{"title":"Opportunities and Challenges of the Management of Chronic Wounds: A Multidisciplinary Viewpoint","authors":"M. Mahmoudi, L. Gould","doi":"10.2147/cwcmr.s260136","DOIUrl":"https://doi.org/10.2147/cwcmr.s260136","url":null,"abstract":"","PeriodicalId":43306,"journal":{"name":"Chronic Wound Care Management and Research","volume":"7 1","pages":"27-36"},"PeriodicalIF":2.1,"publicationDate":"2020-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/cwcmr.s260136","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47450565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of Aloe vera Gel, Calendula officinalis Ointment and Simple Prophylactic Sacral Dressings for Pressure Injury Development","authors":"M. Baghdadi, H. Rafiei, F. Rashvand, S. Oveisi","doi":"10.2147/cwcmr.s256537","DOIUrl":"https://doi.org/10.2147/cwcmr.s256537","url":null,"abstract":"Background and Purpose: Prophylactic dressings play a signi fi cant role in the prevention of pressure injury. However, no herbal products have been used in this regard, so far. Therefore, the present study was designed with the aim of comparing the effect of Aloe vera gel, Calendula of fi cinalis ointment and simple sacral prophylactic dressings on pressure injury development in patients admitted to intensive care unit. Materials and Methods: The sample of this clinical trial study consisted of 90 critically ill patients. Randomization was performed by head nurse in intensive care unit. Patients in group “ A ” received Aloe vera gel prophylactic dressing twice a day; patients in group “ B ” received Calendula of fi cinalis ointment prophylactic dressing twice a day; and patients in group “ C ” received simple prophylactic dressing twice a day. The development of pressure injury was compared between these three groups after the intervention. Results: Demographic variables were similar in all three groups (p> 0.05). The results showed that 3 patients (10%) who received the simple dressing, 2 patients (6.6%) who received the Calendula of fi cinalis ointment dressing were wounded, while the development of pressure injury in patients who received the Aloe vera gel dressing was zero. The results of chi-square test showed that the frequency distribution of the pressure injury development in the two groups receiving Aloe vera gel and simple dressing was different. This difference was statistically signi fi cant (p < 0.05). However, there was no signi fi cant difference between the Aloe vera gel and Calendula of fi cinalis ointment groups as well as the Calendula of fi cinalis ointment group and the simple dressing. Conclusion: The results of the present study demonstrated that using Aloe vera gel and Calendula of fi cinalis ointment prophylactic dressing twice a day can be effective in prevention of pressure injury in patients admitted to intensive care unit.","PeriodicalId":43306,"journal":{"name":"Chronic Wound Care Management and Research","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/cwcmr.s256537","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44763260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ehsan Nezakati, M. Hasani, Pouneh Zolfaghari, M. Rashidan, M. Sohrabi
{"title":"Effects of Lucilia sericata Maggot Therapy in Chronic Wound Treatment: A Randomized Clinical Trial","authors":"Ehsan Nezakati, M. Hasani, Pouneh Zolfaghari, M. Rashidan, M. Sohrabi","doi":"10.2147/cwcmr.s248149","DOIUrl":"https://doi.org/10.2147/cwcmr.s248149","url":null,"abstract":"Background: Chronic ulcers are one of the challenges of treatment today and cost a lot to the health system. The present study was conducted to investigate the effect of Lucilia sericata maggot therapy in chronic wound treatment. Materials and Methods: This study was conducted as a clinical trial study with 90 eligible patients. Patients were randomly assigned to two equal intervention and control groups. Both groups received routine treatments for chronic ulcers. Patients in the intervention group received maggot therapy with larvae of Lucilia sericata . For all patients, a smear and culture of wound discharges were acquired. The condition of wound healing, the type of infection, and the reduction of microorganisms were compared between the two groups. Results: Staphylococcus aureus was present in 68.9% of the patients and was the most abundant infection among all patients. Results of culturing after larval treatment at different times revealed a decrease in the number of all bacteria, especially Pseudomonas aeruginosa, Escherichia coli , and S. aureus , but the response rate for Enterococcus was the lowest. Also, the wound healing rate and reduction in necrotic tissue at the end of the second week (p=0.041) and the third week (p=0.012) was signi fi cantly higher in the intervention group. Conclusion: Larvae of L. sericata have the highest effects on P. aeruginosa and had the least effect on the growth of Enterococcus . Also, our results showed larvae of L . sericata therapy can signi fi cantly improve wound healing rate.","PeriodicalId":43306,"journal":{"name":"Chronic Wound Care Management and Research","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/cwcmr.s248149","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49163679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Assessment of Acceptability and Ease of Use of Haemoglobin Spray (Granulox®) in the Management of Chronic Wounds","authors":"K. Kröger, G. Gäbel, B. Juntermanns","doi":"10.2147/cwcmr.s212108","DOIUrl":"https://doi.org/10.2147/cwcmr.s212108","url":null,"abstract":": Wound healing is a complex and orchestrated process. Oxygen is one of the molecules that is required throughout the wound healing continuum for various underlying processes from innate immune response at the in fl ammatory phase to building of collagen type III at the remodel-ling phase. Therefore, it is not surprising that, due to primary diseases like venous insuf fi ciency and diabetes mellitus, hypoxia caused by sustained lack of oxygen is common in chronic wounds. Adjunct to systemic therapies of the primary disease aimed at revascularizing the tissue, recently developed technologies are now available that provide topical oxygen-enhanced wound healing. Several devices are designed to provide pure oxygen directly to the wound either with or without pressure. Another approach to the provision of additional topical oxygen is to use haemoglobin to facilitate oxygen diffusion. This phenomenon was fi rst shown more than 50 years ago, but it has only recently been discovered as a means of improving wound healing. In vitro and in vivo studies have shown that haemoglobin is capable of transporting oxygen outside of erythrocytes. Furthermore, several clinical studies have shown a bene fi cial effect on wound healing in different wound types. In this review, we summarise publicly available in vitro and in vivo clinical data and discuss the acceptability and ease of use of haemoglobin spray (Granulox ® ) in the management of chronic wounds. In conclusion, currently available data are promising, demonstrating that puri fi ed haemoglobin in an aqueous solution is able to serve as an oxygen shuttle by facilitating diffusion. No severe side effects have been reported in the literature, implying that it is a safe product. In clinical studies, it has been observed to improve the speed of healing of different types of chronic wounds. As a simple spray, it can be used as adjunct treatment in many standard-of-care settings with only a few limitations.","PeriodicalId":43306,"journal":{"name":"Chronic Wound Care Management and Research","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/cwcmr.s212108","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49111600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Treadwell, Donna Walker, BJ Nicholson, M. Taylor, H. Alur
{"title":"Treatment Of Pain In Wounds With A Topical Long Acting Lidocaine Gel","authors":"T. Treadwell, Donna Walker, BJ Nicholson, M. Taylor, H. Alur","doi":"10.2147/cwcmr.s224092","DOIUrl":"https://doi.org/10.2147/cwcmr.s224092","url":null,"abstract":"","PeriodicalId":43306,"journal":{"name":"Chronic Wound Care Management and Research","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2019-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/cwcmr.s224092","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49603176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Craig McDonald, K. Plevey, G. Petrof, Anna E. Martinez
{"title":"Optimal Management Of Chronic Wounds In Paediatric Junctional Epidermolysis Bullosa Patients","authors":"Craig McDonald, K. Plevey, G. Petrof, Anna E. Martinez","doi":"10.2147/cwcmr.s172193","DOIUrl":"https://doi.org/10.2147/cwcmr.s172193","url":null,"abstract":"","PeriodicalId":43306,"journal":{"name":"Chronic Wound Care Management and Research","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2019-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/cwcmr.s172193","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43335291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Management of patients with calciphylaxis: current perspectives","authors":"C. Erfurt-Berge, R. Renner","doi":"10.2147/cwcmr.s182417","DOIUrl":"https://doi.org/10.2147/cwcmr.s182417","url":null,"abstract":": Calciphylaxis (CP) is a rare disorder presenting with painful ischemic skin ulcerations. Its association with end-stage renal disease, but also non-uremic cases have been described. Several risk factors, like metabolic syndrome, calcium-phosphate imbal-ance, anticoagulative medication and female gender have been discussed. Multidisciplinary therapeutic approaches are necessary since evidence-based guidelines are missing due to lack of pathophysiological understanding of the disease and the absence of studies with large patient cohorts. However, strategies for local wound therapy, reduction of risk factors and systemic therapies are being developed. Changes in duration, frequency and method of hemodialysis and speci fi c medication to lower the calcium upload can be effective in uremic CP cases. Systemic treatments with cinacalcet, sodium thiosulfate or bisphosphonates have been applied successfully in CP patients, but large placebo-controlled randomized trials are still needed to gather better insight into this fatal disease.","PeriodicalId":43306,"journal":{"name":"Chronic Wound Care Management and Research","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/cwcmr.s182417","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46161279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Management of chronic wounds in patients with pemphigus","authors":"Ayman Grada, Zaidal Obagi, T. Phillips","doi":"10.2147/cwcmr.s141948","DOIUrl":"https://doi.org/10.2147/cwcmr.s141948","url":null,"abstract":": Pemphigus is a group of chronic IgG-mediated autoimmune blistering diseases that involves both the skin and mucous membranes. It is caused by autoantibodies disrupting intercellular keratinocyte adhesion. Loss of epidermal integrity clinically manifests as fl accid thin-walled blisters, erosions, and crusts on the skin, and painful mucosal erosions. Pemphigus vulgaris and pemphigus foliaceus are the two most common types of pemphigus. Although rare, pemphigus can be life-threatening. Substantial morbidity and mortality can occur as a result of complications of these diseases and their treatments. In general, pemphigus often results in extensive skin loss, leading to scar formation and adherence of articular skin folds, limiting joint and limb movements. The primary goal of treatment is to induce durable remission, decrease blister formation, prevent infections and promote healing of blisters and erosions. The mainstay of treatment for pemphigus is systemic corticosteroids combined with an adjuvant immunosuppressant and wound care. We performed PubMed and Google Scholar searches of the English-language literature for pemphigus disease and wound management for blistering disease (1966 – 2019). In this review, we discuss wound care in patients with pemphigus disease.","PeriodicalId":43306,"journal":{"name":"Chronic Wound Care Management and Research","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/cwcmr.s141948","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49573049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Martorell ulcer: chronic wound management and rehabilitation","authors":"M. Mansour, A. Alavi","doi":"10.2147/CWCMR.S172427","DOIUrl":"https://doi.org/10.2147/CWCMR.S172427","url":null,"abstract":"","PeriodicalId":43306,"journal":{"name":"Chronic Wound Care Management and Research","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2019-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/CWCMR.S172427","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43462996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Fish skin acellular dermal matrix: potential in the treatment of chronic wounds","authors":"Munir Patel, J. C. Lantis Ii","doi":"10.2147/CWCMR.S157211","DOIUrl":"https://doi.org/10.2147/CWCMR.S157211","url":null,"abstract":"php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). Chronic Wound Care Management and Research 2019:6 59–70 Chronic Wound Care Management and Research Dovepress","PeriodicalId":43306,"journal":{"name":"Chronic Wound Care Management and Research","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2019-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/CWCMR.S157211","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47438443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}