{"title":"How to decrease the risk of perforation in endoscopic submucosal dissection (ESD)","authors":"Sang Gyun Kim MD , Joo Ha Hwang MD, PhD","doi":"10.1016/j.tgie.2019.05.001","DOIUrl":"10.1016/j.tgie.2019.05.001","url":null,"abstract":"<div><p><span>Endoscopic submucosal dissection (ESD) is an accepted method for curative resection for various </span>gastrointestinal tumors<span><span>. Although ESD is effective in resecting gastrointestinal tumors, the risk of perforation is a major barrier for training and adoption of this technique. Therefore, techniques for preventing perforation during ESD should be a focus when learning ESD. The most important aspect of preventing perforation during ESD is to have solid basic therapeutic endoscopic skills. Next, extensive supervised hands-on experience in ex vivo training models is important to learn proper ESD techniques prior to performing ESD </span>in patients. Finally, the appropriate endoscopic accessories and methods of ESD should be selected according to the specific characteristics of the lesion. The application of these principles will result in minimizing the risk of perforation while performing ESD.</span></p></div>","PeriodicalId":43887,"journal":{"name":"Techniques in Gastrointestinal Endoscopy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tgie.2019.05.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45615166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Endoscopic management of perforation, leaks, and fistulas","authors":"Peter D. Siersema MD, PhD, FASGE","doi":"10.1016/j.tgie.2019.04.005","DOIUrl":"10.1016/j.tgie.2019.04.005","url":null,"abstract":"","PeriodicalId":43887,"journal":{"name":"Techniques in Gastrointestinal Endoscopy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tgie.2019.04.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46029640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Joshua S. Winder MD, Eric M. Pauli MD, FACS, FASGE
{"title":"Novel endoscopic modalities for closure of perforations, leaks, and fistula in the gastrointestinal tract","authors":"Joshua S. Winder MD, Eric M. Pauli MD, FACS, FASGE","doi":"10.1016/j.tgie.2019.04.004","DOIUrl":"10.1016/j.tgie.2019.04.004","url":null,"abstract":"<div><p><span>Full-thickness gastrointestinal (GI) defects remain a daunting clinical problem in modern medicine. They vary in size, location in the GI tract<span>, etiology, and chronicity. While traditionally managed with surgical techniques or medical management, technological advancements have created a third management option (therapeutic endoscopy), which often result in definitive defect closure. With the advent of these </span></span>endoscopic therapies, many centers have moved to endoscopic management as first-line therapy of such defects. Optimal endoscopic management may require multimodal, multisession therapy, which occurs in the setting of a multispecialty management team. This manuscript reviews the use of endoscopic clips (both through-the-scope and over-the-scope), endolumenal stents, endoscopic suturing, endolumenal vacuum devices, and other emerging technologies in the managing of full-thickness GI defects. We examine the optimal clinical application of each modality and review their limitations.</p></div>","PeriodicalId":43887,"journal":{"name":"Techniques in Gastrointestinal Endoscopy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tgie.2019.04.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48314518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Endoscopic clip placement for the prevention of perforation after colonic endoscopic mucosal resection","authors":"Brian R. Boulay MD, MPH , Simon K. Lo MD, FACP","doi":"10.1016/j.tgie.2019.04.003","DOIUrl":"10.1016/j.tgie.2019.04.003","url":null,"abstract":"<div><p>Endoscopically placed clips have gained a prominent role in the management of bleeding or perforation during endoscopic mucosal resection<span> of large colonic polyps<span>. Clips may be used to treat intraprocedural complications, but may also be placed prophylactically when patients are at an increased risk for post-procedural bleeding or delayed perforation. Polyp size, location, resection technique, and appearance of the resection defect can all influence the decision on whether to place prophylactic clips. Not all post-polypectomy defects require clip placement. The downsides of clip placement include increased cost and the possibility of “clip artifact” mimicking residual polyp on surveillance examinations. When clipping, attention to proper technique can ensure secure closure of the defect and efficient placement of additional clips. Over-the-scope clips and endoscopic suturing are other strategies which can be used for treatment of bleeding or perforation, though each requires attachment to the scope and training for use.</span></span></p></div>","PeriodicalId":43887,"journal":{"name":"Techniques in Gastrointestinal Endoscopy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tgie.2019.04.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45898870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mauro Verra MD, Edoardo Forcignanò MD, Giacomo Lo Secco MD, Alberto Arezzo MD
{"title":"Efficacy of endoscopic vacuum therapy for the treatment of colorectal anastomotic leaks","authors":"Mauro Verra MD, Edoardo Forcignanò MD, Giacomo Lo Secco MD, Alberto Arezzo MD","doi":"10.1016/j.tgie.2019.05.002","DOIUrl":"10.1016/j.tgie.2019.05.002","url":null,"abstract":"<div><p><span>Anastomotic leak is a frequent and a threatening complication following </span>colorectal surgery<span>, and it is associated with early- and long-term morbidity and mortality. Anastomotic leak can be managed with surgical or conservative approaches; clinically stable patients without generalized peritonitis<span> may be managed endoscopically with a view to reducing surgery-related morbidity. A novel minimally invasive approach is the endoscopic vacuum therapy (EVT) that is indicated to treat large anastomotic leaks associated with extraluminal infected cavities. It is based on the application of a local negative pressure inside the extraluminal cavity in order to drain, to induce granulation of the tissue with subsequent leak healing by secondary intention. We performed a review of the literature on the use of EVT in the treatment of colorectal anastomotic leaks. Mean success rate was 81%; the presence of a derivative stoma and early onset of the therapy seem to be positive predicting factor. Few major complications requiring discontinuation of the treatment and no mortality related to the procedure were reported. EVT represents promising alternative to surgery in the treatment of selected cases of anastomotic leak, with few complications and high success rate.</span></span></p></div>","PeriodicalId":43887,"journal":{"name":"Techniques in Gastrointestinal Endoscopy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tgie.2019.05.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46188137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Endoscopic treatment of ERCP-related duodenal perforation","authors":"Nicole Evans MD, James L. Buxbaum MD","doi":"10.1016/j.tgie.2019.04.002","DOIUrl":"10.1016/j.tgie.2019.04.002","url":null,"abstract":"<div><p>Duodenal perforation<span> following ERCP<span><span> is an unusual but severe adverse event. Prompt recognition improves clinical outcomes including mortality, thus endoscopists should have a low threshold to consider perforation in those with abdominal pain, hemodynamic perturbation, and atypical </span>fluoroscopy<span> findings. Classification of perforations as retroperitoneal/periampullary vs free/remote from the papilla is important as the former can be managed nonoperatively in most cases. Nonsurgical therapy typically includes medical therapy supplemented by placement of fully covered self-expandable stents in the bile duct<span> and through-the-scope endoscopic clips over the defect. New endoscopic technology including full thickness suturing devices, over-the-scope clips, fibrin injection, and vacuum therapy may increase the proportion of patients with duodenal perforation who may be amenable to minimally invasive treatment.</span></span></span></span></p></div>","PeriodicalId":43887,"journal":{"name":"Techniques in Gastrointestinal Endoscopy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tgie.2019.04.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46748220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brian Larson MD, Douglas G. Adler MD, FACG, AGAF, FASGE
{"title":"Endoscopic management of esophagorespiratory fistulas","authors":"Brian Larson MD, Douglas G. Adler MD, FACG, AGAF, FASGE","doi":"10.1016/j.tgie.2019.03.012","DOIUrl":"10.1016/j.tgie.2019.03.012","url":null,"abstract":"<div><p><span>Esophagorespiratory fistulas (ERFs) are pathologic communications between the esophagus and respiratory tract. They are devastating conditions of malignant or benign (often iatrogenic) etiologies. Patients with ERF have significantly increased mortality and decreased </span>quality of life<span><span><span>. Multiple management options exist for the treatment of ERFs including surgical, endoscopic, and oncologic approaches. Surgical management, with fistula closure and removal of diseased esophageal or pulmonary tissue, is the time-honored treatment of ERF. However, these surgeries are major undertakings and many patients with ERF are poor surgical candidates. As such oncologic and </span>endoscopic therapies are often employed. Many endoscopic therapies exist for the management of ERF and include: esophageal stenting, airway stenting, combined esophageal, and airway stenting, over-the-scope clip placement, cardiac septal occlusion devices, and other novel therapies (argon plasma coagulation, </span>fibrin glue<span>, endoscopic suturing, and polyglycolic acid sheets). These treatments can be employed alone or in combination. Each endoscopic management strategy has its own clinical success rate and adverse events. Although advances in endoscopic techniques have broadened the tools available to treat ERFs; little if any data are available comparing the various endoscopic management strategies. Despite this an experienced clinician may select the appropriate intervention to maximize the risks/benefits of the procedure based on the size, location, and etiology of the fistula.</span></span></p></div>","PeriodicalId":43887,"journal":{"name":"Techniques in Gastrointestinal Endoscopy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tgie.2019.03.012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42556009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dilhana S. Badurdeen MD , Katherine Lamond MD , Alex Gandsas MD, MBA, FACS , Vivek Kumbhari MD
{"title":"Endoscopic strategies for the treatment of postbariatric surgery leaks and fistulas","authors":"Dilhana S. Badurdeen MD , Katherine Lamond MD , Alex Gandsas MD, MBA, FACS , Vivek Kumbhari MD","doi":"10.1016/j.tgie.2019.03.011","DOIUrl":"10.1016/j.tgie.2019.03.011","url":null,"abstract":"<div><p>Obesity is fast becoming a worldwide epidemic. Bariatric surgery<span> has gained acceptance as an outstanding procedure that provides clinically significant weight loss and metabolic outcomes. Despite improvement in technique and expertise, complications ensue. As the number of postbariatric surgery patients increase, it is crucial that one is able to identify and manage complications. In order to optimally manage these patients, one must be able to understand the postsurgical anatomy<span> and physiology of the stomach. Herein, we discuss the most common sites of leaks after Roux-en-Y gastric bypass and sleeve gastrectomy. We propose a new and unique algorithm for management of sleeve gastrectomy leaks taking into consideration other factors that we feel contribute to successful healing and resolution.</span></span></p></div>","PeriodicalId":43887,"journal":{"name":"Techniques in Gastrointestinal Endoscopy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tgie.2019.03.011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43576012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Diagnosis and endoscopic treatment of esophageal leakage: a systematic review","authors":"Bram D. Vermeulen MD, Peter D. Siersema MD, PhD","doi":"10.1016/j.tgie.2019.04.001","DOIUrl":"10.1016/j.tgie.2019.04.001","url":null,"abstract":"<div><p>When esophageal leakage is suspected, diagnostic work-up usually starts with endoscopy<span><span><span> followed by CT of the </span>thorax<span>. Clinicians should consider esophageal leakage a clinical emergency as early diagnosis and treatment are associated with improved outcome. Upon diagnosis, acute therapeutic management in a specialized center with appropriate multidisciplinary infrastructure and expertise is indicated as innovative endoscopic treatment options have become reasonable alternatives to invasive surgical interventions. Promising endoscopic treatment options include esophageal </span></span>stent placement<span>, endoscopic vacuum therapy, and over-the-scope clip placement. In effort to evaluate the current literature, a systematic literature search was performed on studies reporting clinical outcome of patients treated with these endoscopic treatment options for benign esophageal perforations<span><span> and anastomotic leakage. The systematic search yielded 15 studies (932 patients) discussing stent placement, 14 studies (295 patients) discussing endoscopic vacuum therapy, and 8 studies (41 patients) discussing over-the-scope clip placement. Clinical success was achieved in the majority of all patients. However, the studies predominantly consisted of small single-center retrospective case series. Careful selection of patients is therefore recommended when considering </span>endoscopic therapy for esophageal leakage. Furthermore, clinical tools may aid in predicting patients’ prognosis and selection of patients that could benefit from endoscopic therapy. In the future, randomized studies comparing available endoscopic treatment options are needed to guide treatment choice for patients with esophageal leakage in daily clinical practice.</span></span></span></p></div>","PeriodicalId":43887,"journal":{"name":"Techniques in Gastrointestinal Endoscopy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tgie.2019.04.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44507975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Combined surgical and endoscopic approaches to full-thickness resection","authors":"Thomas C. Tsai MD, MPH, Ozanan R. Meireles MD","doi":"10.1016/j.tgie.2019.03.004","DOIUrl":"10.1016/j.tgie.2019.03.004","url":null,"abstract":"<div><p>With the emergence of advanced endoscopic technologies and techniques, endoscopic resection<span><span> has emerged as an important therapeutic modality. However, endoscopic full-thickness resection can be limited by concerns for R0 resection, margins, potential for seeding the </span>peritoneal cavity<span><span>, perforation, or difficulty in closing the full-thickness defect. Combined laparoscopic surgery with endoscopic-full thickness resection has become an important cooperative strategy that leverages the unique skillsets of both the endoscopist and the laparoscopic surgeon. Several techniques have emerged that range from endoscopic resection with laparoscopic assistance, laparoscopic resection with endoscopic assistance, and finally to truly cooperative laparoendoscopic surgery. The application of combined laparoscopic surgery and endoscopic full-thickness resection shows great promise especially for subepithelial tumors of the </span>upper gastrointestinal tract, but more widespread applications need to be tempered by focusing on clinical benefit to the patient.</span></span></p></div>","PeriodicalId":43887,"journal":{"name":"Techniques in Gastrointestinal Endoscopy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tgie.2019.03.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43276363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}