Asian Pacific Journal of Cancer Care最新文献

{"title":"COVID-19 Prevalence and Survival Outcome in Pediatric Cancer Patients Undergoing Chemotherapy: A Study from Tertiary Cancer Center of North-East India","authors":"M. Hazarika, Raghavender Reddy T, Avdhesh K Rai, Partha S Roy, Asif Iqbal, S. Barbhuiyan, Nithin D. Raj, Sreya Mallik, S. S. Sarangi","doi":"10.31557/apjcc.2022.7.3.475-480","DOIUrl":"https://doi.org/10.31557/apjcc.2022.7.3.475-480","url":null,"abstract":"Background: Pediatric cancer patients are considered one of vulnerable group for Covid-19 infections and its associated complication. We assessed Covid-19 prevalence and implications in pediatric cancer patients of NorthEast India. Methods: Retrospective study was conducted between July 2020 to June 2021 at Dr B Borooah Cancer Institute (BBCI), Guwahati, Assam, India. Medical records of the childhood cancer patients were analyzed. All patients who were tested for SARS-CoV-2 were collected. All childhood cancer patients with age group between one to eighteen years were included. Results: Fifty two out of 701 (7%) cancer patients in children were found to be positive for SARS-CoV2 by RT-PCR testing. Among COVID-19 positive patients, the median age was six years. In COVID-19 positive group, thirty (57.6 %) were suffering from hematological malignancy and twenty two (42.4%) have solid malignancy. In COVID-19 positive group, Among the hematological malignancies; acute lymphoblastic leukemia (ALL) comprises 70% (21), acute myeloid leukemia (AML) 16.66% (5) and lymphoma accounting for 13.33%. Fever, cough and sore throat was presenting symptom in majority of patients. Survival outcome has shown statistically significant association (p=0.0001) between COVID-19 positive and negative pediatric cancer patients. Eight deaths occurred in COVID-19 positive patients but there was only one death in COVID-19 negative patients. Conclusion: Among COVID-19 positive childhood cancer patients risk of death was significantly higher compared to COVID-19 negative patients and majority of deaths occurred in hematological malignancies receiving intensive chemotherapy.","PeriodicalId":436394,"journal":{"name":"Asian Pacific Journal of Cancer Care","volume":"140 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133447945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of Chronic Lymphocytic Leukemia in Sudanese Patients","authors":"Ameen Abdulaziz Basabaeen, E. Abdelgader, Ebtihal Ahmed Babekir, N. Abdelateif, Sadia Osman Abdelrahim, O. Altayeb, E. Fadul, H. Osman, Salem Ahmed Bamusa, Ibrahim Khider Ibrahim","doi":"10.31557/apjcc.2022.7.3.467-474","DOIUrl":"https://doi.org/10.31557/apjcc.2022.7.3.467-474","url":null,"abstract":"Objective: Our study aimed to characterize clinical, hematological and Immunophenotyping patterns in Sudanese patients with Chronic Lymphocytic Leukemia. Methods: A cross-sectional study was conducted in Khartoum state, Sudan, during the period from April 2017 to April 2018, involved 110 CLL patients. Physical examination, Complete Blood Count and Immunophenotyping were performed for all patients to confirm the diagnosis. Clinical staging such as Rai and Binet stages were applied. The statistical analysis was performed by using SPSS version 23.0. Results: In this study, 71.8% were males and 28.2% were females. Lymphadenopathy, splenomegaly, hepatomegaly, leukocytosis, thrombocytopenia, and anemia were seen in 71%, 49%, 13%, 60.9%, 39% and 34.5% of patients respectively. However, about 90% of patients displayed an advanced Rai risk stage and 70% were at Binet stage B or C. All CLL samples expressed CD45, CD19 and CD20. All the CLL cases were negative for the T-cell marker CD3.CD5 was expressed in 80% patients; CD23 was expressed in 92.7% patients. CD22, CD79b and FMC7 were negative in 91.8%, 77.3%, and 96.4% of patients respectively. Conclusions: CLL in Sudan is a disease of the elderly and more frequently in males than females. The incidence at young patients was higher than those reported by Western studies. Most of our patients presented advanced Rai and Binet stages. CD22 may be a highly specific marker for diagnosing CLL in Sudanese patients and should be included in all diagnostic panels used to differentiate CLL from other B cell lymphoproliferative disorders in Sudan.","PeriodicalId":436394,"journal":{"name":"Asian Pacific Journal of Cancer Care","volume":"126 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116190888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clival Metastasis from Lung Primary","authors":"Kanmani Velarasan, Deivanayagam R, Valli S","doi":"10.31557/apjcc.2022.7.3.587-588","DOIUrl":"https://doi.org/10.31557/apjcc.2022.7.3.587-588","url":null,"abstract":"Clivus is a rare location for metastasis. We report a patient with lung cancer presented to us with diplopia and headache. He was found to have clival metastasis and treated with palliative radiation therapy to clivus. Metastasis is also a differential to be considered when patients present with clival lesion.","PeriodicalId":436394,"journal":{"name":"Asian Pacific Journal of Cancer Care","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129142989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review on Cervical Dysplasia: Etiology, Risk Factors, Diagnostic Biomarkers and Possible Nutritional Association","authors":"Shirin Dasgupta","doi":"10.31557/apjcc.2022.7.3.555-563","DOIUrl":"https://doi.org/10.31557/apjcc.2022.7.3.555-563","url":null,"abstract":"Objectives: Cervical dysplasia which is the precursor or premalignant form of cervical cancer is prolonged; hence its diagnosis is essential for the early detection and inhibiting the development of cervical cancer. This review briefs the extensive studies conducted globally to gain knowledge about the development of cervical dysplasia along with the risk factors associated, role of human papilloma virus (HPV), potential diagnostic biomarkers and association with various micronutrient levels. Materials and method: All these data were collected through extensive literature review. Result: Based on the review, it can be stated that HPV virus (HPV 16 most commonly) is the most important etiological agent for the process of cervical carcinogenesis. However, HPV infection solely does not cause cervical cancer. There are various factors which act synergistically to develop cervical dysplasia and cancer. Smoking was found to be an important independent risk factor. There are studies which showed conflicting results regarding oral contraceptive intake association with cervical dysplasia. There are quite a few biomarkers like HPV DNA, p16INK4a, telomerase, and microRNA expression which have been identified as effective in diagnosing cervical dysplasia. Chromosome 3q mutation has been reported to be present in early dysplastic lesions; hence, it can be used in screening early lesions. Various micronutrient studies highlighted the facts that high plasma concentrations of several carotenoids and Vitamin C are inversely proportional to the degree of cervical dysplasia. Low red cell folate levels n plasma increases the risk of cervical dysplasia association. Low dietary intake of Vitamin A is also associated with increased risk of cervical dysplasia. Conclusion: Finally, it can be stated that more extensive studies relating to nutritional and serum markers level need to be conducted with larger cohorts so that an appropriate nutrition plan can be implemented for these patients. ","PeriodicalId":436394,"journal":{"name":"Asian Pacific Journal of Cancer Care","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125169375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Favourable Response to Chemotherapy in Ora-Located Intraocular Retinoblastoma Grade B, C, and D: A Case Series","authors":"Anne Susanty, Susi Susanah, P. Idjradinata, Feti Karfiati","doi":"10.31557/apjcc.2022.7.3.573-576","DOIUrl":"https://doi.org/10.31557/apjcc.2022.7.3.573-576","url":null,"abstract":"Background: We aim to analyze which tumor location gives more favorable chemotherapy response in intraocular retinoblastoma grade B, C, and D as well as to report the first case series in Indonesia. Methods: Six boys with age ranging from 10 weeks to 47 months old were recruited into the study from April 2019 to January 2020 at National Eye Centre, Cicendo Eye Hospital, and Hasan Sadikin General Hospital, Bandung, West Java, Indonesia. Retinoblastoma (RB) patients underwent examination under anesthesia (EUA). Tumor size and location were evaluated by using RetCam pre and post 2 cycles of chemotherapy. The tumors were classified according to the International Intraocular Retinoblastoma Classification. Results: There were two patients with unilateral RB and four patients with bilateral RB. All patients had leukocoria and sought medical advice within 12 months of onset. There were one tumor in the macular zone, six tumors in the equatorial zone, and two tumors in the ora zone. Two cycles of intravenous vincristine, etoposide, and carboplatin (VEC) were administered and the tumor diameter was re-evaluated afterwards. The tumor size was decreased following 2 cycles of chemotherapy. Conclusions: Ora zone showed a more favorable chemotherapy response.","PeriodicalId":436394,"journal":{"name":"Asian Pacific Journal of Cancer Care","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125796856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suprapubic Catheter in a Patient with Bladder Carcinoma, Against the Prohibition: A Systematic Review and Case Report","authors":"Derri Hafa Nurfajri, S. Pramod, Ferry Safriadi, B. S. Hernowo","doi":"10.31557/apjcc.2022.7.3.581-586","DOIUrl":"https://doi.org/10.31557/apjcc.2022.7.3.581-586","url":null,"abstract":"Background: Bladder tumors are the most common neoplasm of the lower urinary tract. Bladder carcinoma arising from a suprapubic cystostomy tract is a relatively rare. Some patients with bladder tumors have difficult urethral access for urinary retention due to inaccessible urethra. Most people think cystostomy in patient with bladder cancer can cause seeding and upstaging to suprapubic cystostomy tract. This study aim of suprapubic cystostomy can cause seeding and upstaging of bladder cancer. Methods: Literature obtained from the search results of Pubmed, Medscape, Science Direct, Scopus, Cochrane Library, and Google Scholar electronic databases with the keywords used are “suprapubic catheter and bladder cancer”, “suprapubic catheter and bladder tumor”, “suprapubic catheter and bladder carcinoma”, “suprapubic cystotomy and bladder carcinoma”, and “suprapubic catheter and bladder cancer upstaging” with no time limits. Results: Eighty two articles were obtained from the electronic database. Following all the inclusion and exclusion criteria, the final selection considered 5 literature with 16 patient eligible for this literature review. The five literature involved a total of 16 bladder cancer patients with a suprapubic catheter. The duration of suprapubic catheter insertion was between 1 to 3 months. As long as it is within the specified time and from the location of cancer, literature result there will be no seeding and upgrading in the suprapubic cystostomy tract. In our case report we have patient with duration suprapubic cystostomy 1 months wih no seeding and upgrading cancer. Conclusion: Although SPC is an effective, inexpensive, easy mode of access for bladder tumors with difficult urethral access for urinary retention due to inaccessible urethra, it also presents a risk of SPC tract bladder cancer, mostly SCC and TCC. It is important to be aware of any suspicious signs and symptoms, duration time of use suprapubic cystostomy and location of the cancer. ","PeriodicalId":436394,"journal":{"name":"Asian Pacific Journal of Cancer Care","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123682709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive Value of Swede Colposcopy Score for Predicting Cervical Intra Epithelial Neoplasia in Cervical Cancer Screening with Visual Inspection with Acetic Acid","authors":"Shubham Bidhuri, S. Shamsunder, H. K, S. Malik, A. Gautam, Priyanka Pangtey, R. Arora, C. Ahluwalia","doi":"10.31557/apjcc.2022.7.3.445-449","DOIUrl":"https://doi.org/10.31557/apjcc.2022.7.3.445-449","url":null,"abstract":"Objectives: To assess the predictive value of Swede score with VIA as the screening method and identify a cut-off score that predicts high grade CIN. Methods: Records of 324 women who were VIA positive and had acetowhite lesion on colposcopy graded according to Swede score followed by biopsy/excisional procedure were included in the analysis. Sensitivity, Specificity, PPV & NPV for each Swede score were calculated and area under the ROC curve (AUROC) for score predicting high grade histopathology (≥ CIN 2) was estimated. A p value less than 0.05 was considered statistically significant. Results: As the swede score increased from 0 to 10, the sensitivity decreased and specificity increased i.e. sensitivity of score < 6 was high whereas specificity of score > 6 was high. At a cut-off of Swede Score ≥6, it predicted high grade histology with a sensitivity of 51%, and a speci-ficity of 79%. The highest diagnostic accuracy was at swede score cut off >6 i.e. 64.6%. Conclusion: We recommend biopsy at a Swede score of 5 or less and treatment by excision at a Swede score of 6 or more.","PeriodicalId":436394,"journal":{"name":"Asian Pacific Journal of Cancer Care","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123628635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long Term Clinical Outcome and Prognostic Factors after Treatment of Patients Diagnosed with Ductal Carcinoma in Situ of Breast","authors":"Ativitch AsavachaIsuvikom, Ongart Somintara, Yotdanai Namuangchan, Chaiwat Aphivatanasiri, Anongporn Wongbuddha","doi":"10.31557/apjcc.2022.7.3.459-465","DOIUrl":"https://doi.org/10.31557/apjcc.2022.7.3.459-465","url":null,"abstract":"Objectives: The retrospective study evaluated the clinical outcome after treatment of patients diagnosed with ductal carcinoma in situ of breast and reanalyzed the prognostic factors related to recurrence rate and disease free survival(DFS) using long-term follow-up. Material & Methods: Between January 2008 and July 2021, 130 patients previously diagnosed ductal carcinoma in situ underwent surgery. We collected retrospective data characteristic data, radiology data, operative data, pathology data, clinical outcome and time to breast tumor recurrence. Median follow-up time was 51.5 months. Results: The 12-year cumulative incidence of tumor recurrence and re- excision in 130 patients were 6.92%(9 patients) and 12.31%(16 patients). Among 9 patients, 5 patients had locoregional recurrence, 3 patients had distant metastasis recurrence and 1 patient had both. Ki-67(OR, 1.06;95% CI 1.00 – 1.11); p-value = 0.045) was associated with an increase risk of recurrence tumor in multivariable analysis. Simple mastectomy(41.54%) and wide excision (38.46%) were the most surgery in this study. Conclusion: The retrospective study showed the 12-year cumulative incidence of recurrence tumor. Although Ki-67 increased risk of recurrence tumor.","PeriodicalId":436394,"journal":{"name":"Asian Pacific Journal of Cancer Care","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114343862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 Anxiety and Related Factors in Cancer Patients Undergoing External Radiation Therapy","authors":"Korosh Saber, N. Hamzian, F. Madadizadeh","doi":"10.31557/apjcc.2022.7.3.451-458","DOIUrl":"https://doi.org/10.31557/apjcc.2022.7.3.451-458","url":null,"abstract":"Introduction: Studies have shown that anxiety caused by the COVID-19 epidemic affects the patient’s decision-making processes regarding treatment and may even force him to refuse to continue treatment or disrupt the function and efficiency of treatment. This study aimed to determine the anxiety caused by COVID-19 and related factors in cancer patients undergoing radiotherapy. Methods: This analytical cross-sectional study included 125 cancer patients which sampled through convenience sampling from patients who admitted to radiotherapy centre in Yazd, Iran, in 2021. Patients had different primary cancers such as Breast, Lung, Head and Neck, Prostate, Stomach, Cervix, Blood, Intestine, Brain, Skin, Lymphoma, Kidney and Oesophagus. The COVID-19 Disease Anxiety Scale (CDSA) questionnaire was used to collect data. The frequency, percentage, mean (standard deviation), median (interquartile range=IQR) were used to description and the Mann–Whitney U and Kruskal-Wallis tests were used for data analysis. All analyses were performed in SPSS software (version 24) with a significance level of 5%. Results: In total, 55.2% of patients (69 patients) were male, 85.6% (107 patients) were married, and the mean (SD) age of participants was 50.16 (13.93) years. Median (IQR) the scores of mental, physical and anxiety symptoms were 11 (13), 4 (8), and 16 (18), respectively, which were moderate in physical and psychological symptoms according to guidelines. In terms of total anxiety classification, total anxiety score in our study was in mild category. Median of the CDSA score was significantly different in levels of age, education, economic status, and type of job (p<0.001). Conclusion: COVID-19 anxiety in cancer patients was in the mild level. Young people and people with lower social, economic, and educational status are more anxious. However, in addition to targeted safety and prevention measures, training and counselling programs may also be useful in reducing anxiety level.","PeriodicalId":436394,"journal":{"name":"Asian Pacific Journal of Cancer Care","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122197443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Profile and Treatment Outcomes of Metastatic Carcinoma with Unknown Primary: A Single Institution Experience","authors":"T. Tali, Fiza Amin, N. Khan, Javaid Ahmad Dar, Arshad Manzoor Najmi, Mushtaq Ahmad Sofi, S. Rashid, Waseem Aijaz Kitab, Murtaza Shaf, Mansoora Akhter","doi":"10.31557/apjcc.2022.7.3.441-444","DOIUrl":"https://doi.org/10.31557/apjcc.2022.7.3.441-444","url":null,"abstract":"Background: Cancer of unknown primary origin (CUP) is a heterogeneous group of cancers defined by the presence of metastatic disease with no identified primary. CUP has been reported to comprise approximately 2% to 5% of all cancer cases. With the availability of sophisticated imaging techniques and targeted therapies in the treatment of cancer, the extent of workup in CUP remains a challenge and should be based on the clinical presentation, radiological imaging, tumour biomarkers, pathology with immunhistochemistry and the patient’s ability to tolerate therapy. Objectives: To study the incidence, clinical presentation, histology, treatment modalities used, survival and lacunae in not establishing the diagnosis of primary.Materials & Methods: This was a retroprospective study done between January 2014 to December 2018. 650 patients of cancer of unknown primary at presentation were enrolled in this study. After going through various investigations, primary of 387 patients were detected & hence, were excluded from this study. Primary could not be detected in 263 patients even after going through comprehensive work up and henceforth, these were taken up for this study. Demographics, imaging, pathology and treatment data were analyzed from the case records retrospectively between 1st January 2014 to June 2017. The data was collected prospectively between July 2017 to December 2018. Patients with histopathological evidence of metastatic lesion were included and patients whose primary were detected after comprehensive work-up were excluded from this study. Results: Incidence of unknown primary was 0.65 per 1 lakh population. Majority of the patients were from rural areas (77.9%) & most of the patients were in the age group of 61-80 years (47.1%). Male to female ratio was 1.45:1. Abdominal pain (29.7%) and bone pain (20.5%) were the most common clinical symptoms reported. Computed Tomography & PET-CT scans detected primary lesions in 156 out of 650 (24%) & 12 out of 33 (33.3%) patients respectively. Adenocarcinoma was the most common histology (58.6%). The most common treatment modality received by the patients was external beam radiotherapy (12.5%). The median survival of the studied patients was 6-12 months. Conclusion: Patients presenting with metastatic carcinoma with unknown primary have poor outcomes. These patients need a patientcentred, streamlined, rapid diagnostic pathway. The outcome of these patients with standard chemotherapy remains poor. Larger studies with other therapeutic and novel agents are warranted to improve the treatment outcomes.","PeriodicalId":436394,"journal":{"name":"Asian Pacific Journal of Cancer Care","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125638100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}