Clinical Medicine Insights- Pathology最新文献

A Colonic Perineurioma. 结肠膜周围瘤。

Clinical Medicine Insights- Pathology Pub Date : 2018-12-06 eCollection Date: 2018-01-01 DOI: 10.1177/1179555718815918

Tomoyuki Otani, Kinta Hatakeyama, Emi Ohtani, Susumu Nakayama, Takashi Fujimoto, Chiho Ohbayashi

引用次数: 1

Intrathecal Methotrexate-Induced Necrotizing Myelopathy: A Case Report and Review of Histologic Features. 鞘内甲氨蝶呤诱导坏死性脊髓病:1例报告及组织学特征回顾。

Clinical Medicine Insights- Pathology Pub Date : 2018-11-04 eCollection Date: 2018-01-01 DOI: 10.1177/1179555718809071

Hamza Tariq, Andrea Gilbert, Francis E Sharkey

{"title":"Intrathecal Methotrexate-Induced Necrotizing Myelopathy: A Case Report and Review of Histologic Features.","authors":"Hamza Tariq, Andrea Gilbert, Francis E Sharkey","doi":"10.1177/1179555718809071","DOIUrl":"https://doi.org/10.1177/1179555718809071","url":null,"abstract":"Central nervous system (CNS) relapse of acute lymphoblastic leukemia (ALL) is associated with a poor prognosis. However, prophylactic measures, including intrathecal (IT) methotrexate, reduce the incidence of CNS relapse in these patients considerably. Unfortunately, IT methotrexate can cause several neurologic complications, including transverse myelopathy; ie, the development of isolated spinal cord dysfunction over hours or days following the IT infusion of methotrexate, but in the absence of a compressive lesion. Transverse myelopathy following IT methotrexate is a well-established clinical phenomenon, but the histologic features have been described only very rarely. We report the autopsy findings from a 31-year-old man with a history of T-cell ALL who received prophylactic IT methotrexate in anticipation of a bone marrow transplant. Microscopic examination showed transverse necrosis of the thoracic cord, with massive infiltration by macrophages and lymphocytes, and perivascular lymphocytic infiltrates. There was cavitary necrosis of cervical and lumbar spinal cord involving the entire gray matter and focal white matter, as well as extensive subpial vacuolar degeneration of the dorsal and lateral columns.","PeriodicalId":43543,"journal":{"name":"Clinical Medicine Insights- Pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1179555718809071","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36693699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Autopsy Patients With Obesity or Metabolic Syndrome as Basic Cause of Death: Are There Pathological Differences Between These Groups? 以肥胖或代谢综合征为基本死因的尸检患者:这两组之间有病理差异吗?

Clinical Medicine Insights- Pathology Pub Date : 2018-07-30 eCollection Date: 2018-01-01 DOI: 10.1177/1179555718791575

Lucas Braz Gonçalves, Helio Amante Miot, Maria Aparecida Custódio Domingues, Cristiano Claudino Oliveira

{"title":"Autopsy Patients With Obesity or Metabolic Syndrome as Basic Cause of Death: Are There Pathological Differences Between These Groups?","authors":"Lucas Braz Gonçalves, Helio Amante Miot, Maria Aparecida Custódio Domingues, Cristiano Claudino Oliveira","doi":"10.1177/1179555718791575","DOIUrl":"https://doi.org/10.1177/1179555718791575","url":null,"abstract":"Background: The objectives of this study were the evaluation of pathological characteristics of patients with obesity or metabolic syndrome (MS) as basic cause of death, associating the autopsy findings with some clinical aspects and the abdominal adipose panicle thickness.Methods: A total of 88 autopsy cases were studied, divided into 2 groups based on the main cause of death: group 1 (n = 15) obesity and group 2 (n = 73) MS. Clinical summaries of autopsy requests, macroscopic findings, and histologic sections were reviewed.Results: The definition of obesity as the basic cause of death is associated with larger thickness of the abdominal adipose panicle, being 8.5 cm (P = .001) the best measurement, according to the receiver operating characteristic curve. Hypertensive cardiopathy (P = .001), ischemic cardiopathy (P = .003), coronary (P = .008)/systemic (P = .005) atherosclerosis, and arterial (P = .014)/arteriolar (P = .027) nephrosclerosis are associated with the diagnosis of MS. Steatohepatitis is associated with the diagnosis of obesity (P = .030); however, its association with the thickness of the abdominal adipose panicle is not statistically significant (P = .211).Conclusions: In the context of an obese patient in autopsy, pathologist may use the information about abdominal adipose panicle associated with heart, kidney, and liver findings, even macroscopic ones, to decide the basic cause death between obesity and MS.","PeriodicalId":43543,"journal":{"name":"Clinical Medicine Insights- Pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1179555718791575","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36377017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Tubular Adenoma of the Breast: A Clinicopathologic Study of a Series of 9 Cases. 乳腺管状腺瘤:9例临床病理分析。

Clinical Medicine Insights- Pathology Pub Date : 2018-02-05 eCollection Date: 2018-01-01 DOI: 10.1177/1179555718757499

Boubacar Efared, Ibrahim S Sidibé, Souley Abdoulaziz, Nawal Hammas, Laila Chbani, Hinde El Fatemi

{"title":"Tubular Adenoma of the Breast: A Clinicopathologic Study of a Series of 9 Cases.","authors":"Boubacar Efared, Ibrahim S Sidibé, Souley Abdoulaziz, Nawal Hammas, Laila Chbani, Hinde El Fatemi","doi":"10.1177/1179555718757499","DOIUrl":"https://doi.org/10.1177/1179555718757499","url":null,"abstract":"Tubular adenoma of the breast is one of the most rare benign neoplasms, accounting for only 0.13% to 1.7% of all breast benign tumors. Little is known about this rare neoplasm as the current literature offers only some case reports or a few number of small series. The aim of our study is to provide some clinicopathologic features of the breast tubular adenoma. We retrospectively analyzed at our department of pathology all cases of breast tubular adenomas confirmed by immunohistochemistry over a period of 9 years (2009-2017). Nine cases of breast tubular adenoma have been recorded, with an average age of 31.44 years. Five tumors were located at the right side (55.55%), and most cases had suspicious aspects on imaging techniques (6 cases out of 9). The diagnosis has been made on 5 resected specimens (lumpectomy) and on 4 core needle biopsies. The tumor size ranged from 0.9 to 7 cm (mean size of 3.08 cm) and had well-circumscribed margins with elastic consistency. The histopathologic analysis showed a typical pattern of proliferating round and uniform tubules lined by regular epithelial cells surrounded by myoepithelial cells, packed in a small amount of stroma, highlighted by CD34 immunostaining. Tubular adenoma is a rare breast benign neoplasm of young premenopausal women. The radiologic aspects are often worrisome and only the histopathologic analysis can achieve the correct definitive diagnosis by excluding all potential differential diagnoses.","PeriodicalId":43543,"journal":{"name":"Clinical Medicine Insights- Pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1179555718757499","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35836102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Effects of Prolonged Treatment With Co-trimoxazole on the Thyroid Gland, Liver, and Epididymal Sperm Reserve in Dogs. 长期服用共三唑对狗甲状腺、肝脏和附睾精子储备的影响

Clinical Medicine Insights- Pathology Pub Date : 2017-12-07 eCollection Date: 2017-01-01 DOI: 10.1177/1179555717742881

Davinson C Anyogu, Vincent So Shoyinka, John I Ihedioha

{"title":"Effects of Prolonged Treatment With Co-trimoxazole on the Thyroid Gland, Liver, and Epididymal Sperm Reserve in Dogs.","authors":"Davinson C Anyogu, Vincent So Shoyinka, John I Ihedioha","doi":"10.1177/1179555717742881","DOIUrl":"10.1177/1179555717742881","url":null,"abstract":"Co-trimoxazole is an antimicrobial drug gotten from potentiation of sulfamethoxazole with trimethoprim. It is widely used for the treatment of bacterial and protozoan infections in humans. It is also used in veterinary clinics against susceptible microorganisms, but thyroid dysfunction has raised concern especially in dogs. This study aimed to determine the effects of prolonged treatment with co-trimoxazole in euthyroid dogs. Dogs were given co-trimoxazole at 30, 60, and 120 mg/kg body weight at 12-hour intervals for 21 days. Standard procedures were used to assay total T4 and T3, thyrotropin, testosterone, aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase in serum. The thyroid gland and testes were weighed. In addition, thyroid and liver were examined histologically. Epididymal sperm count was also performed. Co-trimoxazole caused dose-dependent depression of serum thyroxine levels with severe colloid depletion, intrafollicular hemorrhage, hyperplasia, and hypertrophy of the follicular cells. The liver showed vacuolar hepatopathy. Epididymal sperm count was low in the 120 mg/kg-treated group. The study revealed that thyroid hemorrhage and lowered epididymal sperm reserve were new findings in co-trimoxazole toxicity in dogs.","PeriodicalId":43543,"journal":{"name":"Clinical Medicine Insights- Pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1f/0d/10.1177_1179555717742881.PMC5724629.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35657584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional Studies of CCAAT/Enhancer Binding Protein Site Located Downstream of the Transcriptional Start Site. CCAAT/增强子结合蛋白转录起始位点下游的功能研究。

Clinical Medicine Insights- Pathology Pub Date : 2017-11-15 eCollection Date: 2017-01-01 DOI: 10.1177/1179555717694556

Yujie Liu, Michael R Nonnemacher, Aikaterini Alexaki, Vanessa Pirrone, Anupam Banerjee, Luna Li, Evelyn Kilareski, Brian Wigdahl

{"title":"Functional Studies of CCAAT/Enhancer Binding Protein Site Located Downstream of the Transcriptional Start Site.","authors":"Yujie Liu, Michael R Nonnemacher, Aikaterini Alexaki, Vanessa Pirrone, Anupam Banerjee, Luna Li, Evelyn Kilareski, Brian Wigdahl","doi":"10.1177/1179555717694556","DOIUrl":"https://doi.org/10.1177/1179555717694556","url":null,"abstract":"Previous studies have identified a CCAAT/enhancer binding protein (C/EBP) site located downstream of the transcriptional start site (DS3). The role of the DS3 element with respect to HIV-1 transactivation by Tat and viral replication has not been characterized. We have demonstrated that DS3 was a functional C/EBPβ binding site and mutation of this site to the C/EBP knockout DS3-9C variant showed lower HIV-1 long terminal repeat (LTR) transactivation by C/EBPβ. However, it was able to exhibit similar or even higher transcription levels by Tat compared to the parental LTR. C/EBPβ and Tat together further enhanced the transcription level of the parental LAI-LTR and DS3-9C LTR, with higher levels in the DS3-9C LTR. HIV molecular clone viruses carrying the DS3-9C variant LTR demonstrated a decreased replication capacity and delayed rate of replication. These results suggest that DS3 plays a role in virus transcriptional initiation and provides new insight into C/EBP regulation of HIV-1.","PeriodicalId":43543,"journal":{"name":"Clinical Medicine Insights- Pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1179555717694556","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35273332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Impact of Pathology Review for Decision Therapy in Localized Prostate Cancer. 病理综述对局限性前列腺癌决策治疗的影响。

Clinical Medicine Insights- Pathology Pub Date : 2017-11-02 eCollection Date: 2017-01-01 DOI: 10.1177/1179555717740130

Pedro Luiz Serrano Usón, Ricardo Silvestre E Silva Macarenco, Fernando Nunes Oliveira, Oren Smaletz

{"title":"Impact of Pathology Review for Decision Therapy in Localized Prostate Cancer.","authors":"Pedro Luiz Serrano Usón, Ricardo Silvestre E Silva Macarenco, Fernando Nunes Oliveira, Oren Smaletz","doi":"10.1177/1179555717740130","DOIUrl":"https://doi.org/10.1177/1179555717740130","url":null,"abstract":"Background: The Gleason score is an essential tool in the decision to treat localized prostate cancer. However, experienced pathologists can classify Gleason score differently than do low-volume pathologists, and this may affect the treatment decision. This study sought to assess the impact of pathology review of external biopsy specimens from 23 men with a recent diagnosis of localized prostate cancer.Methods: All external biopsy specimens were reviewed at our pathology department. Data were retrospectively collected from scanned charts.Results: The median patient age was 63 years (range: 46-74 years). All patients had a Karnofsky performance score of 90% to 100%. The median prostate-specific antigen level was 23.6 ng/dL (range: 1.04-13.6 ng/dL). Among the 23 reviews, the Gleason score changed for 8 (35%) patients: 7 upgraded and 1 downgraded. The new Gleason score affected the treatment decision in 5 of 8 cases (62.5%).Conclusions: This study demonstrates the need for pathology review in patients with localized prostate cancer before treatment because Gleason score can change in more than one-third of patients and can affect treatment decision in almost two-thirds of recategorized patients.","PeriodicalId":43543,"journal":{"name":"Clinical Medicine Insights- Pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1179555717740130","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35560713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Prognostic Impact of Extracapsular Lymph Node Invasion and Myofibroblastic Activity in Extrahepatic Bile Duct Cancer. 肝外胆管癌包膜外淋巴结浸润和肌成纤维细胞活性对预后的影响。

Clinical Medicine Insights- Pathology Pub Date : 2017-09-06 eCollection Date: 2017-01-01 DOI: 10.1177/1179555717729652

Tadashi Yoshizawa, Keinosuke Ishido, Kensuke Saito, Toshihiro Haga, Hiroko Seino, Yunyan Wu, Satoko Morohashi, Kenichi Hakamada, Hiroshi Kijima

{"title":"Prognostic Impact of Extracapsular Lymph Node Invasion and Myofibroblastic Activity in Extrahepatic Bile Duct Cancer.","authors":"Tadashi Yoshizawa, Keinosuke Ishido, Kensuke Saito, Toshihiro Haga, Hiroko Seino, Yunyan Wu, Satoko Morohashi, Kenichi Hakamada, Hiroshi Kijima","doi":"10.1177/1179555717729652","DOIUrl":"https://doi.org/10.1177/1179555717729652","url":null,"abstract":"Extrahepatic bile duct carcinoma is a potentially malignant gastrointestinal lesion. Cancer cells spread via the lymphatic system to regional lymph nodes and help in tumor progression. However, there are no reports on the prognostic impact of extracapsular lymph node invasion and myofibroblastic activity in this cancer. Hence, we classified the histopathologic patterns of lymph nodes into 2 patterns: extracapsular lymph node invasion or not. Based on this, we investigated 32 cases of extrahepatic bile duct cancer with lymph node metastasis and classified 21 cases as positive and 11 cases as negative. The extracapsular lymph node invasion cases were associated with poor disease-free survival and overall survival. The myofibroblast density of the metastatic foci was significantly higher in the extracapsular lymph node invasion cases. This is the first study to demonstrate that extracapsular lymph node invasion cases were associated with poor prognosis and that the myofibroblast distribution contributed to malignancy.","PeriodicalId":43543,"journal":{"name":"Clinical Medicine Insights- Pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1179555717729652","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35354664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Pulmonary Cryptococcosis Presenting With Lung Mass: Report of 7 Cases and Review of Literature. 以肺肿块为表现的肺隐球菌病:附7例报告并文献复习。

Clinical Medicine Insights- Pathology Pub Date : 2017-08-04 eCollection Date: 2017-01-01 DOI: 10.1177/1179555717722962

Kanet Kanjanapradit, Zdravko Kosjerina, Wiwatana Tanomkiat, Warangkana Keeratichananont, Siripen Panthuwong

{"title":"Pulmonary Cryptococcosis Presenting With Lung Mass: Report of 7 Cases and Review of Literature.","authors":"Kanet Kanjanapradit, Zdravko Kosjerina, Wiwatana Tanomkiat, Warangkana Keeratichananont, Siripen Panthuwong","doi":"10.1177/1179555717722962","DOIUrl":"https://doi.org/10.1177/1179555717722962","url":null,"abstract":"Pulmonary cryptococcosis is commonly found in immunocompromised patients. This microorganism rarely infects immunocompetent individuals, and when it does, it causes mild symptoms. The radiological findings of this disease may involve an intrapulmonary mass that mimics lung tumor. The objective of this study was to review the clinicopathological information, radiological findings, and treatment of patients who presented with intrapulmonary mass due to cryptococcosis. This study collected data from 7 patients who were treated at Songklanagarind Hospital, Songkhla, Thailand, between 2009 and 2014. Their clinical data, radiological findings, pathological results, and treatment protocols were reviewed. The patients were 2 women and 5 men, ranging in age from 37 to 79 years old. One case was an immunocompromised host. Four cases experienced the chest symptoms of dyspnea, hemoptysis, and chronic cough. The most common location of mass was the left lower lobe (71%). Four cases had a history of bird contact. Lung lobectomy was performed in 3 cases (42%), and all of the patients were treated with oral fluconazole. An intrapulmonary mass caused by this microorganism is mainly found in immunocompetent patients. Treatment with the antifungal drug fluconazole is very effective.","PeriodicalId":43543,"journal":{"name":"Clinical Medicine Insights- Pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1179555717722962","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35329146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Is Tolerance Broken in Autoimmunity? 自身免疫是否破坏了耐受性?

Clinical Medicine Insights- Pathology Pub Date : 2017-05-16 eCollection Date: 2017-01-01 DOI: 10.1177/1179555717712716

Dama Laxminarayana

{"title":"Is Tolerance Broken in Autoimmunity?","authors":"Dama Laxminarayana","doi":"10.1177/1179555717712716","DOIUrl":"10.1177/1179555717712716","url":null,"abstract":"Autoimmune diseases are classified into about 80 different types based on their specificity related to system, organ and/or tissue. About 5% of the western population is affected by this anomaly, but its worldwide incidence is unknown. Autoimmune diseases are heterogeneous in nature and clinical manifestations range from benign disorders to life-threatening conditions. Autoimmunity strikes at any stage of life, but age and/or gender also play role in onset of some of these anomalies. The autoimmune pathogenesis is initiated by the origination of autoantigens, which leads to the development of autoantibodies followed by auto-immunogenicity and the ultimate onset of autoimmunity. There is a lack of suitable therapies to treat autoimmune diseases, because mechanisms involved in the onset of these anomalies were poorly understood. Present therapies are limited to symptomatic treatment and come with severe side effects. Here, I described the molecular mechanisms and cellular events involved in the initiation of autoimmunity and proposed better strategies to modulate such molecular and cellular anomalies, which will help in preventing and/or controlling autoimmune pathogenesis and ultimately aid in enhancing the quality of life.","PeriodicalId":43543,"journal":{"name":"Clinical Medicine Insights- Pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1179555717712716","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35058612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2