Italian Journal of Medicine最新文献

Prevention is better than healing. Clinical and economic implications of oral antiviral agents in COVID-19: a prospective study 预防胜于治疗。口服抗病毒药物对 COVID-19 的临床和经济影响：一项前瞻性研究

IF 0.4

Italian Journal of Medicine Pub Date : 2024-06-03 DOI: 10.4081/itjm.2024.1737

F. Pietrantonio, F. Rosiello, Matteo Ruggeri, M. S. Cattaruzza, Antonio Vinci, Margherita Lordi, Enrica Cipriano

{"title":"Prevention is better than healing. Clinical and economic implications of oral antiviral agents in COVID-19: a prospective study","authors":"F. Pietrantonio, F. Rosiello, Matteo Ruggeri, M. S. Cattaruzza, Antonio Vinci, Margherita Lordi, Enrica Cipriano","doi":"10.4081/itjm.2024.1737","DOIUrl":"https://doi.org/10.4081/itjm.2024.1737","url":null,"abstract":"COVID-19 represents a threat for frailty patients. This study compares molnupiravir and nirmatrelvir for fragile COVID- 19 patients' efficacy, safety, and cost. An observational, prospective study allowed us to evaluate molnupiravir’s efficacy and safety in real life, compare it to a subgroup of patients treated with nirmatrelvir-ritonavir, and analyze its cost-effectiveness. From January to December 2022, 435 patients (225 males, 220 females; median age 72 years), were enrolled; 24 patients were unvaccinated, and 280 patients had ≥2 risk factors. Molnupiravir performed better clinically and economically. Compared to literature data, in these patients, hospitalization was 2.5% vs. 6.8% (P<0.005), overall adverse effects 14,3% vs. 30.4% (P<0.0001), severe adverse effects 2.6 vs. 6.9% (P<0.001), thus involving potential total savings of about € 92.954 per patient (8% of standard of care cost). Early molnupiravir treatment helped fragile patients who partially responded to the vaccine, or with absolute contraindications to vaccination, to overcome COVID-19 without the need for hospitalization. In elderly patients with multiple pathologies and multiple drugs, molnupiravir prevents disease progression clinically and economically.","PeriodicalId":43715,"journal":{"name":"Italian Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141271917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Complete revascularization in coronary artery bypass grafting with coronary artery endarterectomy: updated findings from Vietnam 冠状动脉旁路移植术与冠状动脉内膜剥脱术的完全血管再通：越南的最新研究结果

IF 0.4

Italian Journal of Medicine Pub Date : 2024-05-24 DOI: 10.4081/itjm.2024.1734

Huu Cong Nguyen, Hung Quoc Doan, L. Ngo, U. H. Nguyen, Long Hoang Vo, Thanh Ngoc Le

引用次数: 0

Micronutrition and diabetes: a new view at prevention and treatment 微营养与糖尿病：预防和治疗的新视角

IF 0.4

Italian Journal of Medicine Pub Date : 2024-05-24 DOI: 10.4081/itjm.2024.1728

Karim Ouali, Btihaj AL Ibrahmi, Said Bouchefra, Abdellatif Bour

{"title":"Micronutrition and diabetes: a new view at prevention and treatment","authors":"Karim Ouali, Btihaj AL Ibrahmi, Said Bouchefra, Abdellatif Bour","doi":"10.4081/itjm.2024.1728","DOIUrl":"https://doi.org/10.4081/itjm.2024.1728","url":null,"abstract":"Worldwide, millions of people suffer from diabetes. Our study aimed to describe the sample’s weight status and the effects of providing individualized micronutrient prescriptions and nutritional counseling to individuals with diabetes. Of the 46 patients (26 women and 20 men) enrolled in this study between 2014 and 2021, 41% had insulin-resistant diabetes and were over the age of 18. In compliance with the World Health Organization guidelines, anthropometric measurements were taken. The impedencemeter was used to measure the visceral fat. Diabetes affected 41% of the patients, with women making up the majority (74%). An impedencemeter’s average measurement of 6 for visceral fat loss was encouraging, and a glycated hemoglobin analysis of diabetics revealed an average loss of 1.6%. A good sign for lowering the therapeutic load is that 16% of diabetic patients were able to stop taking any medication at all, and 79% of patients were able to reduce their dosage. This study served as a strong foundation for the creation of customized nutritional management programs in Morocco to enhance the metabolic health of patients who are obese and insulin-resistant.","PeriodicalId":43715,"journal":{"name":"Italian Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141102198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A rare case of thrombocytopenia secondary to taking febuxostat 服用非布索坦导致血小板减少的罕见病例

IF 0.4

Italian Journal of Medicine Pub Date : 2024-04-23 DOI: 10.4081/itjm.2024.1724

Isabella Di Zio, Rodolfo Cisternino

引用次数: 0

Pathological changes of biochemical, hematological and coagulation analyses in patients with COVID-19 disease COVID-19 疾病患者生化、血液和凝血分析的病理变化

IF 0.4

Italian Journal of Medicine Pub Date : 2024-04-22 DOI: 10.4081/itjm.2024.1723

Zafer Gashi, Muhamet Kadrija

{"title":"Pathological changes of biochemical, hematological and coagulation analyses in patients with COVID-19 disease","authors":"Zafer Gashi, Muhamet Kadrija","doi":"10.4081/itjm.2024.1723","DOIUrl":"https://doi.org/10.4081/itjm.2024.1723","url":null,"abstract":"The identification of patients with poor prognosis and early detection of COVID-19 disease complications are made possible by pathological analyses of routine hematological, coagulation, and biochemical tests. Interpreting analyses needs to be done within the framework of each patient’s unique clinical picture. It’s also critical to keep an eye on changes at the individual parameter level. From May 20th, 2021, to March 30th, 2024, a comprehensive search of literature was carried out using international databases, such as PubMed, Embase, Web of Science, Scopus, and the Cochrane Library, in compliance with the PRISMA guidelines. The research question was formulated using the PICO strategy. The following terms were used: biochemical parameters in COVID-19, hematological parameters in COVID-19, blood coagulation parameters in COVID-19, indicators of inflammation, and indicators of tissue damage in SARS-CoV-2. Routine hematological, coagulation, and biochemical tests are primarily used to monitor the progression of the disease and the effectiveness of treatment rather than being utilized for the established diagnosis of COVID-19 due to their low specificity. Molecular genetics and immunological techniques should be used to determine the COVID-19 disease diagnosis.","PeriodicalId":43715,"journal":{"name":"Italian Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140672439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing risk management in hospitals: leveraging artificial intelligence for improved outcomes 加强医院风险管理：利用人工智能改善疗效

IF 0.4

Italian Journal of Medicine Pub Date : 2024-04-15 DOI: 10.4081/itjm.2024.1721

Ranieri Guerra

引用次数: 0

Acute severe renal failure in a patient receiving apixaban: a case report 接受阿哌沙班治疗的患者出现急性严重肾衰竭：病例报告

IF 0.4

Italian Journal of Medicine Pub Date : 2024-04-09 DOI: 10.4081/itjm.2024.1718

A. Pizzini, C. Fantoni, S. Zaccaroni, Mauro Silingardi

引用次数: 0

Point-of-care ultrasonography role in detecting inferior vena cava thrombosis in a patient with low back pain: a case report 护理点超声波检查在检测腰痛患者下腔静脉血栓中的作用：病例报告

IF 0.4

Italian Journal of Medicine Pub Date : 2024-04-09 DOI: 10.4081/itjm.2024.1719

Daniele Castellucci, Miguel Angel Casado Suela, Mercedes Duffort Falco, Juan Salillas Hernando, Pilar Medrano Izquierdo, Alessandra Dimino, A. Carroccio, Juan Torres Macho

{"title":"Point-of-care ultrasonography role in detecting inferior vena cava thrombosis in a patient with low back pain: a case report","authors":"Daniele Castellucci, Miguel Angel Casado Suela, Mercedes Duffort Falco, Juan Salillas Hernando, Pilar Medrano Izquierdo, Alessandra Dimino, A. Carroccio, Juan Torres Macho","doi":"10.4081/itjm.2024.1719","DOIUrl":"https://doi.org/10.4081/itjm.2024.1719","url":null,"abstract":"A 73-year-old woman arrived at the ER claiming to be experiencing low back pain. To investigate the source of her pain, she was admitted to the Internal Medicine department. After a heterogeneous abdominal mass in the right upper quadrant was discovered by abdominal point-of-care ultrasonography (POCUS), it was confirmed by an abdominal CT scan, which also identified a metastatic lytic bone lesion in the L4. This finding is consistent with a malignant tumor of the right adrenal gland. POCUS was repeated right after the occurrence of dyspnea, and a 40x6 mm floating thrombus in the inferior vena cava was detected. A conservative approach with anticoagulants was chosen, with improvement of the clinical conditions. The diagnosis of adrenal carcinoma was ultimately made possible by the mass biopsy. POCUS is a safe, low-cost method that provides prompt results at the patient's bedside. We support the implementation of POCUS in all clinical departments, as it provides significant contributions to the assessment of prognosis and diagnosis.","PeriodicalId":43715,"journal":{"name":"Italian Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140721610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Strong association between angiotensin I-converting enzyme insertion/deletion polymorphism and unexplained recurrent spontaneous abortion of Sudanese women: a case-control study 苏丹妇女血管紧张素 I 转换酶插入/缺失多态性与原因不明的复发性自然流产之间的密切关系：一项病例对照研究

IF 0.4

Italian Journal of Medicine Pub Date : 2024-04-04 DOI: 10.4081/itjm.2024.1717

A. Babker, Hanan Khalid Fadul Ahmed, R. Suliman, Ahmed Luay Osman, A. Alfeel, P. Kandakurti, S. Elzaki

{"title":"Strong association between angiotensin I-converting enzyme insertion/deletion polymorphism and unexplained recurrent spontaneous abortion of Sudanese women: a case-control study","authors":"A. Babker, Hanan Khalid Fadul Ahmed, R. Suliman, Ahmed Luay Osman, A. Alfeel, P. Kandakurti, S. Elzaki","doi":"10.4081/itjm.2024.1717","DOIUrl":"https://doi.org/10.4081/itjm.2024.1717","url":null,"abstract":"This study investigated the link between angiotensin I-converting enzyme insertion/deletion (ACE I/D) polymorphism and unexplained spontaneous abortion. This retrospective analytical case-control was conducted at the Omdurman Maternity Hospital in Sudan. The current study contained 230 individuals, including 119 cases (women who had at least three abortions) of unknown cause and 119 controls (healthy women who had at least two full-term deliveries without spontaneous abortion). Patients and controls were provided five ml of ethylenediaminetetraacetic acid blood and answered questionnaires about their demographics, personal lives, and family histories. ACE I/D polymorphisms were assessed using a conventional polymerase chain reaction approach after total genomic DNA was isolated from blood leukocytes using the GF-1 blood DNA extraction kit. Data was analyzed using the Statistical Package for the Social Sciences version 24. ACE I/D polymorphism is strongly linked to unexplained spontaneous abortion, and women with the I/D and D/D genotypes are more likely to have it than those with the I/I genotype. The current study reveals that ACEI/D polymorphism increases pregnancy problems. Sudanese women may have spontaneous abortions due to the ACE I/D polymorphism.","PeriodicalId":43715,"journal":{"name":"Italian Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140744559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Overcrowding in emergency departments: strategies and solutions for an effective reorganization 急诊科人满为患：有效重组的策略和解决方案

IF 0.4

Italian Journal of Medicine Pub Date : 2024-03-21 DOI: 10.4081/itjm.2024.1714

Chiara Busti, Roberto Marchetti, Manuel Monti

引用次数: 0