Pharmacology & Pharmacy最新文献

Combined Therapy of Pioglitazone and Atorvastatin Alleviate Diabetes in Rats More Effectively than That of Mono Therapy 吡格列酮与阿托伐他汀联合治疗对糖尿病大鼠的治疗效果优于单用

Pharmacology &amp; Pharmacy Pub Date : 2014-05-13 DOI: 10.4236/PP.2014.55060

H. Ali, A. Rahman, S. Islam, A. Mamun, Shaheda Zannah, A. Alam, A. Rahman, M. Rashid

{"title":"Combined Therapy of Pioglitazone and Atorvastatin Alleviate Diabetes in Rats More Effectively than That of Mono Therapy","authors":"H. Ali, A. Rahman, S. Islam, A. Mamun, Shaheda Zannah, A. Alam, A. Rahman, M. Rashid","doi":"10.4236/PP.2014.55060","DOIUrl":"https://doi.org/10.4236/PP.2014.55060","url":null,"abstract":"Present research \u0000was designated to investigate the hypoglycemic, hypolipidemic and antioxidant \u0000activity of the combination of pioglitazone and atorvastatin on long-term \u0000alloxan-induced diabetes rats (AIDRs). The experiments were carried out to \u0000determine blood glucose level, lipid profile, free radial scavenging \u0000activities, superoxide dismutase (SOD) and catalase in liver tissue. In \u0000addition, left ventricular (LV) hypertrophy and cardiomyocyte size were also \u0000determined by histological analysis. It was found that in short-term induction, \u0000pioglitazone significantly reduced the blood glucose level without having any \u0000considerable effect on lipid profile and antioxidant enzymes (SOD and catalase) \u0000in rats. On the other hand, atorvastatin significantly reduced total \u0000cholesterol (TC), triglyceride (TG) and low density lipoprotein cholesterol \u0000(LDL-C) with marked increase in the level of high density lipoprotein \u0000cholesterol (HDL-C) and improved activity of SOD and catalase enzymes. However, \u0000pathological changes of heart and pancreas were not observed after short-term \u0000exposure to alloxan in rats. Long-term diabetes induction resulted in LV \u0000hypertrophy and prominent shrinkage of islets of Langerhans cells. Treatment \u0000with atorvastatin in combination with pioglitazone significantly reduced the LV \u0000hypertrophy, TC, TG and LDL level whereas they noticeably increased HDL \u0000level, DPPH (1,1-Diphenyl-2-picryl-hydrazyl) free radical scavenging activity, \u0000SOD and catalase activity with satisfactory recovery of Langerhans cells. The \u0000result demonstrated that combination therapy was more effective than that of \u0000mono-therapy for preventing diabetes with cardiovascular diseases (CVD) in \u0000rats.","PeriodicalId":432281,"journal":{"name":"Pharmacology &amp; Pharmacy","volume":"94 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127256322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Quality of Drugs Based on Ferrous Sulfate Dispensed in a Basic Health and Commercial Pharmacy in a City in the Amazon Region 基于硫酸亚铁的亚马逊地区某城市基层卫生和商业药房配药质量分析

Pharmacology &amp; Pharmacy Pub Date : 1900-01-01 DOI: 10.4236/pp.2022.139025

A. Mello, Marceonia Costa dos Santos, Ana Gabriela Lisboa Santos, D. T. V. Alves, D. Grisólia, A. Grisólia, Mariceli Baia Leão Barros, Fabrícia de Jesus Paiva da Fonseca, Manoel Samuel da Cruz Neto

引用次数: 0

Phytochemical Analysis and Contractile Effects of Aqueous and Hydroethanolic Extracts of Anastatica hierochuntica L. (Brassicaceae) on the Isolated Uterus of Mice 芸苔科青藤水、醇提取物对小鼠离体子宫的植物化学分析及收缩作用

Pharmacology &amp; Pharmacy Pub Date : 1900-01-01 DOI: 10.4236/pp.2023.148019

Belem-Kabré Esther, Nitiéma Mathieu, Odjo Blondine Saïdath, M. Oumarou, Y. Boubacar, Kaboré Boukaré, Somda Gaëtan Donzéo, Traoré Tata Kadiatou, K. Moumouni, I. Sylvain, Ouédraogo Moussa, Kabré Elie, Ouédraogo Noufou

引用次数: 0

CAR T Cell Immunotherapy That Revolutionary Breakthrough in Human Oncology Treatment: A Review CAR - T细胞免疫疗法在人类肿瘤治疗中的革命性突破:综述

Pharmacology &amp; Pharmacy Pub Date : 1900-01-01 DOI: 10.4236/pp.2022.1311036

Shammi Binte Bashar, Zannat Akhter, B. C. Saha, Md. Mushfiqul Islam Himaloy, U. Kulsum, Md. Rashedur Rahman

引用次数: 0

The Effect of Food Thickeners on the Bitterness and Dissolution of Amlodipine Besilate Powder When Co-Administered with Thickeners to Patients with Dysphagia 食用增稠剂对吞咽困难患者苯磺酸氨氯地平粉苦味及溶出度的影响

Pharmacology &amp; Pharmacy Pub Date : 1900-01-01 DOI: 10.4236/pp.2022.1311034

Akiko Odanaga, Honami Kojima, Azumi Kabeya, Rio Uno, Miyako Yoshida, M. Habara, H. Ikezaki, T. Uchida

{"title":"The Effect of Food Thickeners on the Bitterness and Dissolution of Amlodipine Besilate Powder When Co-Administered with Thickeners to Patients with Dysphagia","authors":"Akiko Odanaga, Honami Kojima, Azumi Kabeya, Rio Uno, Miyako Yoshida, M. Habara, H. Ikezaki, T. Uchida","doi":"10.4236/pp.2022.1311034","DOIUrl":"https://doi.org/10.4236/pp.2022.1311034","url":null,"abstract":"Purpose: The present research was performed to evaluate the effect of food thickeners on the bitterness and dissolution of bitter drugs when co-adminis-tered to patients with dysphagia. Methods: Amlodipine besilate (AMPB) powder was used as a model drug. Starch- and xanthan gum-based food thickeners were examined, with swallowing-aid jelly as a reference. The line-spread test (LST), texture prolife analysis (TPA) were done firstly. In related to AMPB powder mixed with food thickeners solution, a conventional dissolution test simulating the oral cavity was performed, the amlodipine (AMP) concentration and taste sensor output for dissolved medium versus time profiles were developed. The dissolution test at pH 1.2 and 4.5, representing typical gastric conditions for younger or elderly people, was performed in two kinds of thickener solution and swallowing-aid jelly those were mixed with AMPB powder. Results: LST demonstrated that xanthan gum-based food thickeners fulfilled the requirements for patients with dysphagia but that starch-based food thickeners did not. In TPA, hardness and adhesiveness decreased pro-portionally as the concentration increased for both kinds of food thickener. bioavailability in humans. The 7.1 and 4.7 (w/v) % starch-based thickener show bitterness inhibition under simulated oral cavity conditions and complete dissolution of AMP under simulated gastric conditions.","PeriodicalId":432281,"journal":{"name":"Pharmacology &amp; Pharmacy","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131868781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibiotic Prescribing Patterns and Prevalence of Surgical Site Infections in Caesarean Section Deliveries at Two Tertiary Hospitals in Lusaka, Zambia 赞比亚卢萨卡两所三级医院剖宫产手术部位感染的抗生素处方模式和流行情况

Pharmacology &amp; Pharmacy Pub Date : 1900-01-01 DOI: 10.4236/pp.2022.138024

M. Kasanga, M. Chileshe, S. Mudenda, Raphael Mukosha, Maika Kasanga, V. Daka, Tobela Mudenda, M. Chisembele, J. Musuku, B. Solochi, Jian Wu

引用次数: 3

Evaluation of the Safety and Efficacy of Extracts from the Leaves of Five Plants Used for the Treatment of Arterial Hypertension in Benin 贝宁五种植物叶提取物治疗高血压的安全性和有效性评价

Pharmacology &amp; Pharmacy Pub Date : 1900-01-01 DOI: 10.4236/pp.2022.1310027

O. Koukoui, S. Seton, M. Betira, J. Amagbegnon, F. Sonounameto, E. Assou, A. Sezan

引用次数: 1

Antidiabetic Potential of Carthamus oxycantha M.Bieb. Seeds in Alloxan Induced Diabetic Rats 红花的抗糖尿病潜能。四氧嘧啶诱导的糖尿病大鼠种子

Pharmacology &amp; Pharmacy Pub Date : 1900-01-01 DOI: 10.4236/pp.2022.136015

A. Abid, Hira Muzammel, H. Shafi, M. Nisa, Hassani Ali, Muhammad Afzal, N. Khan, Fahad Muzammil

引用次数: 0

Evaluation of the Fasciolicidal/Nematicidal Efficacy of an Intramuscular Combination of Clorsulon/Levamisole in Naturally Infected Dairy Cattle 克罗舒隆/左旋咪唑肌内联合对自然感染奶牛的筋膜虫/线虫杀虫效果评价

Pharmacology &amp; Pharmacy Pub Date : 1900-01-01 DOI: 10.4236/pp.2022.1311033

F. Ibarra-Velarde, Y. Vera‐Montenegro, Ignacio Olave-Leiva, Antonio Figueroa-Castillo, Irene Cruz Mendoza, JoaquÍn Ambía-Medina

{"title":"Evaluation of the Fasciolicidal/Nematicidal Efficacy of an Intramuscular Combination of Clorsulon/Levamisole in Naturally Infected Dairy Cattle","authors":"F. Ibarra-Velarde, Y. Vera‐Montenegro, Ignacio Olave-Leiva, Antonio Figueroa-Castillo, Irene Cruz Mendoza, JoaquÍn Ambía-Medina","doi":"10.4236/pp.2022.1311033","DOIUrl":"https://doi.org/10.4236/pp.2022.1311033","url":null,"abstract":"The aim of the present study was to assess the fasciolicidal and nematicidal efficacy of a new combination of clorsulon/levamisole, which was formulated for intramuscular administration, in dairy cattle. For the study, sixteen Hols-tein-Freisian dairy cows were selected for inclusion in the trial based on finding Fasciola hepatica eggs or gastrointestinal nematodes (GIN) in the feces. Ten of these cows were naturally infected with F. hepatica, and 6 were naturally infected with GIN. On Day 0 (zero), all animals were treated with a combination of clorsulon (2.5 mg/kg/IM and levamisole (2.5 mg/kg/IM) administered at the dose recommended by the manufacturer (1 ml/20kg/bw). Subsequently, their feces were analyzed on days 0, 7, 14 and 21 post treat-ments by the Flukefinder sedimentation method and McMaster technique to determine the percentages of egg reduction in the animals, with reference to the egg load count on day 0. The results obtained in the current work indicated an efficacy of 100% that was determined by the percentage reduction of eggs of F. hepatica and/or GIN. This new fasciolicide/nematicide formulation exerted a remarkable effect and can be considered a new alternative to control F. hepatica and gastrointestinal worms in dairy cattle.","PeriodicalId":432281,"journal":{"name":"Pharmacology &amp; Pharmacy","volume":"87 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133637982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research on the Path of Improving the Technological Innovation Ability of Chinese Pharmaceutical Industry Based on Technology 基于技术的中国医药产业技术创新能力提升路径研究

Pharmacology &amp; Pharmacy Pub Date : 1900-01-01 DOI: 10.4236/pp.2022.138022

Xinyun Gao, Yongfa Chen

引用次数: 0

Pharmacology &amp;amp; Pharmacy最新文献

Pharmacology & Pharmacy最新文献