Acta Oncologica Turcica最新文献_第10页

Retrospective Analysis of the Treatment and Follow-up of 251 Patients with Non-melanoma Skin Cancer in the Mediterranean Region 地中海地区251例非黑色素瘤皮肤癌患者治疗与随访回顾性分析

Acta Oncologica Turcica Pub Date : 1900-01-01 DOI: 10.5505/aot.2019.05924

A. Uslu

{"title":"Retrospective Analysis of the Treatment and Follow-up of 251 Patients with Non-melanoma Skin Cancer in the Mediterranean Region","authors":"A. Uslu","doi":"10.5505/aot.2019.05924","DOIUrl":"https://doi.org/10.5505/aot.2019.05924","url":null,"abstract":"INTRODUCTION: Non-melanoma skin cancer (NMSC) is the most common type of cancer worldwide. Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) constitute 99% of NMSCs, with BCC being 3–5 times more common than SCC. This study analyzed the demographic data, treatment and follow-up of patients with NMSC and compared the results with those of previous studies. METHODS: Patients who had been followed-up and treated for NMSC by a single surgeon between January 2014 and January 2018 were evaluated retrospectively. RESULTS: The average age of the 251 patients treated and followed for NMSC was 69.9 years. The incidence of BCC was found to be two times of the SCC. The most frequent tumor localization was the head and neck. Among the head and neck tumors, the incidence of nasal tumors was the highest. Intact surgical margin excisions of 0.5 cm for BCC and 1 cm for SCC were performed. Local flaps were the most common reconstruction option (61.18%). Eleven patients could not be operated on and four of the unoperable tumors were invased to the eye. Positive surgical margins were determined in 4.43% of the patients, but only four patients had disease recurrence during the 25.82 months of follow-up. A new NMSC developed in a different anatomic region in 17 patients. Three of the patients with recurrence died due to NMSC. DISCUSSION AND CONCLUSION: NMSC is easily diagnosed by physical examination and biopsy is not necessary in every case. The incidence of SCC in our series was higher than reported in previous studies. Local flaps were the preferred reconstruction option. The rates of positive surgical margins (4.27%) and relapse (1.31%) were low. This result can be attributed to adequate depth of the excision from the base through the reconstruction of the defect with flap, and the relatively short (< 5 years) follow-up period.","PeriodicalId":435847,"journal":{"name":"Acta Oncologica Turcica","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129775207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Risk Factors Associated with Progression of Myelodysplastic Syndrome: 13 Years of Experience from a Single Center 与骨髓增生异常综合征进展相关的危险因素:来自单一中心的13年经验

Acta Oncologica Turcica Pub Date : 1900-01-01 DOI: 10.5505/aot.2023.36693

Emine Gültürk

引用次数: 0

Non-infectious Complications in Patients with Allogeneic Hematopoietic Stem Cell Transplantation- Single Center Experience from Eastern Anatolia 同种异体造血干细胞移植患者的非感染性并发症-来自安纳托利亚东部的单中心经验

Acta Oncologica Turcica Pub Date : 1900-01-01 DOI: 10.5505/aot.2022.92668

S. Karaman, A. Sarici, M. Erkurt, S. Biçim, Emine Hidayet, Ahmet Kaya, I. Kuku, S. Yoloğlu, İ. Berber, E. Kaya, M. Özgül

引用次数: 0

Hereditary Breast-Ovarian Cancer and BRCA1 / BRCA2 variants: a single center experience 遗传性乳腺癌和BRCA1 / BRCA2变异:单中心经验

Acta Oncologica Turcica Pub Date : 1900-01-01 DOI: 10.5505/aot.2021.25348

A. Gezdirici, E. Gökpınar İli, B. Değirmenci, Aydeniz Aydın Gümüş, Gizem Özdemir, Nihan Alişya Erman, Cüneyd Yavaş

{"title":"Hereditary Breast-Ovarian Cancer and BRCA1 / BRCA2 variants: a single center experience","authors":"A. Gezdirici, E. Gökpınar İli, B. Değirmenci, Aydeniz Aydın Gümüş, Gizem Özdemir, Nihan Alişya Erman, Cüneyd Yavaş","doi":"10.5505/aot.2021.25348","DOIUrl":"https://doi.org/10.5505/aot.2021.25348","url":null,"abstract":"Objective: In this study, it was aimed to determine the frequency of BRCA1 and BRCA2 variants in patients admitted to our clinic with hereditary breast-ovarian cancer and / or family history and to evaluate them in the light of the literature. Materials and Methods: All patients in our study were selected according to the current NCCN guideline test criteria. The Ion Torrent TM Oncomine TM BRCA Research Assay was used to sequence the coding regions of the BRCA1 and BRCA2 genes in our patients. In addition, all patients with copy number changes were confirmed with SALSA MLPA Probemix P002 BRCA1 and Probemix P090 BRCA2 (MRC Holland). Results: Variants (pathogenic, likely pathogenic, variants of uncertain clinical significance, and copy number variations) were detected in 39 of the 149 patients included in the study. Novel variants that were not previously described in the literature were detected in two patients, one of the BRCA1 and one of the BRCA2 gene, respectively. Conclusion: In our study, the incidence of BRCA1 and BRCA2 variants was found to be 26.1%. This rate was higher than previous studies conducted in Turkey. Further studies are needed to identify common variants in the Turkish population and to evaluate the pathogenity of variants of uncertain clinical significance.","PeriodicalId":435847,"journal":{"name":"Acta Oncologica Turcica","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120980689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Computed tomography findings of a dentigerous cyst associated with an ectopic tooth in the maxillary sinüs 上颌窦异位牙伴含牙囊肿的ct表现

Acta Oncologica Turcica Pub Date : 1900-01-01 DOI: 10.5505/aot.2019.27676

C. Imamoğlu, Aydin Tunc Uzel, Ismail Gedi Ibrahim, Ismail M. Ali

引用次数: 1

Clinical Feature and Survival Outcomes of Lung Cancer with ALK Mutation Positive and Treated with Crizotinib, Single Centre Experience 肺癌ALK突变阳性和克唑替尼治疗的临床特征和生存结果，单中心经验

Acta Oncologica Turcica Pub Date : 1900-01-01 DOI: 10.5505/aot.2019.52523

B. Bilgin, Ş. Yücel

引用次数: 0

Comparison of Adjuvant Modified FOLFIRINOX with Other Adjuvant Chemotherapies in Resected Pancreatic Adenocarcinoma: Real-life Data 辅助改良FOLFIRINOX与其他辅助化疗在胰腺腺癌切除术中的比较:真实数据

Acta Oncologica Turcica Pub Date : 1900-01-01 DOI: 10.5505/aot.2023.41196

C. Erol, E. Hafizoğlu, M. Aykan, D. Güven, B. Dursun, M. Hızal, S. Kahraman, D. Şener Dede, M. Akinci, N. Karadurmuş, Y. Ürün, E. Algın, Ş. Yalçın, B. Yalcin, M. Şendur

引用次数: 0

Dosimetric Comparison of Three-Dimensional Conformal Radiotherapy, Forward-Planned Intensity Modulated Radiotherapy and Volumetric Modulated Arc Therapy in Intact Breast Radiotherapy without Lymphatic Irradiation 三维适形放疗、前计划调强放疗和体积调弧放疗在完整乳腺无淋巴放射治疗中的剂量学比较

Acta Oncologica Turcica Pub Date : 1900-01-01 DOI: 10.5505/aot.2019.06977

Z. A. Cerkesli, F. I. Kayali, R. Habi̇boğlu

引用次数: 1

Acute Renal Failure Due to the Giant Vıllous Adenoma of Colon: McKittrick-Wheelock Syndrome 巨大Vıllous结肠腺瘤所致急性肾衰竭:McKittrick-Wheelock综合征

Acta Oncologica Turcica Pub Date : 1900-01-01 DOI: 10.5505/aot.2019.38991

E. Esen, R. Kerimoğlu

{"title":"Acute Renal Failure Due to the Giant Vıllous Adenoma of Colon: McKittrick-Wheelock Syndrome","authors":"E. Esen, R. Kerimoğlu","doi":"10.5505/aot.2019.38991","DOIUrl":"https://doi.org/10.5505/aot.2019.38991","url":null,"abstract":"Malignant tumors of the colon usually originate from benign adenomas. Adenomas with large size and villous component have higher malignancy potential than other adenomas. Adenomas are usually asymptomatic, but as their size increase, they may cause symptoms such as bleeding, tenesmus, obstruction, intussusception. Mucous diarrhea can be seen due to secretory adenomas that constitute the subgroup of villous adenomas. Secretory adenomas are usually located in the rectosigmoid region and are larger than 4 cm. McKittrick-Wheelock syndrome is characterized by chronic mucous diarrhea, renal failure and electrolyte imbalance due to rectal secretory villous adenoma. Approximately 100 cases have been reported in the literature. Adenoma causing McKittrick Wheelock syndrome carries a hıgh rısk for the development of ınvasıve cancer due to its bıg sıze and hıstologıc sub-type. This syndrome can be fatal due to the metabolic collapse or possible malignancy however early diagnosis and proper treatment may increase quality of life and serve a significant survival advantage for the patients. The importance of being aware of McKittrick-Wheelock syndrome and the need to include this diagnosis in the work up of patients with secretory diarrhea should be highlighted.In this case report, we aimed to present a patient who was diagnosed with rectal cancer and was diagnosed as one of the largest adenomas causing McKittrick-Wheelock","PeriodicalId":435847,"journal":{"name":"Acta Oncologica Turcica","volume":"80 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134083066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immune Thrombocytopenia: A Disease With Many Unresolved Questions 免疫性血小板减少症:一种有许多未解决问题的疾病

Acta Oncologica Turcica Pub Date : 1900-01-01 DOI: 10.5505/aot.2022.89166

S. Yaman, Burcu Aslan Candır, E. Bozan, S. Seçilmiş, S. Başcı, Bahar Uncu Ulu, T. Yiğenoğlu, M. Kızıl Çakar, M. Dal, F. Altuntaş

引用次数: 0