Gastroenterology Insights最新文献_第9页

Cytokines and Biologic Therapy in Patients with Inflammatory Bowel Diseases 炎症性肠病患者的细胞因子与生物治疗

IF 2.9

Gastroenterology Insights Pub Date : 2021-12-01 DOI: 10.3390/gastroent12040042

G. P. Caviglia, D. Ribaldone, A. Nicolosi, R. Pellicano

引用次数: 3

The Role of EUS-Guided Drainage in the Management of Postoperative Fluid Collections after Pancreatobiliary Surgery eus引导引流在胰胆管术后积液处理中的作用

IF 2.9

Gastroenterology Insights Pub Date : 2021-11-05 DOI: 10.3390/gastroent12040041

L. Ong, C. Chong

引用次数: 2

The Association of Irritable Bowel Complaints and Perceived Immune Fitness among Individuals That Report Impaired Wound Healing: Supportive Evidence for the Gut–Brain–Skin Axis 在报告伤口愈合受损的个体中，肠易激症状和感知免疫适应性的关联:肠-脑-皮肤轴的支持证据

IF 2.9

Gastroenterology Insights Pub Date : 2021-11-03 DOI: 10.3390/gastroent12040040

J. Balikji, M. Hoogbergen, J. Garssen, J. Verster

{"title":"The Association of Irritable Bowel Complaints and Perceived Immune Fitness among Individuals That Report Impaired Wound Healing: Supportive Evidence for the Gut–Brain–Skin Axis","authors":"J. Balikji, M. Hoogbergen, J. Garssen, J. Verster","doi":"10.3390/gastroent12040040","DOIUrl":"https://doi.org/10.3390/gastroent12040040","url":null,"abstract":"The gut–brain–skin axis is important in wound healing. The aim of this study was to investigate the association between experiencing irritable bowel syndrome (IBS) symptoms, perceived immune fitness, and impaired wound healing. N = 1942 Dutch students (mean (SD) age 21.3 (2.1), 83.6% women) completed an online survey. They were allocated to one of four groups: (1) control group (N = 1544), (2) wound infection (WI) group (N = 65), (3) slow healing wounds (SHW) group (N = 236), or (4) a combination group (COMBI), which experienced both WI and SHW (N = 87). Participants rated their perceived immune fitness on a scale ranging from very poor (0) to excellent (10), and the severity of IBS symptoms (constipation, diarrhea, and pain) was assessed with the Birmingham IBS Symptom Questionnaire. Compared to the control group, perceived immune fitness was significantly poorer for the SHW group (p < 0.001) and COMBI group (p < 0.001), but not for the WI group. Compared to the control group, constipation was reported significantly more frequently by the SHW group (p < 0.001) and the WI group (p = 0.012), diarrhea was reported significantly more frequent by the SHW group (p = 0.038) and the COMBI group (p = 0.004), and pain was reported significantly more frequent by the SHW group (p = 0.020) and COMBI group (p = 0.001). Correlations between IBS complaints and perceived immune fitness were statistically significant (p < 0.001), and also a highly significant and negative association was found between the percentage of participants that reported impaired wound healing and perceived immune fitness (r = −0.97, p < 0.001). In conclusion, among participants with self-reported impaired wound healing, IBS complaints were significantly more severe, and accompanied by a significantly reduced perceived immune fitness.","PeriodicalId":43586,"journal":{"name":"Gastroenterology Insights","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2021-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41675579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Troubleshooting Difficult Bile Duct Access: Advanced ERCP Cannulation Techniques, Percutaneous Biliary Drainage, or EUS-Guided Rendezvous Technique? 疑难排解胆管通路:先进的ERCP插管技术，经皮胆道引流，还是eus引导的交会技术?

IF 2.9

Gastroenterology Insights Pub Date : 2021-10-27 DOI: 10.3390/gastroent12040039

T. Chan, M. Chew, Raymond S. Y. Tang

{"title":"Troubleshooting Difficult Bile Duct Access: Advanced ERCP Cannulation Techniques, Percutaneous Biliary Drainage, or EUS-Guided Rendezvous Technique?","authors":"T. Chan, M. Chew, Raymond S. Y. Tang","doi":"10.3390/gastroent12040039","DOIUrl":"https://doi.org/10.3390/gastroent12040039","url":null,"abstract":"Despite experienced hands and availability of various well-designed catheters and wires, selective bile duct cannulation may still fail in 10–20% of cases during endoscopic retrograde cholangiopancreatography (ERCP). In case standard ERCP cannulation technique fails, salvage options include advanced ERCP cannulation techniques such as double-guidewire technique (DGW) with or without pancreatic stenting and precut papillotomy, percutaneous biliary drainage (PBD), and endoscopic ultrasound-guided Rendezvous (EUS-RV) ERCP. If the pancreatic duct is inadvertently entered during cannulation attempts, DGW technique is a reasonable next step, which can be followed by pancreatic stenting to reduce risks of post-ERCP pancreatitis (PEP). Studies suggest that early precut papillotomy is not associated with a higher risk of PEP, while needle-knife fistulotomy is the preferred method. For patients with critical clinical condition who may not be fit for endoscopy, surgically altered anatomy in which endoscopic biliary drainage is not feasible, and non-communicating multisegmental biliary obstruction, PBD has a unique role to provide successful biliary drainage efficiently in this particular population. As endoscopic ultrasound (EUS)-guided biliary drainage techniques advance, EUS-RV ERCP has been increasingly employed to guide bile duct access and cannulation with satisfactory clinical outcomes and is especially valuable for benign pathology at centres where expertise is available. Endoscopists should become familiar with each technique’s advantages and limitations before deciding the most appropriate treatment that is tailored to patient’s anatomy and clinical needs.","PeriodicalId":43586,"journal":{"name":"Gastroenterology Insights","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2021-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45505104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

COVID-19 and the Gastrointestinal Tract 新冠肺炎与胃肠道

IF 2.9

Gastroenterology Insights Pub Date : 2021-10-24 DOI: 10.3390/gastroent12040038

María-Jimena Muciño-Bermejo

引用次数: 4

Anemia in Newly Diagnosed Pediatric Patients with Inflammatory Bowel Disease 新诊断的儿童炎症性肠病患者的贫血

IF 2.9

Gastroenterology Insights Pub Date : 2021-09-24 DOI: 10.3390/gastroent12040036

Rayna Shentova-Eneva, D. Kofinova, P. Hadzhiyski, P. Yaneva, E. Lazarova, M. Baycheva

{"title":"Anemia in Newly Diagnosed Pediatric Patients with Inflammatory Bowel Disease","authors":"Rayna Shentova-Eneva, D. Kofinova, P. Hadzhiyski, P. Yaneva, E. Lazarova, M. Baycheva","doi":"10.3390/gastroent12040036","DOIUrl":"https://doi.org/10.3390/gastroent12040036","url":null,"abstract":"Anemia is the most common extraintestinal manifestation and complication of inflammatory bowel disease (IBD). The aim of our study was to assess the prevalence of anemia in newly diagnosed pediatric patients with IBD and to analyze its association with disease type, extent, and severity. We retrospectively reviewed the medical records of all patients with IBD treated in our department in the period of November 2011 to November 2020. The final analysis included the records of 80 children with newly diagnosed IBD: 45 with ulcerative colitis (UC) and 35 with Crohn’s disease (CD). The prevalence of anemia was 60.0% in the UC patients and 77.1% in the CD patients. Of the UC patients with anemia, 37.1% had pancolitis, 18.5% extensive disease, 33.3% left-sided colitis and 11.1% ulcerative proctitis. Of the CD patients with anemia, 81.5% had ileocolonic disease, 11.1% colonic disease and 7.4% ileal disease. Anemia was less common in patients with mild disease than in patients with moderate–severe disease (22.2 vs. 77.8%, p < 0.001 in UC and 25.9% vs. 74.1%, p < 0.001 in CD). Our study confirmed anemia as a frequent problem in pediatric patients with IBD. Children with more extensive and more severe disease are at higher risk to develop anemia.","PeriodicalId":43586,"journal":{"name":"Gastroenterology Insights","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2021-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47813847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Ultrasound-Guided Percutaneous Drainage of Abdominal Collections—An Analysis over 5 Years 超声引导下经皮腹腔积液引流术5年疗效分析

IF 2.9

Gastroenterology Insights Pub Date : 2021-09-19 DOI: 10.3390/gastroent12030035

Mădălina Stan-Ilie, O. Plotogea, E. Rînja, V. Şandru, A. Butuc, G. Gheorghe, C. Diaconu, Anca Monica Macovei Oprescu, B. Popa, Alexandru Scafa-Udriște, G. Constantinescu

{"title":"Ultrasound-Guided Percutaneous Drainage of Abdominal Collections—An Analysis over 5 Years","authors":"Mădălina Stan-Ilie, O. Plotogea, E. Rînja, V. Şandru, A. Butuc, G. Gheorghe, C. Diaconu, Anca Monica Macovei Oprescu, B. Popa, Alexandru Scafa-Udriște, G. Constantinescu","doi":"10.3390/gastroent12030035","DOIUrl":"https://doi.org/10.3390/gastroent12030035","url":null,"abstract":"Introduction. Ultrasound-guided (US-guided) percutaneous drainage (PD) of abdominal collections represents the first-choice alternative to surgical intervention. The aim of our study was to assess the efficacy and safety of PD of visceral and non-visceral abdominal collections by reviewing our personal experience over a period of 5 years. Material and methods. The present study included 66 patients who underwent PD under ultrasound guidance. We analyzed clinical variables (collection size, catheter diameter, collection type, microbiological analysis, antibiotic regimens) along with the outcomes of the procedure. Results. Visceral collections were predominant, encompassing 38 hepatic abscesses and 1 splenic hematoma. Microbiological analysis showed that the majority (54%) were monomicrobial. The most encountered pathogens were Klebsiella pneumoniae and Escherichia coli. Technical success was achieved in all cases and clinical success was observed in 84.6% of the cases. No immediate procedural complications were detected. There were 6 patients who needed reinterventions, either by catheter replacement or by surgical treatment. The mortality rate was 4.5%, due to patients’ poor overall status and oncological comorbidities. Conclusions. Percutaneous drainage under ultrasound guidance is a safe and effective procedure in the management of abdominal collections.","PeriodicalId":43586,"journal":{"name":"Gastroenterology Insights","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2021-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48380896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Should the Endoscopic Restrictions during COVID-19 Pandemic Remain Unchanged? 新冠肺炎大流行期间的内窥镜限制应保持不变吗？

IF 2.9

Gastroenterology Insights Pub Date : 2021-08-25 DOI: 10.3390/gastroent12030034

Emilio Bresky, G. Bresky, D. Lancellotti, J. Madariaga, Sebastian Licuime, Paulette Palma, Fabian Saez, M. J. Rojas, L. Seijas

{"title":"Should the Endoscopic Restrictions during COVID-19 Pandemic Remain Unchanged?","authors":"Emilio Bresky, G. Bresky, D. Lancellotti, J. Madariaga, Sebastian Licuime, Paulette Palma, Fabian Saez, M. J. Rojas, L. Seijas","doi":"10.3390/gastroent12030034","DOIUrl":"https://doi.org/10.3390/gastroent12030034","url":null,"abstract":"(Background) Endoscopic procedures are interventions that have been defined as carrying a high-risk of infection with COVID-19. Most endoscopy units restrict their activity based on pre-endoscopic diagnosis. (Objective) To determine the consequences of endoscopic restrictions as a result of the COVID-19 pandemic and their impact on digestive cancer diagnosis. (Design) A comparison of upper digestive endoscopies and colonoscopies with gastrointestinal cancers diagnosed between three endoscopic centers, two of which restricted their procedures and one that did not but performed the procedures under a strict protocol. (Setting) A retrospective analysis was performed collecting data between 15 March 2019 and 15 August 2020. Two-factor ANOVA and a Tukey’s a posteriori test were used as statistical tests. (Main outcome measures) There was variation in gastrointestinal cancer diagnosis between 2019 and 2020, considering the endoscopic procedures performed each year. (Result) There was a significant decrease in the total endoscopic procedures performed between 2019 and 2020 (p < 0.001), the result of reduced testing at the two centers (p < 0.001) with pre-endoscopic restrictions, which was not compensated for by a slight increase in procedures at the center without restrictions (p = 0.139). Regarding the total cancers diagnosed, while a significant decrease was observed for the two centers with pre-endoscopic restrictions (p = 0.007), a significant increase was registered in the center that maintained its endoscopic productivity (p < 0.001). After 851 procedures (537 upper digestive endoscopies and 314 colonoscopies) there was no evidence of COVID-19 infection in the endoscopic staff. (Conclusion) Endoscopic restrictions based on pre-endoscopic diagnosis should be reassessed in consideration of local pandemic situations, and a balance should be sought between COVID-19 infection risk and the detrimental delay of potential cancer diagnosis.","PeriodicalId":43586,"journal":{"name":"Gastroenterology Insights","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2021-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49632080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Multi-Organ Involvement of Immunoglobulin G4-Related Disease 免疫球蛋白G4相关疾病的多器官参与

IF 2.9

Gastroenterology Insights Pub Date : 2021-08-21 DOI: 10.3390/gastroent12030033

E. Nour, A. Hammami, N. Missaoui, Ahlem Bdioui, W. Dahmani, W. Ben Ameur, A. Braham, S. Ajmi, A. Ben Slama, M. Ksiaa, H. Jaziri, S. Hmissa, A. Jmaa

{"title":"Multi-Organ Involvement of Immunoglobulin G4-Related Disease","authors":"E. Nour, A. Hammami, N. Missaoui, Ahlem Bdioui, W. Dahmani, W. Ben Ameur, A. Braham, S. Ajmi, A. Ben Slama, M. Ksiaa, H. Jaziri, S. Hmissa, A. Jmaa","doi":"10.3390/gastroent12030033","DOIUrl":"https://doi.org/10.3390/gastroent12030033","url":null,"abstract":"Immunoglobulin G4-related disease (IgG4-RD) is a fibroinflammatory condition of unknown etiology, with presumed autoimmune mechanisms. It is characterized by high levels of IgG4 and variable clinical manifestations. It can involve one or multiple organs. Herein, we reported the case of a 62-year-old man with three organs involvement. He initially presented with recurrent jaundice. Laboratory analysis revealed cholestasis, high gamma-globulin levels, renal failure, and proteinuria. Abdominal Magnetic Resonance Imaging (MRI) showed segmental strictures of the left intrahepatic bile ducts and the wirsung duct with an increased volume of the pancreas and diffuse bilateral enlargement of the kidneys. Laboratory tests revealed high IgG4 levels (770 mg/dL). Based on the biological and radiological findings, we have suggested the diagnosis of systemic IgG4-related disease involving bile ducts, the pancreas, and probably the kidneys. Renal biopsy revealed lymphoplasmacytic infiltrate and fibrosis, but no IgG4-positive cell. The patient received corticosteroid therapy with a complete resolution of all symptoms and a rapid normalization of all blood tests. The present case underlines the complexity of IgG4-RD because of its variable clinical presentation. The diagnosis is challenging and should be carefully assessed for possible multi-organ involvement.","PeriodicalId":43586,"journal":{"name":"Gastroenterology Insights","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2021-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43139677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

An Age-Old Problem: The Surgical Treatment of Complete Rectal Prolapse 高龄问题：完全性直肠脱垂的外科治疗

IF 2.9

Gastroenterology Insights Pub Date : 2021-08-19 DOI: 10.3390/gastroent12030032

G. Gallo, A. Sakuraba, U. Grossi

引用次数: 0