Gastroenterology Insights最新文献_第9页

The Role of Cholangioscopy and EUS in the Evaluation of Indeterminate Biliary Strictures 胆道镜和超声心动图在评估不确定性胆道狭窄中的作用

IF 2.9

Gastroenterology Insights Pub Date : 2022-06-14 DOI: 10.3390/gastroent13020020

W. Siu, Raymond S. Y. Tang

引用次数: 3

Correlation between the Lymphocyte-To-Monocyte Ratio (LMR) and Child–Pugh and MELD/MELDNa Scores in Vietnamese Patients with Liver Cirrhosis 越南肝硬化患者淋巴细胞与单核细胞比值（LMR）与Child-Pugh和MELD/MELDNa评分的相关性

IF 2.9

Gastroenterology Insights Pub Date : 2022-05-31 DOI: 10.3390/gastroent13020019

D. Nguyen, Nhân Hữu Kha, N. Thai, Trang Diem Kha, P. K. Bo, Khoa Tran Dang Dang, H. Y. Tran, Thang Nguyen

{"title":"Correlation between the Lymphocyte-To-Monocyte Ratio (LMR) and Child–Pugh and MELD/MELDNa Scores in Vietnamese Patients with Liver Cirrhosis","authors":"D. Nguyen, Nhân Hữu Kha, N. Thai, Trang Diem Kha, P. K. Bo, Khoa Tran Dang Dang, H. Y. Tran, Thang Nguyen","doi":"10.3390/gastroent13020019","DOIUrl":"https://doi.org/10.3390/gastroent13020019","url":null,"abstract":"Objectives: This study aims to determine cirrhotic patients’ clinical and laboratory characteristics, thereby examining the correlation between lymphocyte-to-monocyte ratio and Child–Pugh and MELD/MELDNa scores. Methods: A cross-sectional study with an analysis of 153 patients admitted to the Department of Gastroenterology–Clinical Hematology at Can Tho Central General Hospital. Data were collected via patient interviews and medical records. Results: The included patients were more likely to be male (66.7%) and were ≥60 years old (51.6%). Excessive alcohol consumption and hepatitis B were the dominant causes of cirrhosis (35.3% and 34.0%). The clinical and laboratory characteristics were similar to previous studies in cirrhotic patients. The mean Child score was 9.3 ± 2.1, including 9.8% of patients with Child A, 44.4% for Child B, and 45.8% for Child C. The mean MELD and MELDNa scores were 16.9 ± 7.1 and 19.4 ± 8.1, respectively. The mean lymphocyte-to-monocyte ratio (LMR) is 2.0 ± 2.2 (from 0.09 to 25.3), being negatively correlated with the other scores (Pearson correlation coefficients were −0.238; −0.211 and −0.245, respectively, all p-values < 0.01). Patients with LMR below 3.31 were more likely to be classified as Child–Pugh B and C. Conclusion: The correlation between LMR with Child–Pugh, MELD, and MELDNa scores was weak and negative.","PeriodicalId":43586,"journal":{"name":"Gastroenterology Insights","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2022-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48160266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydrocolonic Sonography: Description of the Technique and Its Application in a Case of Intracolonic Lipoma: Report about a Case 液体结肠超声:技术描述及其在结肠内脂肪瘤中的应用:1例报告

IF 2.9

Gastroenterology Insights Pub Date : 2022-05-11 DOI: 10.3390/gastroent13020018

Diego Martínez García, Maria Teresa Belmonte Alcaráz, Guilda Morell González, Javier Emilio Brugal Molina, C. Rosique, Francisco Jose Menarguez Pina, M. A. Rodenas

引用次数: 0

High-Quality Colonoscopy: A Review of Quality Indicators and Best Practices 高质量结肠镜检查:质量指标和最佳实践综述

IF 2.9

Gastroenterology Insights Pub Date : 2022-05-01 DOI: 10.3390/gastroent13020017

Mason Soeder, Alla Turshudzhyan, Lisa Rosenberg, Micheal Tadros

引用次数: 3

The Role of Interferon Regulatory Factors in Non-Alcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis 干扰素调节因子在非酒精性脂肪肝和非酒精性脂性肝炎中的作用

IF 2.9

Gastroenterology Insights Pub Date : 2022-04-26 DOI: 10.3390/gastroent13020016

Chunye Zhang, Shuai Liu, Ming Yang

{"title":"The Role of Interferon Regulatory Factors in Non-Alcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis","authors":"Chunye Zhang, Shuai Liu, Ming Yang","doi":"10.3390/gastroent13020016","DOIUrl":"https://doi.org/10.3390/gastroent13020016","url":null,"abstract":"Non-alcoholic fatty liver disease (NAFLD) is becoming the most common chronic liver disease with many metabolic comorbidities, such as obesity, diabetes, and cardiovascular diseases. Non-alcoholic steatohepatitis (NASH), an advanced form of NAFLD, accompanies the progression of hepatic steatosis, inflammation, cell death, and varying degree of liver fibrosis. Interferons (IFNs) have been shown to play important roles in the pathogenesis of NAFLD and NASH. Their regulating transcriptional factors such as interferon regulatory factors (IRFs) can regulate IFN expression, as well as genes involved in macrophage polarization, which are implicated in the pathogenesis of NAFLD and advanced liver disease. In this review, the roles of IRF-involved signaling pathways in hepatic inflammation, insulin resistance, and immune cell activation are reviewed. IRFs such as IRF1 and IRF4 are also involved in the polarization of macrophages that contribute to critical roles in NAFLD or NASH pathogenesis. In addition, IRFs have been shown to be regulated by treatments including microRNAs, PPAR modulators, anti-inflammatory agents, and TLR agonists or antagonists. Modulating IRF-mediated factors through these treatments in chronic liver disease can ameliorate the progression of NAFLD to NASH. Furthermore, adenoviruses and CRISPR activation plasmids can also be applied to regulate IRF-mediated effects in chronic liver disease. Pre-clinical and clinical trials for evaluating IRF regulators in NAFLD treatment are essential in the future direction.","PeriodicalId":43586,"journal":{"name":"Gastroenterology Insights","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2022-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41795854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Value of Acute Kidney Injury in Predicting Mortality in Vietnamese Patients with Decompensated Cirrhosis 越南失代偿期肝硬化患者急性肾损伤预测死亡率的价值

IF 2.9

Gastroenterology Insights Pub Date : 2022-03-22 DOI: 10.3390/gastroent13020015

N. Nguyen, T. H. N. Mai, Nghia H. Vo, C. T. Vo, N. Ngo, M. Vi, Thang Nguyen

{"title":"Value of Acute Kidney Injury in Predicting Mortality in Vietnamese Patients with Decompensated Cirrhosis","authors":"N. Nguyen, T. H. N. Mai, Nghia H. Vo, C. T. Vo, N. Ngo, M. Vi, Thang Nguyen","doi":"10.3390/gastroent13020015","DOIUrl":"https://doi.org/10.3390/gastroent13020015","url":null,"abstract":"Background: Acute kidney injury remains a common complication with a poor prognosis, and is a significant predictor of mortality in cirrhosis patients. We aimed to determine the percentage of acute kidney injury in decompensated cirrhosis patients and evaluate the treatment results of acute kidney injury as well as several factors related to the mortality of decompensated cirrhosis patients. Methods: A prospective study was conducted on decompensated cirrhosis patients in Can Tho City, Vietnam, from 2019 to 2020. Decompensated cirrhosis patients were found to have acute kidney injury on admission by a blood creatinine test. They were treated according to ICA 2015 standards, after which they were monitored and evaluated for treatment outcomes during hospitalization. Results: Of 250 decompensated cirrhosis patients, 64 (25.6%) had acute kidney injury and 37.5% died. Several factors were associated with mortality in decompensated cirrhosis patients, such as Child–Pugh C (p = 0.02; OR = 3, 95% CI 1.5–6.3), acute kidney injury (p < 0.0001; OR = 9.5, 95% CI 4.3–21.1), hyponatremia (p = 0.01; OR = 2.5, 95% CI 1.2–5.1), elevated total bilirubin > 51 µmol/L (p = 0.03; OR = 2.2, 95% CI 1.1–4.6), and prothrombin < 70% (p = 0.03; OR = 6.8, 95% CI 1–51.6). Hypoalbuminemia was unrelated to mortality in these patients (p = 0.8; OR = 1.2, 95% CI 0.5–2.7), but gastrointestinal bleeding significantly increased mortality in these patients up to 2.3 times (p = 0.03; OR = 2.3, 95% CI 1.1–4.9). Three independent factors regarding mortality in decompensated cirrhosis patients included acute kidney injury, hepatic encephalopathy, and gastrointestinal bleeding. The rate of acute kidney injury in patients with decompensated cirrhosis was 25.6%; the mortality rate was 37.5%. Conclusions: Acute kidney injury was a valuable predictor of mortality in Vietnamese patients with decompensated cirrhosis.","PeriodicalId":43586,"journal":{"name":"Gastroenterology Insights","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2022-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47317111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

What Gastroenterologists Should Know about Carcinoid Syndrome 关于类癌综合征，胃肠病学家应该知道些什么

IF 2.9

Gastroenterology Insights Pub Date : 2022-03-13 DOI: 10.3390/gastroent13010014

L. Magi, M. Rinzivillo, F. Panzuto

引用次数: 2

COVID-19 Pandemic and Its Impact on Training Programs of Medical Residency in Romania COVID-19大流行及其对罗马尼亚住院医师培训计划的影响

IF 2.9

Gastroenterology Insights Pub Date : 2022-03-01 DOI: 10.3390/gastroent13010012

G. Constantinescu, G. Gheorghe, V. Ionescu, O. Plotogea, V. Şandru, C. Diaconu, V. Varlas, N. Bacalbaşa, C. Diaconu, Mădălina Stan-Ilie

{"title":"COVID-19 Pandemic and Its Impact on Training Programs of Medical Residency in Romania","authors":"G. Constantinescu, G. Gheorghe, V. Ionescu, O. Plotogea, V. Şandru, C. Diaconu, V. Varlas, N. Bacalbaşa, C. Diaconu, Mădălina Stan-Ilie","doi":"10.3390/gastroent13010012","DOIUrl":"https://doi.org/10.3390/gastroent13010012","url":null,"abstract":"Background: The COVID-19 pandemic has had a negative impact on the training process for resident physicians. The objective of this study was to evaluate the impact of the COVID-19 pandemic on professional training, and also the subjective perception of the levels of stress, anxiety, and depression among resident doctors specializing in gastroenterology in Romania. Methods: We conducted an observational cross-sectional study, for a period of two months, among 180 resident doctors specializing in gastroenterology, working in university hospitals in Romania. A questionnaire consisting of 29 questions distributed through social media platforms was completed in Google Forms. Statistical analyses were performed using IBM SPSS software v.20. Results: A linear relationship was identified between the number of daily hospitalizations in the gastroenterology department and the rate of SARS-CoV-2 infection among resident physicians. In total, 80% of the participants reported an increase in the levels of stress, anxiety, and depression during the COVID-19 pandemic, and 88.3% stated that they were unsatisfied by online courses. Conclusions: The COVID-19 pandemic has had negative effects on both professional training and levesl of stress, anxiety and depression of resident doctors specializing in gastroenterology. In the specialty of gastroenterology there may be certain peculiarities, due to the interventional aspects that this medical specialty involves, for example, endoscopic procedures. Thus, the necessity to acquire practical skills in addition to theoretical knowledge increases the negative impact on gastroenterology internship.","PeriodicalId":43586,"journal":{"name":"Gastroenterology Insights","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43098309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Publisher’s Note: We Changed Page Numbers to Article Numbers for Articles Published in Gastroenterology Insights, Volumes 1–10 出版商注:我们将页码改为文章编号发表在胃肠病学见解，卷1-10

IF 2.9

Gastroenterology Insights Pub Date : 2022-02-23 DOI: 10.3390/gastroent13010011

引用次数: 0

Irradiation Induces Tuft Cell Hyperplasia and Myenteric Neuronal Loss in the Absence of Dietary Fiber in a Mouse Model of Pelvic Radiotherapy 在没有膳食纤维的情况下，辐射诱导小鼠盆腔放射治疗模型中的绒毛细胞增生和骨髓间神经元损失

IF 2.9

Gastroenterology Insights Pub Date : 2022-02-22 DOI: 10.3390/gastroent13010010

Ulrikke Voss, D. Malipatlolla, P. Patel, Sravani Devarakonda, F. Sjöberg, Rita Grandér, A. Rascón, M. Nyman, G. Steineck, Cecilia Bull

{"title":"Irradiation Induces Tuft Cell Hyperplasia and Myenteric Neuronal Loss in the Absence of Dietary Fiber in a Mouse Model of Pelvic Radiotherapy","authors":"Ulrikke Voss, D. Malipatlolla, P. Patel, Sravani Devarakonda, F. Sjöberg, Rita Grandér, A. Rascón, M. Nyman, G. Steineck, Cecilia Bull","doi":"10.3390/gastroent13010010","DOIUrl":"https://doi.org/10.3390/gastroent13010010","url":null,"abstract":"Pelvic radiotherapy is associated with chronic intestinal dysfunction. Dietary approaches, such as fiber enrichment during and after pelvic radiotherapy, have been suggested to prevent or reduce dysfunctions. In the present paper, we aimed to investigate whether a diet rich in fermentable fiber could have a positive effect on radiation-induced intestinal damage, especially focusing on tuft cells and enteric neurons. Male C57BL/6 mice were fed either a purified non-fiber diet or the same purified diet with 5% or 15% oat fiber added, starting two weeks prior to sham-irradiation or irradiation with four fractions of 8 Gray. The animals continued on the diets for 1, 6 or 18 weeks, after which the gross morphology of the colorectum was assessed together with the numbers of enteric neurons, tuft cells and crypt-surface units. The results showed that dietary fiber significantly affected the intestinal morphometrics, both in the short and long-term. The presence of dietary fiber stimulated the re-emergence of crypt-surface unit structures after irradiation. At 18 weeks, the animals fed with the non-fiber diet displayed more myenteric neurons than the animals fed with the dietary fibers, but irradiation resulted in a loss of neurons in the non-fiber fed animals. Irradiation, but not diet, affected the tuft cell numbers, and a significant increase in tuft cells was found 6 and 18 weeks after irradiation. In conclusion, dietary fiber intake has the potential to modify neuronal pathogenesis in the colorectum after irradiation. The long-lasting increase in tuft cells induced by irradiation may reflect an as yet unknown role in the mucosal pathophysiology after pelvic irradiation.","PeriodicalId":43586,"journal":{"name":"Gastroenterology Insights","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2022-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49003566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2