Al-Rafidain Journal of Medical Sciences ( ISSN: 2789-3219 )最新文献

Analyzing the Potential Antioxidative Effects of Omega-369 in Preventing Acetaminophen-Induced Liver Damage 分析Omega-369在预防对乙酰氨基酚所致肝损伤中的潜在抗氧化作用

Al-Rafidain Journal of Medical Sciences ( ISSN: 2789-3219 ) Pub Date : 2023-06-03 DOI: 10.54133/ajms.v4i.126

Yousif Hashim Mohammed, A. Hassan

{"title":"Analyzing the Potential Antioxidative Effects of Omega-369 in Preventing Acetaminophen-Induced Liver Damage","authors":"Yousif Hashim Mohammed, A. Hassan","doi":"10.54133/ajms.v4i.126","DOIUrl":"https://doi.org/10.54133/ajms.v4i.126","url":null,"abstract":"Background: As acetaminophen (APAP) toxicity has become more common in many countries, related cases of poisoning, whether deliberate or unintentional, have been identified as a key contributor to acute liver failure. Aime: To discover if omega-369 fatty acids could protect the liver of male mice from the effects of acetamiophen. Methods: Thirty-five albino male mice were allocated to one of five groups at random. Group 1 served as the \"negative control\" and received a single intraperitoneal injection (10 ml/kg) of normal saline on the eleventh day of the test following ten days of receiving liquid paraffin orally at a dose of 10 ml/kg. The liquid paraffin was given to group 2 \"positive control\". Group 3 received Omega 369 (50 mg/kg/80 ml). Group 4 received Omega 369 (100 mg/kg/35 ml). Group 5 received N-acetylcysteine (100 mg/kg/10 ml). The mice were given Omega-369, N-acetylcysteine, and liquid paraffin via oral gavage for 10 days. Results: Group 2 had significantly lower levels of glutathione peroxidase (GP-X) and superoxide dismutase (SOD) than group 1, but significantly greater levels of malondialdehyde (MDA). GP-X and SOD levels were significantly higher in mice given the doses of omega-369, and N-acetylcysteine prior to acetaminophen administration, whereas MDA levels were significantly lower in groups 3, 4, and 5 when compared with group 2. Conclusion: Omega-369 fatty acids, when taken orally, exhibit antioxidative effects and may reduce the risk of acetaminophen-induced liver injury.","PeriodicalId":433524,"journal":{"name":"Al-Rafidain Journal of Medical Sciences ( ISSN: 2789-3219 )","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125944161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COVID-19 in Baghdad: Examining Knowledge, Attitude and Practice Through a Medical Lens 2019冠状病毒病在巴格达:从医学角度审视知识、态度和实践

Al-Rafidain Journal of Medical Sciences ( ISSN: 2789-3219 ) Pub Date : 2023-05-16 DOI: 10.54133/ajms.v4i.112

Jasim Aymen Khaleefah

{"title":"COVID-19 in Baghdad: Examining Knowledge, Attitude and Practice Through a Medical Lens","authors":"Jasim Aymen Khaleefah","doi":"10.54133/ajms.v4i.112","DOIUrl":"https://doi.org/10.54133/ajms.v4i.112","url":null,"abstract":"Background: The COVID-19 epidemic has had a devastating influence on health, even in the Iraqi metropolis of Baghdad. Aim: From the standpoint of healthcare professionals, assess the population's knowledge, attitudes, and practices (KAP) on COVID-19 in Baghdad. Methods: For the cross-sectional study design, a sample size of 384 participants was chosen using a multi-stage cluster sampling process. The data were gathered using a standardized questionnaire that had three sections: knowledge, attitudes, and practices. Results: The results demonstrated that most participants had a high level of COVID-19 knowledge, with a mean knowledge score of 77.2%. The participants had favorable views toward COVID-19 prevention initiatives, scoring a mean attitude score of 80.4%. The individuals demonstrated a high level of adherence to preventive actions, with a mean practice score of 88.3%. A positive correlation between participant KAP scores and medical education and training was also found by the study. Conclusion: This study emphasizes the significance of healthcare professionals in public education and support of preventive actions to halt the development of infectious diseases like COVID-19. To curb the spread of COVID-19, the healthcare system and the general public must collaborate. Medical experts must educate the public about the condition.","PeriodicalId":433524,"journal":{"name":"Al-Rafidain Journal of Medical Sciences ( ISSN: 2789-3219 )","volume":"105 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124701737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anticancer Activities of Some Heterocyclic Compounds Containing an Oxygen Atom: A Review 含氧原子杂环化合物抗癌活性的研究进展

Al-Rafidain Journal of Medical Sciences ( ISSN: 2789-3219 ) Pub Date : 2023-04-27 DOI: 10.54133/ajms.v4i.109

Sumayah Saadi Abbas, Azhar Mahdi Jasim, Tayseer Hamid Shakir, Iman Saadi Abbas

引用次数: 1

Role of Probiotics in the Prevention and Treatment of GIT Cancers: Updated Review 益生菌在预防和治疗胃肠道肿瘤中的作用:最新综述

Al-Rafidain Journal of Medical Sciences ( ISSN: 2789-3219 ) Pub Date : 2023-04-07 DOI: 10.54133/ajms.v4i.103

Dastan salim Hassan, Hemin Jumaa Hasary, Zhwan Salim Hassan

引用次数: 1

ChatGPT and Nursing Education: Challenges and Opportunities 通信技术与护理教育:挑战与机遇

Al-Rafidain Journal of Medical Sciences ( ISSN: 2789-3219 ) Pub Date : 2023-03-29 DOI: 10.54133/ajms.v4i.110

Ahmed Lateef Alkhaqani

引用次数: 9

Frequency of Vitamins and Nutritional Supplements Use among Iraqi People in Baghdad City 巴格达市伊拉克人使用维生素和营养补充剂的频率

Al-Rafidain Journal of Medical Sciences ( ISSN: 2789-3219 ) Pub Date : 2023-03-24 DOI: 10.54133/ajms.v4i.104

A. Shanshal, Raghda Hisham Aljorani, Reema Naeel Taha, A. Hussein

{"title":"Frequency of Vitamins and Nutritional Supplements Use among Iraqi People in Baghdad City","authors":"A. Shanshal, Raghda Hisham Aljorani, Reema Naeel Taha, A. Hussein","doi":"10.54133/ajms.v4i.104","DOIUrl":"https://doi.org/10.54133/ajms.v4i.104","url":null,"abstract":"Background: Dietary supplements are used to provide the body with nutrients necessary for the regulation of metabolic processes, to increase the nutritional value of a typical diet, and to enhance or maintain health. Aim: To assess the use frequency and demographics of dietary supplements consumers in Baghdad, Iraq. Method: From July to September 2022, a cross-sectional study was conducted by distributing a self-administered survey to consumers attending community pharmacies in the Baghdad metropolitan area. About 150 participants took part in this investigation. Results: The study revealed that the majority of participants were female, constituting 58% of the total, while male subjects constituted 42% of the total. 16% of the subjects were taking multivitamins, with vitamin D3 being the most popular supplement (22.7%). Only 40% of all respondents relied on their physician's advice when using dietary supplements. 73.3% of them did not conduct any laboratory tests before or after ingesting these supplements. Conclusion: Significant numbers of users used calcium and vitamin D3 without obtaining lab results or being monitored by a physician; instead, they consulted the internet for information.","PeriodicalId":433524,"journal":{"name":"Al-Rafidain Journal of Medical Sciences ( ISSN: 2789-3219 )","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124181334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting IL-6 Signaling Pathways for Musculoskeletal Disorders Treatment: Risks and Benefits 靶向IL-6信号通路治疗肌肉骨骼疾病:风险和益处

Al-Rafidain Journal of Medical Sciences ( ISSN: 2789-3219 ) Pub Date : 2023-03-12 DOI: 10.54133/ajms.v4i.101

A. Shanshal, Raghda Hisham Aljorani, S. Hussain

{"title":"Targeting IL-6 Signaling Pathways for Musculoskeletal Disorders Treatment: Risks and Benefits","authors":"A. Shanshal, Raghda Hisham Aljorani, S. Hussain","doi":"10.54133/ajms.v4i.101","DOIUrl":"https://doi.org/10.54133/ajms.v4i.101","url":null,"abstract":"Pro-inflammatory mediators like IL-6 effectively mediated the majority of musculoskeletal disorders such rheumatoid arthritis (RA), osteoarthritis (OA), and tendinitis. Increased levels of IL-6 are found in the serum or synovial fluid of patients with these disorders, and these levels are correlated with the incidence and severity of the disease. IL-6 is crucial for the development of cartilage pathology, for example, by inducing a variety of pathways that are involved in the induction and spread of inflammation. The expression of anti-catabolic factors is similarly increased by IL-6, indicating a protective function. The differential impacts of IL-6 classic and trans-signaling may be the reason for this dual role of IL-6, which has so far remained poorly understood. In this article, the experimental and clinical data on the function of inhibiting IL-6 signaling in the development and progression of pathologies of the synovium, cartilage, and bones were thoroughly reviewed. By evaluating the IL-6 targeting approaches that are currently being considered in research and clinical practice, it may provide a glimpse into the future of these illnesses' treatment.","PeriodicalId":433524,"journal":{"name":"Al-Rafidain Journal of Medical Sciences ( ISSN: 2789-3219 )","volume":"70 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121526942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Association of Genetic Polymorphisms in Tumor Necrosis Factor-Alpha and Interleukins with Disease Severity or Response to Biological Therapy in Iraqi Rheumatoid Arthritis Patients: A Narrative Review 伊拉克类风湿关节炎患者肿瘤坏死因子- α和白细胞介素基因多态性与疾病严重程度或对生物治疗反应的关系:一项叙述性综述

Al-Rafidain Journal of Medical Sciences ( ISSN: 2789-3219 ) Pub Date : 2023-02-17 DOI: 10.54133/ajms.v4i.100

Samer Imadr Mohammed, Mohammad Yawuz Jamal, Iman Obaid Alshamari

{"title":"The Association of Genetic Polymorphisms in Tumor Necrosis Factor-Alpha and Interleukins with Disease Severity or Response to Biological Therapy in Iraqi Rheumatoid Arthritis Patients: A Narrative Review","authors":"Samer Imadr Mohammed, Mohammad Yawuz Jamal, Iman Obaid Alshamari","doi":"10.54133/ajms.v4i.100","DOIUrl":"https://doi.org/10.54133/ajms.v4i.100","url":null,"abstract":"Background: Tumor necrosis factor-alpha (TNF-α) and interleukins play important roles in the pathogenesis of rheumatoid arthritis (RA). Genetic research has been employed to find many of the missing connections between genetic risk variations and causal genetic components. Objective: The goal of this study is to look at the genetic variations of TNF-α and interleukins in Iraqi RA patients and see how they relate to disease severity or response to biological therapy. Method: Using specific keywords, the authors conducted a systematic and comprehensive search to identify relevant Iraqi studies examining the genetic variations of TNF-α and interleukins in Iraqi RA patients and how they relate to disease severity or response to biological therapy. Results: Thirteen studies have looked at TNF-α and interleukin genetic polymorphisms in Iraqi RA patients. Only the IL-2, IL-4, IL-6, IL-17, and IL-23 receptor gene polymorphisms were explored for interleukins; however, the results of studies indicate no association between genetic polymorphism and the severity of RA. Very few researchers examine the correlation between genetic variation and TNF-α inhibitor responsiveness. Numerous studies have been conducted to investigate the genetic variations of the TNF-α promoter. The -308 G/A region in the promotor region was the most studied location.","PeriodicalId":433524,"journal":{"name":"Al-Rafidain Journal of Medical Sciences ( ISSN: 2789-3219 )","volume":"77 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121738410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Urgent Supplies of Beta-blockers are Required to Mitigate the Deleterious Cardiac Effects of the Recent Turkish and Syrian Earthquakes 需要紧急供应β受体阻滞剂以减轻最近土耳其和叙利亚地震对心脏的有害影响

Al-Rafidain Journal of Medical Sciences ( ISSN: 2789-3219 ) Pub Date : 2023-02-10 DOI: 10.54133/ajms.v4i.102

Ehab Mudher Michael, A. A. Al-Jumaili

引用次数: 0

Epithelial-Mesenchymal Transition and Tumour Progression: An Overview 上皮-间质转化和肿瘤进展:综述

Al-Rafidain Journal of Medical Sciences ( ISSN: 2789-3219 ) Pub Date : 2023-02-07 DOI: 10.54133/ajms.v4i.99

Ismail I. Al-Janabi

引用次数: 0