Middle East Journal of Cancer最新文献_第8页

In Vitro Stem Cell Isolation from Human Breast Cancer 癌症干细胞的体外分离

IF 0.4

Middle East Journal of Cancer Pub Date : 2021-01-27 DOI: 10.30476/MEJC.2021.83672.1181

Azam Bozorgi, F. Khazaei, Maryam Bozorgi, M. Khazaei

{"title":"In Vitro Stem Cell Isolation from Human Breast Cancer","authors":"Azam Bozorgi, F. Khazaei, Maryam Bozorgi, M. Khazaei","doi":"10.30476/MEJC.2021.83672.1181","DOIUrl":"https://doi.org/10.30476/MEJC.2021.83672.1181","url":null,"abstract":"Background: Breast cancer (BC) is the most prevalent cancer among women worldwide with significant incidence and death rates. Nowadays, researchers hold that tumor formation, failure in therapy, and disease progression are all related to the presence of a small fraction of cancer cells with self-renewal capability known as “breast cancer stem cells” (BCSCs). Therefore, the study of this cancer cell population can be conducive to eradicating the tumor. The objective of the present study was to survey the existence and in vitro isolation of human BCSCs. Method: An in vitro research study was conducted under controlled laboratory settings to isolate, enrich, and identify breast cancer stem cells. Briefly, fresh breast tumors were carried to the lab immediately after surgery, Followed by mechanical and enzymatic digestion (2 mg/ml collagenase I). Then, digested samples were passed through cell strainers (70 and 40 µm), and obtained cell suspension was cultured under the serum-free medium supplemented with growth factors for 21 days. The expression of CD44 and CD24 surface markers was assessed using immunocytochemistry, and stem cell gene expression was analyzed via RT PCR. Results: BCSCs were able to survive in serum-free conditions and form floating spheres in vitro. Cells obtained from mammospheres expressed CD44 as the membranous and cytoplasmic pattern while CD24 expression was negative. Also, OCT4 and SOX2 gene expression was observed in BCSCs. Conclusion: The presence of stem cells was confirmed in Iranian women BC, and an efficient in vitro mammosphere culture model was used to enrich and propagate BCSCs. In our opinion, this in vitro model could be a suitable method for isolating and enriching BCSCs.","PeriodicalId":44005,"journal":{"name":"Middle East Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2021-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43035687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Double-Blind Randomized Trial on the Effectiveness of Mometasone 0.1% Cream and Hydrocortisone 1% Cream on the Prevention of Acute Radiation Dermatitis in Breast Cancer Patients following Breast Conserving Surgery 0.1%莫米松乳膏和1%氢化可的松乳膏预防乳腺癌症保乳术后急性放射性皮炎的双盲随机试验

IF 0.4

Middle East Journal of Cancer Pub Date : 2021-01-27 DOI: 10.30476/MEJC.2021.83528.1173

M. Kianinia, M. Roayaei, Hoda Mahdavi, S. Hemati

{"title":"A Double-Blind Randomized Trial on the Effectiveness of Mometasone 0.1% Cream and Hydrocortisone 1% Cream on the Prevention of Acute Radiation Dermatitis in Breast Cancer Patients following Breast Conserving Surgery","authors":"M. Kianinia, M. Roayaei, Hoda Mahdavi, S. Hemati","doi":"10.30476/MEJC.2021.83528.1173","DOIUrl":"https://doi.org/10.30476/MEJC.2021.83528.1173","url":null,"abstract":"Background: Despite the high prevalence of acute radiation dermatitis (ARD) in breast radiation treatment, data about its prevention is inconsistent. We conducted the present research to investigate whether the use of topical corticosteroids with different potencies or moisturizing cream could prevent ARD. \u0000Method: In this double-blind randomized trial, 120 patients, who had undergone breast conserving surgery for breast cancer, were randomly assigned to use Mometasone 0.1% cream or hydrocortisone 1% cream or moisturizing base cream from the first day of radiotherapy (RT) throughout the entire course. CTCAE v. 4 scale was utilized to score the grade of ARD. The outcomes were analysed with relevant statistical methods. \u0000Results: 105 subjects were analysed. Mometasone delayed the incidence of grade 1 ARD in a week. However, no differences were observed among the groups concerning the incidence of the maximum ARD grade. 𝜒2 (6, N= 104)=8.12, P=0.2. Moreover, the timing of the maximum ARD was not significantly different among the groups. 𝜒2 (4, N =84) = 2.87, P=0.58. \u0000Conclusion: This study demonstrated that the application of corticosteroid creams (hydrocortisone 1% or Mometasone 0.1%) does not result into a significant difference concerning the timing and incidence of ARD occurrence when compared with daily skin care and use of emollient.","PeriodicalId":44005,"journal":{"name":"Middle East Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2021-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46536936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Low-Dose Cytarabine versus Best Supportive Care for Patients with Acute Myeloid Leukaemia Unfit for the Standard of Care: Egyptian Centre Experience 低剂量阿糖胞苷与最佳支持性护理对急性髓细胞白血病患者的治疗不符合护理标准：埃及中心经验

IF 0.4

Middle East Journal of Cancer Pub Date : 2021-01-27 DOI: 10.30476/MEJC.2021.83644.1179

Amrallah A. Mohammed, F. M. Elsayed

{"title":"Low-Dose Cytarabine versus Best Supportive Care for Patients with Acute Myeloid Leukaemia Unfit for the Standard of Care: Egyptian Centre Experience","authors":"Amrallah A. Mohammed, F. M. Elsayed","doi":"10.30476/MEJC.2021.83644.1179","DOIUrl":"https://doi.org/10.30476/MEJC.2021.83644.1179","url":null,"abstract":"Background: Acute myeloid leukaemia (AML) in the elderly is not strong enough to tolerate aggressive chemotherapy. We conducted the present study to compare the efficacy and safety of low-dose cytarabine (LDAC) with best supportive care (BSC) in Egyptian patients. \u0000Method: A prospective randomized study included 60 eligible patients aged over 60 years with newly diagnosed AML. They were randomized to receive LDAC or BSC. The overall survival (OS) was the primary endpoint while the secondary endpoint was to compare the quality of life in the form of a length of hospital stays (LOHS), mode and frequency of admission in the two studied groups. \u0000Results: Herein, 30 patients received LDAC and 30 patients received BSC. The mean survival time was 7.5 months in the BSC group compared to 10.2 months in the LDAC group. Even though the median OS was 8.4 months in the BSC group, it did not reach in the LDAC group; HR, = 2.047, CI 95% (0.541-7.743), (P=0.2). There was a statistically significant association with LDAC and the frequency of hospital admission through the emergency department (ED) due to neutropenic fever and prolonged LOHS (P<0.001, P<0.002, and P<0.001, respectively). Meanwhile, the admission through the outpatient clinic (OPC) and for transfusion support were statistically insignificant in the two groups (P< 0.12, P< 0.6, respectively). \u0000Conclusion: Despite, there were no OS statistically significant benefits of the use of LDAC over BSC in our patients, poor quality of life in the form of frequent admission through the ED, more incidence of neutropenic fever, and prolonged LOHS were reported more to patients received LDAC.","PeriodicalId":44005,"journal":{"name":"Middle East Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2021-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49578239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study of the Effect of Linoleic Acid on the Expression Level of MicroRNA-106b and MicroRNA-20a and their Related Target MHC Class I Chain-related Protein A in Docetaxel-treated Gastric Cancer Cells 亚油酸对多西他赛处理胃癌细胞中MicroRNA-106b、MicroRNA-20a及其相关靶MHC I类链相关蛋白A表达水平的影响研究

IF 0.4

Middle East Journal of Cancer Pub Date : 2021-01-09 DOI: 10.30476/MEJC.2021.87303.1406

N. Shekari, Tohid Kazemi, Maedeh Moradi, E. Eghbali, B. Sepehri, V. K. Shahgoli, M. Shirmohamadi

{"title":"Study of the Effect of Linoleic Acid on the Expression Level of MicroRNA-106b and MicroRNA-20a and their Related Target MHC Class I Chain-related Protein A in Docetaxel-treated Gastric Cancer Cells","authors":"N. Shekari, Tohid Kazemi, Maedeh Moradi, E. Eghbali, B. Sepehri, V. K. Shahgoli, M. Shirmohamadi","doi":"10.30476/MEJC.2021.87303.1406","DOIUrl":"https://doi.org/10.30476/MEJC.2021.87303.1406","url":null,"abstract":"Background: MicroRNAs are involved in response to therapeutic agents and have the ability to regulate the expression level of the targets associated with cancer growth and progression. As a dangerous signal in tumor cells, increased expression level of MHC class I chain-related protein A (MICA) could activate the immune system and induce responses to tumor cells. We conducted the present research to study the effect of linoleic acid (LA) and docetaxel alone or in combination with miR-106b, miR-20a, and MICA expression level in metastatic gastric cancer (GC) cell line, MKN-45. Method: The study was an in vitro study using the gastric cancer cell line MKN-45, which was cultured and treated with docetaxel and LA. Subsequently, the expression level of miR-106b, miR-20a, and MICA were assessed with quantitative real-time PCR. Results: MiR-106b decreased in LA and LA/docetaxel (p p =0.002), and increased in docetaxel alone (p =0.01). Meanwhile, miR-20a significantly decreased in docetaxel and LA/docetaxel (p <0.0001), increased in LA treatment (p =0.02). Regarding MICA, it significantly decreased in all the treated cells (p <0.0001, p <0.0001, and p =0.0002 for docetaxel, LA and docetaxel/LA, respectively) but with different reduction intensities. Conclusion: Using LA or docetaxel alone had a different effect on miR-106b, miR-20a, and MICA expression level, yet in a simultaneous treatment, their positive effects were intensified. LA enhanced the effect of docetaxel concerning the expression level of miR-106b, miR-20a, and MICA and vice versa, which suggested that LA could be employed as an effective complementary agent in GC along with docetaxel.","PeriodicalId":44005,"journal":{"name":"Middle East Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2021-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42399406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extramedullary Hematopoiesis and Osseous Metaplasia in Thyroid Gland in Association with Papillary Thyroid Carcinoma: A Report of two Cases 甲状腺髓外造血和骨质增生伴甲状腺乳头状癌2例报告

IF 0.4

Middle East Journal of Cancer Pub Date : 2020-12-30 DOI: 10.30476/MEJC.2020.83426.1166

S. Fatima, S. Sadek, W. Siddiqui

引用次数: 1

Breast Cancer Risk Factors: A Case-control Study in Iranian Women 乳腺癌危险因素:伊朗妇女的病例对照研究

IF 0.4

Middle East Journal of Cancer Pub Date : 2020-12-30 DOI: 10.30476/MEJC.2020.83442.1168

M. Motie, A. Taghizadeh, L. Pourali, Mohammad Oshibnetaj, Elahe Hasanzadeh, L. Jarahi, Somayeh Moein Darbari, Shadi Mehdizadeh

{"title":"Breast Cancer Risk Factors: A Case-control Study in Iranian Women","authors":"M. Motie, A. Taghizadeh, L. Pourali, Mohammad Oshibnetaj, Elahe Hasanzadeh, L. Jarahi, Somayeh Moein Darbari, Shadi Mehdizadeh","doi":"10.30476/MEJC.2020.83442.1168","DOIUrl":"https://doi.org/10.30476/MEJC.2020.83442.1168","url":null,"abstract":"Background: Breast cancer is the most frequent malignancy and the leading cause of cancer-related death among women all around the world. In Iran, the mean age of the patients is approximately 10 years younger than that in other countries. We conducted the present study to assess the risk factors of breast cancer among Iranian women in Mashhad. \u0000Method: This case-control study was carried out between February 2016 and January 2018 on 460 women (230 cases and 230 controls), in the academic hospitals of Mashhad. The data from our cases and controls were collected and analyzed using SPSS version 18.0 software (SPSS Inc., Chicago, IL, USA). We employed logistic regression models and frequency tables to estimate odds ratio (OR) and to examine the predictive effect of each factor on breast cancer risk. P<0.05 was considered to be significant. \u0000Results: According to multivariate analysis, there was significant associations between breast cancer risk and body mass index (BMI) (Odds ratio (OR), 1.1; 95% Confidence interval (CI), 1.0-1.2), age at menarche (OR, 0.56; 95% CI, 0.47-0.68), menopausal age (OR, 1.1; 95% CI, 1.0-1.1), family history of non-breast malignancies (OR, 7.9; 95% CI, 2.2-21.1), and oral contraception pills (OR, 3.1; 95% CI, 8.34-1.16). \u0000Conclusion: This study revealed that age at menarche, family history of non-breast cancer malignancies, BMI, menopausal age, and oral contraception pills were significantly associated with breast cancer.","PeriodicalId":44005,"journal":{"name":"Middle East Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46725969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A Bone Marrow Study; Report of Chromosomal Variations in Hematologic Malignancies Including Acute Myeloid Leukemia, Acute Lymphoid Leukemia, and Myelodisplastic Syndrome (Northeast Iran) 骨髓研究;伊朗东北地区急性髓系白血病、急性淋巴系白血病和骨髓增生综合征等血液系统恶性肿瘤的染色体变异报告

IF 0.4

Middle East Journal of Cancer Pub Date : 2020-12-30 DOI: 10.30476/MEJC.2020.82641.1092

Sepideh Shakeri, H. Ayatollahi, M. Sadeghian, S. Shams

{"title":"A Bone Marrow Study; Report of Chromosomal Variations in Hematologic Malignancies Including Acute Myeloid Leukemia, Acute Lymphoid Leukemia, and Myelodisplastic Syndrome (Northeast Iran)","authors":"Sepideh Shakeri, H. Ayatollahi, M. Sadeghian, S. Shams","doi":"10.30476/MEJC.2020.82641.1092","DOIUrl":"https://doi.org/10.30476/MEJC.2020.82641.1092","url":null,"abstract":"Background: Chromosomal aberrations which occur in different hematologic malignancies are believed to be highly applicable for identifying the prognosis and treatment protocols. We conducted the present study to investigate the chromosomal and molecular abnormalities in bone marrow of acute myeloid leukemia (AML), acute lymphoid leukemia (ALL), and myelodysplastic syndrome patients. Method: We performed this cross-sectional study in molecular pathology and cancer research center of Mashhad University of Medical Sciences (MUMS), during 2017-2019; the total number of our cases was 252. We did all the molecular and cytogenetic tests on these patients. SPSS V.16 software was utilized for the analysis of our data. Results: In this research, the ALL patients were meaningfully younger than AML ones. There were significant associations between karyotype patterns and types of malignancy; normal diploid was more frequent in myelodysplastic syndrome (p <0.05). Among numerical abnormalities, trisomy 3 and monosomy 14 were the most prevalent ones. Conclusion: The results of similar studies from different areas with different ethnics would help to identify new parameters for prognosis determination. Cytogenetic analysis is highly applicable for leukemia diagnosis and prognosis.","PeriodicalId":44005,"journal":{"name":"Middle East Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44886953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship between Clinicopathologic Features and Recurrence in Ovarian Germ Cell Tumor 卵巢生殖细胞肿瘤的临床病理特征与复发的关系

IF 0.4

Middle East Journal of Cancer Pub Date : 2020-12-30 DOI: 10.30476/MEJC.2020.83404.1160

M. Momtahan, M. Akbarzadeh-Jahromi, S. Jokar, Shaghayegh Moradialamdarloo, F. Aslani, M. Rohani

{"title":"Relationship between Clinicopathologic Features and Recurrence in Ovarian Germ Cell Tumor","authors":"M. Momtahan, M. Akbarzadeh-Jahromi, S. Jokar, Shaghayegh Moradialamdarloo, F. Aslani, M. Rohani","doi":"10.30476/MEJC.2020.83404.1160","DOIUrl":"https://doi.org/10.30476/MEJC.2020.83404.1160","url":null,"abstract":"Background: We conducted the present study to analyze the clinicopathologic features of patients with malignant ovarian germ cell tumor (MOGCT) with recurrence after 2 and 5 years. \u0000Method: In this retrospective and analytical-descriptive study, the obtained data included: age, tumor size, histopathological type, tumor stage, lymph node involvement, ‌laterality of tumor, ‌tumor necrosis, and mitosis. We also evaluated the Cox Regression analysis between these variables with recurrence after 2 and 5 years. \u0000Results: According to our exclusion criteria, we eliminated 81 cases. These cases consisted of the subjects with dysgerminoma (48.1%), immature teratoma (22.2%), yolk sac (16%), mix germ cell (11.1%), non-gestational choriocarcinoma (1.2%), and embryonal carcinoma (1.2%). We did not observe pure polyembryoma or polyembryoma in combination with mixed germ cell.‌All the patients received the treatment. The ‌patients’ mean age was 23.3±8.4 years.‌MOGCT reoccurred in 10 patients after 2 years and in 13 patients after 5 years (10 cases in the first 2 years, and 3 new cases in the next 3 years). Most of the cases (64.2%) were diagnosed to be at stage1. The Cox Regression analysis between positive lymph node and the recurrence of MOGCT after 2 years and between stage IV of disease and the recurrence after 2 years were significant. The Cox Regression analysis between laterality, mitosis and necrosis in pathologic slides of the recurrence after 2 and 5 years was not significant. \u0000Conclusion: Stages and involvement of lymph nodes are two major factors concerning the recurrence of MOGCT. Most recurrences occur in the first 2 years. Pathologic features‌‌‌‌ (mitosis and necrosis) of MOGCt‌ in the time of diagnosis not correlated with the recurrence of the disease.","PeriodicalId":44005,"journal":{"name":"Middle East Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47203317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Definitive Radiotherapy with or without Concomitant or Induction Chemotherapy in Patients with Hypopharyngeal Squamous Cell Carcinoma: A Single Center Study in Iran 下咽鳞状细胞癌患者的最终放疗伴或不伴或诱导化疗:伊朗的单中心研究

IF 0.4

Middle East Journal of Cancer Pub Date : 2020-11-16 DOI: 10.30476/MEJC.2020.87158.1404

A. Kazemian, R. Ghalehtaki, Mahdieh Razmkhah, Maryam Taheriyoun, Negin Mohammadi, Mohammad Narimani Kali, F. Farhan, M. Aghili, E. Esmati

{"title":"Definitive Radiotherapy with or without Concomitant or Induction Chemotherapy in Patients with Hypopharyngeal Squamous Cell Carcinoma: A Single Center Study in Iran","authors":"A. Kazemian, R. Ghalehtaki, Mahdieh Razmkhah, Maryam Taheriyoun, Negin Mohammadi, Mohammad Narimani Kali, F. Farhan, M. Aghili, E. Esmati","doi":"10.30476/MEJC.2020.87158.1404","DOIUrl":"https://doi.org/10.30476/MEJC.2020.87158.1404","url":null,"abstract":"Background: Hypopharyngeal carcinoma (HPC) is a rare head and neck cancer which poses many therapeutic challenges. There is limited evidence regarding the outcomes of HPC treatment in Iran. \u0000Method: In this retrospective cohort study, we evaluated patients treated with chemoradiation or radiation alone, between 2007 and 2016 in the radiation oncology ward of a cancer institute affiliated to Tehran University of Medical Sciences. The design of the study was reviewed and approved by the local institutional review board (code: 86100142). All patients underwent definitive radiotherapy with or without concurrent or sequential chemotherapy. We assessed the two-year overall survival (OS) as the primary outcome. The progression-free survival (PFS) was our secondary outcome. \u0000Results: We studied 40 patients whose median age was 58 years. Thirty-seven patients were stage 3 or 4 while the most common stage was T3N1-2, observed in 35% of the cases. The most common site of involvement was pyriform sinus (47.5%). The two-year OS rate was 29%. The two-year PFS was 22%. In the univariate analysis, N0-1 vs. N 2-3 and Stage 2 vs. Stage 3-4 were significant predictors of OS. In addition, distant metastasis had almost a significant association with lower OS. \u0000Conclusion: The outcome of locally advanced HPC was not promising using 3DCRT alone. It is necessary to implement dramatic changes in the management of these patients to achieve better outcomes.","PeriodicalId":44005,"journal":{"name":"Middle East Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2020-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46978685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Cognitive-Behavioral Therapy and Hypnosis Intervention on Anxiety, Depression, and Quality of Life in Patients with Breast Cancer Undergoing Chemotherapy: A Clinical Trial 认知行为疗法和催眠干预对乳腺癌化疗患者焦虑、抑郁和生活质量的影响:一项临床试验

IF 0.4

Middle East Journal of Cancer Pub Date : 2020-11-11 DOI: 10.30476/MEJC.2020.83225.1149

F. Elyasi, F. Taghizadeh, M. Zarghami, M. Moosazadeh, Samira Abdollahi Chirani, M. Babakhanian

{"title":"Cognitive-Behavioral Therapy and Hypnosis Intervention on Anxiety, Depression, and Quality of Life in Patients with Breast Cancer Undergoing Chemotherapy: A Clinical Trial","authors":"F. Elyasi, F. Taghizadeh, M. Zarghami, M. Moosazadeh, Samira Abdollahi Chirani, M. Babakhanian","doi":"10.30476/MEJC.2020.83225.1149","DOIUrl":"https://doi.org/10.30476/MEJC.2020.83225.1149","url":null,"abstract":"Background: Women with breast cancer undergo painful and distressing treatment procedures. Hypnotherapy and cognitive-behavioral therapy (CBT) could be considered as an effective therapy. \u0000Method: In this clinical trial, 50 women aged 25 to 65 were assigned to three groups (CBT, hypnosis, and control groups). Eight one-hour treatment sessions were run for each of the hypnosis and cognitive-behavioral therapy groups. We utilized The European Organization for Research and Treatment of Breast Cancer-specific Quality of Life (QoL), The European Organization for Research and Treatment of Cancer QoL questionnaires, and The Hospital Anxiety and Depression Scale for the evaluation of the QoL, anxiety, and depression at the beginning and end of the treatment, as well as 6 months post-treatment. \u0000Results: The improvements in the stress, depression, and QoL amongst the three groups were significant, although these improvements in CBT group were more than those in hypnosis group, and in hypnosis and CBT groups were not significant. Physical functioning, body image, sexual functioning, arm symptoms, breast symptoms, future perspective, pain, digestive problems, and functional scale significantly changed in CBT and hypnosis groups (P-value < 0.05). Memory and social functioning, however, did not change in the groups and across the three groups. In addition, sleeping disorders and emotional malfunctioning were recovered only in the hypnosis group, which was statistically significant. \u0000Conclusion: We found hypnosis exclusively effective on reducing certain problems of breast cancer patients, such as sleeping disorders and emotional malfunctioning; therefore, it is suggested as an efficient solution for these patients’ problems.","PeriodicalId":44005,"journal":{"name":"Middle East Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2020-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47366333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5