Hamidiye Medical Journal最新文献

{"title":"Therapeutic Potential of Tannic Acid in the Management of Polycystic Ovarian Syndrome (PCOS) in Letrozole Induced Rat Model: A Histological and a Biochemical Study","authors":"Fatma Gumuskaya, T. Sapmaz, Halime Tuba Canbaz, Sude Topkaraoğlu, Kubra Sevgin, Muhammetnur Tekayev, S. Aktaş, M. Pence, O. Irkorucu","doi":"10.4274/hamidiyemedj.galenos.2022.07078","DOIUrl":"https://doi.org/10.4274/hamidiyemedj.galenos.2022.07078","url":null,"abstract":"Background: To investigate the effects of tannic acid (TA) use on ovarian folliculogenesis, p53 expression, and serum luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone (T) levels in rats with polycystic ovary syndrome (PCOS) model. Materials and Methods: A total of 18 Wistar female rats were used and divided into 3 experimental groups. Group 1 (G1, control), group 2 (G2, PCOS), group 3 (G3, PCOS+TA). Rats were induced with letrozole for 21 days to form a PCOS model. After 21 days, TA (40 mg/kg) was given by gavage for 10 days and the rats were sacrificed on the 10 th day. PCOS formation was evaluated by daily estrous cycle follow-up. Hematoxylin & eosin and p53 immunohistochemical staining was performed on ovaries. Serum FSH, LH, and T levels were determined by ELISA. Data were analyzed with the One-Way ANOVA test and Kruskal-Wallis H test. P<0.05 was considered statistically significant. Results: The number of cystic follicles was significantly increased in the PCOS group compared to the TA treatment group (p<0.05). The number of primary follicles was significantly increased in the TA treatment group (p<0.001). No significant change was observed in the number of primordial, secondary, and Graaf follicles between the experimental groups. A significant increase in LH and T was observed in the PCOS group (p<0.05). The increase in LH has significantly decreased TA administered rats (p<0.05). Although it was not significant, serum FSH level was increased in the PCOS+TA group. No immunoreactivity was detected in p53 staining in experimental groups. Conclusion: TA can decrease cystic follicle formation and increase primary follicle formation in PCOS. Also, it can regulate the hormonal expression of serum LH, FSH, and T in PCOS-modeled rats. PCOS+TA exhibited displayed a few corpus luteum compared to other groups cells were decreased cells with nuclei (red a marker of follicle atresia, were observed in and oocyte and pellucida were also","PeriodicalId":433356,"journal":{"name":"Hamidiye Medical Journal","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130765236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatotoxicity in Patients Using Favipiravir for COVID-19: A Retrospective Study","authors":"Sinem Akkaya Işık, Burak Sarıkaya","doi":"10.4274/hamidiyemedj.galenos.2022.32032","DOIUrl":"https://doi.org/10.4274/hamidiyemedj.galenos.2022.32032","url":null,"abstract":"Background: Antimalarial drugs (hydroxychloroquine sulfate), antiretroviral drugs (lopinavir/ritonavir), and antivirals (oseltamivir, remdesivir and favipiravir) are medications used for the treatment of Coronavirus disease-2019 (COVID-19). A detailed safety analysis of favipiravir, which is used extensively in the treatment of COVID-19 in our country under pandemic conditions, is important. Investigation of the hepatotoxicity risk of favipiravir in COVID-19 patients. Our study was designed retrospectively. Materials and Methods: Demographic characteristics, comorbid diseases and liver function test (LFT) values of the patients were retrospectively scanned and recorded. The patients were divided into two groups as died and recovered according to their results. The changes in the mean values of the LFT results and patients with different results than the reference value was evaluated according to the treatment time. Results: Mean age of the 175 patients included in the study was 60.9±16.4 years and 122 of them were male. In the total patient population, significant (p<0.05) differences were found between the mean values of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and albumin on day 1 and on the days 3 and 5. As for gamma glutamyl transferase (GGT), the difference between all three consecutive measurements was significant (p<0.05). The change in the number of patients with abnormal, international normalized ratio (INR), alkaline phosphatase (ALP), GGT, AST, ALT, and albumin values based on treatment days was statistically significant (p<0.05). Analysis of this difference according to groups showed a significant difference for GGT, AST, and ALT in the survivors and for total bilirubin, ALP, INR, and albumin in the deceased (p<0.05). Conclusion: It was observed that GGT, AST and ALT increased after the drug loading dose. This condition was evaluated as drug-related hepatotoxicity. However, no serious height was found in any patient to require discontinuation of favipiravir. Therefore, close monitoring for hepatotoxicity is recommended in patients treated with favipiravir, especially after the loading dose.","PeriodicalId":433356,"journal":{"name":"Hamidiye Medical Journal","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114142731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Pain Severity with VAS Score in Preoperative and Postoperative Periods After Laparoscopic Cystectomy in Isolated Endometriomas","authors":"Serpil Akyüz, E. Tamburacı, B. Karadağ, B. Mülayim","doi":"10.4274/hamidiyemedj.galenos.2022.25733","DOIUrl":"https://doi.org/10.4274/hamidiyemedj.galenos.2022.25733","url":null,"abstract":"Background: In this study, it was investigated whether laparoscopic surgery reduces dysmenorrhea, pelvic pain, dyspareunia and abdominal distension evaluated with visual analog scale (VAS) in the postoperative period compared to the preoperative period in patients diagnosed with isolated endometrioma. Materials and Methods: The preoperative and postoperative VAS scores of 36 cases with isolated endometrioma were compared among 197 patients who applied with pelvic pain and underwent laparoscopic surgery with an endometrioma diagnosis between 2017 and 2020. Patients were asked to complete a questionnaire containing a 100 mm VAS scale that included the four components of pre- and post-operative endometriosis-related pain (dysmenorrhea, pelvic pain, dyspareunia, and abdominal distension). Patients with deep infiltrative endometriosis, peritoneal endometriosis, related severe intraoperative adhesions, those who had previously undergone endometriosis surgery, and those who had received hormonal therapy for endometriosis or endometrioma before the surgery were found to be excluded from the study. Results: The VAS scores of the patients for cyclic-non-cyclic pelvic pain, dysmenorrhea, dyspareunia, and abdominal distension decreased significantly in the postoperative period compared to the preoperative period (p<0.05). Conclusion: This study determined that the symptoms of cyclic-non-cyclic pelvic pain, dysmenorrhea, dyspareunia, and abdominal distension after laparoscopic surgery in patients with isolated endometrioma were significantly reduced compared to the period before surgery. In addition, CA-125 biomarker results were significantly reduced after laparoscopic surgery in patients with isolated endometrioma.","PeriodicalId":433356,"journal":{"name":"Hamidiye Medical Journal","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131450404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Meta-analysis of the Hospital Stay and Hypoxic Effect of Neuromuscular Blocking Agent Antagonists, Sugammadex and Neostigmine","authors":"Habip Yılmaz, F. Özçelik","doi":"10.4274/hamidiyemedj.galenos.2022.29494","DOIUrl":"https://doi.org/10.4274/hamidiyemedj.galenos.2022.29494","url":null,"abstract":"It was found that the duration of hospital stay and SPO 2 levels after surgery were not different in patients given sugammadex and neostigmine [standardised mean difference (SMD)=-0.0042; 95% confidence interval (CI) (-0.0459-0.0375), p=0.8438; SMD=-0.0017; 95% CI (-0.01076-0.1111); p=0.9753]. Conclusion: The results of this meta-analysis show that sugammadex is no more effective in recovery from neuromuscular blockade than neostigmine in terms of hospital stay and SPO 2 .","PeriodicalId":433356,"journal":{"name":"Hamidiye Medical Journal","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124687200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resveratrol and Its Anticancer Effects","authors":"Beyza Nur Özkan, E. Güler","doi":"10.4274/hamidiyemedj.galenos.2022.33043","DOIUrl":"https://doi.org/10.4274/hamidiyemedj.galenos.2022.33043","url":null,"abstract":"","PeriodicalId":433356,"journal":{"name":"Hamidiye Medical Journal","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125707833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship Between Vitamin D Level and Prognostic Factors in Patients Diagnosed with Breast Cancer","authors":"Levent Emirzeoğlu, S. Arıcı","doi":"10.4274/hamidiyemedj.galenos.2022.49469","DOIUrl":"https://doi.org/10.4274/hamidiyemedj.galenos.2022.49469","url":null,"abstract":"Background: To examine the relationship between vitamin D level at the time of diagnosis and disease prognostic factors in patients diagnosed with breast cancer. Materials and Methods: We studied 150 patients with breast cancer whose vitamin D levels were measured before treatment. The patients’ vitamin D levels were compared with their estrogen receptor (ER) levels, progesterone receptor (PR) levels, human epidermal growth factor receptor 2 (Her-2/neu) status, ki-67 levels, and histopathological features. Results: Vitamin D was found to be significantly positively correlated with ER (p<0.001) and PR (p=0.032) staining intensities and significantly negatively correlated with ki-67 level (p=0.001). Both the ER (p=0.003) and ki-67 index (p=0.024) were found to be significantly correlated with vitamin D level, 20 ng/mL below and above, and its relation with prognostic factors. Conclusion: There may be a relationship between serum 25 hydroxy vitamin D [25(OH)D] level and breast cancer prognosis. Our study can be used as a guide for examining the contribution of supportive treatments that provide normal vitamin D levels (>30 ng/mL) to decrease breast cancer aggressiveness. More studies are needed to elucidate the relationship between breast cancer and vitamin D.","PeriodicalId":433356,"journal":{"name":"Hamidiye Medical Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133932938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Upgrade Rates of DCIS, Intraductal Papilloma, and the Other High-risk Breast Lesions","authors":"Emine Yıldırım, S. Bektaş, Muhammed Özdemir, Ahenk Karagülle, A. Er, Neşe Uçar","doi":"10.4274/hamidiyemedj.galenos.2022.24633","DOIUrl":"https://doi.org/10.4274/hamidiyemedj.galenos.2022.24633","url":null,"abstract":"Background: In benign breast lesions such as intraductal papilloma (IDP), atypical hyperplasia (AH), flat epithelial atypia (FEA) and lobular carcinoma in situ (LCIS), there is a 3-20% risk of upgrade to invasive or in situ breast cancer following excision. The aim of this study was to determine the upgrade rates for high-risk breast lesions (HRBL), which were diagnosed by core needle biopsy (CNB), to invasive or in situ breast carcinoma, and to determine to upgrade rates for ductal carcinoma in situ (DCIS) to invasive breast carcinoma in the second group. In addition, we investigated in which patient groups these rates are higher. Materials and Methods: It was planned to include all female patients who had undergone surgical procedures following the determination of IDP, AH, FEA, LCIS, or DCIS after CNB under ultrasonographic guidance between April 2014 and August 2020. As there were no patients diagnosed with pure LCIS with biopsy, this was not included in the analysis. Patients were excluded from the study if more than 6 months had elapsed between CNB and excision, or if they had a history of breast cancer or radiotherapy. Demographic data, radiological findings and histopathological results were collected retrospectively from the hospital records. Results: A total of 123 patients with diagnosis following CNB were evaluated. The diagnoses were IDP in 70.7% of patients, AH in 8.9%, FEA in 4.9%, and DCIS in 15.5%. The upgrade rates for invasive breast cancer were 30%, 0%, 16.7%, and 31.6%. The upgrade rates for DCIS were calculated as 3.5% in IDP, 45.5% in AH, and 0% in FEA. Especially, in IDP group upgrade was seen more at older ages, and when there were more than 2 two papilloma (p<0.05). The upgrade risk for DCIS after excision was 31.6%. Conclusion: The upgrade risk for HRBL was found to vary between 5.8% and 45.5%, and the upgrade risk for DCIS after excision was 31.6%. In patients with HBRL; older ages, the presence of a multifocal lesion, a palpable mass, and radiological-histopathological discordance were seen to be risk factors for upgrade.","PeriodicalId":433356,"journal":{"name":"Hamidiye Medical Journal","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115289321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Reflection of Pre- and Post-COVID-19 Symptoms in COVID-19 Patients","authors":"B. Demirkol, Süleyman Gül, Mustafa Çörtük, Aysu Sinem Koç, Umut İlhan, K. N. Baydili, E. Çetinkaya","doi":"10.4274/hamidiyemedj.galenos.2022.18480","DOIUrl":"https://doi.org/10.4274/hamidiyemedj.galenos.2022.18480","url":null,"abstract":"","PeriodicalId":433356,"journal":{"name":"Hamidiye Medical Journal","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117020929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Inflammatory Parameters in the Prognosis of Patients with COVID-19","authors":"Kadir Canoğlu, Tayfun Çalışkan, Ecem Sinmez, Ö. Ayten","doi":"10.4274/hamidiyemedj.galenos.2022.92063","DOIUrl":"https://doi.org/10.4274/hamidiyemedj.galenos.2022.92063","url":null,"abstract":"Background: The prognostic significance of inflammatory parameters in patients with Coronavirus disease-2019 (COVID-19) has been investigated. Materials and Methods: Neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio, C-reactive protein (CRP) albumin ratio (CAR), systemic inflammation index (SII), CRP-lymphocyte ratio (CRP/L), neutrophil to lymphocyte, platelet ratio (NLPR), red cell volume distribution width index (RDW-SD), and procalcitonin were evaluated in relation to admission to intensive care unit (ICU) and mortality in 419 patients with moderate-to-severe COVID-19. Results: NLR, CAR, CRP/L, NLPR, RDW-SD and procalcitonin levels were higher both in those who needed ICU compared to those who did not (p=0.001, 0.005, 0.002, 0.001, 0.001 and 0.001; respectively), and in those who died compared to the survival group (p=0.001, 0.024, 0.009, 0.001, 0.001 and 0.001; respectively). SII was higher only in those who needed ICU (p=0.001). NLR (0.610, p=0.002), CAR (0.602, p=0.005), SII (0.573, p=0.043), CRP/L (0.593, p=0.010), and NLPR (0.618, p=0.001) were statistically significant for admission to ICU; and NLR (0.637, p=0.006), CAR (0.613, p=0.024), CRP/L (0.605, p=0.035) and NLPR (0.660, p=0.001) were statistically significant for mortality in the evaluation of area under curve in ROC analysis. RDW-SD was an independent risk factor for both ICU admission [odds ratio (OR): 1.194, p=0.024] and mortality (OR: 1.263, p=0.002), and procalcitonin was an independent risk factor for ICU admission (OR: 1.492, p=0.034) in multivariate analysis. Conclusion: NLR, CAR, CRP/L, NLPR, RDW-SD and procalcitonin were determined as prognostic parameters in terms of both the need for ICU and mortality in patients with COVID-19. SII was a prognostic parameter only for the need for ICU.","PeriodicalId":433356,"journal":{"name":"Hamidiye Medical Journal","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131120804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can the Progression of COVID-19 Pneumonia be Predicted?","authors":"Fatma Demirci Üçsular, G. Karadeniz, G. Polat, Damla Serçe Unat, A. Ayrancı, E. Yalnız, F. Güldaval","doi":"10.4274/hamidiyemedj.galenos.2022.03164","DOIUrl":"https://doi.org/10.4274/hamidiyemedj.galenos.2022.03164","url":null,"abstract":"Background: Coronavirus disease-2019 (COVID-19) remains a major cause of morbidity and mortality. There are many parameters affecting the progression of the disease. The purpose of the present study was to evaluate and compare the initial data of patients hospitalized with the diagnosis of COVID-19 pneumonia, who progressed during the hospitalization period, with other patients who recovered or remained stable, and to investigate the risk factors that can be used to predict the disease progression. Materials and Methods: Patients, who received inpatient treatment with the diagnosis of COVID-19 pneumonia, were included in the study retrospectively. Two groups were created from all patients according to their progression in hospital follow-ups: Group 1: Progression group and group 2: Recovery/stabilization group. If patients had clinical, laboratory and/or radiological deterioration or died during follow-up, these patients were included in the progression group. If patients recovered or remained stable, these patients were also included in the recovery/stabilization group. The demographic data, initial hemogram, biochemical parameters and radiological data of the patients were recorded. Results: It was determined in the univariate analysis that the age, smoking status, comorbidity, heart disease, chronic obstructive pulmonary disease, cancer, dyspnea, fever, leukocytosis, lymphopenia, elevated neutrophil-lymphocyte ratio (NLR), C-reactive protein, albumin, lactate dehydrogenase, ferritin, D-dimer, troponin-T, pro-B-type natriuretic peptide (pro-BNP) were risk factors predicting disease progression all p-values<0.05. In the multivariate logistic regression analysis, it was found that fever, NLR, and D-dimer could be used to predict the disease progression (p<0.05). In the ROC analysis, the sensitivity of NLR was 83.3%, specificity 57.5%, and cut-off >3.545 [area under curve (AUC)=0.752; p<0.001]; the sensitivity of pro-BNP was 71.8%, specificity 73.8%, and cut-off >332.8 (AUC=0.752; p<0.001), the sensitivity of troponin-T was 81.2%, specificity was 60.6%, and cut-off was >4.58 (AUC=0.730; p<0.001) in predicting progression. Conclusion: The identification of risk factors predicting progression is important in reducing morbidity and mortality rates. Fever, NLR, D-dimer troponin-T and pro-BNP are important parameters that can be used to predict progression.","PeriodicalId":433356,"journal":{"name":"Hamidiye Medical Journal","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132324614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}