Prognostic Impact of Extracapsular Lymph Node Invasion and Myofibroblastic Activity in Extrahepatic Bile Duct Cancer.

Q3 Medicine

Clinical Medicine Insights- Pathology Pub Date : 2017-09-06 eCollection Date: 2017-01-01 DOI:10.1177/1179555717729652

Tadashi Yoshizawa, Keinosuke Ishido, Kensuke Saito, Toshihiro Haga, Hiroko Seino, Yunyan Wu, Satoko Morohashi, Kenichi Hakamada, Hiroshi Kijima

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引用次数: 3

Abstract

Extrahepatic bile duct carcinoma is a potentially malignant gastrointestinal lesion. Cancer cells spread via the lymphatic system to regional lymph nodes and help in tumor progression. However, there are no reports on the prognostic impact of extracapsular lymph node invasion and myofibroblastic activity in this cancer. Hence, we classified the histopathologic patterns of lymph nodes into 2 patterns: extracapsular lymph node invasion or not. Based on this, we investigated 32 cases of extrahepatic bile duct cancer with lymph node metastasis and classified 21 cases as positive and 11 cases as negative. The extracapsular lymph node invasion cases were associated with poor disease-free survival and overall survival. The myofibroblast density of the metastatic foci was significantly higher in the extracapsular lymph node invasion cases. This is the first study to demonstrate that extracapsular lymph node invasion cases were associated with poor prognosis and that the myofibroblast distribution contributed to malignancy.

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肝外胆管癌包膜外淋巴结浸润和肌成纤维细胞活性对预后的影响。

肝外胆管癌是一种潜在的胃肠道恶性病变。癌细胞通过淋巴系统扩散到局部淋巴结，促进肿瘤进展。然而，尚无关于这种癌症的囊外淋巴结浸润和肌成纤维细胞活性对预后影响的报道。因此，我们将淋巴结的组织病理类型分为两种类型:囊外淋巴结浸润和未浸润。在此基础上，我们分析了32例肝外胆管癌伴淋巴结转移的病例，其中阳性21例，阴性11例。囊外淋巴结浸润病例与较差的无病生存期和总生存期相关。在囊外淋巴结浸润的病例中，转移灶的肌成纤维细胞密度明显较高。这是第一个证明囊外淋巴结浸润病例与不良预后相关的研究，并且肌成纤维细胞的分布有助于恶性肿瘤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Medicine Insights- Pathology PATHOLOGY-

CiteScore

1.90

自引率

0.00%

发文量

审稿时长

4 weeks