Chronic Wound Care Management and Research最新文献

{"title":"Complementary and alternative therapies for management of odor in malignant fungating wounds: a critical review","authors":"G. Gethin, C. Mcintosh, S. Probst","doi":"10.2147/CWCMR.S85472","DOIUrl":"https://doi.org/10.2147/CWCMR.S85472","url":null,"abstract":"php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). Complementary and alternative therapies for management of odor in malignant fungating wounds: a critical review","PeriodicalId":43306,"journal":{"name":"Chronic Wound Care Management and Research","volume":"3 1","pages":"51-57"},"PeriodicalIF":2.1,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/CWCMR.S85472","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68339595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of resilience in the recovery of the burn-injured patient: an integrative review","authors":"R. Kornhaber, Heather Bridgman, Loyola M Mclean, J. Vandervord","doi":"10.2147/CWCMR.S94618","DOIUrl":"https://doi.org/10.2147/CWCMR.S94618","url":null,"abstract":"Severe burn injuries are catastrophic life events resulting in significant physical and psychological effects. With long periods of hospitalization and rehabilitation, burn survivors encounter many issues, including an altered body image and loss of function and independence that subsequently influence quality of life and the family unit. Consequently, resilience has been identified as a fundamental concept that facilitates the adaptability required to navigate the lengthy and complex recovery process. However, over time, the notion of resilience has shifted from a static, innate trait to a fluid and multidimensional concept. Here, we review the evidence surrounding the role of resilience in the recovery of burn injury. This integrative review was based on a systematic search of five electronic databases. Of the 89 articles identified, ten primary research papers met the inclusion criteria. Three key themes were identified encompassing relational strengths, positive coping, and the resistance to trauma symptoms that are fundamental constructs associated with developing and sustaining resilience that resonate with the broader literature on burn recovery. However, limited evidence is currently available within the burns context. While resilience appears to be a vital component influencing the recovery from burns trauma, it still remains a broad construct within the burns framework. Regular assessment of resilience in burn-injured patients is recommended in clinical practice in addition to longitudinal and intervention studies to best inform patient care.","PeriodicalId":43306,"journal":{"name":"Chronic Wound Care Management and Research","volume":"3 1","pages":"41-50"},"PeriodicalIF":2.1,"publicationDate":"2016-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/CWCMR.S94618","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68339565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Matrix metalloproteinases in the wound microenvironment: therapeutic perspectives","authors":"A. Krejner, M. Litwiniuk, T. Grzela","doi":"10.2147/CWCMR.S73819","DOIUrl":"https://doi.org/10.2147/CWCMR.S73819","url":null,"abstract":"Matrix metalloproteinases (MMPs) are key effector molecules responsible for extracellular matrix (ECM) turnover. They are involved in tissue remodeling and regeneration. Although the main targets for MMPs are ECM components, they are also able to digest a variety of non-ECM molecules including cytokines, their receptors, or carriers. Therefore, the activity of the MMPs remains under tight control. However, when controlling mechanisms are ineffec- tive, MMPs may become highly dangerous molecules, which have a strong destructive effect on affected tissues. Apart from cancer metastasis, aneurysm formation, or airway remodeling in asthma, MMPs have also been identified as main detrimental factors in delayed healing of chronic wounds. In this short review, we describe main representatives of MMPs family, their role in pathophysiology of chronic wounds, as well as current and possible therapeutic strategies for modulation of MMPs' activity, which may be useful in management of chronic wounds.","PeriodicalId":43306,"journal":{"name":"Chronic Wound Care Management and Research","volume":"39 1","pages":"29-39"},"PeriodicalIF":2.1,"publicationDate":"2016-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/CWCMR.S73819","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68337608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stem cells and chronic wound healing: state of the art","authors":"Tripp Leavitt, Michael S. Hu, Clement D. Marshall, L. Barnes, M. Longaker, H. Lorenz","doi":"10.2147/CWCMR.S84369","DOIUrl":"https://doi.org/10.2147/CWCMR.S84369","url":null,"abstract":"Currently available treatments for chronic wounds are inadequate. A clearly effective therapy does not exist, and treatment is often supportive. This is largely because the cellular and molecular processes underlying failure of wound repair are still poorly understood. With an increase in comorbidities, such as diabetes and vascular disease, as well as an aging population, the incidence of these intractable wounds is expected to rise. As such, chronic wounds, which are already costly, are rapidly growing as a tremendous burden to the health-care system. Stem cells have garnered much interest as a therapy for chronic wounds due to their inherent ability to differentiate into multiple lineages and promote regeneration. Herein, we discuss the types of stem cells used for chronic wound therapy, as well as the proposed means by which they do so. In particular, we highlight mesenchymal stem cells (including adipose-derived stem cells), endothelial progenitor cells, and induced pluripotent stem cells. We include the results of recent in vitro and in vivo studies in both animal models and human clinical trials. Finally, we discuss the current studies to improve stem cell therapies and the limitations of stem cell-based thera- peutics. Stem cells promise improved therapies for healing chronic wounds, but further studies","PeriodicalId":43306,"journal":{"name":"Chronic Wound Care Management and Research","volume":"3 1","pages":"7-27"},"PeriodicalIF":2.1,"publicationDate":"2016-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/CWCMR.S84369","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68337899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complex pediatric wound care with a dedicated pediatric wound care service: A review of our 12-year experience","authors":"K. Bernabe","doi":"10.2147/CWCMR.S81228","DOIUrl":"https://doi.org/10.2147/CWCMR.S81228","url":null,"abstract":": Pediatric skin and soft tissue infections and wounds are on the rise. The effects of this increase are being felt in the emergency department and inpatient hospital settings. The costs associated with evaluation and management of children with surgical wounds and soft tissue infections are not insignificant. This is a review of our single institutional experience with delivery of wound care for the increasing pediatric skin infection and wound population utilizing a specific model for the past 12 years. It is especially tailored for complex pediatric wounds that would otherwise be cared for in the operating room setting.","PeriodicalId":43306,"journal":{"name":"Chronic Wound Care Management and Research","volume":"3 1","pages":"1-5"},"PeriodicalIF":2.1,"publicationDate":"2016-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/CWCMR.S81228","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68337319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A single-center, prospective, randomized, open-label, clinical trial of ceramide 2-containing hydrocolloid dressings versus polyurethane film dressings for pressure ulcer prevention in high-risk surgical patients","authors":"M. Kohta, Kazumi Sakamoto, Y. Kawachi, T. Oh‐i","doi":"10.2147/CWCMR.S93555","DOIUrl":"https://doi.org/10.2147/CWCMR.S93555","url":null,"abstract":"Purpose: There have been previous clinical studies regarding the impact of dressings on the prevention of pressure ulcer development. However, it remains unclear whether one type of dressing is better than any other type for preventing ulcer development during surgery. Therefore, we compared the effects of ceramide 2-containing hydrocolloid dressing with film dressings in high-risk patients with regard to reducing the incidence of pressure ulcer development during surgery. Patients and methods: A prospective, randomized, open-label, clinical trial was conducted involving patients who were at a high risk of developing pressure ulcers at a Japanese hospital. The intervention group received ceramide 2-containing hydrocolloid dressings (n = 66), and the control group received film dressings (n = 64). The primary end point was the incidence rate of pressure ulcer development in both groups; skin damage, such as blanchable erythema, skin discoloration, contact dermatitis, and stripped skin, was recorded as the secondary end point. The relative risk (RR) and 95% confidence interval (CI) were assessed to compare the probability ratios of pressure ulcer development between the groups. Results: There were significantly fewer patients who developed pressure ulcers in the intervention group than in the control group (RR, 0.37; 95% CI, 0.05–0.99; P = 0.04). In the post hoc subgroup analysis, the superiority of the intervention group was more marked when patients had a lower body mass index ( P = 0.02), lower albumin values ( P = 0.07), and operation time of 3 hours or more and less than 6 hours ( P = 0.03). There was no evidence of any statistically significant differences in the types of skin damage reported. Conclusion: Application of ceramide 2-containing hydrocolloid dressing reduced the risk of pressure ulcer development in patients who were at a high risk during surgery compared with film dressings.","PeriodicalId":43306,"journal":{"name":"Chronic Wound Care Management and Research","volume":"2 1","pages":"171-179"},"PeriodicalIF":2.1,"publicationDate":"2015-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/CWCMR.S93555","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68339286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Local management of deep cavity wounds – current and emerging therapies","authors":"N. Smith, J. Overland, J. Greenwood","doi":"10.2147/CWCMR.S62553","DOIUrl":"https://doi.org/10.2147/CWCMR.S62553","url":null,"abstract":"Cavity wounds, defined as a loss of continuity of the skin or mucous membrane with associated tissue loss, represent a complex management issue for health care providers. The successful management of a deep cavity wound centers on assessment of the patient, assessment of the wound, and treating the underlying etiology. Adequate debridement and an appropriate dressings plan aim to create the optimum conditions that promote healing. Regular follow-up and serial examinations are essential to ensure progress and address any complication in a timely manner. Finally, continued patient education and the management of patient concerns are important to encourage compliance with management goals. In this review, we discuss the main management issues surrounding deep cavity wounds, review the current and emerging therapies available in the treatment of deep cavity wounds, discuss options for the management of pain, and discuss the impacts on quality of life for these patients.","PeriodicalId":43306,"journal":{"name":"Chronic Wound Care Management and Research","volume":"2676 1","pages":"159-170"},"PeriodicalIF":2.1,"publicationDate":"2015-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/CWCMR.S62553","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68335830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing chronic wound perfusion in the lower extremity: current and emerging approaches","authors":"K. Woo, T. Brandys, J. Marin","doi":"10.2147/CWCMR.S60326","DOIUrl":"https://doi.org/10.2147/CWCMR.S60326","url":null,"abstract":": Current evidence suggests that vascular and wound bed perfusion assessment should be integral to the care of people with chronic wounds in the lower extremities. Peripheral artery diseases can be insidious, with many affected individuals unaware of circulation issues and failing to seek medical help until they develop foot ulcers, gangrene, and other related complications. Measuring tissue perfusion is a useful diagnostic marker for chronic wounds and may help determine a wound’s potential for healing. A complete patient history and physical examination is imperative to help determine the correct diagnosis of lower extremity ulcers. This article aims to discuss current and emerging wound perfusion assessment techniques, including ankle–brachial index,","PeriodicalId":43306,"journal":{"name":"Chronic Wound Care Management and Research","volume":"2 1","pages":"149-157"},"PeriodicalIF":2.1,"publicationDate":"2015-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/CWCMR.S60326","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68335685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postoperative abdominal wound infection – epidemiology, risk factors, identification, and management","authors":"S. Azoury, N. E. Farrow, Q. Hu, K. Soares, C. Hicks, F. Azar, N. Rodriguez-Unda, K. Poruk, P. Cornell, K. Burce, C. Cooney, H. Nguyen, F. Eckhauser","doi":"10.2147/CWCMR.S62514","DOIUrl":"https://doi.org/10.2147/CWCMR.S62514","url":null,"abstract":"Surgical site infections (SSIs) complicate the postoperative course of a significant proportion of general abdominal surgical patients and are associated with excessive health care costs. SSIs increase postoperative morbidity and mortality, and may require hospital admission, intravenous antibiotics, and even surgical reintervention. Risks associated with SSIs are related to both host and perioperative factors. However, a vast majority of these infections are preventable. More recently, quality initiative programs such as American College of Surgeons National Sur- gical Quality Improvement Program are expanding their roles to help better monitor adherence to improvement measures. Indeed, standardizing preoperative antibiotic prophylaxis timing is perhaps the most persuasive example and this has been integral to reducing postoperative SSI rates. Herein, the authors provide an update on the epidemiology, risk factors, identification, and management of wound infections following abdominal surgery.","PeriodicalId":43306,"journal":{"name":"Chronic Wound Care Management and Research","volume":"2 1","pages":"137-148"},"PeriodicalIF":2.1,"publicationDate":"2015-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/CWCMR.S62514","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68335782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetic foot ulcers in conjunction with lower limb lymphedema: pathophysiology and treatment procedures","authors":"M. Kanapathy, M. Portou, J. Tsui, T. Richards","doi":"10.2147/CWCMR.S62919","DOIUrl":"https://doi.org/10.2147/CWCMR.S62919","url":null,"abstract":"Diabetic foot ulcers (DFUs) are complex, chronic, and progressive wounds, and have a significant impact on morbidity, mortality, and quality of life. A particular aspect of DFU that has not been reviewed extensively thus far is its management in conjunction with peripheral limb edema. Peripheral limb edema is a feature of diabetes that has been identified as a significant risk factor for amputation in patients with DFU. Three major etiological factors in development of lymphedema with concurrent DFU are diabetic microangiopathy, failure of autonomic regulation, and recurrent infection. This review outlines the pathophysiology of lymphedema formation in patients with DFU and highlights the cellular and immune components of impaired wound healing in lymphedematous DFU. We then discuss the principles of management of DFU in conjunction with lymphedema.","PeriodicalId":43306,"journal":{"name":"Chronic Wound Care Management and Research","volume":"2 1","pages":"129-136"},"PeriodicalIF":2.1,"publicationDate":"2015-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/CWCMR.S62919","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68337042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}