Journal of Mind and Medical Sciences最新文献_第7页

The comparison of local tumor control after microwave ablation, surgical resection and combined treatment for colorectal liver metastases 结直肠癌肝转移灶微波消融、手术切除及联合治疗后局部肿瘤控制的比较

IF 1.8

Journal of Mind and Medical Sciences Pub Date : 2022-04-10 DOI: 10.22543/7674.91.p125132

F. Güngören, C. Erol, A. Bilici, M. Dayangaç, M. Şeker, Ö. Ölmez, O. Yaprak, Özcan Yıldız, Mustafa Öncel

{"title":"The comparison of local tumor control after microwave ablation, surgical resection and combined treatment for colorectal liver metastases","authors":"F. Güngören, C. Erol, A. Bilici, M. Dayangaç, M. Şeker, Ö. Ölmez, O. Yaprak, Özcan Yıldız, Mustafa Öncel","doi":"10.22543/7674.91.p125132","DOIUrl":"https://doi.org/10.22543/7674.91.p125132","url":null,"abstract":"Aim. We aimed to compare the local therapeutic efficiency of microwave ablation (MWA), surgical resection, and combined treatment, assess the outcomes, and identify predictive factors for local treatment response in colorectal liver metastases (CLMs). Methods. From March 2013 to September 2019, a total of 54 patients with 302 CLMs were enrolled in this retrospective study. Eleven patients (20.4%) were treated with MWA, 9 patients (16.7%) with surgery, and 34 patients (63%) with the combined method. Univariate and multivariate analyses were performed to investigate overall survival (OS) and hepatic progression-free survival (HPFS) using the Cox proportional hazard regression model. The logistic regression analysis was used to identify the predictive factors for the local treatment response. Results. Total treatment response was achieved in 46.3% (n=25) of the patients. Local tumor progression was seen in 7.4% (n=4) of the patients, and the rate of intrahepatic distal recurrence was 46.3% (n=25). There were no significant differences in HPFS and OS between the three groups (p=0.56 and 0.90, respectively). Younger age (<60), smaller (≤ 2 cm) or fewer (≤3) liver metastases, and wild-type RAS were predictive for higher rates of local treatment response (OR 0.22, 95% CI 0.15-0.93, p=0.04; OR 1.12, 95% CI 0.54-2.12, p=0.029; OR 1.37, 95% CI 0.97-2.37, p=0.035; OR 0.23, 95% CI 0.10-0.85, p=0.028, respectively). Conclusions. The results of this study reveal that the use of MWA, alone or combined with resection, may achieve high local treatment response and similar survival rates compared to patients undergoing resection, suggesting that MWA could potentially be preferred over surgical procedures.","PeriodicalId":43987,"journal":{"name":"Journal of Mind and Medical Sciences","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2022-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42947973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Laboratory findings in COVID-19 - alterations of hematological, immunological, biochemical, hormonal and other lab panels: a narrative review COVID-19的实验室结果-血液学、免疫学、生化、激素和其他实验室检测结果的改变:叙述性回顾

IF 1.8

Journal of Mind and Medical Sciences Pub Date : 2022-04-10 DOI: 10.22543/7674.91.p3855

Yousef Rasmi, L. Saavedra, M. Cozma, H. El-Nashar, S. Aly, Nouran M. Fahmy, O. Eldahshan, M. El-Shazly, E. Dobrica, H. Kord-Varkaneh, Camelia Diaconu, M. Gaman

引用次数: 3

Modern interpretation of risk factors in breast cancer of women 女性乳腺癌危险因素的现代解释

IF 1.8

Journal of Mind and Medical Sciences Pub Date : 2022-04-10 DOI: 10.22543/7674.91.p8895

O. Bălălău, R. Scaunasu, O. Olaru, A. Dumitriu, S. Păunică, L. Andronache, A. Stănescu

{"title":"Modern interpretation of risk factors in breast cancer of women","authors":"O. Bălălău, R. Scaunasu, O. Olaru, A. Dumitriu, S. Păunică, L. Andronache, A. Stănescu","doi":"10.22543/7674.91.p8895","DOIUrl":"https://doi.org/10.22543/7674.91.p8895","url":null,"abstract":"Breast cancer is a major public health problem, being the most common cancer diagnosed in women and accounting for more than 1 in 10 new diagnoses of cancer each year. It is the most common neoplasm of women under the age of 40 and the second leading cause of cancer death in this age group, with more frequent detection of pathogenic mutations in breast cancer susceptibility genes. Women with BRCA1 and BRCA2 mutations are about 70% more likely to develop breast cancer. The incidence is rising in most countries and it is expected to have a growing trend in the next 20 years, despite the current efforts to prevent the disease. In order to improve the survival rate, it is necessary to make a diagnosis as early as possible and to initiate the appropriate therapeutic management as soon as possible. Therefore, in order to detect breast formations, mammography screening is very important, breast density being an important factor in predicting the risk of breast cancer. Thus, the presence of high breast density represents a 4-6 times higher risk of developing breast cancer compared to women with low breast density. Aging and menopause are also risk factors for breast cancer. Hormone replacement therapy for postmenopausal women has the benefit of relieving symptoms such as hot flashes, depression or sleep disturbances, but it increases the risk of developing breast cancer.","PeriodicalId":43987,"journal":{"name":"Journal of Mind and Medical Sciences","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2022-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45199792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Inflammatory bowel disease: pathogenesis, diagnosis and current therapeutic approach 炎症性肠病:发病机制、诊断和目前的治疗方法

IF 1.8

Journal of Mind and Medical Sciences Pub Date : 2022-04-10 DOI: 10.22543/7674.91.p5677

A. Silaghi, V. Constantin, B. Socea, P. Banu, Vladimir Sandu, L. Andronache, A. Dumitriu, S. Păunică

{"title":"Inflammatory bowel disease: pathogenesis, diagnosis and current therapeutic approach","authors":"A. Silaghi, V. Constantin, B. Socea, P. Banu, Vladimir Sandu, L. Andronache, A. Dumitriu, S. Păunică","doi":"10.22543/7674.91.p5677","DOIUrl":"https://doi.org/10.22543/7674.91.p5677","url":null,"abstract":"Inflammatory bowel disease is a group of conditions of unknown etiology, represented by Crohn’s disease and ulcerative colitis and characterized by the presence of intestinal wall inflammation. From the first cases described to date, several studies have been performed to elucidate the cause of inflammatory bowel disease. Generally, the genetic factors predispose to their occurrence while epigenetic and environmental factors trigger them. Genetic factors are mutations of the genes involved in the response and recognition of immune cells to different pathogens. The most studied epigenetic and environmental factors are smoking (which predisposes to Crohn’s disease and can be protective for ulcerative colitis), lack of vitamin D, a diet rich in sugars and low in flavonoids and fibers. The diagnosis is usually established by endoscopy and biopsy. Recent technologies can perform live biopsies such as endocytoscopy or confocal laser endomicroscopy, with an accuracy of 100% compared to classical methods. Therapy involves several classes of drugs, preferably in association with diet and lifestyle changes. In case of complications or in non-responsive diseases, surgery must be considered, as documented for ulcerative colitis that can be cured by removing the entire colon. The purpose of this review is to present recent findings on pathology, as well as modern diagnosis and treatment methods for IBD.","PeriodicalId":43987,"journal":{"name":"Journal of Mind and Medical Sciences","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2022-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47198780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Anxiety sensitivity, uncertainty and recursive thinking: A continuum on Cyberchondria conditions during the Covid Outbreak 焦虑敏感性、不确定性和递归思维:新冠疫情期间网络病症的连续体

IF 1.8

Journal of Mind and Medical Sciences Pub Date : 2022-04-10 DOI: 10.22543/7674.91.p7887

C. Mento, Maria Catena Silvestri, Pilar Amezaga, Maria R. Anna Muscatello, Valentina Romeo, Antonio Bruno, C. Cedro

{"title":"Anxiety sensitivity, uncertainty and recursive thinking: A continuum on Cyberchondria conditions during the Covid Outbreak","authors":"C. Mento, Maria Catena Silvestri, Pilar Amezaga, Maria R. Anna Muscatello, Valentina Romeo, Antonio Bruno, C. Cedro","doi":"10.22543/7674.91.p7887","DOIUrl":"https://doi.org/10.22543/7674.91.p7887","url":null,"abstract":"Background. Cyberchondria is a term used to refer to excessive surfing the web looking for health care information, excessive checking behavior being related to health-related anxiety. This period of quarantine for the Covid-19 pandemic is increasing the pathological use of the internet, and the excessive surfing the web looking for health care information. Another dimension related to the Covid-19 outbreak refers to uncertainty intolerance, for this reason being necessary for the healthcare professionals to provide clear and linear information. Aim. The aim of this review is to identify the psychological correlations connected to cyberchondria in the quarantine period. Methods. Following the PRISMA guidelines, we carried out a systematic review of the literature on PubMed. The terms used for the search were “Cyberchondria” OR “Anxiety” AND “Quarantine”. Results. As resulting from the reviewed literature, there is a relationship between anxiety for one’s own state of health and cyberchondria, with negative psychological effects of quarantine, including post-traumatic stress symptoms, depression, anxiety, low mood, irritability, insomnia, uncertainty, emotional exhaustion, this condition being associated with hypervigilance, and catastrophic misinterpretation of bodily signs. Conclusion. In the light of this and according to the literature, it would be desirable that research can further explore the factors influencing the increase in cyberchondria in the future.","PeriodicalId":43987,"journal":{"name":"Journal of Mind and Medical Sciences","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2022-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42702985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diet and Food chemicals increasing the risk of colorectal cancer – literature review 饮食和食品化学物质增加结直肠癌癌症风险——文献综述

IF 1.8

Journal of Mind and Medical Sciences Pub Date : 2022-04-10 DOI: 10.22543/7674.91.p118124

M. Tudosie, Andreea Pauna, C. Stefani, I. Staicu

{"title":"Diet and Food chemicals increasing the risk of colorectal cancer – literature review","authors":"M. Tudosie, Andreea Pauna, C. Stefani, I. Staicu","doi":"10.22543/7674.91.p118124","DOIUrl":"https://doi.org/10.22543/7674.91.p118124","url":null,"abstract":"Colorectal cancer is a common form of cancer nowadays. There are many risk factors in the pathogenesis of colorectal cancer. The malignant proliferation is caused by one or more genetic mutations, which activate oncogenes and deactivate tumor suppressor genes. Some factors cannot be changed, such as a person's age or family history. An essential aspect in the pathogenesis of colorectal cancer is the choice of lifestyles, such as a high-fat diet, smoking, and excess alcohol. Carcinogens can be either natural or chemical. The mechanisms by which carcinogens initiate tumor formation are genetic or non-genotoxic. The most common form of colorectal cancer is found in people who ingest chemicals that, once ingested, reach the large intestine, thus causing malignant lesions. The Western diet and the metabolic syndrome are risk factors for colorectal cancer, due to gut microbiota changes and low-grade chronic inflammation. Among the most important diet carcinogens are nitrosamines, hydrazines, organophosphates, acetaldehyde, and heterocyclic amines. Screening programs, especially among people over 50 years of age, and with multiple risk factors are extremely important in detecting colorectal cancers in the early stages and in improving the long-term prognosis in such patients.","PeriodicalId":43987,"journal":{"name":"Journal of Mind and Medical Sciences","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2022-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41923684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

The obstetrical management of HIV-positive pregnancy 艾滋病毒阳性妊娠的产科管理

IF 1.8

Journal of Mind and Medical Sciences Pub Date : 2022-04-10 DOI: 10.22543/7674.91.p111117

M. Loghin, Petre Gorescki, R. Sima, L. Pleș, D. Balan, I. Păunică, O. Bălălău

{"title":"The obstetrical management of HIV-positive pregnancy","authors":"M. Loghin, Petre Gorescki, R. Sima, L. Pleș, D. Balan, I. Păunică, O. Bălălău","doi":"10.22543/7674.91.p111117","DOIUrl":"https://doi.org/10.22543/7674.91.p111117","url":null,"abstract":"The human immunodeficiency virus (HIV) infection is a real public health problem in both developing and developed countries. HIV infection has not been treated efficiently for a long time, with HIV-positive women at increased risk of transmitting the infection to their newborns. Without the appropriate treatment, the evolution of the infection is relatively fast. Due to the antiretroviral treatment, the progression of the disease is blocked during the period of asymptomatic infection, and the risk of neonatal transmission is very low. HIV-positive patients undergoing antiretroviral therapy develop undetectable viremia and, in such situations, patients no longer have a risk of transmitting the infection. The antiretroviral medication is a combination of several classes of drugs (protease inhibitors, nucleoside and non-nucleoside reverse transcriptase inhibitors, integrase inhibitors and CCR5 inhibitors) whose aim is to stop the viral replication at different stages. The infection is most often transmitted in the perinatal period, so it is very important that we know the maternal viremia and choose the type of birth with the lowest risk of transmitting the infection to the fetus. For this reason, any HIV-positive patient with detectable viremia at childbirth should receive treatment during labor and delivery, with a nucleoside or non-nucleoside reverse transcriptase inhibitor that crosses the fetal-placental barrier.","PeriodicalId":43987,"journal":{"name":"Journal of Mind and Medical Sciences","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2022-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44813545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The VESPA Project: Virtual Reality Interventions for Neurocognitive and Developmental Disorders VESPA项目：神经认知和发育障碍的虚拟现实干预

IF 1.8

Journal of Mind and Medical Sciences Pub Date : 2022-04-10 DOI: 10.22543/7674.91.p1627

Emanuele Merlo, Liam Myles, Salvatore Pappalardo

{"title":"The VESPA Project: Virtual Reality Interventions for Neurocognitive and Developmental Disorders","authors":"Emanuele Merlo, Liam Myles, Salvatore Pappalardo","doi":"10.22543/7674.91.p1627","DOIUrl":"https://doi.org/10.22543/7674.91.p1627","url":null,"abstract":"VESPA is a financed project supported by the Sicilian Regional Research and Development funds, and it is structured by the development, research and validation of Virtual Reality (VR) based application for the diagnosis and treatment of neurocognitive conditions. In particular, this article presents its characteristics, referred to as the first (2013-2015) and second (2021-ongoing) generations of VESPA, with particular reference to literature regarding the VR technology application and development, the VR treatment of neurocognitive conditions and prior versions of this intervention. Through a comprehensive review of the research conducted over the last 5 years, evidence has emerged supporting VESPA’s aim and scopes, highlighting how the application of VR can be considered to add value to typical rehabilitation/therapeutic paths. VESPA project generations are then presented in detail, including specific session/task battery characteristics, 2.5D, 3D and 5D typologies, system usability and architecture and pathological domain-based dynamics and features. The discussion about VESPA will highlight the current advantages along with limitations and future directions.","PeriodicalId":43987,"journal":{"name":"Journal of Mind and Medical Sciences","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2022-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45650382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Acetaminophen, a therapeutic or an extremely toxic remedy – a review 对乙酰氨基酚，一种治疗或剧毒的药物-回顾

IF 1.8

Journal of Mind and Medical Sciences Pub Date : 2022-04-10 DOI: 10.22543/7674.91.p102110

Genica Caragea, Oana Avram, Andreea Pauna, A. Costea, M. Tudosie

{"title":"Acetaminophen, a therapeutic or an extremely toxic remedy – a review","authors":"Genica Caragea, Oana Avram, Andreea Pauna, A. Costea, M. Tudosie","doi":"10.22543/7674.91.p102110","DOIUrl":"https://doi.org/10.22543/7674.91.p102110","url":null,"abstract":"When a new coronavirus appeared in the late 2019, identified as the cause of several cases of pneumonia in Wuhan, Paracetamol was initially reported to be the preferable antipyretic medication, choice which was detrimental to the use of other drugs. People have resorted to buying large stocks of Paracetamol and some have used it in large doses, regardless of the consequences. However, the Paracetamol (Acetaminophen) overdose remains the leading cause of death or transplantation due to acute liver failure in many parts of the world. This review aims at presenting the pharmacokinetics, the clinical signs, and the risk factors for systemic toxicity associated with Paracetamol overdose, as well as the current therapeutic approach. Paracetamol is primarily metabolized in the liver, by glucuronidation and sulfation. In case of a Paracetamol overdose, a large amount of NAPQI is conjugated with glutathione, and this process is due to a major depletion of glutathione, thus leading to hepatic necrosis, renal failure, and encephalopathy. The evaluation of serum acetaminophen levels by analytical methods is extremely useful both for the diagnosis and the therapy monitoring.","PeriodicalId":43987,"journal":{"name":"Journal of Mind and Medical Sciences","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2022-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45574600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

The surgical management of pancreatic pseudocysts – outcomes on a group of seven patients 胰腺假性囊肿的外科治疗——一组7名患者的结果

IF 1.8

Journal of Mind and Medical Sciences Pub Date : 2022-04-10 DOI: 10.22543/7674.91.p168174

Mihai Faur, A. Moisin, A. Sabău, D. Sabau

引用次数: 4