Asian Pacific Journal of Cancer Care最新文献_第6页

Hematological Toxicity in Carcinoma Cervix Patients Undergoing Concurrent Chemo Radiation Therapy or Radiation Therapy alone in a Tertiary Hospital of North East India: A Prospective Study 印度东北部某三级医院宫颈癌患者同期化疗或单独放疗的血液学毒性:一项前瞻性研究

Asian Pacific Journal of Cancer Care Pub Date : 2022-11-10 DOI: 10.31557/apjcc.2022.7.4.651-655

Chiranjiv Baruah, T. Paul, Biswajit Sarma, Kankan Jyoti Deka, Partha Pratim Patowory

{"title":"Hematological Toxicity in Carcinoma Cervix Patients Undergoing Concurrent Chemo Radiation Therapy or Radiation Therapy alone in a Tertiary Hospital of North East India: A Prospective Study","authors":"Chiranjiv Baruah, T. Paul, Biswajit Sarma, Kankan Jyoti Deka, Partha Pratim Patowory","doi":"10.31557/apjcc.2022.7.4.651-655","DOIUrl":"https://doi.org/10.31557/apjcc.2022.7.4.651-655","url":null,"abstract":"Introduction: The current standard of treatment for locally advanced cancer of cervix is cisplatin based concurrent chemo radiation therapy followed by brachytherapy. Concurrent chemo radiotherapy causes acute hematological toxicities, which in turn leads to prolongation of therapy. Objective: The main purpose of our study, was to analyze the acute hematological toxicity in cervical cancer patients undergoing radiation or chemo radiation therapy. Materials and Methods: This is a hospital based observational study done at department of Radiation Oncology, Assam medical college and hospital. All the biopsy proven cervical cancer patients attending the department, within the study period from September 2020 to May 2021 are included in the study. Results: Out of 26 patients in the study sample, grade 1 hematologicaltoxicity is seen in 2 patients (7.5%), grade 2 hematological toxicity seen in 20 patients (77%), grade 3 hematological toxicities in 4 patients (15.5%) and none of the patients developed grade 4 nor grade 5 hematological toxicity or any other life threatening complications. Conclusion: Hematological toxicity is more common with conventional external beam therapy in locally advanced carcinoma cervix patients. Compared to conventional external beam radiotherapy and 3DCRT, patients undergoing treatment with IMRT experiences significantly less acute grade ≥2 hematological toxicities.","PeriodicalId":436394,"journal":{"name":"Asian Pacific Journal of Cancer Care","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134261206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Mixed Neuroendocrine-Non-neuroendocrine Neoplasm (MiNEN) of the Esophagus: A Case Report 食道混合性神经内分泌-非神经内分泌肿瘤1例

Asian Pacific Journal of Cancer Care Pub Date : 2022-11-10 DOI: 10.31557/apjcc.2022.7.4.755-756

D. Cristina G., Cornelio Gerardo H

引用次数: 0

Malignant Melanoma of the Palate: Report of a Metastatic Case 上颚恶性黑色素瘤:一例转移病例报告

Asian Pacific Journal of Cancer Care Pub Date : 2022-11-10 DOI: 10.31557/apjcc.2022.7.4.757-761

Mel Valerie B. Cruz-Ordinario, Carlo Antonio Dg. Boado, A. Gorospe

引用次数: 0

Knowledge and Experience of Women with Breast Cancer Receiving Chemotherapy in Selected Public Hospitals, Addis Ababa Ethiopia, 2021: Cross-sectional Study 2021年埃塞俄比亚亚的斯亚贝巴选定公立医院乳腺癌妇女接受化疗的知识和经验:横断面研究

Asian Pacific Journal of Cancer Care Pub Date : 2022-11-10 DOI: 10.31557/apjcc.2022.7.4.657-664

Kalkidan Ayalew, Y. Ayalew, T. Alemu, T. Gebru

{"title":"Knowledge and Experience of Women with Breast Cancer Receiving Chemotherapy in Selected Public Hospitals, Addis Ababa Ethiopia, 2021: Cross-sectional Study","authors":"Kalkidan Ayalew, Y. Ayalew, T. Alemu, T. Gebru","doi":"10.31557/apjcc.2022.7.4.657-664","DOIUrl":"https://doi.org/10.31557/apjcc.2022.7.4.657-664","url":null,"abstract":"Background: Breast cancer is the most common cancer in women worldwide, in 2018 2.1 million new cases are diagnosed. In Ethiopia due to the increasing awareness of breast cancer patients are taking chemotherapy in different parts of the country but patients’ knowledge of chemotherapy and experience of chemotherapy have not been assessed very well and this study tried to assess patients’ knowledge about chemotherapy. Objective: The objective of the study is to assess the knowledge and experience of women with breast cancer receiving chemotherapy in selected public hospitals in Addis Ababa Ethiopia, in 2021. Methods: Institutional based cross-sectional study was conducted and data was collected from Tikur Anbessa Specialised Hospital and Saint Paul Hospital Millennium Medical College from February 8 to March 1, 2020. Data was entered into Epi-data version 4.6.0 and exported to SPSS version 26. Descriptive statics such as frequency, percentages, mean and standard deviation were done and displayed in tables. Bivariate and multivariate logistic regression analysis was employed. Results: The study involved 250 participants. The mean age of the respondents was (43.35±11.1). Of the total 135 (54%) respondents were not knowledgeable and 115 (46%) were knowledgeable. Age >45 years and patients who lived in Addis Ababa were associated with higher knowledge. Respondents who took chemotherapy fourth to the sixth cycle and who are currently single were associated with the worst experience and the distance-time it takes to get to the hospital when is three to six hours were associated with the tolerable experience. Conclusion and recommendations: The study revealed that more than half of the participants were not knowledgeable and more than half of the participants had the worst experience. Hence healthcare providers should provide information about chemotherapy to their patients and should teach them how to manage the possible side effects.","PeriodicalId":436394,"journal":{"name":"Asian Pacific Journal of Cancer Care","volume":"382 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123496383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EGFR Mutation-positive Lung Cancer in Real-world Treatment Outcomes: A Multicenter Study from Thailand EGFR突变阳性肺癌在现实世界的治疗结果:一项来自泰国的多中心研究

Asian Pacific Journal of Cancer Care Pub Date : 2022-11-10 DOI: 10.31557/apjcc.2022.7.4.643-650

S. Sukauichai, Kulthida Maneenil, A. Supavavej, Vinai Paul, Duangnapa Benjawongsathien, C. Chantharakhit, S. Neesanun, C. Chayangsu, Thissawan Bowornkitiwong, N. Sukaraphat

{"title":"EGFR Mutation-positive Lung Cancer in Real-world Treatment Outcomes: A Multicenter Study from Thailand","authors":"S. Sukauichai, Kulthida Maneenil, A. Supavavej, Vinai Paul, Duangnapa Benjawongsathien, C. Chantharakhit, S. Neesanun, C. Chayangsu, Thissawan Bowornkitiwong, N. Sukaraphat","doi":"10.31557/apjcc.2022.7.4.643-650","DOIUrl":"https://doi.org/10.31557/apjcc.2022.7.4.643-650","url":null,"abstract":"Background: Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI) have been the standard of care as first-line (1L) therapy for patients with advanced EGFR mutated lung cancer since 2009. In Thailand, however, it was not fully introduced to all health care funds until 2020. The purpose of this study was to determine the overall survival (OS) and treatment pattern in the period before EGFR-TKI became universally available to all patients. \u0000Methods: This was a retrospective study conducted at 10 medical centers in Thailand. Patients harboring the common mutation (exon 19 deletion or exon 21 L858R) diagnosed during January 2013 and December 2019 were enrolled. \u0000Results: This study included 284 patients with a median follow-up time of 19.8 months and a death rate of 80.3% (228/284). Clinical characteristics included median age 62.5 years, female 65.5%, never-smoking 74.3%, stage 3B/4/recurrence 2.1/93.3/4.6%, exon 19/exon 21- 60.9/38.7%. Treatment patterns to EGFR-TKI included not receiving (NR) (9.5%), first-line (1L) (56.0%), switch maintenance (MN) (3.5%), second-line (2L) (21.8%) and third-line (3L) or more (9.2%). Median OS of patient receiving EGFR-TKI as NR, 1L+MN, 2L and 3L or more was 11.10 (95%CI: 8.21 to14.00), 19.08 (95%CI: 15.76 to 22.41), 23.06 (95%CI: 15.91 to 30.21) and 32.46 (95%CI: 21.61 to 43.30) months (p=0.006), respectively. Factors contributing to poor prognosis in the multivariate model included poor ECOG-PS (HR 3.17, 95%CI: 1.96-5.13), not receiving EGFR-TKI (HR 3.83, 95%CI, 1.94-7.56) and receiving EGFR-TKI 1L (HR 2.30, 95%CI: 1.40-3.79) \u0000Conclusion: OS of patients with EGFR mutation positive lung cancer treated with EGFR-TKIs in Thailand was comparable to clinical studies. EGFR-TKI treatment should be provided to patients as early as possible, but TKI remained beneficial at later points in the treatment timeline. ","PeriodicalId":436394,"journal":{"name":"Asian Pacific Journal of Cancer Care","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121823119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Predictors of Coping Strategies among Cervical Cancer Patients at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia: A Cross-sectional Study 亚的斯亚贝巴Tikur Anbessa专科医院宫颈癌患者应对策略的预测因素:一项横断面研究

Asian Pacific Journal of Cancer Care Pub Date : 2022-11-10 DOI: 10.31557/apjcc.2022.7.4.629-636

A. Dirar, W. Mekonnen, Zena Berhanu

{"title":"Predictors of Coping Strategies among Cervical Cancer Patients at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia: A Cross-sectional Study","authors":"A. Dirar, W. Mekonnen, Zena Berhanu","doi":"10.31557/apjcc.2022.7.4.629-636","DOIUrl":"https://doi.org/10.31557/apjcc.2022.7.4.629-636","url":null,"abstract":"Background: The diagnosis and treatment of cervical cancer could result in psychological distress. Greater understanding of patients’ coping strategies, and influencing factors, can aid in developing appropriate psychosocial support. The aim of this study was to assess the prevalence of coping strategies and associated factors among cervical cancer patients. Materials and methods: A cross-sectional study was conducted among 299 cervical cancer patients on follow-up treatment at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia. Data were collected through face-to-face interview to assess patients’ sociodemographic characteristics, self-efficacy, meaning in life, perceived social support, uncertainty, cognitive appraisal, and coping strategies. Pearson’s correlation coefficient and linear regression analysis was conducted. Results: Findings reveal that women utilized both problem-focused and emotion-focused coping strategies. However, emotion-focused coping strategies were more frequently employed than problem-focused coping strategies by cervical cancer patients. Self-efficacy (ß=.27, p<.001), meaning in life-presence (ß= -.25, p=.015), perceived social support from friend (ß= .36, p<.001), and perceived social support from significant others (ß= -.27, p=.048) predicted emotion-focused coping strategies. Moreover, self-efficacy (ß=.25, p<.001), uncertainty (ß= -.13, p=.003), meaning in life-presence (ß= -.12, p=.003), meaning in life-search (ß= .12, p=.009), perceived social support from family (ß= .11, p=.021), and challenge appraisals (ß= .13, p=.010) were determinants of problem-focused coping strategies. Conclusion: This study demonstrates that women with cervical cancer adopt varied coping strategies to deal with their illness. Since coping strategies adopted are influenced by the extent of personal and environmental factors, there is a need to take these factors into account when developing tailored interventions to support patients’ coping strategies.","PeriodicalId":436394,"journal":{"name":"Asian Pacific Journal of Cancer Care","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116458608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Comparison of Survival Estimation Methods in the Analysis of Breast Cancer Data 乳腺癌资料分析中生存估计方法的比较

Asian Pacific Journal of Cancer Care Pub Date : 2022-10-15 DOI: 10.31557/apjcc.2022.7.4.601-605

O. Oladuti, Paul Olopha

{"title":"Comparison of Survival Estimation Methods in the Analysis of Breast Cancer Data","authors":"O. Oladuti, Paul Olopha","doi":"10.31557/apjcc.2022.7.4.601-605","DOIUrl":"https://doi.org/10.31557/apjcc.2022.7.4.601-605","url":null,"abstract":"Objective: In many epidemiological studies or clinical trials, Cox Proportional Hazard model is the most commonly used technique for the analysis of effects of covariates on survival time when time are continuous and ties are present. It is important to handle the presence of ties in the data to prevent the inherent effect which may lead to unreliable result in the analysis. Therefore, this study was carried out handle the inadvertent inclusion of ties in survival time with three different estimation methods; Breslow, Efron and exact partial likelihood estimation methods of Cox regression model. Material and Methods: Analysis were carried out using data collected on 300 breast cancer patients from University of Ilorin Teaching Hospital to evaluate the factors affecting the survival of patients with breast cancer. The estimation methods used in handling ties in the breast cancer data are compared using Akaike Information Criterion. All analyses were performed using STATA version 14.0. Result: Of a total of 300 patients, 97 (32.33%) died of breast cancer. The result of the data analysis using Cox model with different estimation methods were approximately alike. The risk of dying from the breast cancer was associated with age of the patients; patients with Cytological diagnosis had an increased risk for death. Conclusion: The hazard ratios of the estimators are approximately similar but based on Akaike Information Criteria, exact partial likelihood outperformed the other methods of handling ties in breast cancer data since it has the smallest value.","PeriodicalId":436394,"journal":{"name":"Asian Pacific Journal of Cancer Care","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129492975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Benign Diseases Masquerading as Cholangiocarcinoma: Can we Differentiate before Surgery? 伪装成胆管癌的良性疾病:能否在手术前鉴别?

Asian Pacific Journal of Cancer Care Pub Date : 2022-10-15 DOI: 10.31557/apjcc.2022.7.4.621-628

Thitiporn Wannasri, Vor Luvira, Arada Wongwattanachai, Attapol Titapun, Tharatip Srisuk, Supot Kamsa-Ard, Theerawee Tipwaratorn, Suapa Theeragul, A. Pugkhem, Apiwat Jarearnrat, N. Khuntikeo, C. Pairojkul, V. Bhudhisawasdi

{"title":"Benign Diseases Masquerading as Cholangiocarcinoma: Can we Differentiate before Surgery?","authors":"Thitiporn Wannasri, Vor Luvira, Arada Wongwattanachai, Attapol Titapun, Tharatip Srisuk, Supot Kamsa-Ard, Theerawee Tipwaratorn, Suapa Theeragul, A. Pugkhem, Apiwat Jarearnrat, N. Khuntikeo, C. Pairojkul, V. Bhudhisawasdi","doi":"10.31557/apjcc.2022.7.4.621-628","DOIUrl":"https://doi.org/10.31557/apjcc.2022.7.4.621-628","url":null,"abstract":"Background: Cholangiocarcinoma (CCA) is a potentially lethal disease that requires surgical treatment. There are many benign conditions, those that do not require surgical treatment, displaying imaging characteristics that resemble CCA, leading to therapeutic misadventures. This study aimed to evaluate the proportion of benign conditions that underwent hepatic resection for presumed CCA, and explore the differences between the characteristics of these two entities stratified by primary imaging features of the lesions. Methods: This retrospective study ran between January 2004 and December 2011. We reviewed the pathological records of all 1,402 patients who underwent curative-intent hepatic resection for preoperatively diagnosed CCA. All clinical and pathological parameters were analyzed. Results: The proportion of benign conditions that underwent hepatic resection was 3.78% (53/1,402). For mass-forming lesions, CCA was associated with higher age, alkaline phosphatase, tumor markers, neutrophil to lymphocyte ratio, and mass size. The patients with mass-forming benign conditions were more associated with diabetes mellitus. For lesions with bile duct dilatation, intraductal tumor, including CCA, had higher CA19-9 level and NLR with statistical significance. For cystic lesions, biliary cystic neoplasm had statistical significance in the rate of abdominal pain. Conclusions: The proportion of hepatic resection for benign conditions was quite low. There were many characteristic differences used to differentiate benign mass-forming conditions from CCA, whereas only few markers in the setting of cystic lesions and biliary dilatation. We recommend performing standard hepatic resection in every case, regardless of the type of imaging features, if the lesion has a chance of being CCA.","PeriodicalId":436394,"journal":{"name":"Asian Pacific Journal of Cancer Care","volume":"126 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133857133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Haematological Parameters and Lymphocyte Monocyte Ratio as a Prognostic Marker in Diffuse Large B-cell Lymphoma and T Cell Lymphoma Patients- An Observational Study 血液学参数和淋巴细胞单核细胞比例作为弥漫性大b细胞淋巴瘤和T细胞淋巴瘤患者预后指标的评估-一项观察性研究

Asian Pacific Journal of Cancer Care Pub Date : 2022-10-15 DOI: 10.31557/apjcc.2022.7.4.607-613

Antholi Keloth Kavya, Chandran K Nair, M. Padmanabhan, Edakkadath Raghavan Sindhu

{"title":"Evaluation of Haematological Parameters and Lymphocyte Monocyte Ratio as a Prognostic Marker in Diffuse Large B-cell Lymphoma and T Cell Lymphoma Patients- An Observational Study","authors":"Antholi Keloth Kavya, Chandran K Nair, M. Padmanabhan, Edakkadath Raghavan Sindhu","doi":"10.31557/apjcc.2022.7.4.607-613","DOIUrl":"https://doi.org/10.31557/apjcc.2022.7.4.607-613","url":null,"abstract":"Background: The present study is a retrospective observational analysis of patients diagnosed with DLBCL and T cell lymphoma during the period of January 2011 to December 2015 at Malabar Cancer Centre, Thalassery. Several studies have shown that ALC and LMR can be used as prognostic indicators for diagnosis, treatment and survival in DLBCL. But there were very few studies done on the correlation of these parameters with T cell lymphoma. So we analysed the influence of haematological parameters in both DLBCL and T cell lymphomas. The primary objective of the present study was to correlate haematological parameters and LMR as predictors of DLBCL and T cell lymphomas. Methods: We analysed total cases of 108 with DLBCL and 25 with T cell lymphomas. The study was done to determine the changes in haematological parameters including WBC count, Platelet count, Hb, HCT, lymphocyte count, monocyte count, ALC, AMC and lymphocyte monocyte ratio in diffuse large B cell lymphoma and T cell lymphomas before and after chemotherapy. Results: The results showed a significant decrease (p˂ 0.05) in the blood platelet counts after chemotherapy in DLBCL. AMC in female patients with DLBCL were decreased (0.69 ± 0.36 to 0.53 ± 0.31; p-value = 0.023) and this was highly significant. LMR was also increased (3.47 ± 3.05 to 5.22 ± 4.34; p-value = 0.048) in female patients with DLBCL. Conclusion: Haematological parameters can be used as a prognostic marker in predicting the extent of disease progression and the effectiveness of the treatment adopted.","PeriodicalId":436394,"journal":{"name":"Asian Pacific Journal of Cancer Care","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127797529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Impact of Colon Cancer Sites on Survival Rates after Curative Resection and Adjuvant Chemotherapy: A SingleCenter Study 结肠癌部位对治愈性切除和辅助化疗后生存率的影响:一项单中心研究

Asian Pacific Journal of Cancer Care Pub Date : 2022-10-15 DOI: 10.31557/apjcc.2022.7.4.615-620

S. Jaruhathai, Athit Santidamrongkul, J. Wiwitkeyoonwong, Benjawongsathien Duangnapa

{"title":"The Impact of Colon Cancer Sites on Survival Rates after Curative Resection and Adjuvant Chemotherapy: A SingleCenter Study","authors":"S. Jaruhathai, Athit Santidamrongkul, J. Wiwitkeyoonwong, Benjawongsathien Duangnapa","doi":"10.31557/apjcc.2022.7.4.615-620","DOIUrl":"https://doi.org/10.31557/apjcc.2022.7.4.615-620","url":null,"abstract":"Background: Most recent studies indicate that right-sided colon cancer is associated with a significantly higher mortality rate. Multivariate analyses showed that the patient’s age, sex, mode of presentation, co-morbidity, and the stage had significantly influenced their survival. Although the primary tumor location has an impact on the overall survival in metastatic settings, the laterality of early-stage colon cancer might also affect the disease-free survival and determine the duration of adjuvant chemotherapy for each side. This study aimed to compare overall survival and disease-free survival between left-sided and right-sided high-risk stage II and stage III colon cancer in patients from a single institute. Methods: This retrospective cohort study was conducted between January 2004 and December 2017. Data on 153 patients who underwent curative resection and adjuvant chemotherapy for colon cancer were retrieved from an existing database. Results: We found that the five-year disease-free survival rates were 63.20% for left-sided colon cancer and 51.11% for right-sided colon cancer (P-value < 0.05). The five-year overall survival rates were 66.98% for left-sided colon cancer and 57.77% for right-sided colon cancer (P-value 0.063). The right-sided primary tumor location was associated with a significantly higher mortality rate (HR: 2.28; 95%CI 1.38–5.8; P-value: 0.004). Conclusion: The results of this study confirmed that patients with high-risk stage II and stage III colon cancer who had right-sided tumors were significantly more likely to have decreased disease-free survival and overall survival. Further prospective studies should focus on tumor genetics and proper durations of adjuvant chemotherapy to maximize the benefit of treatment with acceptable toxicity.","PeriodicalId":436394,"journal":{"name":"Asian Pacific Journal of Cancer Care","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129902750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1