Italian Journal of Medicine最新文献

Management of large traumatic pneumothorax: when the patient is an experienced Internist 大面积创伤性气胸的处理：当患者是一名经验丰富的内科医生时

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Italian Journal of Medicine Pub Date : 2024-01-09 DOI: 10.4081/itjm.2024.1677

Nathan Artom, Paola Maineri, Luca Paris, Chiara Lagasio, Francesco Artom, P. Artom, Alberto Artom

引用次数: 0

Assessment and predictors of inappropriate dose of direct oral anticoagulants 直接口服抗凝剂剂量不当的评估和预测因素

IF 0.4

Italian Journal of Medicine Pub Date : 2024-01-09 DOI: 10.4081/itjm.2024.1679

M. Almegren

{"title":"Assessment and predictors of inappropriate dose of direct oral anticoagulants","authors":"M. Almegren","doi":"10.4081/itjm.2024.1679","DOIUrl":"https://doi.org/10.4081/itjm.2024.1679","url":null,"abstract":"Direct-Acting Oral Anticoagulants (DOACs) have revolutionized the management of Atrial Fibrillation (AF) and Venous Thromboembolism (VTE). However, recent audits reveal a significant burden of inappropriate dosages in the prescribing of direct-acting oral anticoagulants. Our aim is to identify the prevalence and predictors of such inappropriate dosing in our patients. This retrospective study was conducted from June 2016 to January 2018. Patients who received dabigatran, rivaroxaban, or apixaban for treatment of venous thromboembolism or atrial fibrillation were included. Appropriateness of direct-acting oral anticoagulants dosing was assessed using US Food and Drug Administration guidelines. Data was analyzed using IBM® SPSS Version 26. 337 patients were included, with a mean age of 62.9±18.7 years. The majority were female (196, 58.3%). Of the patients, 194 (57.6%) received apixaban, 99 (29.4%) received rivaroxaban, and 44 (13.1%) received dabigatran. A total of 242 (71.8%) patients were prescribed direct-acting oral anticoagulants appropriately. Under-dosing and over-dosing were identified in 74 (22%) and 21 (6.2%) patients, respectively. Predictors of inappropriate dosing were age greater than 75 years (OR: 2.76, 95% CI: 1.67-4.56, p<0.001) and creatinine clearance less than 50 ml/minute (OR: 0.38, 95% CI: 0.19-0.74, p: 0.005). Inappropriate dosing was significantly associated with mortality (p=0.010).One-third of our patients received an inappropriate dose of direct-acting oral anticoagulants, mostly from underdosing. Elderly age and low creatinine clearance are significant predictors of inappropriate dose administration.","PeriodicalId":43715,"journal":{"name":"Italian Journal of Medicine","volume":"16 3","pages":""},"PeriodicalIF":0.4,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139441597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adherence to interferon β treatment in Kosovan multiple sclerosis registry 科索沃多发性硬化症登记处坚持干扰素 β 治疗的情况

IF 0.4

Italian Journal of Medicine Pub Date : 2024-01-09 DOI: 10.4081/itjm.2024.1672

Blerim Myftiu, E. Komoni, Edita Malazogu, F. Jashari, Shpresa Beqiri Rashiti, Melihate Pushka, Adnan Biqku, Syzana Aliçkaj Prebreza, Valbona Rrahmani Spanca, Jehona Rrustemi Bytyqi, N. Shala, Afrim Blyta

{"title":"Adherence to interferon β treatment in Kosovan multiple sclerosis registry","authors":"Blerim Myftiu, E. Komoni, Edita Malazogu, F. Jashari, Shpresa Beqiri Rashiti, Melihate Pushka, Adnan Biqku, Syzana Aliçkaj Prebreza, Valbona Rrahmani Spanca, Jehona Rrustemi Bytyqi, N. Shala, Afrim Blyta","doi":"10.4081/itjm.2024.1672","DOIUrl":"https://doi.org/10.4081/itjm.2024.1672","url":null,"abstract":"Background. Because of side effects, adherence to the treatment with β interferons in multiple sclerosis (MS) is low, leading to decreased treatment efficacy. This can be challenging, especially in healthcare systems where these medications are the only therapeutic option for the treatment of MS. Materials and Methods. The number of missed doses was calculated as a difference between the number of doses a patient had to withdraw from the treatment start to the cut-off date and the real number of doses taken from the MS unit. Missed doses were compared to gender, age, time since the diagnosis, time from the diagnosis to the treatment start, clinical type of MS, expanded disability status scale (EDSS), and duration of the treatment. Results. The adherence rate during the follow-up period was 73.8%. Patients above 40 years of age (P<0.005), higher EDSS (P<0.001), longer duration of the disease (P<0.001), longer waiting time from the diagnosis to the treatment initiation (P<0.001), and longer time on interferons (P<0.001) had lower adherence rates to the treatment. Conclusions. The findings were in correlation with studies that have used similar criteria for the determination of adherence and supported reports that adherence rate decreases with time and poses a challenge to the overall efficacy of the treatment.","PeriodicalId":43715,"journal":{"name":"Italian Journal of Medicine","volume":"27 26","pages":""},"PeriodicalIF":0.4,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139443405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The pharmacological deprescription in elderly patients 老年患者的药物处方

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Italian Journal of Medicine Pub Date : 2023-12-19 DOI: 10.4081/itjm.2023.1676

Chelsey Ali, Daniel Huang, Charlene Tugwete, Stefano Del Canale, Vittorio Maio

引用次数: 0

Linea Guida Multisocietaria per il paziente adulto con diabete o con iperglicemia ricoverato in setting clinico non critico 非危重临床环境中收治的成年糖尿病或高血糖患者的多协会指南

IF 0.4

Italian Journal of Medicine Pub Date : 2023-12-19 DOI: 10.4081/itjm.q.2023.4

R. Pastorelli, A. Maffettone, M. Nizzoli, G. Bordin

{"title":"Linea Guida Multisocietaria per il paziente adulto con diabete o con iperglicemia ricoverato in setting clinico non critico","authors":"R. Pastorelli, A. Maffettone, M. Nizzoli, G. Bordin","doi":"10.4081/itjm.q.2023.4","DOIUrl":"https://doi.org/10.4081/itjm.q.2023.4","url":null,"abstract":"\u0000Introduzione\u0000Gruppo di sviluppo della Linea Guida\u0000Caratteristiche di una Linea Guida dell’ISS pubblicata sul Sito Nazionale Linee Guida\u0000Elenco dei quesiti\u0000Quesito 1: premesse, sintesi delle evidenze, raccomandazione, commento\u0000Quesito 2: premesse, sintesi delle evidenze, raccomandazione, commento\u0000Quesito 3: premesse, sintesi delle evidenze, raccomandazione, commento\u0000Quesito 4: premesse, sintesi delle evidenze, raccomandazione, commento\u0000Quesito 5: premesse, sintesi delle evidenze, raccomandazione, commento\u0000Quesito 6: premesse, sintesi delle evidenze, raccomandazione, commento\u0000Quesito 7: premesse, sintesi delle evidenze, raccomandazione, commento\u0000Quesito 8: premesse, sintesi delle evidenze, raccomandazione, commento\u0000Quesito 9: premesse, sintesi delle evidenze, raccomandazione, commento\u0000Quesito 10: premesse, sintesi delle evidenze, raccomandazione, commento\u0000Quesito 11: premesse, sintesi delle evidenze, raccomandazione, commento\u0000Quesito 12: premesse, sintesi delle evidenze, raccomandazione, commento\u0000Discussione\u0000Conclusioni","PeriodicalId":43715,"journal":{"name":"Italian Journal of Medicine","volume":" 22","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138994574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The 2023 hypertension guidelines of the European Society of Hypertension: a commentary 欧洲高血压学会 2023 年高血压指南：评述

IF 0.4

Italian Journal of Medicine Pub Date : 2023-12-19 DOI: 10.4081/itjm.2023.1675

G. Mancia, Guido Grassi, Enrico Agabiti-Rosei, Claudio Borghi, M. Muiesan, Paolo Palatini, Gianfranco Parati, Stefano Taddei, Reinhold Kreutz

引用次数: 0

COVID-19 effects on mental health of children and adolescents with intellectual disabilities in North Kosovo COVID-19 对科索沃北部智障儿童和青少年心理健康的影响

IF 0.4

Italian Journal of Medicine Pub Date : 2023-12-04 DOI: 10.4081/itjm.2023.1667

Snežana R. Markovic-Jovanovic, Aleksandar N. Jovanovic, Marina Petrovic, Dragoslava Ristic, Gordana Dželetović, Ana Karanovic, Dejan Tabakovic, Danijela Jovanovic

{"title":"COVID-19 effects on mental health of children and adolescents with intellectual disabilities in North Kosovo","authors":"Snežana R. Markovic-Jovanovic, Aleksandar N. Jovanovic, Marina Petrovic, Dragoslava Ristic, Gordana Dželetović, Ana Karanovic, Dejan Tabakovic, Danijela Jovanovic","doi":"10.4081/itjm.2023.1667","DOIUrl":"https://doi.org/10.4081/itjm.2023.1667","url":null,"abstract":"Background. People with intellectual disabilities (ID) are susceptible to physical, mental and social implications of the COVID-19 pandemic. Aim. Learning the way young individuals with disabilities dealt with the COVID-19 pandemic and how it affected their lives. Materials and Methods. An epidemiological questionnaire including information on the person’s health, mental state, behavior, educational capabilities, and epidemiological and clinical features of the COVID-19 infection was completed by 41 children/young adults and their family members. Results. During the two-year period of the pandemic, we monitored the frequency of COVID-19 infection in children and adolescents with intellectual disorders, children’s mental condition, and the occurrence of post-COVID symptoms. We also discussed the role of society regarding economic stability and support for families with a disabled member. Conclusions. The severity of COVID-19 symptoms was the independent predictor of mental status deterioration. Children and adolescents with ID experienced a greater prevalence of COVID-19 infection as well as post-COVID sequelae.","PeriodicalId":43715,"journal":{"name":"Italian Journal of Medicine","volume":"18 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138603087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lung damages of malaria: a differential diagnosis and treatment in emergency room of a rare case 疟疾引起的肺损伤：一例罕见病例的鉴别诊断和急诊治疗

IF 0.4

Italian Journal of Medicine Pub Date : 2023-11-29 DOI: 10.4081/itjm.2023.1603

N. Carannante, S. Scarica, Raffaele Disarno, Gerardo Langella, P. Di Micco, G. Fiorentino

引用次数: 0

STAT3 eye-opener in COVID-19 STAT3 在 COVID-19 中大放异彩

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Italian Journal of Medicine Pub Date : 2023-11-28 DOI: 10.4081/itjm.2023.1650

C. Mozzini, Giuseppe Lucchini, Mauro Pagani

{"title":"STAT3 eye-opener in COVID-19","authors":"C. Mozzini, Giuseppe Lucchini, Mauro Pagani","doi":"10.4081/itjm.2023.1650","DOIUrl":"https://doi.org/10.4081/itjm.2023.1650","url":null,"abstract":"Among the elevated inflammatory mediators, blood Interleukin-6 (IL-6) level is highly correlated with COVID-19 mortality and predicts the need for mechanical ventilation. IL-6 is the major activator of signal transducers and activators of transcription-3 (STAT3) during inflammatory responses. The primary objective of the study is to explore STAT3 activation in different subsets of circulating cells derived from 25 COVID-19 patients (patients) admitted to an Internal Medicine department compared to 25 healthy donors (HD). Higher percentages of classical and intermediate monocytes were observed in patients, compared to HD (respectively P<0.01 and P<0.001). The active form of STAT3, phosphorylated STAT3 (pSTAT3) was significantly higher in patients, compared to HD, both in non-classical and in intermediate monocytes (P<0.001). Low-density neutrophils (LDN) count was significantly higher in patients compared to HD (P<0.001). The pSTAT3 was significantly higher in LDN derived from patients (P<0.05). High pSTAT3 was significantly directly related to d-dimer and inversely related to vitamin D levels (P<0.01). This study gives information about STAT3 activation and the possible role of Vitamin D as a tool against COVID-19.","PeriodicalId":43715,"journal":{"name":"Italian Journal of Medicine","volume":"7 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139218911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prolonged prothrombin time in a rare case of vitamin K deficiency: a case report and a narrative review 一例罕见的维生素 K 缺乏症患者凝血酶原时间延长：病例报告和综述

IF 0.4

Italian Journal of Medicine Pub Date : 2023-11-21 DOI: 10.4081/itjm.2023.1665

Matteo Nicoletto, Eleonora Galli, Alice Cerato, Cristina Olivero, Francisca Bulai, Irene Praticò, Fulvio Pomero

引用次数: 0