Venoms and Toxins最新文献_第3页

Design, Fabrication and Characterization of Nanoliposomes Containing Snake Venom of Pseudocereaster percius 含假皮蛇毒纳米脂质体的设计、制备与表征

Venoms and Toxins Pub Date : 2022-01-06 DOI: 10.2174/2666121702666220106102156

T. Emami, A. Shirvan, M. Jaafari, R. Madani, F. Golchinfar, N. M. Dounighi, M. Samianifard

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引用次数: 0

Stability of Parkinson's Diseased Animal Models Induced by Neurotoxins; a Serious Drawback to Success of Parkinson’s Disease Therapeutic Studies 神经毒素诱导帕金森病动物模型的稳定性研究帕金森病治疗研究成功的一个严重障碍

Venoms and Toxins Pub Date : 2021-12-13 DOI: 10.2174/2666121701666211213100634

S. Okyere, Yanchun Hu

引用次数: 0

Evaluation of venom as a promising tool for drug discovery [focusing on Neurological disorders] 蛇毒作为一种有前途的药物发现工具的评估[专注于神经系统疾病]

Venoms and Toxins Pub Date : 2021-11-24 DOI: 10.2174/2666121701666211124151529

Soodeh Omidi, M. Mehrpouya, M. Oladnabi, A. Azadmehr, F. Kazemi-Lomedasht, N. Yardehnavi

引用次数: 1

Toxins and venoms from marine cnidarians and gastropods: diversity and potential drugs targeting the ion channels 海洋刺胞动物和腹足动物的毒素和毒液:针对离子通道的多样性和潜在药物

Venoms and Toxins Pub Date : 2021-11-24 DOI: 10.2174/2666121701666211124154216

Sofiene Tlili, Raoua Ben Brahim, J. Sabatier, I. Regaya

引用次数: 0

Neurotoxic Mechanism and Shortcomings of MPTP, 6-OHDA, Rotenone and Paraquat-induced Parkinson’s Disease Animal Models MPTP、6-羟多巴胺、鱼藤酮和百草枯诱导帕金森病动物模型的神经毒性机制及不足

Venoms and Toxins Pub Date : 2021-05-06 DOI: 10.2174/2666121701999201104163407

S. Okyere, Chao-rong Zeng, Dong Yue, Yanchun Hu

{"title":"Neurotoxic Mechanism and Shortcomings of MPTP, 6-OHDA, Rotenone and Paraquat-induced Parkinson’s Disease Animal Models","authors":"S. Okyere, Chao-rong Zeng, Dong Yue, Yanchun Hu","doi":"10.2174/2666121701999201104163407","DOIUrl":"https://doi.org/10.2174/2666121701999201104163407","url":null,"abstract":"\u0000\u0000Parkinson’s disease (PD) has caused most economies to lose their active human capital.\u0000Due to poor understanding of the pathophysiology of PD, PD animal models were developed to aid\u0000the investigation of PD pathogenesis and therapy. Currently, the toxin-induced and the genetic animal\u0000models are being used for most PD research.\u0000Most neurotoxin animal model studies on PD are focused on the motor features and economic importance\u0000associated with dopamine depletion; however, the molecular pathways for cell loss by\u0000these models and its usefulness in PD drug development have not been reported fully. In this review,\u0000we have provided a summary of the toxic mechanism and shortcomings of four neurotoxins (6-OHDA,\u0000MPTP, Rotenone and, Paraquat) that are frequently used to mimic PD in animal models. This review\u0000will give readers basic knowledge for selecting the best toxin for a specific PD experiment and\u0000also provide information that will help in the future development of toxins with fewer shortcomings.\u0000This review also summarizes the mechanism and features of some PD genetic models.\u0000","PeriodicalId":438678,"journal":{"name":"Venoms and Toxins","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128598762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Meet Our Editorial Board Member 认识我们的编辑委员会成员

Venoms and Toxins Pub Date : 1900-01-01 DOI: 10.2174/266612170101210324160217

C. Fimognari

引用次数: 0