Clinical Medicine Insights- Pathology最新文献_第2页

A Little Help From the Follicles: Understanding the Germinal Center Response to Human Immunodeficiency Virus 1 Infection and Prophylactic Vaccines. 卵泡的一点帮助：了解人类免疫缺陷病毒1型感染和预防性疫苗的生殖中心反应。

Clinical Medicine Insights- Pathology Pub Date : 2017-03-30 eCollection Date: 2017-01-01 DOI: 10.1177/1179555717695548

Ebony N Gary, Michele A Kutzler

引用次数: 1

cAMP Signaling Enhances HIV-1 Long Terminal Repeat (LTR)-directed Transcription and Viral Replication in Bone Marrow Progenitor Cells. cAMP 信号增强骨髓祖细胞中 HIV-1 长末端重复 (LTR) 引导的转录和病毒复制。

Clinical Medicine Insights- Pathology Pub Date : 2017-03-10 eCollection Date: 2017-01-01 DOI: 10.1177/1179555717694535

Anupam Banerjee, Luna Li, Vanessa Pirrone, Fred C Krebs, Brian Wigdahl, Michael R Nonnemacher

{"title":"cAMP Signaling Enhances HIV-1 Long Terminal Repeat (LTR)-directed Transcription and Viral Replication in Bone Marrow Progenitor Cells.","authors":"Anupam Banerjee, Luna Li, Vanessa Pirrone, Fred C Krebs, Brian Wigdahl, Michael R Nonnemacher","doi":"10.1177/1179555717694535","DOIUrl":"10.1177/1179555717694535","url":null,"abstract":"CD34+ hematopoietic progenitor cells have been shown to be susceptible to HIV-1 infection, possibly due to a low-level expression of CXCR4, a coreceptor for HIV-1 entry. Given these observations, we have explored the impact of forskolin on cell surface expression of CXCR4 in a cell line model (TF-1). The elevation of intracellular cyclic adenosine monophosphate (cAMP) by forskolin through adenylyl cyclase (AC) resulted in transcriptional upregulation of CXCR4 with a concomitant increase in replication of the CXCR4-utilizing HIV-1 strain IIIB. Transient expression analyses also demonstrated an increase in CXCR4-, CCR5-, and CXCR4-/CCR5-utilizing HIV-1 (LAI, YU2, and 89.6, respectively) promoter activity. Studies also implicated the protein kinase A (PKA) pathway and the downstream transcription factor CREB-1 in interfacing with cAMP response elements located in the CXCR4 and viral promoter. These observations suggest that the cAMP signaling pathway may serve as a regulator of CXCR4 levels and concomitantly of HIV-1 replication in bone marrow (BM) progenitor cells.","PeriodicalId":43543,"journal":{"name":"Clinical Medicine Insights- Pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d5/00/10.1177_1179555717694535.PMC5398651.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9982303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hanging Fatalities in Central Bangkok, Thailand: A 13-Year Retrospective Study. 泰国曼谷中部的上吊死亡率:一项13年的回顾性研究。

Clinical Medicine Insights- Pathology Pub Date : 2017-02-23 eCollection Date: 2017-01-01 DOI: 10.1177/1179555717692545

Nattapong Tulapunt, Swarin Phanchan, Vichan Peonim

{"title":"Hanging Fatalities in Central Bangkok, Thailand: A 13-Year Retrospective Study.","authors":"Nattapong Tulapunt, Swarin Phanchan, Vichan Peonim","doi":"10.1177/1179555717692545","DOIUrl":"https://doi.org/10.1177/1179555717692545","url":null,"abstract":"Hanging is violent asphyxial death. The objective of this study is to assess the data of hanging cases. A descriptive-retrospective study was conducted. We studied 244 hanging cases autopsied in Forensic Division, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand, between January 2001 and December 2013. The study included 197 men (80.7%) and 47 women (19.2%). Their age ranged from 14 to 93 years. Most of these cases were incomplete hanging (83.6%). Features of hanging victims, such as tongue protrusion; congestion of face; petechial hemorrhage of face, conjunctiva, and internal organs; and neck injuries, significantly correlated with complete hanging. The predominant occupation of hanging victims was in the service industry (63.1%). Suicides usually occurred in private homes or apartments (84.8%). A suicide note was found in 6.1% of cases. The most common ligature material used was nylon rope, found in 61.1% of cases. The most underlying diseases of the victims in hanging cases were tuberculosis and human immunodeficiency virus infection, 9 cases each. Blood ethanol levels of 29 cases (11.8%) were detected to be higher than 150 mg%. Methamphetamine and benzodiazepine were detected in 5.3% and 3.3% of cases, respectively. This study provides comprehensive baseline data of hanging cases in central Bangkok.","PeriodicalId":43543,"journal":{"name":"Clinical Medicine Insights- Pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1179555717692545","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34965922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Primary Melanotic Paraganglioma of Thyroid Gland: Report of a Rare Case With Clinicopathologic and Immunohistochemical Analysis and a Literature Review. 原发性甲状腺黑色素副神经节瘤:罕见临床病理及免疫组化分析1例并文献复习。

Clinical Medicine Insights- Pathology Pub Date : 2017-02-22 eCollection Date: 2017-01-01 DOI: 10.1177/1179555716684670

Yan-Jun Dong, Zhi-Wen Zhang, Zhen Wang, Xin-Ying Wang, Zhi-Zhen Tian, Xiang-Sheng Zhang

{"title":"Primary Melanotic Paraganglioma of Thyroid Gland: Report of a Rare Case With Clinicopathologic and Immunohistochemical Analysis and a Literature Review.","authors":"Yan-Jun Dong, Zhi-Wen Zhang, Zhen Wang, Xin-Ying Wang, Zhi-Zhen Tian, Xiang-Sheng Zhang","doi":"10.1177/1179555716684670","DOIUrl":"https://doi.org/10.1177/1179555716684670","url":null,"abstract":"Background: Pigmented paraganglioma is a special type of paraganglioma, and it is rare in the thyroid.Case presentation: We report a case of a 41-year-old woman who had complained of a mass in the thyroid gland. Histology revealed tumor cells arranged in a nest-like or organoid pattern, separated by delicate fibrovascular septa. Two distinct components were observed. In the first, which constituted the majority of the tumor cells, no pigments were observed. In the second, a few cells with pigment showed intercellular substance, but the structure was unclear. Using immunohistochemistry, cells in the first component were confirmed to be diffuse strong positive for synaptophysin, but negative for chromogranin A, pan-cytokeratin, calcitonin, and thyroglobulin. About 1% of tumor cells were stained by Ki-67. In the margins of the tumor, a few cells were observed to be positive for HMB-45 and Melan A after bleaching by oxalic acid. The stromal cells were positive for S-100. Using electron microscopy, a few cells containing many round melanin bodies with greater electron density granules of nonuniform size were observed. The diagnosis of primary melanotic paraganglioma of the thyroid gland was made.Conclusion: Primary melanotic paraganglioma of the thyroid gland is a rare, low malignant potential tumor. To the best of our knowledge, this is the first case described.","PeriodicalId":43543,"journal":{"name":"Clinical Medicine Insights- Pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1179555716684670","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34965921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Phyllodes Tumor in a Lactating Breast. 哺乳期乳腺叶状瘤。

Clinical Medicine Insights- Pathology Pub Date : 2016-04-06 eCollection Date: 2016-01-01 DOI: 10.4137/CPath.S38476

Sudha S Murthy, K V V N Raju, Haripreetha G Nair

引用次数: 9

A Case Report: A Third/Fourth Branchial Pouch Anomaly Presented by Solid Thyroid and Lateral Cervical Neck Masses 以实性甲状腺及颈侧肿物为表现之第三/第四鳃袋异常1例

Clinical Medicine Insights- Pathology Pub Date : 2016-01-01 DOI: 10.4137/CPath.S31734

Magda H. A. Nasreldin, E. Ibrahim, Somaia A. Saad El-Din

引用次数: 1

Modulation of Immune Responses by Exosomes Derived from Antigen-Presenting Cells 抗原提呈细胞衍生的外泌体对免疫反应的调节

Clinical Medicine Insights- Pathology Pub Date : 2016-01-01 DOI: 10.4137/CPath.S39925

Botros B. Shenoda, Seena K. Ajit

引用次数: 65

Cytopathological Diagnosis of an Unusual Cause of Malignant Hydrocele 恶性鞘膜积液罕见病因的细胞病理学诊断

Clinical Medicine Insights- Pathology Pub Date : 2016-01-01 DOI: 10.4137/CPath.S40517

Ankur Jain, A. Khadwal, G. Prakash, N. Gupta, S. Varma, P. Malhotra

{"title":"Cytopathological Diagnosis of an Unusual Cause of Malignant Hydrocele","authors":"Ankur Jain, A. Khadwal, G. Prakash, N. Gupta, S. Varma, P. Malhotra","doi":"10.4137/CPath.S40517","DOIUrl":"https://doi.org/10.4137/CPath.S40517","url":null,"abstract":"Testicular involvement in a case of acute lymphoblastic leukemia (ALL) is well reported, but occurrence of “isolated” malignant hydrocele is extremely uncommon. We herein report a case of a 22-year-old man who presented to our hematology clinic with fever and easy fatiguability of 2 weeks' duration. Examination revealed pallor, cervical lymphadenopathy, and bilateral scrotal swellings. He was diagnosed as a case of Philadelphia-positive ALL (B-cell type) based on peripheral smear, bone marrow examination, and flow cytometry of the marrow aspirate. Ultrasonography of scrotum revealed bilateral hydrocele with normal testes. Cytopathological analysis of the hydrocele fluid showed the presence of lymphoblasts. The patient was treated with modified BFM-90 protocol along with imatinib mesylate (600 mg/day). He achieved complete remission with a minimal residual disease of <0.001% at the end of induction therapy. However, the hydrocele persisted and a repeat cytological examination of the aspirate did not reveal any lymphoblasts. The patient was treated with consolidation (high-dose methotrexate), bilateral testicular irradiation, and re-induction following which the hydrocele disappeared. The patient is currently on maintenance phase of BFM-90 protocol and is alive at one year of follow-up. Contiguous spread from the subclinical testicular involvement is hypothesized as the mechanism for development of hydrocele in the current case. The role of cytopathology in the early diagnosis of testicular involvement in ALL is emphasized here.","PeriodicalId":43543,"journal":{"name":"Clinical Medicine Insights- Pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80303408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Diagnostic Implication and Clinical Relevance of Ancillary Techniques in Clinical Pathology Practice 辅助技术在临床病理实践中的诊断意义和临床意义

Clinical Medicine Insights- Pathology Pub Date : 2016-01-01 DOI: 10.4137/CPath.S32784

J. Makki

引用次数: 21

IDO2: A Pathogenic Mediator of Inflammatory Autoimmunity IDO2:炎症自身免疫的致病介质

Clinical Medicine Insights- Pathology Pub Date : 2016-01-01 DOI: 10.4137/CPath.S39930

Lauren M F Merlo, L. Mandik-Nayak

引用次数: 38