Int. J. Bioinform. Res. Appl.最新文献_第9页

Evaluating a hierarchical approach for heartbeat classification from ECG 评价一种基于ECG的分层心跳分类方法

Int. J. Bioinform. Res. Appl. Pub Date : 2017-03-24 DOI: 10.1504/IJBRA.2017.10003488

Eduardo José da S. Luz, L. Merschmann, D. Menotti, G. Moreira

引用次数: 3

Using conditional inference forest to identify variable importance 利用条件推理林识别变量重要性

Int. J. Bioinform. Res. Appl. Pub Date : 2017-03-24 DOI: 10.1504/IJBRA.2017.10003483

N. Settouti, Mostafa EL HABIB DAHO, Amine Chikh

{"title":"Using conditional inference forest to identify variable importance","authors":"N. Settouti, Mostafa EL HABIB DAHO, Amine Chikh","doi":"10.1504/IJBRA.2017.10003483","DOIUrl":"https://doi.org/10.1504/IJBRA.2017.10003483","url":null,"abstract":"Variable importance measure with Random Forests (RF) have received increased attention as a means of variable selection in classification tasks. The measure of variable importance in Random Forests is a smart way of variable selection in many applications, but is not reliable in situations where potential predictor variables vary in their scale of measurement or their number of categories. In this paper, we have implemented Random Forest built from Conditional Inference Trees (CIT) that is called Conditional Inference Forest (CIF). In each tree in the forest of conditional inference, the division of the nodes is based on the way to have a good associativity. The chi-square test statistics is used to measure the association. In addition to identifying variables that improve the classification accuracy, the methodology also clearly identifies the variables that are neutral to the accuracy, and also those who interfere in the right classification. In this paper, we are particularly interested in the overall algorithm Conditional Inference Forest (CIF) for the classification of large biological data. The algorithm is evaluated on its ability to select a reduced number of features while preserving a very satisfactory classification rate.","PeriodicalId":434900,"journal":{"name":"Int. J. Bioinform. Res. Appl.","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125583854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prediction of Homo sapiens cancer cells by electrical network modelling of amino acid sequence 利用氨基酸序列的电网络模型预测智人癌细胞

Int. J. Bioinform. Res. Appl. Pub Date : 2017-02-09 DOI: 10.1504/IJBRA.2017.10002833

Tanusree Roy, S. Barman

引用次数: 1

Annotation transfer by homology among closely related genomes helps to identify protein function in Plasmodium species 在密切相关的基因组之间通过同源性的注释转移有助于鉴定疟原虫物种的蛋白质功能

Int. J. Bioinform. Res. Appl. Pub Date : 2017-02-09 DOI: 10.1504/IJBRA.2017.10002824

Devaraj Raghul Rajan, B. Chandramohan

引用次数: 0

A new neural unsupervised classification approach using amended competitive Hebbian learning: PET image segmentation insights 利用改进的竞争性Hebbian学习的一种新的神经无监督分类方法:PET图像分割洞察

Int. J. Bioinform. Res. Appl. Pub Date : 2017-02-09 DOI: 10.1504/IJBRA.2017.10002820

M. Timouyas, S. Eddarouich, A. Hammouch

引用次数: 2

An empirical study of self-training and data balancing techniques for splice site prediction 剪接位置预测的自我训练和数据平衡技术的实证研究

Int. J. Bioinform. Res. Appl. Pub Date : 2017-02-09 DOI: 10.1504/IJBRA.2017.10002831

A. Stanescu, Doina Caragea

引用次数: 0

P-gp and BCRP inhibition induced by some new 1, 4-Dihydropyridine and Dihydropyrimidines 一些新的1,4 -二氢吡啶和二氢嘧啶对P-gp和BCRP的抑制作用

Int. J. Bioinform. Res. Appl. Pub Date : 2017-02-09 DOI: 10.1504/IJBRA.2017.10002832

S. M. E. Kamrani, F. Mosaffa, J. Behravan, F. Hadizadeh

{"title":"P-gp and BCRP inhibition induced by some new 1, 4-Dihydropyridine and Dihydropyrimidines","authors":"S. M. E. Kamrani, F. Mosaffa, J. Behravan, F. Hadizadeh","doi":"10.1504/IJBRA.2017.10002832","DOIUrl":"https://doi.org/10.1504/IJBRA.2017.10002832","url":null,"abstract":"Overexpression of ABC transporters leads to MDR (Multiple Drug Resistance). MDR is considered to be the major contributor to failure of chemotherapy in metastatic cancers. ABC transporters have protective role in normal cells by extruding xenobiotics of cytotoxic compounds from the cell. The development of selective inhibitors of P-gp, MRP1, MRP2, and BCRP has been a major goal of many research groups in the last few years. Previous studies have shown that 1,4-dihydropyridines could inhibit these transporters. In this study, some new 1,4-dihydropyridine and pyrimidine have been developed and their inhibitory effect on the resistant cancer cell lines was examined. In order to elucidate the binding mode of these compounds, a molecular docking and molecular dynamic simulation was performed for the protein-ligand complex. Dihydropyridines were more potent than dihydropyrimidines. However, one of the dihydropyrimidine derivatives selectively inhibited BCRP. The binding mode of these compounds showed that methoxy groups and heterocyclic rings could create hydrogen bonds with polar residues at the active sites. These regions were more stable during MD simulation.","PeriodicalId":434900,"journal":{"name":"Int. J. Bioinform. Res. Appl.","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131319127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Recent advancement in next-generation sequencing techniques and its computational analysis 新一代测序技术及其计算分析的最新进展

Int. J. Bioinform. Res. Appl. Pub Date : 2016-06-15 DOI: 10.1504/IJBRA.2019.10022508

Khalid Raza, Sabahuddin Ahmad

{"title":"Recent advancement in next-generation sequencing techniques and its computational analysis","authors":"Khalid Raza, Sabahuddin Ahmad","doi":"10.1504/IJBRA.2019.10022508","DOIUrl":"https://doi.org/10.1504/IJBRA.2019.10022508","url":null,"abstract":"Next Generation Sequencing (NGS), a recently evolved technology, have served a lot in the research and development sector of our society. This novel approach is a newbie and has critical advantages over the traditional Capillary Electrophoresis (CE) based Sanger Sequencing. The advancement of NGS has led to numerous important discoveries, which could have been costlier and time taking in case of traditional CE based Sanger sequencing. NGS methods are highly parallelized enabling to sequence thousands to millions of molecules simultaneously. This technology results into huge amount of data, which need to be analysed to conclude valuable information. Specific data analysis algorithms are written for specific task to be performed. The algorithms in group, act as a tool in analysing the NGS data. Analysis of NGS data unravels important clues in quest for the treatment of various life-threatening diseases; improved crop varieties and other related scientific problems related to human welfare. In this review, an effort was made to address basic background of NGS technologies, possible applications, computational approaches and tools involved in NGS data analysis, future opportunities and challenges in the area.","PeriodicalId":434900,"journal":{"name":"Int. J. Bioinform. Res. Appl.","volume":"114 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124125631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

In silico pathway analysis of MAPKs and computational investigation of bipyrazole analogues as novel p38alpha MAPK inhibitors MAPK的硅通路分析和双吡唑类似物作为新型p38 α MAPK抑制剂的计算研究

Int. J. Bioinform. Res. Appl. Pub Date : 2016-03-01 DOI: 10.1504/IJBRA.2016.075395

Deepak Nedunuri, Y. Adimulam, K. Reddi

引用次数: 3

An improved gSVM-SCADL2 with firefly algorithm for identification of informative genes and pathways 基于萤火虫算法的改进gSVM-SCADL2信息基因和路径识别

Int. J. Bioinform. Res. Appl. Pub Date : 2016-03-01 DOI: 10.1504/IJBRA.2016.075404

Weng Howe Chan, M. S. Mohamad, S. Deris, J. Corchado, S. Omatu, Z. Ibrahim, S. Kasim

引用次数: 6