Chelsey Ali, Daniel Huang, Charlene Tugwete, Stefano Del Canale, Vittorio Maio
{"title":"The pharmacological deprescription in elderly patients","authors":"Chelsey Ali, Daniel Huang, Charlene Tugwete, Stefano Del Canale, Vittorio Maio","doi":"10.4081/itjm.2023.1676","DOIUrl":"https://doi.org/10.4081/itjm.2023.1676","url":null,"abstract":"<jats:p>N/A</jats:p>","PeriodicalId":43715,"journal":{"name":"Italian Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138962655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Pastorelli, A. Maffettone, M. Nizzoli, G. Bordin
{"title":"Linea Guida Multisocietaria per il paziente adulto con diabete o con iperglicemia ricoverato in setting clinico non critico","authors":"R. Pastorelli, A. Maffettone, M. Nizzoli, G. Bordin","doi":"10.4081/itjm.q.2023.4","DOIUrl":"https://doi.org/10.4081/itjm.q.2023.4","url":null,"abstract":"\u0000Introduzione\u0000Gruppo di sviluppo della Linea Guida\u0000Caratteristiche di una Linea Guida dell’ISS pubblicata sul Sito Nazionale Linee Guida\u0000Elenco dei quesiti\u0000Quesito 1: premesse, sintesi delle evidenze, raccomandazione, commento\u0000Quesito 2: premesse, sintesi delle evidenze, raccomandazione, commento\u0000Quesito 3: premesse, sintesi delle evidenze, raccomandazione, commento\u0000Quesito 4: premesse, sintesi delle evidenze, raccomandazione, commento\u0000Quesito 5: premesse, sintesi delle evidenze, raccomandazione, commento\u0000Quesito 6: premesse, sintesi delle evidenze, raccomandazione, commento\u0000Quesito 7: premesse, sintesi delle evidenze, raccomandazione, commento\u0000Quesito 8: premesse, sintesi delle evidenze, raccomandazione, commento\u0000Quesito 9: premesse, sintesi delle evidenze, raccomandazione, commento\u0000Quesito 10: premesse, sintesi delle evidenze, raccomandazione, commento\u0000Quesito 11: premesse, sintesi delle evidenze, raccomandazione, commento\u0000Quesito 12: premesse, sintesi delle evidenze, raccomandazione, commento\u0000Discussione\u0000Conclusioni","PeriodicalId":43715,"journal":{"name":"Italian Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138994574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Mancia, Guido Grassi, Enrico Agabiti-Rosei, Claudio Borghi, M. Muiesan, Paolo Palatini, Gianfranco Parati, Stefano Taddei, Reinhold Kreutz
{"title":"The 2023 hypertension guidelines of the European Society of Hypertension: a commentary","authors":"G. Mancia, Guido Grassi, Enrico Agabiti-Rosei, Claudio Borghi, M. Muiesan, Paolo Palatini, Gianfranco Parati, Stefano Taddei, Reinhold Kreutz","doi":"10.4081/itjm.2023.1675","DOIUrl":"https://doi.org/10.4081/itjm.2023.1675","url":null,"abstract":"<jats:p>N/A</jats:p>","PeriodicalId":43715,"journal":{"name":"Italian Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138960952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Snežana R. Markovic-Jovanovic, Aleksandar N. Jovanovic, Marina Petrovic, Dragoslava Ristic, Gordana Dželetović, Ana Karanovic, Dejan Tabakovic, Danijela Jovanovic
{"title":"COVID-19 effects on mental health of children and adolescents with intellectual disabilities in North Kosovo","authors":"Snežana R. Markovic-Jovanovic, Aleksandar N. Jovanovic, Marina Petrovic, Dragoslava Ristic, Gordana Dželetović, Ana Karanovic, Dejan Tabakovic, Danijela Jovanovic","doi":"10.4081/itjm.2023.1667","DOIUrl":"https://doi.org/10.4081/itjm.2023.1667","url":null,"abstract":"Background. People with intellectual disabilities (ID) are susceptible to physical, mental and social implications of the COVID-19 pandemic. Aim. Learning the way young individuals with disabilities dealt with the COVID-19 pandemic and how it affected their lives. Materials and Methods. An epidemiological questionnaire including information on the person’s health, mental state, behavior, educational capabilities, and epidemiological and clinical features of the COVID-19 infection was completed by 41 children/young adults and their family members. Results. During the two-year period of the pandemic, we monitored the frequency of COVID-19 infection in children and adolescents with intellectual disorders, children’s mental condition, and the occurrence of post-COVID symptoms. We also discussed the role of society regarding economic stability and support for families with a disabled member. Conclusions. The severity of COVID-19 symptoms was the independent predictor of mental status deterioration. Children and adolescents with ID experienced a greater prevalence of COVID-19 infection as well as post-COVID sequelae.","PeriodicalId":43715,"journal":{"name":"Italian Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138603087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Carannante, S. Scarica, Raffaele Disarno, Gerardo Langella, P. Di Micco, G. Fiorentino
{"title":"Lung damages of malaria: a differential diagnosis and treatment in emergency room of a rare case","authors":"N. Carannante, S. Scarica, Raffaele Disarno, Gerardo Langella, P. Di Micco, G. Fiorentino","doi":"10.4081/itjm.2023.1603","DOIUrl":"https://doi.org/10.4081/itjm.2023.1603","url":null,"abstract":"Pulmonary involvement occurs in 3 to 10% of the cases of Plasmodium falciparum malaria and represents the most severe complication of this infection, with a lethality of about 70%. The antigens released by the parasite play an important role in the induction and worsening of lung damage. Capillary endothelial cells, which control the flux of fluids to the interstitial space, appear to be the most complicated structures. The clinical manifestations of pulmonary involvement may start suddenly at any time during the course of malaria, even after the disappearance of the circulating parasite. Hyperparasitemia predisposes to these factors. Treatment with corticosteroids is optional, and that is not often a benefit.","PeriodicalId":43715,"journal":{"name":"Italian Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139210749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"STAT3 eye-opener in COVID-19","authors":"C. Mozzini, Giuseppe Lucchini, Mauro Pagani","doi":"10.4081/itjm.2023.1650","DOIUrl":"https://doi.org/10.4081/itjm.2023.1650","url":null,"abstract":"Among the elevated inflammatory mediators, blood Interleukin-6 (IL-6) level is highly correlated with COVID-19 mortality and predicts the need for mechanical ventilation. IL-6 is the major activator of signal transducers and activators of transcription-3 (STAT3) during inflammatory responses. The primary objective of the study is to explore STAT3 activation in different subsets of circulating cells derived from 25 COVID-19 patients (patients) admitted to an Internal Medicine department compared to 25 healthy donors (HD). Higher percentages of classical and intermediate monocytes were observed in patients, compared to HD (respectively P<0.01 and P<0.001). The active form of STAT3, phosphorylated STAT3 (pSTAT3) was significantly higher in patients, compared to HD, both in non-classical and in intermediate monocytes (P<0.001). Low-density neutrophils (LDN) count was significantly higher in patients compared to HD (P<0.001). The pSTAT3 was significantly higher in LDN derived from patients (P<0.05). High pSTAT3 was significantly directly related to d-dimer and inversely related to vitamin D levels (P<0.01). This study gives information about STAT3 activation and the possible role of Vitamin D as a tool against COVID-19.","PeriodicalId":43715,"journal":{"name":"Italian Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139218911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prolonged prothrombin time in a rare case of vitamin K deficiency: a case report and a narrative review","authors":"Matteo Nicoletto, Eleonora Galli, Alice Cerato, Cristina Olivero, Francisca Bulai, Irene Praticò, Fulvio Pomero","doi":"10.4081/itjm.2023.1665","DOIUrl":"https://doi.org/10.4081/itjm.2023.1665","url":null,"abstract":"Prolonged prothrombin time increases the risk of bleeding complications in proportion to prolongation severity. We reported the case of a 72-year-old woman with a recent hospitalization for methicillin-susceptible Staphylococcus aureus endocarditis complicated by spondylodiscitis who developed a severe prolongation of clotting time during treatment with cefazolin due to a vitamin K deficiency. Cefazolin is a first-generation cephalosporin active against gram-positive bacteria. Like other cephalosporins, it is potentially able to inhibit the enzymes involved in recycling vitamin K metabolites, leading to a fall in gamma-carboxylation of vitamin K-dependent clotting factors. Clinicians should be aware of the necessity of regular monitoring of clotting times for the duration of antimicrobial therapy, especially in those patients with several risk factors for a poor vitamin K nutritional status. Prompt detection of vitamin K deficiency should be recognized and adequately supplemented.","PeriodicalId":43715,"journal":{"name":"Italian Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139252803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Di Micco, F. F. Bernardi, Giovanni Maria Fusco, Alessandro Perrella
{"title":"How artificial intelligence during the pandemic modified the role of a biomarker as d-dimer","authors":"P. Di Micco, F. F. Bernardi, Giovanni Maria Fusco, Alessandro Perrella","doi":"10.4081/itjm.2023.1656","DOIUrl":"https://doi.org/10.4081/itjm.2023.1656","url":null,"abstract":"Artificial intelligence (AI) was introduced in medicine to make some difficult decision-making regarding diagnostics and/or treatments easy. Its application derives from the improvement of information obtained with computer sciences and informatics, in particular with information derived by algorithms obtained with special informatics support as machine learning. The scenario of hospital changes induced by the COVID-19 pandemic makes easy the application of AI for some clinical updates. Being lung failure with pulmonary embolism is the most common cause of death for inpatients with COVID-19, some biomarkers such as the d-dimer are constantly used associated with other clinical features in order to improve medical assistance. For this reason, d-dimer during the pandemic changed its traditional use for predictive negative value in patients with suspected pulmonary embolism and took relevance for its values giving the chance to change the intensity of anticoagulation for several inpatients. In most cases, according to data reported from several cohorts, these changes improved the morbidity and mortality of a significant percentage of inpatients with COVID-19. The International medical prevention registry on venous thromboembolism and d-dimer and modified sepsis-induced coagulopathy scores were the most used scores derived from AI and dedicated to these clinical aspects in inpatients with COVID-19. Therefore, this review was dedicated to flexible changes that we can use after d-dimer values in different clinical scenarios that vary from disseminated intravascular coagulation to pulmonary embolism to COVID-19.","PeriodicalId":43715,"journal":{"name":"Italian Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139255018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Suhaila A. Ali, Ahmad Y. Alqassim, Fatmah O. Alshekh, Atheer M. Alshammakhi, Rawan N. Omar, Roaa A. Areeshi, Roaa Alhazmi, Lamees A. Zaalah, Mohammed A. Muaddi, Abdullah A. Alharbi
{"title":"Correlation between extended surgical mask usage and adverse health effects during the COVID-19 pandemic among healthcare personnel in Jazan, Saudi Arabia","authors":"Suhaila A. Ali, Ahmad Y. Alqassim, Fatmah O. Alshekh, Atheer M. Alshammakhi, Rawan N. Omar, Roaa A. Areeshi, Roaa Alhazmi, Lamees A. Zaalah, Mohammed A. Muaddi, Abdullah A. Alharbi","doi":"10.4081/itjm.2023.1636","DOIUrl":"https://doi.org/10.4081/itjm.2023.1636","url":null,"abstract":"The global prevalence of COVID-19 has necessitated the use of personal protective equipment, particularly face masks, amongst healthcare workers (HCWs). However, extended face mask usage has led to adverse health effects. This cross-sectional study investigates the relationship between prolonged surgical mask-wearing and the development of adverse effects among 500 HCWs in Jazan, Saudi Arabia. The study utilized an anonymous questionnaire distributed across multiple departments in Jazan and Sabya Hospitals. The results indicated that most participants believed that wearing face masks for extended periods led to adverse skin and respiratory effects. The primary respiratory complaints were difficulty breathing and nasal itching, while skin-related issues included sweating, itching, and acne. Therefore, this study concludes that extended surgical mask usage during the COVID-19 pandemic could potentially lead to adverse health implications among HCWs in Jazan. Further research into this correlation is needed.","PeriodicalId":43715,"journal":{"name":"Italian Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139257928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Healthy diet, prevalence and factors associated among adults of Nekemte dwellers, Oromia State, Western Ethiopia","authors":"Alemu Adeba, Dessalegn Tamiru, T. Belachew","doi":"10.4081/itjm.2023.1630","DOIUrl":"https://doi.org/10.4081/itjm.2023.1630","url":null,"abstract":"Introduction. Adaption and adoption of a healthy lifestyle remain challenging worldwide. An unhealthy diet is the core risk of lifestyle illnesses. However, the status of a healthy diet and its predictors were not assessed in Nekemte town targeting middle-aged adulthoods. The study was designed to assess healthy diet, prevalence and factors associated among middle-aged adults in Nekemte town from January 15, 2019, to February 30, 2019. Materials and Methods. A descriptive epidemiological study design typically cross-sectional analysis was applied in Nekemte town on middle-aged adults. Primary data was gathered by using a questionnaire and checked for its normality. Factors associated with dependent variables were analyzed with logistic regressions and their significance was determined at P<0.05. Results. The status of dieting practice was 73.31% (unhealthy) and 26.69% (healthy), respectively. This study showed that being low income (P=0.001), not married (P=0.001), and daily meal frequency [adjusted odds ratio (AOR): 1.91, 95% confidence interval (CI): [1.04, 2.71]) are associated with unhealthy diets. The odds of having an unhealthy diet were almost 3 times (AOR=3.20, [95% CI: (2.04, 5.98) higher for illiterate compared to literate participants. In addition, an unhealthy diet was nearly 5 times (AOR: 4.87, 95% CI: [3.23, 7.65]) higher for having poor knowledge of healthy diet compared to alert participants. Conclusions. The researchers identified unhealthy diets practiced highly by the study samples of the populations.","PeriodicalId":43715,"journal":{"name":"Italian Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139255178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}