2010 Biomedical Circuits and Systems Conference (BioCAS) Pub Date : 2010-11-01 DOI: 10.1109/BIOCAS.2010.5709629
Lin Li, W. Qureshi, Xiaowen Liu, A. Mason
{"title":"Amperometric instrumentation system with on-chip electrode array for biosensor application","authors":"Lin Li, W. Qureshi, Xiaowen Liu, A. Mason","doi":"10.1109/BIOCAS.2010.5709629","DOIUrl":"https://doi.org/10.1109/BIOCAS.2010.5709629","url":null,"abstract":"An integrated amperometric instrumentation system with on-chip electrodes for biosensor arrays is presented. The mixed-signal integrated circuit supports a variety of electrochemical measurement techniques including linear sweep, constant potential, cyclic and pulse voltammetry. Implemented in 0.5μm CMOS, the 3×3 mm2 chip dissipates 22.5mW for a 200 kHz clock. The highly programmable chip provides a wide range of user-controlled rate and amplitude parameters with a maximum scan range of 2V and scan rate ranging between 1mV/sec to 400V/sec. The amperometric readout circuit provides ± 0.5pA linear resolution and supports inputs up to 100μA. A 2×2 array gold electrode electrochemical cells was fabricated on the surface of the CMOS instrumentation chip. An all-parylene packaging scheme was developed for compatibility with liquid test environments as well as harsh piranha electrode cleaning processes. The chip was tested using cyclic voltammetry of 0.1M potassium ferrocyanide, and results were comparable to measurements using commercial instruments.","PeriodicalId":440499,"journal":{"name":"2010 Biomedical Circuits and Systems Conference (BioCAS)","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131647943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
A ultra low power, wide input range MICS band channel selection filter on 65 nm CMOS 一个超低功耗，宽输入范围的MICS频带通道选择滤波器65纳米CMOS
2010 Biomedical Circuits and Systems Conference (BioCAS) Pub Date : 2010-11-01 DOI: 10.1109/BIOCAS.2010.5709610
J. Yang, N. Tran, S. Bai, M. Fu, E. Skafidas, I. Mareels, M. Halpern
{"title":"A ultra low power, wide input range MICS band channel selection filter on 65 nm CMOS","authors":"J. Yang, N. Tran, S. Bai, M. Fu, E. Skafidas, I. Mareels, M. Halpern","doi":"10.1109/BIOCAS.2010.5709610","DOIUrl":"https://doi.org/10.1109/BIOCAS.2010.5709610","url":null,"abstract":"This paper proposes a low power MICS band receiver channel selection filter on 65 nm CMOS for implantable biomedical devices. This 5th-order elliptic OTA-C bandpass filter utilizes sub-threshold inverter based OTAs. In order to broaden input range of the filter, the first OTA stage is linearized by using the active-error feedforward technique. The overall filter only consumes 300 μA DC current under 1 V supply, while having an input range up to 0.6 Vpp. The total harmonic distortion (THD) is −58 dB for 1.3 MHz input signal at 0.5 Vpp swing. As a MICS band channel selection filter, it has 300 kHz bandwidth and exhibits more than 45 dB attenuation to the ajacent channel. By using NFET capacitors as OTAs, load, the chip area of this filter is minimized.","PeriodicalId":440499,"journal":{"name":"2010 Biomedical Circuits and Systems Conference (BioCAS)","volume":"110 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134551768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
An integrated and mixed technology LOC hydrodynamic focuser for cell counting application 一种用于细胞计数应用的集成和混合技术LOC流体动力聚焦器
2010 Biomedical Circuits and Systems Conference (BioCAS) Pub Date : 2010-11-01 DOI: 10.1109/BIOCAS.2010.5709574
A. Laki, Ismael Rattalino, A. Sanginario, N. Piacentini, K. Iván, D. Lăpădatu, J. Taylor, D. Demarchi, P. Civera
{"title":"An integrated and mixed technology LOC hydrodynamic focuser for cell counting application","authors":"A. Laki, Ismael Rattalino, A. Sanginario, N. Piacentini, K. Iván, D. Lăpădatu, J. Taylor, D. Demarchi, P. Civera","doi":"10.1109/BIOCAS.2010.5709574","DOIUrl":"https://doi.org/10.1109/BIOCAS.2010.5709574","url":null,"abstract":"In our project a standard microfluidic analyzer background system and its construction steps were developed to analyze biologic fluids. The obtained micro-Total-Analysis-System (μTAS) is based on the integration of different microflu-idic systems. Each part follows well-defined rules to make the integration of the large-scale production microchip technology with the cheap polymer support system possible. The compiled system is based on the SensoNor glass/silicon/glass multilayer technology [1] and ThinXXS plastic slide technology, which are made from low cost materials, easily producible in large-scale and in the same time biocompatible. In this project hydrodynamic focusers were designed to sort and analyze particles and cells in one continuous focused line, in a 50 μm wide channel. The advantage of this Lab-On-a-Chip (LOC) structure is the easy interfaceability with electrodes and optical systems. The designed microchannels contain electrodes for electrical characterization and because of the anodic bonding process it is possible to observe the channel with an upright microscope [2]. With these two fundamental methods our system is able to analyze and measure any biological liquid, which contain less than 10 μm size particles or cells, and count the number of morphologically well-separated different elements in the focused liquid flow with image processing algorithms.","PeriodicalId":440499,"journal":{"name":"2010 Biomedical Circuits and Systems Conference (BioCAS)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130015995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Blood glucose optical bio-implant: Preliminary design guidelines 血糖光学生物植入物:初步设计指南
2010 Biomedical Circuits and Systems Conference (BioCAS) Pub Date : 2010-11-01 DOI: 10.1109/BIOCAS.2010.5709593
A. Trabelsi, M. Boukadoum, M. Siaj
{"title":"Blood glucose optical bio-implant: Preliminary design guidelines","authors":"A. Trabelsi, M. Boukadoum, M. Siaj","doi":"10.1109/BIOCAS.2010.5709593","DOIUrl":"https://doi.org/10.1109/BIOCAS.2010.5709593","url":null,"abstract":"A preliminary investigation into the design of a near-infrared (NIR) optical bio-implant for accurate measurement of blood glucose concentration is reported. The use of an array of electrically pumped vertical-cavity surface-emitting laser (VCSEL) diodes at specific wavelengths for high-power narrow single-frequency emission leads to a high signal-to-noise ratio (SNR) in the measured NIR absorption spectrum while maximizing the sensor's sensitivity to small absorption changes. A Quantum well infrared (QWI) photodetector senses the received optical power after passage through the blood sample, followed by an artificial neural network (ANN) for the measurement of glucose in a whole blood matrix. For an independent test set made with bovine blood, the optimal ANN topology for processing the two selected spectral bands yielded a standard error of prediction of 0.42 mM (i.e., 7.56 mg/dl) over the concentration range of 4–20 mM.","PeriodicalId":440499,"journal":{"name":"2010 Biomedical Circuits and Systems Conference (BioCAS)","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130927211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
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