Journal of medical and bioengineering最新文献

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Relative Warp Analysis of Parasite–Induced Plasticity in the Shell Shape of the O. Quadrasi 寄生物诱导稻壳塑性的相对翘曲分析
Journal of medical and bioengineering Pub Date : 1900-01-01 DOI: 10.12720/JOMB.2.2.120-125
E. Vasallo, M. Torres, C. Demayo
{"title":"Relative Warp Analysis of Parasite–Induced Plasticity in the Shell Shape of the O. Quadrasi","authors":"E. Vasallo, M. Torres, C. Demayo","doi":"10.12720/JOMB.2.2.120-125","DOIUrl":"https://doi.org/10.12720/JOMB.2.2.120-125","url":null,"abstract":"The shell morphology of O. quadrasi is hypothesized to be driven through coevolution between S. japonicum infectivity capacities with O. quadrasi. This hypothesis predicts that measures of geometricmorphometric variations of snail populations parallel varied schistosome infections thus was evaluated in two provinces of Mindanao, Philippines where there were reported infections. Relative Warp Analysis was used in the investigation to determine shell shape divergence. For statistical analysis, Discriminant analysis and KruskalWallis test were performed. The results showed that parasitism in O. quadrasi had significant effects on some morphometric dimensions of the snailapertural and apical sculptures based on the shell shapes. These phenotypic variations accounted for more than 40% of the variance in shell morphology relative to mean shape. Even at low infection levels, 4.05% of the local populations being infected, the effects were even detectable. Analysis of geometric morphometrics of the two populations (cercariaeinfected and uninfected shells) of O. quadrasi based on shell characters generally has demonstrated dimorphic features","PeriodicalId":437476,"journal":{"name":"Journal of medical and bioengineering","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121195087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Finding DNA Regulatory Motifs with Position-dependent Models 利用位置依赖模型寻找DNA调控基序
Journal of medical and bioengineering Pub Date : 1900-01-01 DOI: 10.12720/JOMB.2.2.103-109
Huihai Wu, Prudence W. H. Wong, M. Caddick, Christopher Sibthorp
{"title":"Finding DNA Regulatory Motifs with Position-dependent Models","authors":"Huihai Wu, Prudence W. H. Wong, M. Caddick, Christopher Sibthorp","doi":"10.12720/JOMB.2.2.103-109","DOIUrl":"https://doi.org/10.12720/JOMB.2.2.103-109","url":null,"abstract":"We consider the problem of de novo DNA motif discovery. The position weight matrix (PWM) model has been extensively used, yet this model makes the assumption that nucleotides at different positions are independent of each other. Recent results have shown that nucleotides bound by transcription factors often exhibit adjacent or nonadjacent dependencies. We address this problem by devising positional dependency models capable of capturing adjacent dependencies and non-adjacent dependencies (SPWDM). Our algorithms are based on Gibbs sampling to update the model parameter and dependencies structure. We compare two scoring functions:   -score and a conditional probability based score. We also improve several Gibbs sampling stages. Experiments are carried out on simulated and real data, showing that the SPWDM model makes improvement over pure PWM. The modifications to the Gibbs sampling algorithm are also shown to be effective. ","PeriodicalId":437476,"journal":{"name":"Journal of medical and bioengineering","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116948640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
NIM, A Novel Computational Method for Predicting Nuclear-Encoded Chloroplast Proteins 预测核编码叶绿体蛋白的新计算方法NIM
Journal of medical and bioengineering Pub Date : 1900-01-01 DOI: 10.12720/JOMB.2.2.115-119
Jun Ding, Haiyan Hu, X. Li
{"title":"NIM, A Novel Computational Method for Predicting Nuclear-Encoded Chloroplast Proteins","authors":"Jun Ding, Haiyan Hu, X. Li","doi":"10.12720/JOMB.2.2.115-119","DOIUrl":"https://doi.org/10.12720/JOMB.2.2.115-119","url":null,"abstract":"The identification of nuclear-encoded chloroplast proteins is important for the understanding of their functions and their interaction in chloroplasts. Despite various endeavors in predicting these proteins, there is still room for developing novel computational methods for further improving the prediction accuracy. Here we developed a novel computational method called NIM based on interpolated Markov chains to predict nuclear-encoded chloroplast proteins. By testing the method on real data, we show NIM has an average sensitivity larger than 92% and an average specificity larger than 97%. Compared with the state-of-the-art methods, we demonstrate that NIM performs better or is at least comparable with them. Our study thus provides a novel and useful tool for the prediction of nuclear-encoded chloroplast proteins. ","PeriodicalId":437476,"journal":{"name":"Journal of medical and bioengineering","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117085211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Physical and Human Factors on Temporal and Spatial Variations of Dissolved Oxygen in Kuwait Bay 自然和人为因素对科威特湾溶解氧时空变化的影响
Journal of medical and bioengineering Pub Date : 1900-01-01 DOI: 10.12720/jomb.3.4.231-235
Ahmed M. Al-Hasem, H. Alazmi
{"title":"Effect of Physical and Human Factors on Temporal and Spatial Variations of Dissolved Oxygen in Kuwait Bay","authors":"Ahmed M. Al-Hasem, H. Alazmi","doi":"10.12720/jomb.3.4.231-235","DOIUrl":"https://doi.org/10.12720/jomb.3.4.231-235","url":null,"abstract":"The primary aim of this research is to obtain a better understanding of (a) temporal and spatial variations of dissolved oxygen in Kuwait Bay and (b) the physical and human factors involved in controlling these variations. For this purpose, we performed various statistical and field investigations to analyse and interpret the main factors, which included temperature, salinity and power stations. Data obtained from the Environment Public Authority, the Ministry of Electricity and Water, and field-work were analysed statistically to determine whether a relationship between dissolved oxygen and other factors exists and which factors have a significant effect on dissolved oxygen. The results revealed varying degrees of dissolved oxygen, temperature and salinity in Kuwait Bay throughout the year, whereas spatial variations were less noticeable. Conversely, power stations increase production during summer months; the Western Doha Station recorded its highest production and the Alshuwaikh its lowest. Based on an analysis of the relationship between dissolved oxygen and other factors, only temperature among the physical factors has an inverse relationship, while dissolved oxygen is controlled positively by the distance from power stations.","PeriodicalId":437476,"journal":{"name":"Journal of medical and bioengineering","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114610864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human Papillomavirus and Esophageal Carcinoma: A Study in China 人乳头瘤病毒与食管癌:在中国的研究
Journal of medical and bioengineering Pub Date : 1900-01-01 DOI: 10.12720/JOMB.4.5.386-390
M. Mehryar, Jintao Li, Yi Zeng
{"title":"Human Papillomavirus and Esophageal Carcinoma: A Study in China","authors":"M. Mehryar, Jintao Li, Yi Zeng","doi":"10.12720/JOMB.4.5.386-390","DOIUrl":"https://doi.org/10.12720/JOMB.4.5.386-390","url":null,"abstract":"Eesophagealsquamous cell carcinoma (ESCC) is considered as the ninth most common malignancy in the world. There are a number of suspected casual reasons of this type of carcinoma. The association of viral infection with EC (esophageal carcinoma) has been reported in last 30 years. Human papillomavirus (HPV) is said to be a major aetiology in areas with high incidence of esophageal carcinoma, but the prevalence and the role of HPV virus in the aetiology of esophageal squamous cell carcinoma (ESCC) is still uncertain. In this study we designed to evaluate the prevalence of HPV in EC cases diagnosed in pathology department of Hebei, China. In this study 170 cases that were pathologically diagnosed as esophagealcarcinoma were obtained from department of pathology files at Hebei provincebetween2011-2013. DNA material was extracted from formalin-fixed paraffin-embedded tissues (FFPET) and PCR was performed to detect HPV genome. In this study negative and positive control were used for HPV 16/18 and beta-globin PCR as internal control. More than 95% of FFPETs had acceptable result in DNA qualification PCR test. Overall prevalence of HPV in tumour tissues was 81.17% in GP6+/GP5+ PCR, 40.58% by HPV16 and 49.41% for HPV18. The presence of HPV DNA in esophagus tumours (high risk HPV types 16 and 18) implicates HPV as one of the possible aetiology factors in esophageal carcinoma.","PeriodicalId":437476,"journal":{"name":"Journal of medical and bioengineering","volume":"115 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127149671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vermicompost Production by Using Tomato Residue and Yard Waste 利用番茄渣和庭院垃圾生产蚯蚓堆肥
Journal of medical and bioengineering Pub Date : 1900-01-01 DOI: 10.12720/JOMB.2.4.270-273
Saroj Klangkongsub, P. Sohsalam
{"title":"Vermicompost Production by Using Tomato Residue and Yard Waste","authors":"Saroj Klangkongsub, P. Sohsalam","doi":"10.12720/JOMB.2.4.270-273","DOIUrl":"https://doi.org/10.12720/JOMB.2.4.270-273","url":null,"abstract":" Abstract—Tomato residue and yard waste were used as substrate for vermicompost production. These two organic wastes were suitable for feeding Eudrilus eugeniae. E. eugeniae was cultivated under four feeding conditions; control (no organic waste added), adding tomato residue, adding grass waste and adding tomato and grass. Vermicomposts from all conditions provided major nutrients (N, P, K) higher than the standard of organic fertilizer. All vermicomposts were applied to Chinese cabbage and zinnia. The results showed that all formula of vermicomposts supported crop plants as good as chemical fertilizer. Vermicomposts may benefits both economical and environmental purposes. Index Terms—waste reduction, tomato residue, yard waste, Vermicompost.","PeriodicalId":437476,"journal":{"name":"Journal of medical and bioengineering","volume":"46 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126911066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Evaluation of Polyphenol Content and Antioxidant Activities of Some Selected Organic and Aqueous Extracts of Cornsilk (Zea Mays Hairs) 玉米丝有机和水提物多酚含量及抗氧化活性评价
Journal of medical and bioengineering Pub Date : 1900-01-01 DOI: 10.12720/JOMB.1.1.48-51
A. R. Nurhanan, W. Rosli
{"title":"Evaluation of Polyphenol Content and Antioxidant Activities of Some Selected Organic and Aqueous Extracts of Cornsilk (Zea Mays Hairs)","authors":"A. R. Nurhanan, W. Rosli","doi":"10.12720/JOMB.1.1.48-51","DOIUrl":"https://doi.org/10.12720/JOMB.1.1.48-51","url":null,"abstract":"","PeriodicalId":437476,"journal":{"name":"Journal of medical and bioengineering","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126943601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 23
Robustness Analysis of the PI3K/AKT Cell Signaling Module PI3K/AKT细胞信号模块的鲁棒性分析
Journal of medical and bioengineering Pub Date : 1900-01-01 DOI: 10.12720/JOMB.2.2.93-97
Tianhai Tian, Fuke Wu
{"title":"Robustness Analysis of the PI3K/AKT Cell Signaling Module","authors":"Tianhai Tian, Fuke Wu","doi":"10.12720/JOMB.2.2.93-97","DOIUrl":"https://doi.org/10.12720/JOMB.2.2.93-97","url":null,"abstract":"Cell responses are actuated by tightly controlled signal transduction pathways. Due to the complex nature of molecular processes inside the cell, mathematical models recently have been used as a powerful tool to analyze the dynamic properties of cell signaling pathways. Although the concept of an integrated signaling network replete with inter-pathway crosstalk and feedback regulation is broadly appreciated, kinetic data of the type needed to characterize such interactions in conjunction with mathematical models are lacking. In recent years a number of additional criteria such as robustness property have been proposed to validate the proposed mathematical models that should maintain certain important properties of biological systems. In this work we analyze the robustness property of the PI3K/Akt module using the method of perturbation to model rate constants. Simulation results suggested that the perturbation to the activation of Akt and PI3K kinases has more influence on the signal output of the module than other processes in the system. Index Terms—Cell signaling pathway, PI3K/Akt module, mathematical model, robustness analysis, perturbation.","PeriodicalId":437476,"journal":{"name":"Journal of medical and bioengineering","volume":"152 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124240355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Inhibitory Effects of Lamiaceae Plants on the Formation of Advanced Glycation Endproducts (AGEs) in Model Proteins Lamiaceae植物对模型蛋白中晚期糖基化终产物(AGEs)形成的抑制作用
Journal of medical and bioengineering Pub Date : 1900-01-01 DOI: 10.12720/JOMB.2.4.224-227
Khwanta Kaewnarin, L. Shank, Hataichanoke Niamsup, N. Rakariyatham
{"title":"Inhibitory Effects of Lamiaceae Plants on the Formation of Advanced Glycation Endproducts (AGEs) in Model Proteins","authors":"Khwanta Kaewnarin, L. Shank, Hataichanoke Niamsup, N. Rakariyatham","doi":"10.12720/JOMB.2.4.224-227","DOIUrl":"https://doi.org/10.12720/JOMB.2.4.224-227","url":null,"abstract":"Protein glycation and oxidative stress caused by chronic hyperglycemia play vital role in diabetic complications. This study focused on the evaluation of the antiglycation effect of four Lamiaceae plants (Ocimum sanctum, O. basilicum, O. americanum and Metha cordifolia opiz.). Among the ethanolic extracts, O. sanctum extract exhibited high content of phenolic compounds and strong antioxidant activity. Chemical composition analyzed by HPLC revealing two major phenolic conpounds in O. sanctum extracts as rosmarinic acid (4.43 mg/g) and luteolin (0.96 mg/g). In the antiglycation assays, bovine serum albumin (BSA) and histone which were used as model proteins for investigation in the presence of methylglyoxal (MGO) with or without the extracts comparing with the authentic phenolic compounds. The results showed that O. sanctum extract possessed a potent antiglycation activity in both BSA and histone models with 23.4% and 43.0 % inhibition at the concentration of 500 and 250μg/mL, respectively. The results indicated that O. sanctum which contained high phenolic compounds has potential to prevent protein glycation caused by oxidative stress.","PeriodicalId":437476,"journal":{"name":"Journal of medical and bioengineering","volume":"229 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123307464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Electrical Potential on Boundary of Osseointegrated Implant and Bone 骨整合种植体与骨交界面电位的研究
Journal of medical and bioengineering Pub Date : 1900-01-01 DOI: 10.12720/JOMB.2.1.37-39
Hunhee Kim, Junghwa Hong
{"title":"Electrical Potential on Boundary of Osseointegrated Implant and Bone","authors":"Hunhee Kim, Junghwa Hong","doi":"10.12720/JOMB.2.1.37-39","DOIUrl":"https://doi.org/10.12720/JOMB.2.1.37-39","url":null,"abstract":"Osseointegration could be described as the modality for stable fixation of titanium implant to bone structure. The OI has become a realized phenomenon of importance in the dental and rehabilitation sciences since recently developed dentures and artificial limbs are directly attached to human skeleton by using osseointegrated (OI) implants. Previously, the electricity-generating capability of bone had been investigated when it is subjected to mechanical loads. This is related to static and dynamic capability of bone, so-called linear piezoelectric and streaming potential effect respectively. Streaming potential or bone strain generated potential (SGP) is an electrical potential and considered to be generated by fluid flow in bone. Bone Piezoelectric potential (PZP) is an electrical potential and considered to be generated by deformation in bone. Since changes in boundaries on bone-implant affect deformations of bone matrix and interstitial bone fluid flow, it could be postulated that SGPZP could be used as a parameter to examine the amount of osseointegration on bone-implant interface. Since no study was performed to understand effects of loading rate changes on behavior of SGPZP for the bone-implant composite, rate dependent behavior of SGPZP was investigated in this study. Magnitude of SGPZP was found to be significantly increased as the rate increased for OI bone-implant composite. In contrast, the time duration of SGPZP was decreased as the rate increased. These results could imply that the temporal SGPZP behavior of bone-implant composite is significantly affected by the loading rate. ","PeriodicalId":437476,"journal":{"name":"Journal of medical and bioengineering","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121031911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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