The impact of mismatch repair status to the preoperative staging of colon cancer: implications for clinical management

IF 2.7 Q3 ONCOLOGY

Colorectal Cancer Pub Date : 2020-02-01 DOI:10.1200/jco.2020.38.4_suppl.16

E. Erbs, S. Rafaelsen, J. Lindebjerg, L. Jensen, T. Hansen

引用次数: 3

Abstract

Aims: We sought to investigate if mismatch repair (MMR) status influences the preoperative staging of local colon cancer. Methods: Data from 590 patients in the Danish Colorectal Cancer Group national clinical database who were operated on for stage I-III colon cancer in 2010-15 were included. MMR status was determined by immunohistochemistry. Results: 22.9% had deficient(d) MMR tumors. Correlation of the clinical and pathological T-category was significant for both groups. The correlation of pre- and postoperative N-category was inferior (p >0.05) in dMMR cancers compared to a significant (p <0.01) correlation in proficient MMR cancers. 64.8% of dMMR tumors assessed node-positive demonstrated no sign of metastatic involvement at the postoperative assessment. Conclusion: MMR status seems to impact the accuracy of preoperative lymph node staging.

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错配修复状态对癌症术前分期的影响：对临床管理的启示

目的：我们试图研究错配修复（MMR）状态是否影响局部结肠癌癌症的术前分期。方法：纳入2010年至2015年丹麦癌症大肠癌集团国家临床数据库中590名癌症I-III期患者的数据。MMR状态通过免疫组织化学测定。结果：22.9%的患者存在MMR缺陷（d）肿瘤。两组患者的临床和病理T分类具有显著相关性。与精通MMR癌症的显著相关性（p<0.01）相比，dMMR癌症的术前和术后N类的相关性较差（p>0.05）。64.8%评估为淋巴结阳性的dMMR肿瘤在术后评估中没有转移灶的迹象。结论：MMR状态可能影响术前淋巴结分期的准确性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Colorectal Cancer ONCOLOGY-

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期刊介绍： Colorectal cancer is a major cause of morbidity and mortality, particularly in the developed world. Risk factors for colorectal cancer are on the rise in many countries; populations are aging, and obesity and diabetes are increasing. National screening programs are helping to detect cancer while it is still curable; however, colorectal cancer remains the third leading cause of cancer deaths in the USA and options are still limited for those with more advanced disease. Consequently, colorectal cancer is a major research priority for government, pharmaceutical companies and non-profit organizations. Research into diagnosis and optimum treatment of the disease is progressing rapidly, with new advances reported every day. Colorectal Cancer presents reviews, analysis and commentary. on all aspects of colorectal cancer.