Italian Journal of Medicine最新文献_第7页

Independent correlation between ischemia modified albumin and parathormone in hemodialysis patients 血液透析患者缺血修饰白蛋白与甲状旁激素的独立相关性

Italian Journal of Medicine Pub Date : 2023-01-12 DOI: 10.4081/itjm.2022.1560

Kenan Güçlü, Kağan Tur, Serdar Şahin, Aydın Güçlü

{"title":"Independent correlation between ischemia modified albumin and parathormone in hemodialysis patients","authors":"Kenan Güçlü, Kağan Tur, Serdar Şahin, Aydın Güçlü","doi":"10.4081/itjm.2022.1560","DOIUrl":"https://doi.org/10.4081/itjm.2022.1560","url":null,"abstract":"Introduction. Hemodialysis patients are the group which oxidative stress is found more exacerbated. Ischemia modified albumin (IMA) is a new and sensitive marker for ischemia and oxidative stress. At current study we evaluated relation between IMA and biochemical parameters in hemodialysis patients. Materials and Methods. Thirty-four patients on maintenance hemodialysis were included. Pre-hemodialysis and post-hemodialysis blood samples were taken. Serum IMA and biochemistry parameters were measured. Results. There was a positive correlation between alkaline phosphatase (ALP) and IMA (r=0,268, p<0,05), CRP and IMA (r=0,452, p=0,007), parathormone and IMA (r=0,436, p=0,010), There was a negative correlation between albumin and IMA (r=-0,338, p=0,05). Multiple regression analysis was run to predict IMA levels from parathormone, CRP and creatinine the model statistically significantly predicted relation p<0,05, R=0,506, out of four two variables added statistically significant to the prediction, PTH (p=0,006), CRP (p=0,029). In multiregression analysis, IMA was found to be associated with PTH and CRP independent of creatinine value. Conclusions. We showed for the first time that PTH is associated with IMA in hemodialysis patients, independent of the level of renal function.","PeriodicalId":43715,"journal":{"name":"Italian Journal of Medicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135996301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Independent correlation between ischemia modified albumin and parathormone in hemodialysis patients 血液透析患者缺血修饰白蛋白与甲状旁激素的独立相关性

IF 0.4

Italian Journal of Medicine Pub Date : 2023-01-12 DOI: 10.4081/itjm.2023.1560

K. Güçlü, Kağan Tur, S. Şahin, Aydın Güçlü

{"title":"Independent correlation between ischemia modified albumin and parathormone in hemodialysis patients","authors":"K. Güçlü, Kağan Tur, S. Şahin, Aydın Güçlü","doi":"10.4081/itjm.2023.1560","DOIUrl":"https://doi.org/10.4081/itjm.2023.1560","url":null,"abstract":"Introduction. Hemodialysis patients are the group which oxidative stress is found more exacerbated. Ischemia modified albumin (IMA) is a new and sensitive marker for ischemia and oxidative stress. At current study we evaluated relation between IMA and biochemical parameters in hemodialysis patients.\u0000Materials and Methods. Thirty-four patients on maintenance hemodialysis were included. Pre-hemodialysis and post-hemodialysis blood samples were taken. Serum IMA and biochemistry parameters were measured.\u0000Results. There was a positive correlation between alkaline phosphatase (ALP) and IMA (r=0,268, p<0,05), CRP and IMA (r=0,452, p=0,007), parathormone and IMA (r=0,436, p=0,010), There was a negative correlation between albumin and IMA (r=-0,338, p=0,05). Multiple regression analysis was run to predict IMA levels from parathormone, CRP and creatinine the model statistically significantly predicted relation p<0,05, R=0,506, out of four two variables added statistically significant to the prediction, PTH (p=0,006), CRP (p=0,029). In multiregression analysis, IMA was found to be associated with PTH and CRP independent of creatinine value.\u0000Conclusions. We showed for the first time that PTH is associated with IMA in hemodialysis patients, independent of the level of renal function.","PeriodicalId":43715,"journal":{"name":"Italian Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46783236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Delayed diagnosis of plasma cell disorder-related Fanconi syndrome in young adults presenting as osteomalacia: report of two cases with normokalemia and normal haematological parameters at the time of presentation. 表现为骨软化症的年轻人血浆细胞紊乱相关Fanconi综合征的延迟诊断：两例表现时血钾正常且血液学参数正常的病例报告。

IF 0.4

Italian Journal of Medicine Pub Date : 2023-01-12 DOI: 10.4081/itjm.2022.1559

J. Franklin, Praveen V. Pavithran, N. Sidharthan, Seethalkshmy Nv, N. Abraham, V. U. Menon, V. Nair, H. Kumar

{"title":"Delayed diagnosis of plasma cell disorder-related Fanconi syndrome in young adults presenting as osteomalacia: report of two cases with normokalemia and normal haematological parameters at the time of presentation.","authors":"J. Franklin, Praveen V. Pavithran, N. Sidharthan, Seethalkshmy Nv, N. Abraham, V. U. Menon, V. Nair, H. Kumar","doi":"10.4081/itjm.2022.1559","DOIUrl":"https://doi.org/10.4081/itjm.2022.1559","url":null,"abstract":"Adult-onset hypophosphatemic osteomalacia is rare and diagnosis is frequently delayed. Fanconi syndrome (FS) due to monoclonal gammopathy is a well-recognized, but rare cause of hypophosphatemia. The relatively young age of patients and normal routine hematological parameters often results in late recognition of this treatable disease entity. Low phosphorus, elevated alkaline phosphatase, mildly impaired renal function and hypokalemia are often the only abnormalities on routine evaluation. We summarize the clinico-pathological features of two cases who initially presented with fractures and proximal myopathy and were subsequently found to have FS secondary to light chain proximal tubulopathy. Atypical features like absence of hypokalemia at presentation and elevated Fibroblast Growth Factor 23(FGF 23), a marker of oncogenic osteomalacia were noted. Marked clinical improvement and recovery of renal parameters were evident with phosphate supplements and chemotherapy for the plasma cell disorder. FS due to monoclonal gammopathy may present with atypical features and diagnosis may be challenging","PeriodicalId":43715,"journal":{"name":"Italian Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46973150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Delayed diagnosis of plasma cell disorder-related Fanconi syndrome in young adults presenting as osteomalacia: report of two cases with normokalemia and normal haematological parameters at the time of presentation 以骨软化症为表现的年轻成人浆细胞疾病相关范可尼综合征的延迟诊断:报告两例在表现时血液学参数正常且血液学参数正常的病例

Italian Journal of Medicine Pub Date : 2023-01-12 DOI: 10.4081/itjm.2023.1559

Joel Franklin, Praveen V. Pavithran, Neeraj Sidharthan, Seethalkshmy NV, Nithya Abraham, V. Usha Menon, Vasantha Nair, Harish Kumar

{"title":"Delayed diagnosis of plasma cell disorder-related Fanconi syndrome in young adults presenting as osteomalacia: report of two cases with normokalemia and normal haematological parameters at the time of presentation","authors":"Joel Franklin, Praveen V. Pavithran, Neeraj Sidharthan, Seethalkshmy NV, Nithya Abraham, V. Usha Menon, Vasantha Nair, Harish Kumar","doi":"10.4081/itjm.2023.1559","DOIUrl":"https://doi.org/10.4081/itjm.2023.1559","url":null,"abstract":"Adult-onset hypophosphatemic osteomalacia is rare and diagnosis is frequently delayed. Fanconi syndrome (FS) due to monoclonal gammopathy is a well-recognized, but rare cause of hypophosphatemia. The relatively young age of patients and normal routine hematological parameters often results in late recognition of this treatable disease entity. Low phosphorus, elevated alkaline phosphatase, mildly impaired renal function and hypokalemia are often the only abnormalities on routine evaluation. We summarize the clinico-pathological features of two cases who initially presented with fractures and proximal myopathy and were subsequently found to have FS secondary to light chain proximal tubulopathy. Atypical features like absence of hypokalemia at presentation and elevated Fibroblast Growth Factor 23(FGF 23), a marker of oncogenic osteomalacia were noted. Marked clinical improvement and recovery of renal parameters were evident with phosphate supplements and chemotherapy for the plasma cell disorder. FS due to monoclonal gammopathy may present with atypical features and diagnosis may be challenging","PeriodicalId":43715,"journal":{"name":"Italian Journal of Medicine","volume":"58 7","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136039260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Atypical presentation of West Nile encephalitis 西尼罗河脑炎的非典型表现

IF 0.4

Italian Journal of Medicine Pub Date : 2023-01-12 DOI: 10.4081/itjm.2022.1535

G. Cioni, A. Fedeli, G. Bellandi, Rossella Squillante, M. Zuccotti, G. Buffini

引用次数: 0

Pattern and sweep visual evoked potential in the objective determination of visual acuity 模式和扫描视觉诱发电位在视觉敏锐度客观测定中的应用

Italian Journal of Medicine Pub Date : 2023-01-12 DOI: 10.4081/itjm.2022.1556

Mualla Hamurcu

{"title":"Pattern and sweep visual evoked potential in the objective determination of visual acuity","authors":"Mualla Hamurcu","doi":"10.4081/itjm.2022.1556","DOIUrl":"https://doi.org/10.4081/itjm.2022.1556","url":null,"abstract":"Purpose: To investigate the effects of pattern visual evoked potential (pVEP) and sweep visual evoked potential (sVEP) on the accurate visual acuity (VA) measurement in adults.  Methods: Medical files of 282 eyes of 141 patients who underwent VA measurement in our electrophysiology laboratory and did not undergo simulation were retrospectively analyzed. The VA was measured using the Snellen chart. Only those with a VA of higher than 1/10 on the Snellen chart were included in the study. The VA was assessed and reported by the pVEP (VA-pVEP) and sVEP test (VA-sVEP). The correlation analysis was performed using the Pearson correlation analysis. Results: Of 141 patients, 92 were males and 49 were females with a mean age of 37.7±18.4 years. There was a strong positive correlation between the VA measured by the Snellen chart and the VA measured by pVEP (VA-pVEP) (r=0.858, p<0.001). There was a weak positive correlation (r=0.267, p<0.001) between the VA measured by the Snellen chart and the VA measured by the sVEP (VA-sVEP). A weak positive correlation was found for the VA-pVEP and VA-sVEP (r=0.313, p<0.001). Conclusions: For the measurement of the degree of the VA, it seems reasonable to use pVEP initially, while sVEP should be used in cases with short attention span and those who are noncooperative and in infants.","PeriodicalId":43715,"journal":{"name":"Italian Journal of Medicine","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135995379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interplay between lymphocyte subpopulation, inflammatory cytokines and their correlation with oxidative stress parameters in COVID-19 COVID-19患者淋巴细胞亚群、炎症因子及其与氧化应激参数的相互作用

IF 0.4

Italian Journal of Medicine Pub Date : 2023-01-12 DOI: 10.4081/itjm.2022.1543

M. Petrusevska, D. Zendelovska, E. Atanasovska, K. Spasovska, K. Grozdanovski, S. Stojanovska, Irina Panovska Stavridis, A. Eftimov

{"title":"Interplay between lymphocyte subpopulation, inflammatory cytokines and their correlation with oxidative stress parameters in COVID-19","authors":"M. Petrusevska, D. Zendelovska, E. Atanasovska, K. Spasovska, K. Grozdanovski, S. Stojanovska, Irina Panovska Stavridis, A. Eftimov","doi":"10.4081/itjm.2022.1543","DOIUrl":"https://doi.org/10.4081/itjm.2022.1543","url":null,"abstract":"Our objective was to investigate the inflammatory and oxidative stress markers in patients with moderate and severe form of COVID-19. In addition, we show the correlation between changes in lymphocyte subsets and markers of oxidative stress as a tool for patient classification. IL-6 and VEGF were analysed by utilizing a High Sensitivity Evidence Investigator™ Biochip Array technology. The total antioxidant capacity (PAT) and the free radical concentrations (d-ROM) were measured in serum utilizing analytical photometric system FRAS5. Peripheral blood was used to determine CD45 + mononuclear, B, T, and NK cells using a multi-parameter flow cytometric immunophenotypic test. \u0000Statistically significant differences in IL-6 and VEGF levels were observed between the two patient groups. Decreased values of the absolute number of lymphocytes and their CD4 + and CD8 + positive T cells, NK cells, and CD8 were obtained. In the moderate group, good correlations were found between IL-6 and VEGF and NK cells (r = 0.6973, p <0.05; for IL6 and r = 0.6498, p <0, for VEGF. 05). Cytokines were correlated with CD45+ (r = 0.5610, p <0.05; for IL-6 and r = 0.5462, p <0.05 for VEGF). The oxidative stress index can be used as a cheaper alternative and as a triage tool between severe and moderate illnesses, after showing good correlation with more expensive patient classification analysis.","PeriodicalId":43715,"journal":{"name":"Italian Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45000206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Organizational actions to tackle distrust: Building Trust Italy. 解决不信任的组织行动:建立信任意大利。

IF 0.4

Italian Journal of Medicine Pub Date : 2023-01-12 DOI: 10.4081/itjm.2022.1554

D. Colimberti, R. Frediani

{"title":"Organizational actions to tackle distrust: Building Trust Italy.","authors":"D. Colimberti, R. Frediani","doi":"10.4081/itjm.2022.1554","DOIUrl":"https://doi.org/10.4081/itjm.2022.1554","url":null,"abstract":"According to the italian Code of Medical Deontology, mutual trust and mutual respect for values and rights are the care relationship foundation. To establish reciprocal trust and respect, the communication between care providers and patients must be skilled and appropriate, and the time devoted to communication must be considered time of care. But in Italy, in the last decades costs containment policy in the organizations of the National Health Service critically shortened the time available for care. Today, doctors and other healthcare professionals literally do not have the time to establish appropriate care relationships, and this causes a widespread and increasing distrust of patients and their families in the care system. During Covid-19 pandemic also vaccine hesitancy, defined by experts as a delay in acceptance or refusal of vaccination despite availability of vaccination services, was mainly due to a lack of confidence in care system and in scientific research. Slow Medicine ETS, an italian proactive movement of healthcare professional and citizen, following the example of the initiative “Building Trust” recently activated by the ABIM Foundation in the USA, launched a national initiative aimed to promote and plan concrete actions to restore and consolidate people’s trust in health professionals and organizations, in researchers, in scientific and rational approach to knowledge and in its use for the improvement of health and quality of life. Slow Medicine ETS, still successfully leading and supporting the “Choosing Wisely Italy” project, will be engaged in assembling the national network of the new project “Building Trust Italy”.","PeriodicalId":43715,"journal":{"name":"Italian Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46760069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Le cure palliative nel malato internistico: focus sulle malattie croniche in fase avanzata 内科患者的姑息治疗:关注晚期慢性病

IF 0.4

Italian Journal of Medicine Pub Date : 2022-12-16 DOI: 10.4081/itjm.q.2022.5

M. Carbone, Fabio Gilioli, R. Antonione

{"title":"Le cure palliative nel malato internistico: focus sulle malattie croniche in fase avanzata","authors":"M. Carbone, Fabio Gilioli, R. Antonione","doi":"10.4081/itjm.q.2022.5","DOIUrl":"https://doi.org/10.4081/itjm.q.2022.5","url":null,"abstract":"\u0000Prefazione - Il ruolo del palliativista in medicina internaGino Gobber\u0000Il ruolo del medico internista nelle cure palliativeDario Manfellotto\u0000Le cure palliative nel malato non-oncologicoItalo Penco\u0000La cura del malato fragile alla fine della vitaAndrea Fontanella\u0000La scuola di specializzazione in Medicina e Cure PalliativeGino Gobber; Dario Manfellotto\u0000IntroduzioneFabio Gilioli\u0000Strumenti per identificare la complessità dei bisogni clinici-assistenziali dei malati e delle loro famiglieFilippo Canzani; Claudio Santini\u0000Gestione dei sintomi in fase avanzata: dispnea, delirium, rantolo, nausea e vomito, occlusione intestinaleMatteo Moroni\u0000Gestione dei sintomi in fase avanzata e nel fine vita: doloreGiuseppe Civardi\u0000Approccio assistenziale ai sintomi in fase avanzata e nel fine vitaGabriella Bordin; Michela Guarda\u0000De-prescrizione, rimodulazione e sospensione diagnostiche e terapeutiche in fase avanzata di malattiaCarlo Lorenzo Muzzulini; Michele Berardi; Alessandro Valle\u0000Antibioticoterapia nelle cure palliativeMatteo Moroni; Filippo Costanzo\u0000Emotrasfusioni in cure palliativeFilomena Panzone; Raffaella Antonione\u0000Terapia anticoagulante in cure palliativeMauro Silingardi; Raffaella Antonione\u0000Ventilazione non invasiva in cure palliativeFederico Lari; Raffaella Antonione\u0000Scelte terapeutiche in medicina interna: come non perdersi nella complessità del fine vitaMiriam Cappelli; Mauro Carbone\u0000Raccomandazioni conclusive","PeriodicalId":43715,"journal":{"name":"Italian Journal of Medicine","volume":"9 3","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41304824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

La riscoperta della Medicina Narrativa come metodologia di intervento clinico-assistenziale: focus su dolore cronico e fine vita nel contesto pandemico 叙事医学作为一种临床护理干预方法的重新发现：关注疫情背景下的慢性疼痛和生命终结

IF 0.4

Italian Journal of Medicine Pub Date : 2022-12-05 DOI: 10.4081/itjm.q.2022.4

A. Fontanella, Stefania Polvani

引用次数: 0