Middle East Journal of Cancer最新文献_第6页

Psychological Status during COVID-19 Pandemic on the Patients with Cancer 新冠肺炎大流行期间癌症患者的心理状态

IF 0.4

Middle East Journal of Cancer Pub Date : 2021-04-21 DOI: 10.30476/MEJC.2021.89195.1511

K. Novin, B. Hassanlouei, M. Motamed, S. Faraji, M. Najafi, P. Fadavi, M. Sanei, A. G. Jolfaei, M. Garousi

{"title":"Psychological Status during COVID-19 Pandemic on the Patients with Cancer","authors":"K. Novin, B. Hassanlouei, M. Motamed, S. Faraji, M. Najafi, P. Fadavi, M. Sanei, A. G. Jolfaei, M. Garousi","doi":"10.30476/MEJC.2021.89195.1511","DOIUrl":"https://doi.org/10.30476/MEJC.2021.89195.1511","url":null,"abstract":"Background: Coronavirus disease 2019 (COVID-19) emerged in December 2019 in China and exhibited as a highly contagious viral infection which led to a high level of mortality and morbidity. It is followed by a great deal of complications, such as serious psychological disorders. There are a few studies evaluating the psychological status of COVID-19 on the patients with cancer in Iran. Method: This was a cross-sectional study carried out on 94 patients with cancer who referred to Haft-e-Tir hospital for radiotherapy and chemotherapy from 20 April to 15 may, 2020. The data collection tool was the impact of events scale-revised (IES-R). Results: The prevalence of anxiety disorders and obsessive compulsive disorder based on past psychiatric history in the patients was 11.7% and 2.1%, respectively. The results revealed that age was significantly related to avoidance dimension score (B=-0. 209, 95% CI: -0.084 to - 0.335). Regarding hyper arousal dimension score, the results were as follows: rural residency (B=5.091, 95% CI: 0.610 to 9.573), past psychiatric history (PPH) (B = 8.312, 95% CI: 4.314 to 12.310), and radiotherapy (B=-2.976, 95% CI: -5.878 to -0.074) had a statistically significant relationship with the hyper arousal dimension score. Conclusion: The patients with cancer had a severe form of COVID-19. Individuals with cancer who had a previous psychiatric history are more vulnerable to post-traumatic stress disorder symptoms after trauma.","PeriodicalId":44005,"journal":{"name":"Middle East Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2021-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42088483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

MicroRNAs Contribute to Metastasis by Regulating Autophagy: Recent Concepts 微小RNA通过调节自噬促进转移：最新概念

IF 0.4

Middle East Journal of Cancer Pub Date : 2021-04-18 DOI: 10.30476/MEJC.2021.88044.1452

S. Irani

引用次数: 0

Evaluation of Curcumin Nano-micelle on Proliferation and Apoptosis of HT29 and Hct116 Colon Cancer Cell Lines 姜黄素纳米胶束对HT29和Hct116结肠癌细胞增殖和凋亡的影响

IF 0.4

Middle East Journal of Cancer Pub Date : 2021-04-10 DOI: 10.30476/MEJC.2021.87699.1429

H. Mohammadi, M. Shokrzadeh, Omid Akbari-Dafsari, Nahid Amani, Mona Modanlou, Abbas Mohammadpour, M. Jafari-Sabet, R. Ataee

{"title":"Evaluation of Curcumin Nano-micelle on Proliferation and Apoptosis of HT29 and Hct116 Colon Cancer Cell Lines","authors":"H. Mohammadi, M. Shokrzadeh, Omid Akbari-Dafsari, Nahid Amani, Mona Modanlou, Abbas Mohammadpour, M. Jafari-Sabet, R. Ataee","doi":"10.30476/MEJC.2021.87699.1429","DOIUrl":"https://doi.org/10.30476/MEJC.2021.87699.1429","url":null,"abstract":"Background: Curcumin is a natural polyphenolic material with antioxidative, anti-inflammatory, and anticancer effects. In this study, we attempted to assay anti proliferative and apoptotic properties of polymeric micelles of curcumin on two colorectal cancer cell lines and normal human fibroblast cells. \u0000Method: In this experimental study, cancer cells HT29, HCT116 and normal human fibroblast cells (HGF) were subjected to concentrations of Nano- curcumin (1, 50, 100, 250, and 500 µg/ml). After incubation for 48 hours, cell viability was assessed with \"MTT\"(3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide) assay. Annexin V-FITC and Propidium iodide staining were done with flow cytometry for evaluation of apoptosis. The results were shown as mean ± standard deviation. Statistical significance was assessed utilizing ANOVA and Dunnetts t-test (P < 0.01). \u0000Results: According to MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay results, IC50 value of Nano- curcumin in HT29, HCT116, and HGF were 70.63, 123.9, and 168.53 µg/ml, respectively. We also discovered that Nano-curcumin can make indicative apoptosis in cancer cells, which could be compared with cisplatin<0.01. \u0000Conclusion: These results revealed remarkable anti-proliferative and apoptotic effects of polymeric Nano-micelles of curcumin in colorectal cancer cell lines.","PeriodicalId":44005,"journal":{"name":"Middle East Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2021-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46321070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum Interleukin-24 Levels in Gastric and Breast Cancers and Non-cancerous Inflammations 血清白细胞介素-24在胃癌、乳腺癌和非癌性炎症中的水平

IF 0.4

Middle East Journal of Cancer Pub Date : 2021-04-01 DOI: 10.30476/MEJC.2020.82945.1122

M. Khoshroo, M. Yazdanpanah, S. Yasrebi

{"title":"Serum Interleukin-24 Levels in Gastric and Breast Cancers and Non-cancerous Inflammations","authors":"M. Khoshroo, M. Yazdanpanah, S. Yasrebi","doi":"10.30476/MEJC.2020.82945.1122","DOIUrl":"https://doi.org/10.30476/MEJC.2020.82945.1122","url":null,"abstract":"Background: Human interleukin-24 (IL-24) is a cytokine belonging to the interleukin-10 (IL-10) family of cytokines, also known as melanoma differentiation-associated gene 7, due to its discovery as a tumor-suppressing protein. A tumor-suppressing protein, IL-24 is produced by a variety of cells, including cancerous and non-cancerous healthy cells. The aim of the present study was to evaluate serum IL-24 concentrations in different cancers and compare them with non-cancerous inflammations. \u0000Method: In this case-control study, we divided a total of 200 subjects into five groups of 40 control subjects without cancer and without Helicobacter Pylori (H. Pylori) infection, patients with gastric cancer and H. Pylori infection, patients with H. Pylori infection without cancer, and patients with breast cancer and without H. Pylori infection. We measured the serum IL-24 level using specific enzyme-linked immunosorbent assay (ELISA) kit; we analysed the data with SPSS software. \u0000Results: The level of IL-24 was significantly higher in breast cancer group (160.65±55pg/mL) (mean± SD) followed by gastric cancer with (76.2±16.27 pg/mL) (mean±SD) and without (72.5±17.84 pg/mL) (mean± SD) H. Pylori infection groups. The level of IL-24 in H. Pylori infected patients and controls were (32.78±12.96 pg/mL) (mean±SD) and (27.4±8.5 pg/mL (mean±SD)), respectively. \u0000Conclusion: The mechanisms by which IL-24 is produced may be different between immune and cancer cells and serum IL-24 is more likely generated by immune cells than tumor cells. In breast cancer patients, estrogen or other sex hormones may provoke IL-24 production.","PeriodicalId":44005,"journal":{"name":"Middle East Journal of Cancer","volume":"12 1","pages":"183-189"},"PeriodicalIF":0.4,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47025390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Improvement in the Survival of Esophageal Cancer Patients at Cancer Institute of Iran after Implementation of the Neo-adjuvant Chemo-radiation: Retrospective Cohort Study 伊朗癌症研究所实施新辅助化疗后食管癌症患者生存率的提高：回顾性队列研究

IF 0.4

Middle East Journal of Cancer Pub Date : 2021-03-28 DOI: 10.30476/MEJC.2021.84185.1205

Saeed Nemati, Maryam Hadji, Parissa Seifi, Mohammad Shirkhoda, M. Rajabpour, Nazanin Rajaei, M. Aghili, M. Mohagheghi, K. Zendehdel

{"title":"Improvement in the Survival of Esophageal Cancer Patients at Cancer Institute of Iran after Implementation of the Neo-adjuvant Chemo-radiation: Retrospective Cohort Study","authors":"Saeed Nemati, Maryam Hadji, Parissa Seifi, Mohammad Shirkhoda, M. Rajabpour, Nazanin Rajaei, M. Aghili, M. Mohagheghi, K. Zendehdel","doi":"10.30476/MEJC.2021.84185.1205","DOIUrl":"https://doi.org/10.30476/MEJC.2021.84185.1205","url":null,"abstract":"Background: Iran is a high-risk area with a poor prognosis for esophageal cancer. We conducted the present study to evaluate the survival rate of esophageal cancer after the introduction of neo-adjuvant chemo-radiation at the Cancer Institute of Iran. \u0000Method: We performed a retrospective cohort study and abstracted the data of 421 patients who referred to the Cancer Institute of Iran between 2007 and 2011. Life table and Kaplan-Meier approaches were applied to estimate 1, 3, and 5-year survival rates and corresponding 95% confidence intervals (CI). Multiple Cox regression model was recruited for investigating the association between 5-year survival rate and prognostic factors. \u0000Results: We found that 1, 3, and 5-year survival rates were 66.7%, 28.2, and 20.9%, respectively. The hazard ratio was significantly higher among the patients who has received definitive chemo-radiation therapy (Hazard ratio (HR) = 2.2, 95% CI: 1.1, 4.2), surgery (HR= 2.0 95% CI: 1.0, 3.7), and palliative care (HR= 4.2, 95% CI: 2.1, 1.8) compared to those who received neo-adjuvant chemo-radiation and surgery. We also found that the 5-year survival rate was doubled in the current study conducted between 2007 and 2011 (20.9%) compared to the previous one conducted between 1997 and 2006 (10.0%). Additionally, a considerable improvement was observed in 1 and 3-year survival rate of esophageal cancer at the Cancer Institute of Iran. \u0000Conclusion: Following the administration of neo-adjuvant chemo-radiation therapy, the prognosis of esophageal cancer has improved significantly at the Cancer Institute of Iran during the last decade. More data from other cancer centers and provinces of Iran are required.","PeriodicalId":44005,"journal":{"name":"Middle East Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2021-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42897433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

The Efficacy of siRNA Specific MDM2 in the Induction of Apoptosis in MCF-7 Breast Cancer Cell Line siRNA特异性MDM2在诱导MCF-7乳腺癌症细胞凋亡中的作用

IF 0.4

Middle East Journal of Cancer Pub Date : 2021-03-28 DOI: 10.30476/MEJC.2021.89554.1532

T. Kalantari, Bahram Mohseni-Aghdam, F. Nasri, G. Tamaddon, M. Kalantari

{"title":"The Efficacy of siRNA Specific MDM2 in the Induction of Apoptosis in MCF-7 Breast Cancer Cell Line","authors":"T. Kalantari, Bahram Mohseni-Aghdam, F. Nasri, G. Tamaddon, M. Kalantari","doi":"10.30476/MEJC.2021.89554.1532","DOIUrl":"https://doi.org/10.30476/MEJC.2021.89554.1532","url":null,"abstract":"Background: A high number of human breast cancers overexpress the murine double minute (MDM2) gene which blocks the p53 protein which plays an important role in arresting the cell growth. The present study aimed to investigate the efficacy of siRNA specific MDM2 in knocking down MDM2 and its subsequent effects on p53 to exert antiproliferative effects on Michigan Cancer Foundation-7 (MCF-7) breast cancer cells. \u0000Method: In this in vitro study, we used the specific siRNA of the MDM2 gene to knock down the expression of the MDM2 protein in the MCF-7 cell line. The expression of MDM2, BCL2-associated X (BAX), BH3 interacting-domain death agonist (BID), and B cell lymphoma 2 (BCL2) genes was evaluated using the Real-time PCR technique. The apoptosis level was also assessed using the flow cytometry technique by the Annexin V test. \u0000Results: The results showed that the entry of MDM2 siRNA into MCF-7 cells significantly reduced the mRNA expression of MDM2 gene (P-value <0.05). Besides, the expression of the anti-apoptotic gene of BCL2 significantly decreased (P-value <0.05) in transfected MCF-7 cells, while that of BAX and BID genes increased (P-value <0.05). \u0000Conclusion: Based on the results, MDM2 inhibition is conducive to prevent cancer metastasis by the induction of cancer cell apoptosis. Moreover, it can be considered in cancer therapy along with chemotherapy.","PeriodicalId":44005,"journal":{"name":"Middle East Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2021-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47370580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Antiproliferative Effects of Different Concentrations of Auraptene on MCF7 Cancer Cell 不同浓度Auraptene对MCF7癌细胞的抗增殖作用

IF 0.4

Middle East Journal of Cancer Pub Date : 2021-03-14 DOI: 10.30476/MEJC.2021.87927.1448

M. Abroudi, G. Dadashizadeh, Mohamadreza Sam’e, K. Goudarzi, Omid Gholami, Abolfazl Shakiba, D. Mahdian

{"title":"Antiproliferative Effects of Different Concentrations of Auraptene on MCF7 Cancer Cell","authors":"M. Abroudi, G. Dadashizadeh, Mohamadreza Sam’e, K. Goudarzi, Omid Gholami, Abolfazl Shakiba, D. Mahdian","doi":"10.30476/MEJC.2021.87927.1448","DOIUrl":"https://doi.org/10.30476/MEJC.2021.87927.1448","url":null,"abstract":"Background: Auraptene is a coumarin derivative extracted from citrus species, such as lemon, grapefruit, and orange. To date, auraptene has shown antioxidant, antibacterial, anti-inflammatory, antiproliferative, antiapoptotic, and antitumor activities. Among these, antitumor activity has become more important over the recent years while its underlying mechanism is not fully understood. The current study was conducted to evaluate the antiproliferative effect of auraptene and its mechanisms on MCF7 cell line. \u0000Method: This experimental study investigated whether hesperidin affected the proliferation of MCF-7 human breast cancer cells. MCF7 cells were cultured in DMEM medium with 10% fetal bovine serum, 100 µg/ml streptomycin, and 100 units/ml penicillin. The cells were incubated in order to be treated with different concentrations of auraptene and time points. Subsequently, the amount of cytotoxicity and apoptosis was measured utilizing MTT and PI staining. \u0000Results: The MTT assay revealed that auraptene had a significant effect on cell viability and induced apoptosis in MCF7 cells at concentrations of 75, 100, 130, 170, and 200 μM. \u0000Conclusion: In this study, through the induction of apoptosis, auraptene prevented the growth and inhibited the proliferation of MCF7 cells at high concentrations in a dose-dependent manner. However, further investigation is needed to reveal the mechanisms of auraptene concerning apoptosis induction.","PeriodicalId":44005,"journal":{"name":"Middle East Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2021-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47494436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Ovarian Yolk Sac Tumor Coexisting with the Involvement of the Fallopian Tube in an Eight-Month-Old Girl: A Rare Case Report 8个月女童卵巢卵黄囊肿瘤伴输卵管累及1例罕见病例报告

IF 0.4

Middle East Journal of Cancer Pub Date : 2021-03-13 DOI: 10.30476/MEJC.2021.89096.1505

S. Delshad, N. Piri, F. Sharifi, Zahra Mirmoghadam

引用次数: 0

Kimura Disease: Report of a Rare Case 木村病：一例罕见病例报告

IF 0.4

Middle East Journal of Cancer Pub Date : 2021-03-13 DOI: 10.30476/MEJC.2021.85062.1259

N. Moazzen, Farahzad Jabbari, Samaneh Norooziasl, N. Ariaee, A. Amirabadi

{"title":"Kimura Disease: Report of a Rare Case","authors":"N. Moazzen, Farahzad Jabbari, Samaneh Norooziasl, N. Ariaee, A. Amirabadi","doi":"10.30476/MEJC.2021.85062.1259","DOIUrl":"https://doi.org/10.30476/MEJC.2021.85062.1259","url":null,"abstract":"Kimura disease is a rare entity causing subcutaneous swellings and lymphadenopathy, with hardly 120 cases reported worldwide. It is mainly seen in Asian men. Herein, we present a typical case that presents with submandibular mass and persistent eosinophilia. The patient was a 38-year-old man suffering from left submandibular mas for the last 5 years. It has happened upon a dental infection. Treatment with prednisolone resulted temporary decrease in the size of the lesion, but it wouldn't disappear totally. Since the swelling didn't get improved an excisional biopsy was conducted. The high rate of the eosinophil and histopathology results conducted us to diagnose him with Kimoura. Histologically Kimura disease presents as lymphadenopathy with preserved lymph node architecture and reactive and prominent germinal centers. Dense eosinophilic infiltration of the interfollicular zones, lysis of the follicles, and occasionally microabscesses are seen. Granuloma formations contain infiltration of eosinophils, lymphocytes, plasma cells, and histiocytes. Tissue fibrosis, sclerosis, and vascular proliferation are also present. Vessels remain thin-walled with cubical endothelial cells. This was in line with our patient symptoms.","PeriodicalId":44005,"journal":{"name":"Middle East Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2021-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49429425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autophagy Flux Correlates with Upregulation of AKT-1 in RAS Mutated Colon Cancer Cells RAS突变的癌症细胞自噬流量与AKT-1上调的关系

IF 0.4

Middle East Journal of Cancer Pub Date : 2021-03-09 DOI: 10.30476/MEJC.2021.85836.1307

Hamid Behrouj, A. Mahmoudzadeh, S. Ghavami, P. Mokarram

{"title":"Autophagy Flux Correlates with Upregulation of AKT-1 in RAS Mutated Colon Cancer Cells","authors":"Hamid Behrouj, A. Mahmoudzadeh, S. Ghavami, P. Mokarram","doi":"10.30476/MEJC.2021.85836.1307","DOIUrl":"https://doi.org/10.30476/MEJC.2021.85836.1307","url":null,"abstract":"Background: The AKT/PKB (protein kinase B) kinase is the main regulator of autophagy in mammalian cells, which consists of three isoforms, including AKT-1, AKT-2, and AKT-3. Rat sarcoma viral oncogene homolog (RAS), known as the most frequently mutated oncogene in colorectal cancers, is one of the major activators of AKT signaling. However, the relationship between AKT isoforms expression and autophagy level in RAS-driven cancer cells has not been fully investigated. \u0000Method: In this experimental in vitro study, RAS mutated colon cancer cell lines (HCT116, SW480, and LS180) and HT29 cells, which are the wild type of RAS, were cultured and real-time polymerase chain reaction (RT-PCR) was utilized to determine the mRNA level of AKT-1, AKT-2, and autophagy markers, including microtubule-associated protein 1 light chain-3B (LC3B) and p62/sequestosome-1 (p62). In addition, Western blotting was performed to assess the protein expression of p62 and LC3B lipidation. \u0000Results: We found that RAS mutated colon cancer cells up-regulate basal autophagy. Moreover, highly expressed AKT-1 was observed in RAS mutated colon cancer cells. However, no significant differences were found in AKT-2 expression between RAS-driven cells and HT29 cells. \u0000Conclusion: Our obtained data suggested that RAS-driven colon cancer cells regulated the autophagy machinery, possibly, through the upregulation of AKT-1 isoform.","PeriodicalId":44005,"journal":{"name":"Middle East Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2021-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49567342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4