Acta Oncologica Turcica最新文献_第5页

Retrospective evaluation of brain metastates in lung cancer patients treated with stereotactic radiosurgery alone 单纯立体定向放射治疗肺癌患者脑转移的回顾性评价

Acta Oncologica Turcica Pub Date : 1900-01-01 DOI: 10.5505/aot.2019.30932

S. Değirmencioğlu, O. Unal, E. Oktay, A. Demiray, M. Arslan, H. Aslan, E. Sağtaş, B. Y. Taskoylu, Ilker Kiraz, G. Dogu, A. Yaren

{"title":"Retrospective evaluation of brain metastates in lung cancer patients treated with stereotactic radiosurgery alone","authors":"S. Değirmencioğlu, O. Unal, E. Oktay, A. Demiray, M. Arslan, H. Aslan, E. Sağtaş, B. Y. Taskoylu, Ilker Kiraz, G. Dogu, A. Yaren","doi":"10.5505/aot.2019.30932","DOIUrl":"https://doi.org/10.5505/aot.2019.30932","url":null,"abstract":"INTRODUCTION: Due to new systemic treatment modalities, overall survival in lung cancer is increasing. Incidence of brain metastases in lung cancer are more common for this reason. The utilisation of stereotactic radiosurgery for one and oligo (two-four) brain metastases, has provided this treatment strategy as a promt treatment alternative. In this study we aimed to investigate the efficiency of stereotactic radiosurgery in lung cancer patients with brain metastasis, the effectiveness of adding diffusion magnetic resonance imaging (MRI) to conventional MRI for treatment evaluation and the relationship between clinical parameters retrospectively. METHODS: Seventy-nine lung cancer patients treated between January 2016 and December 2017 in our clinic with stereotactic radiosurgery whose eastern cooperative oncology group (ECOG) performance status were 0-1 and had less than 5 brain metastases, has retrsopectively analysed. RESULTS: The median age of patients was 59 years (43-78). Diffusion MRI has provided no more benefit for evaluation of treatment. There was no statistically significant mortality difference between subgroups of small cell and non small cell lung carcinoma. The presence of extracranial metastases has shortened the overall survival time significantly (p=0,042). DISCUSSION AND CONCLUSION: The lung cancer patients with brain metastases have histopathological and genetic heterogenity. Multivariate analysis showed the presence of extracranial metastases had only unfavorable impact on overall survival in our study. Orijinal Çalışma 204 Adress for correspondence: Dr. Öğr. Üyesi Serkan Değirmencioğlu, Pamukkale Üniversitesi Hastanesi Fahri Gökşin Onkoloji Merkezi Üniversite sokak no: 7 Bağbaşı 20160 Denizli Türkiye e-mail: sdegirmencioglu@pau.edu.tr Available at www.actaoncologicaturcica.com Copyright ©Ankara Onkoloji Hastanesi","PeriodicalId":435847,"journal":{"name":"Acta Oncologica Turcica","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130324746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of BRCA2 Gene K3326X Variant in Patients with Breast and Ovarian Cancer by Next-Generation Sequencing Technique 应用新一代测序技术研究乳腺癌和卵巢癌患者BRCA2基因K3326X变异

Acta Oncologica Turcica Pub Date : 1900-01-01 DOI: 10.5505/aot.2023.68815

Neslihan Düzkale, C. Karaçin, S. Yörübulut, H. Erdem, Özlem Öz, M. Altınbaş

{"title":"Investigation of BRCA2 Gene K3326X Variant in Patients with Breast and Ovarian Cancer by Next-Generation Sequencing Technique","authors":"Neslihan Düzkale, C. Karaçin, S. Yörübulut, H. Erdem, Özlem Öz, M. Altınbaş","doi":"10.5505/aot.2023.68815","DOIUrl":"https://doi.org/10.5505/aot.2023.68815","url":null,"abstract":"Introduction: The BRCA2 gene is a tumor suppressor gene involved in the repair of double-stranded DNA damage by homologous recombination. Until now, many cancer-related variants of the BRCA2 gene have been reported. There are conflicting publications in studies of the possible effect of the K3326X variant of this gene in cancer. This study investigates the K3326X BRCA2 gene variant and its role in the cancer pathogenesis of Turkish patients diagnosed with breast and ovarian cancer. Materials and methods: In the study, 1957 patients with cancer diagnosis for BRCA1 and BRCA2 genetic analysis and 432 healthy individuals without a history of cancer were included. The K3326X variant was investigated using the next-generation sequencing method from the genomic DNA sample obtained from the individuals. Results: K3326X variant was detected in 54 of 1957 (2.75%) cancer patients. For the non-cancerous group, 11 of 432 (2.5%) patients were carrying the K3326X variant. When both groups were compared in terms of K3326X variant carriage, a statistically significant result could not be obtained for the individuals (p=0.934). Discussion: BRCA2 K3326X variant did not have a significant role in cancer etiopathogenesis. As a result, the variant whose clinical significance is not still been fully understood, was investigated for the first time for Turkish population. Our results suggest that the variant could be a benign variant.","PeriodicalId":435847,"journal":{"name":"Acta Oncologica Turcica","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130356112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive Value of Complete Blood Count Inflammatory Parameters for Epithelial Ovarian Cancers in Women During Reproductive Period 全血细胞计数炎症参数对育龄期女性上皮性卵巢癌的预测价值

Acta Oncologica Turcica Pub Date : 1900-01-01 DOI: 10.5505/aot.2021.30922

Hilal Korkmaz, Mustafa Akşar, Halis Doğukan Özkan, V. Korkmaz, N. Boran

{"title":"Predictive Value of Complete Blood Count Inflammatory Parameters for Epithelial Ovarian Cancers in Women During Reproductive Period","authors":"Hilal Korkmaz, Mustafa Akşar, Halis Doğukan Özkan, V. Korkmaz, N. Boran","doi":"10.5505/aot.2021.30922","DOIUrl":"https://doi.org/10.5505/aot.2021.30922","url":null,"abstract":"Background: Comparison of predictive values of complete blood count inflammatory parameters and serum CA-125 levels in the differential diagnosis of patients with epithelial ovarian tumor (EOTs) diagnosed in the reproductive period. Materials: In this study, 105 women patients in the reproductive period were retrospectively analyzed. The patients included were examined in terms of clinical, laboratory and pathological features. Results: The mean age of the patients was 41.5 ± 8.6 years and BMI was 28.6 ± 5.8 kg/m2. Of the whole study population, 54 (51.5%) were benign EOTs, 18 (17.1%) were borderline EOTs and 33 (31.4%) were malignant EOTs. When comparing these three tumor groups, a significant difference was found in terms of serum CA-125 [14.7 U/mL (2.7-238.6) vs 60.2 U/mL (7.8 – 557) vs 416.5 U/mL (2.4-7695), p<0.001, respectively], platelet count [294 x103/ μL (133-744) vs 303, x103/ μL (160-468) vs 383 x103/ μL (128-725), p = 0.018, respectively], neutrophil count [4.2, x103/ μL (1.9 -8.9) vs 4.9 x103/ μL (2.610.9) vs 5.1 x103/ μL (2.2 – 10.7), p = 0.012], neutrophil-to-lymphocyte ratio (NLR) [2.1 (0.1-8.2) vs 2.6 (1.2 – 5.9) vs 3.1 (1-6.8), p = 0.021, respectively] and platelet-to-lymphocyte ratio (PLR) [154.4 (82.1-658.4) vs 168.1 (91.1-377.8) vs 201.5 (29.6-499.2), p = 0.008, respectively] values. In the ROC analyses, serum CA-125 levels (AUC= 0.818, p <0.001), platelet count (AUC= 0.673, p = 0.005) and PLR (AUC= 0.690, p = 0.002) values significantly predicted malignant EOTs. Conclusion: Preoperative platelet count, neutrophil count and PLR predict epithelial ovarian cancers significantly. However, diagnostic predictive values of all three parameters are lower than CA-125. Therefore, CA-125 is still the most valuable serum biochemical marker that can be used in the preoperative differential diagnosis of EOTs.","PeriodicalId":435847,"journal":{"name":"Acta Oncologica Turcica","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133515886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Rare Case of Multiple Primary Malignancy Diagnosed with Pancreatic Adenocarcinoma After Diffuse Large B Cell Lymphoma 一例罕见的多发性原发恶性肿瘤在弥漫性大B细胞淋巴瘤后被诊断为胰腺腺癌

Acta Oncologica Turcica Pub Date : 1900-01-01 DOI: 10.5505/aot.2019.26879

A. Kutlucan, L. Kutlucan, Esra Zeynep Coşkunoğlu, A. Basturk

引用次数: 0

Investigation of Clinical and Histopathological Features in Invasive Lobular Breast Cancers 浸润性小叶性乳腺癌的临床和组织病理学特征研究

Acta Oncologica Turcica Pub Date : 1900-01-01 DOI: 10.5505/aot.2023.92678

Giray Akgül, E. Esen, M. Turan, Ş. B. Morkavuk, Simay Akyüz, Yasin Gülap, Pelin Seçken, M. Gülçelik

引用次数: 0

The effect of metastatic focus on survival after cytoreductive nephrectomy in renal cell carcinoma: Experience of a single center 转移灶对肾细胞癌减数切除后存活的影响:单一中心的经验

Acta Oncologica Turcica Pub Date : 1900-01-01 DOI: 10.5505/aot.2019.48403

I. Selvi, E. Öztürk

引用次数: 0

Molecular Characterization Reveals the Importance and Diversity of Germline and Somatic RET Mutations in Cancer 分子特征揭示了生殖系和体细胞RET突变在癌症中的重要性和多样性

Acta Oncologica Turcica Pub Date : 1900-01-01 DOI: 10.5505/aot.2021.25932

I. Sahin, H. Erdem

引用次数: 0

Comparison of infiltration analgesia and pectoral nerve block in the pain management after mastectomy for breast cancer 浸润镇痛与胸神经阻滞治疗乳腺癌乳房切除术后疼痛的比较

Acta Oncologica Turcica Pub Date : 1900-01-01 DOI: 10.5505/aot.2019.26928

G. Argun, İ. Kaya, S. Ünver

{"title":"Comparison of infiltration analgesia and pectoral nerve block in the pain management after mastectomy for breast cancer","authors":"G. Argun, İ. Kaya, S. Ünver","doi":"10.5505/aot.2019.26928","DOIUrl":"https://doi.org/10.5505/aot.2019.26928","url":null,"abstract":"INTRODUCTION: In this study, we aimed to compare the superiority of infiltration analgesia and pectoral nerve block methods on pain scores, total opioid consumption and discharge time from post anesthesia care unit (PACU) of patients after oncologic mastectomy. METHODS: After approval of the ethics committee and patient consent, sixty patients who underwent mastectomy for breast cancer between 18-80 years of age were included in the study. Patients were divided into two groups, who underwent pectoral nerve block for postoperative analgesia as Group I and infiltration analgesia as Group II. Intraoperative tenoxicam of 20 mg was applied to all patients. Postoperative pain was evaluated with Visual Analog Scala (VAS) at the 1st, 6th, 12th and 24th hours. Patients with a VAS of more than 3 were given tramadol 1 mg/kg and morphine (05-1 mg) if necessary. In the first 24 hours postoperatively, total analgesic consumption, discharge time from PACU, rates of nausea, vomiting and other side effects of patients were recorded and results were evaluated statistically. RESULTS: Demographic characteristics were similar in two groups. Postoperative VAS scores were significantly lower in the pectoral nerve block group at the 1st, 6th, 12th and 24th hours compared to the infiltration analgesia group. The total analgesic consumption, nauseavomiting rate, and discharge time from PACU were significantly lower in the pectoral nerve block group. DISCUSSION AND CONCLUSION: In our study, pectoral nerve block method was found superior to infiltration analgesia method on postoperative pain management in oncologic breast surgery. In conclusion, we recommend the pectoral nerve block to supply effective pain management and early discharge time from PACU after mastectomy for breast cancer.","PeriodicalId":435847,"journal":{"name":"Acta Oncologica Turcica","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124421410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The predictive value of FDG-PET / CT in assessing bone marrow involvement in Hodgkin Lymphoma patients; A single center experience FDG-PET / CT对霍奇金淋巴瘤患者骨髓受累的预测价值单中心体验

Acta Oncologica Turcica Pub Date : 1900-01-01 DOI: 10.5505/aot.2021.08941

Merih Reis Aras, M. Albayrak, A. Yıldız, S. Maral, H. B. Afacan Öztürk, P. Akyol, M. Tığlıoğlu, B. Sağlam, F. Yılmaz

引用次数: 0

Efficacy of Pazopanib in Patients with Pretreated Advanced Stage Soft Tissue Sarcomas 帕唑帕尼治疗晚期软组织肉瘤的疗效

Acta Oncologica Turcica Pub Date : 1900-01-01 DOI: 10.5505/aot.2022.37108

M. Aykan, G. Keskin, Ece Ornek, Alper Topal, Çağlar Köseoğlu, Aysegul Dumludag, İ. Ertürk, N. Karadurmuş

引用次数: 1