Norge Vergara MD, Roseann I. Wu MD, MPH, Stuti Shroff MD, PhD, Cindy M. McGrath MD
{"title":"Cytology and histology: Complementary diagnostic modalities during endoscopic ultrasound-guided tissue acquisition","authors":"Norge Vergara MD, Roseann I. Wu MD, MPH, Stuti Shroff MD, PhD, Cindy M. McGrath MD","doi":"10.1016/j.tgie.2017.10.005","DOIUrl":"10.1016/j.tgie.2017.10.005","url":null,"abstract":"<div><p><span>Endoscopic ultrasound-guided fine needle aspiration (FNA) has become the preferred method of sampling accessible intraintestinal and extraintestinal abdominal masses<span>, as well as peri-intestinal lymphadenopathy. Despite the success of endoscopic ultrasound-guided-FNA, there are settings in which </span></span>FNA<span><span> appears to underperform when compared to other techniques. To overcome some of the limitations of FNA, endoscopists have used small-gauge cutting and core needle biopsies<span> in conjunction with or as an alternative to FNA. This review, from the pathologists′ perspective, will cover these complementary techniques, including definitions, advantages, and limitations, as well as the role of rapid on-site evaluation. Our conclusions include that cytologic specimens, which use alcohol-based fixation during processing, appear preferable for molecular testing that relies on nucleic acid preservation, such as next-generation sequencing. However, core biopsy should be considered when </span></span>immunohistochemistry and tissue architectural details are required for diagnosis.</span></p></div>","PeriodicalId":43887,"journal":{"name":"Techniques in Gastrointestinal Endoscopy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tgie.2017.10.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44558447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Saurabh S. Mukewar MD, V. Raman Muthusamy MD, MAS, FACG, FASGE, AGAF
{"title":"Future directions in endoscopic ultrasound-guided tissue acquisition","authors":"Saurabh S. Mukewar MD, V. Raman Muthusamy MD, MAS, FACG, FASGE, AGAF","doi":"10.1016/j.tgie.2017.11.004","DOIUrl":"10.1016/j.tgie.2017.11.004","url":null,"abstract":"<div><p>Endoscopic ultrasound-guided tissue acquisition (EUS-TA) is safe and has a high diagnostic yield. Multiple factors affect the outcome of EUS-TA such as operator experience, procedure technique, needle-type, and cytopathologist training and experience. There have been numerous advances aiming to increase the diagnostic yield of EUS-TA. These include novel devices, modified tissue acquisition techniques, enhancements in EUS imaging, improved tissue processing methods, and increasingly frequent molecular and genetic testing of acquired tissue. Importantly, recent advances in personalized medicine may require greater amounts of tissue to be acquired to guide subsequent oncotherapy. As a result of all these new developments, several additional questions have arisen including defining the precise role of EUS-guided fine-needle biopsy, the optimal technique for EUS-TA, and standardization of tissue processing protocols. This review discusses recent advances and future directions regarding EUS-TA.</p></div>","PeriodicalId":43887,"journal":{"name":"Techniques in Gastrointestinal Endoscopy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tgie.2017.11.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41428366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jared J. Rejeski MD, Girish Mishra MD, MS, FASGE, FACG, FACP
{"title":"Endoscopic ultrasound-guided tissue acquisition of subepithelial masses","authors":"Jared J. Rejeski MD, Girish Mishra MD, MS, FASGE, FACG, FACP","doi":"10.1016/j.tgie.2017.12.001","DOIUrl":"10.1016/j.tgie.2017.12.001","url":null,"abstract":"<div><p>Difficult to diagnose on routine endoscopy<span>, subepithelial masses typically require further investigation given their potential for malignancy<span>. Endoscopic ultrasound has become an indispensable addition to the clinical algorithm; however, tissue sampling may still be necessary to provide an accurate diagnosis. Several modalities and variations within each modality exist for endoscopic tissue acquisition. While bite-on-bite techniques have traditionally produced disappointing results, newer techniques may improve clinical use. Fine-needle aspiration, currently recognized as the standard bearer, is plagued by modest diagnostic yields in randomized studies. Similar to fine-needle aspiration in technique, fine-needle biopsy is emerging as safe and successful with the introduction of improved needle technology. Additionally, new and exciting endoscopic techniques such as submucosal tunneling may change the paradigm of subepithelial management in the future. The following article will discuss techniques specific to endoscopic ultrasound-guided tissue acquisition.</span></span></p></div>","PeriodicalId":43887,"journal":{"name":"Techniques in Gastrointestinal Endoscopy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tgie.2017.12.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47903462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ihab I. El Hajj MD, MPH, Mohammad Al-Haddad MBBS, MSc
{"title":"Endoscopic ultrasound-guided tissue acquisition of pancreatic masses","authors":"Ihab I. El Hajj MD, MPH, Mohammad Al-Haddad MBBS, MSc","doi":"10.1016/j.tgie.2018.01.002","DOIUrl":"10.1016/j.tgie.2018.01.002","url":null,"abstract":"<div><p><span>Endoscopic ultrasound (EUS) has assumed an increasing role in the management of pancreaticobiliary disease over the past 2 decades but its impact is particularly evident in the management of pancreatic masses. EUS helps improve patients′ outcomes by enhancing tumor detection and staging while providing safe and reliable tissue diagnosis. This review provides an evidence-based approach to the use of EUS for the diagnosis of </span>pancreatic cancer, its staging, and for the determination of resectability compared to other imaging modalities. We will focus on techniques specific to obtaining tissue from solid pancreatic masses and will review best practices in EUS-guided tissue acquisition.</p></div>","PeriodicalId":43887,"journal":{"name":"Techniques in Gastrointestinal Endoscopy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tgie.2018.01.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55156067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Endoscopic ultrasound-guided tissue acquisition of lymph nodes","authors":"Juan Reyes Genere MD , Uzma D. Siddiqui MD, FASGE","doi":"10.1016/j.tgie.2018.01.004","DOIUrl":"10.1016/j.tgie.2018.01.004","url":null,"abstract":"<div><p><span><span>One of the most common indications for endoscopic ultrasound (EUS)-guided tissue sampling is to diagnose the etiology of suspicious </span>lymphadenopathy. Although most cases of lymphadenopathy are benign and self-limiting, patients with deep-seated lymph nodes living in tuberculosis endemic areas or with suspected </span>malignancy<span><span><span> require tissue diagnosis to guide treatment. Fine-needle aspirate and fine-needle biopsy systems have excellent reliability for evaluating both benign and malignant lymph node diseases. The advent of new technologies and addition of ancillary </span>molecular diagnostics have improved the diagnostic potential obtained by fine-needle sampling. In turn, the clinical applications of EUS tissue sampling have evolved and further expanded to include </span>granulomatous diseases and lymphoma. Optimizing tissue acquisition to obtain high-quality specimens is of utmost importance and may be achieved with operative strategies unique to lymph node sampling. This chapter discusses the powerful clinical impact of EUS-guided lymph node sampling and technical considerations of optimizing diagnostic yield.</span></p></div>","PeriodicalId":43887,"journal":{"name":"Techniques in Gastrointestinal Endoscopy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tgie.2018.01.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55156125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ahmed Akhter MD , Mark E. Benson MD , Deepak V. Gopal MD, FRCP(C), FACP, AGAF, FASGE, FACG
{"title":"Endosonographic drainage of pancreatic fluid collections and walled-off necrosis","authors":"Ahmed Akhter MD , Mark E. Benson MD , Deepak V. Gopal MD, FRCP(C), FACP, AGAF, FASGE, FACG","doi":"10.1016/j.tgie.2017.11.002","DOIUrl":"10.1016/j.tgie.2017.11.002","url":null,"abstract":"<div><p><span>Endosonographic drainage of pseudocysts<span><span> and walled-off necrosis (WON) has not been standardized. Drainage of pseudocysts via endosonographic guidance has high rates of technical success via the transmural approach. Alternative modalities including transpapillary endoscopic retrograde pancreatography with </span>pancreatic duct<span> sphincterotomy and pancreatic duct </span></span></span>stent placement are options for patients with small pseudocysts and in the presence of pancreatic duct disruption. Drainage of WON has a variety of approaches and may require a combination of endoscopic or percutaneous techniques to achieve the optimal outcome. Endosonographic drainage of WON has lower rates of mortality and morbidity compared to surgical intervention. Several options regarding stent placement exist including the use of fully covered self-expandable metal stents and lumen-apposing metal stents. Depending upon their properties, each type of stent carries its own risk including the risk of migration. The endoscopist performing drainage of these fluid collections must take into account the number and size of these collections as well as the presence and amount of necrotic debris in order to choose the most appropriate technique and equipment in order to achieve optimal outcomes.</p></div>","PeriodicalId":43887,"journal":{"name":"Techniques in Gastrointestinal Endoscopy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tgie.2017.11.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48562672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Role and technique of endoscopic ultrasound placement of fiducial markers in gastrointestinal malignancies","authors":"Antonio R. Cheesman MD, Christopher J. DiMaio MD","doi":"10.1016/j.tgie.2017.10.009","DOIUrl":"10.1016/j.tgie.2017.10.009","url":null,"abstract":"<div><p><span>Stereotactic body radiation therapy<span> may be used in the neoadjuvant, adjuvant, or palliative treatment of </span></span>multiple cancers<span>. Fiducials serve as radiographic reference points for real-time dynamic tracking and accurate radiation delivery. Endoscopic ultrasound<span><span> with real-time Doppler imaging is a safe minimally invasive approach for fiducial implantation in lesions both within and adjacent to the gastrointestinal lumen. The decision to incorporate image-guided radiotherapy and specifics regarding fiducials and their use in a patient’s treatment<span> plan depends on the multidisciplinary collaboration between gastroenterologists, radiation oncologists, medical oncologists, and surgical oncologists. This article will review the indications, controversies in timing, and use of endoscopic ultrasound-guided fiducial placement, the various types of </span></span>fiducial markers, delivery systems, and deployment techniques available. Also covered will be associated technical and clinical success rates, in addition to previously reported complications.</span></span></p></div>","PeriodicalId":43887,"journal":{"name":"Techniques in Gastrointestinal Endoscopy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tgie.2017.10.009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44442886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Endoscopic ultrasound directed gastroenterostomy","authors":"Theodore W. James MD, Todd H. Baron MD","doi":"10.1016/j.tgie.2017.10.001","DOIUrl":"10.1016/j.tgie.2017.10.001","url":null,"abstract":"<div><p><span><span>Gastric outlet obstruction (GOO) is typically caused by intrinsic or extrinsic obstruction of the pyloric channel or </span>duodenum. Surgical approaches to bypassing the obstruction have been the mainstay of therapy, though recent developments in </span>endoscopy<span><span> have allowed for a minimally invasive approach to managing GOO. The development of endoscopic ultrasound-guided gastroenterostomy<span> (EUS-GE) represents a major advancement in the management of GOO. EUS-GE involves placement of a covered self-expandable metal stent into either the third or fourth portion of the duodenum to create a gastroduodenostomy or into the </span></span>jejunum<span> to create a gastrojejunostomy. In this review, we will discuss the different approaches to EUS-GE and the indications for each approach including direct EUS-GE, EUS-guided balloon-occluded GE, assisted EUS-GE, and contrast-enhanced EUS-GE.</span></span></p></div>","PeriodicalId":43887,"journal":{"name":"Techniques in Gastrointestinal Endoscopy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tgie.2017.10.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46463680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Endoscopic ultrasound celiac plexus block and neurolysis","authors":"Ashley Faulx MD, Peter J. Lee MBChB","doi":"10.1016/j.tgie.2017.10.007","DOIUrl":"10.1016/j.tgie.2017.10.007","url":null,"abstract":"<div><p><span><span>Over the last decade, endoscopic ultrasound-guided celiac plexus block and celiac plexus </span>neurolysis (CPN) have been established as effective and safe interventions to palliate visceral abdominal pain resulting from </span>chronic pancreatitis<span><span><span> and pancreatic cancer<span>, respectively. Endoscopic ultrasound-guided approach has advantages over the percutaneous methods because it facilitates precise injection into the region owing to its more direct access. More recently, celiac ganglion neurolysis has been promoted as a safe alternative to CPN and it may be a more efficacious technique than CPN. Although large, adequately powered randomized trials are lacking, observational studies and small randomized trials support the use of celiac plexus block and CPN in </span></span>palliation<span> of pain in patients with chronic pancreatitis or pancreatic cancer, respectively. However, these interventions’ affect on </span></span>quality of life and survival is unclear and further large randomized studies are needed.</span></p></div>","PeriodicalId":43887,"journal":{"name":"Techniques in Gastrointestinal Endoscopy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tgie.2017.10.007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41263466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cover","authors":"","doi":"10.1016/S1096-2883(17)30089-X","DOIUrl":"https://doi.org/10.1016/S1096-2883(17)30089-X","url":null,"abstract":"","PeriodicalId":43887,"journal":{"name":"Techniques in Gastrointestinal Endoscopy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1096-2883(17)30089-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138250848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}