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SPECIAL FOCUS: Early-onset colorectal cancer 特别关注：早发结直肠癌癌症
IF 4.2
Colorectal Cancer Pub Date : 2020-09-01 DOI: 10.2217/crc-2020-0030
F. Berger
{"title":"SPECIAL FOCUS: Early-onset colorectal cancer","authors":"F. Berger","doi":"10.2217/crc-2020-0030","DOIUrl":"https://doi.org/10.2217/crc-2020-0030","url":null,"abstract":"","PeriodicalId":43638,"journal":{"name":"Colorectal Cancer","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45449238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diet and weight management by people with nonmetastatic colorectal cancer during chemotherapy: mixed methods research 非转移性癌症患者化疗期间的饮食和体重管理：混合方法研究
IF 4.2
Colorectal Cancer Pub Date : 2020-07-01 DOI: 10.2217/crc-2019-0017
J. Hopkinson, Catherine Kazmi, Jayne Elias, S. Wheelwright, Rhiannon Williams, A. Russell, C. Shaw
{"title":"Diet and weight management by people with nonmetastatic colorectal cancer during chemotherapy: mixed methods research","authors":"J. Hopkinson, Catherine Kazmi, Jayne Elias, S. Wheelwright, Rhiannon Williams, A. Russell, C. Shaw","doi":"10.2217/crc-2019-0017","DOIUrl":"https://doi.org/10.2217/crc-2019-0017","url":null,"abstract":"Aim: To investigate self-management of dietary intake by colorectal cancer patients receiving chemotherapy. Methods: A questionnaire was administered to 92 patients with nonmetastatic colorectal cancer receiving chemotherapy treatment at a UK cancer center in 2018–19. A maximum variation sample of 20 patients who completed the questionnaire were interviewed. Results: More than three in five patients were at nutritional risk but fewer than one in five were concerned about dietary intake or weight. Self-management of diet and weight was inconsistent with achieving the nutritional intake recommended by clinical guidelines on nutrition in cancer. Conclusion: There is potential for psychoeducation to support change in self-management of nutritional risk, with implications for better treatment tolerance and outcomes including quality of life.","PeriodicalId":43638,"journal":{"name":"Colorectal Cancer","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47350090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Therapeutic challenges in colorectal surgery practice during COVID-19 outbreak: a case series COVID-19爆发期间结直肠手术实践中的治疗挑战:病例系列
IF 4.2
Colorectal Cancer Pub Date : 2020-06-01 DOI: 10.2217/crc-2020-0014
M. Alemrajabi, M. Moradi, E. Amiri, Masoud Vahdani
{"title":"Therapeutic challenges in colorectal surgery practice during COVID-19 outbreak: a case series","authors":"M. Alemrajabi, M. Moradi, E. Amiri, Masoud Vahdani","doi":"10.2217/crc-2020-0014","DOIUrl":"https://doi.org/10.2217/crc-2020-0014","url":null,"abstract":"After the outbreak of COVID-19, several issues in the field of general surgery have remained unknown. Here we present two consecutive patients operated on in a coronavirus center in February 2020, during the outbreak in Tehran, Iran. Moreover, we highlight some challenges surgeons face in the management of these patients during the outbreak. We suggest surgeons to perform the safest technique with the least risk. In borderline conditions, it is suggested to prefer stoma over anastomosis. This lessens the course of hospitalization and probable complication rates. We suggest establishing clean centers and prepare guidelines for the general surgery team members to lessen the risk for patients and healthcare providers.","PeriodicalId":43638,"journal":{"name":"Colorectal Cancer","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43525809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Official French SARS-CoV-2 guidelines for cancer patients, a triage solution with precision medicine. 法国官方针对癌症患者的SARS-CoV-2指南，一种精准医学的分诊解决方案。
IF 4.2
Colorectal Cancer Pub Date : 2020-05-01 DOI: 10.2217/crc-2020-0018
Juan Manuel O'Connor, Federico Esteso, Matías Chacón
{"title":"Official French SARS-CoV-2 guidelines for cancer patients, a triage solution with precision medicine.","authors":"Juan Manuel O'Connor, Federico Esteso, Matías Chacón","doi":"10.2217/crc-2020-0018","DOIUrl":"10.2217/crc-2020-0018","url":null,"abstract":"One of the early guidelines to protect cancer patients against the novel coronavirus (SARS-CoV-2) was developed in early March by the French High Council for Public Health at the request of the French Health Ministry. These guidelines were prepared by a representative group of medical oncologists and radiation oncologists, working in both academic and private practice. The results of this initiative were published by You et al. in Lancet Oncology on 25 March [1]. In addition to ethical and practical considerations for the management of cancer patients in the context of the COVID-19 pandemic, these official guidelines provide helpful recommendations [1]:","PeriodicalId":43638,"journal":{"name":"Colorectal Cancer","volume":"9 2","pages":"CRC21"},"PeriodicalIF":4.2,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/crc-2020-0018","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38451753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Evolution of RAS testing over time: factors influencing mutation rates in metastatic colorectal cancer patients RAS检测随时间的演变：影响转移性结直肠癌癌症患者突变率的因素
IF 4.2
Colorectal Cancer Pub Date : 2020-03-01 DOI: 10.2217/crc-2019-0013
K. Dufraing, C. Keppens, V. Tack, A. Siebers, G. Kafatos, S. Dube, L. Kroeze, M. Ligtenberg, J. V. Krieken, E. Dequeker
{"title":"Evolution of RAS testing over time: factors influencing mutation rates in metastatic colorectal cancer patients","authors":"K. Dufraing, C. Keppens, V. Tack, A. Siebers, G. Kafatos, S. Dube, L. Kroeze, M. Ligtenberg, J. V. Krieken, E. Dequeker","doi":"10.2217/crc-2019-0013","DOIUrl":"https://doi.org/10.2217/crc-2019-0013","url":null,"abstract":"Aim: Correct identification of RAS gene variants is key for targeted treatment decisions in patients with metastatic colorectal cancer. Published RAS mutation rates differ and could be influenced by several factors including testing methods. This study aimed to describe the performance of laboratories to correctly identify RAS variants over time and to understand how RAS testing has evolved in Europe. Materials & methods: Misclassification and test failure rates were calculated and related to the used test methodology for 239 unique laboratories participating in external quality assessment for metastatic colorectal cancer between 2013 and 2018. In addition, 33 laboratories completed a survey aiming to obtain more details on their routine testing strategies, number of samples analyzed and RAS mutation rates between 2013 and 2017. Results: The mutation status was correctly analyzed in 96.1% (N = 5471) RAS and BRAF tests. A total of 4.6% (N = 2860) RAS tests included false-negative results. In 1.6% (N = 5562) RAS and BRAF tests, an analysis failure occurred. Misclassifications and technical failures both decreased between 2013 and 2018. The number of next-generation sequencing users increased from 6.9% (N = 130) in 2013 to 44.6% (N = 112) in 2018. Over time, more codons were included in the methodologies, yet 23.2% (N = 112) did not offer full RAS testing (exon 2, 3, 4) in 2018. Based on the survey the overall RAS mutation rate was estimated as 45.2% (N = 27,325). Conclusion: This is the largest observational study reporting RAS mutation rates to-date. There was no trend of RAS mutation rates over time despite having a clear shift to more sensitive tests and increased quality of testing.","PeriodicalId":43638,"journal":{"name":"Colorectal Cancer","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/crc-2019-0013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47817522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Unintended consequences of treating early rectal cancers for complete clinical response with chemoradiotherapy 放化疗治疗早期直肠癌完全临床反应的意外后果
IF 4.2
Colorectal Cancer Pub Date : 2020-03-01 DOI: 10.2217/crc-2019-0010
R. Glynne-Jones, N. Bhuva, M. Harrison
{"title":"Unintended consequences of treating early rectal cancers for complete clinical response with chemoradiotherapy","authors":"R. Glynne-Jones, N. Bhuva, M. Harrison","doi":"10.2217/crc-2019-0010","DOIUrl":"https://doi.org/10.2217/crc-2019-0010","url":null,"abstract":"The aim was to examine the current trend in rectal cancer, which is to extend ’watch-and-wait’ to earlier-stage tumors, not normally treated with chemoradiotherapy, to define the up-side and down-side regarding quality of life (QOL) and anorectal/sexual/urinary function from this approach. We reviewed the literature regarding a ‘watch-and-wait’ strategy after neoadjuvant chemoradiotherapy. The primary outcome measure was complete clinical response. Secondary measures included colostomy rate, functional outcomes and QOL. There is a trend to use chemoradiotherapy in earlier tumors using dose-escalation of radiation and/or additional chemotherapy, resulting in high rates of complete clinical response, which may impact adversely on QOL if radical surgery is subsequently required. Focusing on organ-preservation as the primary goal of treatment rather than overall functional outcomes and QOL for the whole population, may not provide patients with sufficient information for optimal decision-making.","PeriodicalId":43638,"journal":{"name":"Colorectal Cancer","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/crc-2019-0010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44062170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Colorectal cancer care in the age of coronavirus: strategies to reduce risk and maintain benefit 冠状病毒时代的大肠癌癌症护理：降低风险和保持效益的策略
IF 4.2
Colorectal Cancer Pub Date : 2020-03-01 DOI: 10.2217/crc-2020-0010
J. Marshall, R. Yarden, B. Weinberg
{"title":"Colorectal cancer care in the age of coronavirus: strategies to reduce risk and maintain benefit","authors":"J. Marshall, R. Yarden, B. Weinberg","doi":"10.2217/crc-2020-0010","DOIUrl":"https://doi.org/10.2217/crc-2020-0010","url":null,"abstract":"John L Marshall*,1, Ronit I Yarden2 & Benjamin A Weinberg3 1Hematology & Oncology, The Ruesch Center for the Cure of GI Cancers, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington DC 20057, USA 2Colorectal Cancer Alliance, 1025 Vermont Ave., Washington DC 20005, USA 3Ruesch Center for the Cure of Gastrointestinal Cancers, Lombardi Comprehensive Cancer Center, Georgetown University, Washington DC 20007, USA *Author for correspondence: Tel.: +202 444 2223; Fax: +202 444 1229; marshalj@georgetown.edu","PeriodicalId":43638,"journal":{"name":"Colorectal Cancer","volume":"0 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/crc-2020-0010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45770492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
The impact of mismatch repair status to the preoperative staging of colon cancer: implications for clinical management 错配修复状态对癌症术前分期的影响：对临床管理的启示
IF 4.2
Colorectal Cancer Pub Date : 2020-02-01 DOI: 10.1200/jco.2020.38.4_suppl.16
E. Erbs, S. Rafaelsen, J. Lindebjerg, L. Jensen, T. Hansen
{"title":"The impact of mismatch repair status to the preoperative staging of colon cancer: implications for clinical management","authors":"E. Erbs, S. Rafaelsen, J. Lindebjerg, L. Jensen, T. Hansen","doi":"10.1200/jco.2020.38.4_suppl.16","DOIUrl":"https://doi.org/10.1200/jco.2020.38.4_suppl.16","url":null,"abstract":"Aims: We sought to investigate if mismatch repair (MMR) status influences the preoperative staging of local colon cancer. Methods: Data from 590 patients in the Danish Colorectal Cancer Group national clinical database who were operated on for stage I-III colon cancer in 2010-15 were included. MMR status was determined by immunohistochemistry. Results: 22.9% had deficient(d) MMR tumors. Correlation of the clinical and pathological T-category was significant for both groups. The correlation of pre- and postoperative N-category was inferior (p >0.05) in dMMR cancers compared to a significant (p <0.01) correlation in proficient MMR cancers. 64.8% of dMMR tumors assessed node-positive demonstrated no sign of metastatic involvement at the postoperative assessment. Conclusion: MMR status seems to impact the accuracy of preoperative lymph node staging.","PeriodicalId":43638,"journal":{"name":"Colorectal Cancer","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47741944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Fine-tuning immunotherapy in MMR-D/MSI-H colorectal cancer MMR-D/MSI-H结直肠癌癌症的精细调节免疫疗法
IF 4.2
Colorectal Cancer Pub Date : 2019-12-01 DOI: 10.2217/crc-2019-0014
I. Sahin
{"title":"Fine-tuning immunotherapy in MMR-D/MSI-H colorectal cancer","authors":"I. Sahin","doi":"10.2217/crc-2019-0014","DOIUrl":"https://doi.org/10.2217/crc-2019-0014","url":null,"abstract":"","PeriodicalId":43638,"journal":{"name":"Colorectal Cancer","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/crc-2019-0014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45936700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
BRAF mutations as a therapeutic target in metastatic colorectal cancer patients: a long due success BRAF突变作为转移性结直肠癌癌症患者的治疗靶点：长期的成功
IF 4.2
Colorectal Cancer Pub Date : 2019-12-01 DOI: 10.2217/crc-2019-0012
I. Sahin, J. Klostergaard
{"title":"BRAF mutations as a therapeutic target in metastatic colorectal cancer patients: a long due success","authors":"I. Sahin, J. Klostergaard","doi":"10.2217/crc-2019-0012","DOIUrl":"https://doi.org/10.2217/crc-2019-0012","url":null,"abstract":"","PeriodicalId":43638,"journal":{"name":"Colorectal Cancer","volume":"8 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44162733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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