哺乳动物系统中诱导基因表达的多功能合成网络的分析与设计

2010 Biomedical Circuits and Systems Conference (BioCAS) Pub Date : 2010-11-01 DOI:10.1109/BIOCAS.2010.5709601

A. Polynikis, G. Cuccato, S. Criscuolo, S. Hogan, M. di Bernardo, D. di Bernardo

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引用次数: 0

摘要

本文提出了一种新型合成基因调控网络的数学模型。该电路的目的是作为一个双稳态开关，在体内传递短发夹RNA (shRNA)，可以诱导靶mRNA的RNA干扰(RNAi)。通过这里进行的数学分析，将显示如何通过两种不同诱导分子的瞬时输入来控制电路以诱导shRNA的持续表达。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Analysis and design of a versatile synthetic network for inducible gene expression in mammalian systems

This paper presents a mathematical model for a novel synthetic gene regulatory network. The aim of this circuit is to behave as a bistable switch for in vivo delivery of short hairpin RNA (shRNA) which can induce RNA interference (RNAi) of a target mRNA. Through the mathematical analysis performed here, it will be shown how the circuit can be controlled to induce sustained expression of a shRNA, with a transient input of two different inducer molecules.

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2010 Biomedical Circuits and Systems Conference (BioCAS)

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