Eurasian Journal of Pulmonology最新文献

{"title":"Manual chest physiotherapy during whole-lung lavage in pulmonary alveolar proteinosis","authors":"Umut Bahçaci, S. Uysal","doi":"10.4103/ejop.ejop_33_20","DOIUrl":"https://doi.org/10.4103/ejop.ejop_33_20","url":null,"abstract":"Pulmonary alveolar proteinosis (PAP) is a diffuse lung disease that appears after the accumulation of lipoproteinaceous material in the alveoli. We aimed to compare the effects of using chest physiotherapy during a whole-lung lavage (WLL) to those without its use in a PAP case. A 33-year-old male patient with complaints of difficulty breathing, coughing, and dyspnea was admitted to the hospital. After the patient underwent a chest screening and diagnostic tests, WLLs were planned for his left and right lungs on separate days. Manual chest physiotherapy, including tapotement and vibration, was performed during the right WLL at the physician's request. Much more lipoproteinaceous material was visually detected in the saline collection bottles after the WLL using manual tapotement and vibration when compared to the WLL without tapotement and vibration. The improvement in the patient's clinical status was supported by chest X-ray and auscultation results.","PeriodicalId":42933,"journal":{"name":"Eurasian Journal of Pulmonology","volume":"23 1","pages":"132 - 135"},"PeriodicalIF":0.2,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49054478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intrathoracic manifestations of immunoglobulin G4-related disease: A pictorial review","authors":"U. Sertcelik, Asli Oncel, D. Koksal","doi":"10.4103/ejop.ejop_112_20","DOIUrl":"https://doi.org/10.4103/ejop.ejop_112_20","url":null,"abstract":"Immunoglobulin G4-related disease (IgG4-RD) is an increasingly recognized systemic fibro-inflammatory disease associated with elevated serum IgG4 levels. It affects virtually any organ system including the gastrointestinal system, salivary glands, periorbital tissues, kidneys, lungs, lymph nodes, central nervous system, large vessels, thyroid, and skin. Although the involved organ systems vary between studies and are influenced by the medical center and specialty, the most frequent manifestation of IgG4-RD is regarded to be type 1 autoimmune pancreatitis. The incidence of intrathoracic involvement is not known exactly, but it is thought to be relatively rare. Intrathoracic manifestations of IgG4-RD can be observed in airways (tracheobronchial stenosis, thickening of bronchovascular bundles), pulmonary parenchyma (nodules, masses, interstitial lung disease), pleura (pleural thickening, nodules, effusion), and mediastinum (lymphadenopathy, fibrosing mediastinitis). This review aimed to briefly describe the pathogenesis, histopathology, clinical features, diagnosis, and treatment of IgG4-RD; and make a pictorial review of its intrathoracic manifestations.","PeriodicalId":42933,"journal":{"name":"Eurasian Journal of Pulmonology","volume":"23 1","pages":"83 - 88"},"PeriodicalIF":0.2,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43186953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current challenges and future scope of nanoparticles in chronic obstructive pulmonary disease","authors":"Sarika Pandey, R. Garg, S. Kant, A. Verma, P. Gaur, Megha Agarwal","doi":"10.4103/ejop.ejop_57_19","DOIUrl":"https://doi.org/10.4103/ejop.ejop_57_19","url":null,"abstract":"Chronic obstructive pulmonary disease (COPD), characterized by airway inflammation and progressive airflow limitation, is one of the leading causes of mortality worldwide. Bronchodilators, corticosteroids, or antibiotics are used for treatment of COPD, but the drugs are not delivered properly to the target cells or a tissue, which remains a challenge. Nanoparticles (NPs) have gained a tremendous interest in respiratory medicine due to their smaller size, higher surface to volume ratio, and advantages such as targeting effects, patient compliance, and improved pharmacotherapy. Sustained delivery of drugs mediated by NPs to the targeted site is needed to control cell chemotaxis, fibrosis, and chronic obstruction of lungs in COPD. Development of multifunctional biodegradable NPs that are nontoxic and can help in overcoming airway defense will be beneficial in future for COPD.","PeriodicalId":42933,"journal":{"name":"Eurasian Journal of Pulmonology","volume":"23 1","pages":"10 - 13"},"PeriodicalIF":0.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43627115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of catheter-directed thrombolysis and anticoagulation in intermediate-risk pulmonary embolism: A retrospective analysis","authors":"D. Omaygenç, M. Omaygenc","doi":"10.4103/ejop.ejop_73_20","DOIUrl":"https://doi.org/10.4103/ejop.ejop_73_20","url":null,"abstract":"BACKGROUND AND OBJECTIVES: The selection of escalation of care strategies for the treatment of intermediate-risk pulmonary embolism (PE) is a matter of debate. Here, we aimed to assess the features of our population treated either with anticoagulation (AC) alone or catheter-directed thrombolysis (CDT). We also sought to identify a relationship between high residual systolic pulmonary artery pressure (sPAP) and demographic and clinical variables. PATIENTS AND METHODS: The retrospective data of 30 intermediate-high-risk PE patients were analyzed. CDT was used in 14 (46.7%) cases. Enoxaparin (b. i. d) injections were administered in the AC group. In the CDT group, patients received 5 mg bolus dose of alteplase followed by 1 mg/h infusion for 24 h. Estimated sPAP at presentation and discharge was recorded. A value equal to or greater than 40 mmHg in the latter was accepted as a significant rise. RESULTS: The patients in the CDT group had a lower HAS-BLED score (2 [0–3] vs. 1 [0–3], P = 0.03). Although initial sPAP values were comparable among treatment arms, sPAP at discharge was significantly lower in the CDT group (mmHg, 42 ± 11.2 vs. 33.6 ± 9.7, P = 0.04). The reduction in sPAP at discharge was also significantly higher in this group. The degree of reduction in sPAP was considerably correlated with baseline sPAP (r: 63.2, P < 0.001). Finally, the baseline sPAP measurement and HAS-BLED score of the patients with high residual sPAP were significantly higher (56.6 ± 13.1 vs. 67.3 ± 11.3, P = 0.02, and 1 [0–3] vs. 2 [0–3], P = 0.02, respectively). CONCLUSION: CDT was preferred over AC when lower bleeding risk was anticipated for intermediate-high-risk PE patients in our sample population. Eventually, CDT provided lower discharge sPAP levels and a greater reduction in sPAP. However, the factors associated with high sPAP at discharge were only high baseline sPAP measurement and HAS-BLED score.","PeriodicalId":42933,"journal":{"name":"Eurasian Journal of Pulmonology","volume":"23 1","pages":"50 - 58"},"PeriodicalIF":0.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47565855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Importance of pulmonary involvement in Crimean–Congo hemorrhagic fever","authors":"A. Pazarlı, H. Yakar, Zafer Parlak","doi":"10.4103/ejop.ejop_43_21","DOIUrl":"https://doi.org/10.4103/ejop.ejop_43_21","url":null,"abstract":"BACGROUND AND AIM: Crimean-Congo hemorrhagic fever (CCHF) is a zoonotic disease caused by a virus belonging to the Bunyaviridae family. The aim of this study is to evaluate respiratory and radiological findings of cases and the impact on mortality. MATERIALS AND METHODS: This retrospective study included patients who were diagnosed by the polymerase chain reaction test as CCHF and examined in terms of pulmonary and radiological findings. Two hundred and forty-one patients reviewed retrospectively. Clinical, laboratory, demographic characteristics, pulmonary symptoms, examination and radiological findings, and treatment results were recorded, and data of all surviving and nonsurviving patients were compared. RESULTS: A total of 241 patients (157 males and 84 females) were enrolled in the current study. The mean age of the patients was 49.7 ± 19.50 years. A total of 66 patients had chest X‐ray (CXR) findings, and the most common were ground-glass opacity (n = 31, 33.7%), consolidation (n = 23, 25%), and pleural effusion (12%, 13%). The presence of respiratory system examination findings, pulmonary symptoms, and CXR findings were statistically significant in the nonsurvival group (P < 0.005). CONCLUSIONS: Respiratory system findings seem to be an important factor in mortality patients with CHF cases, so we believe that detailed pulmonary evaluation and timely supportive treatment will be important in these cases.","PeriodicalId":42933,"journal":{"name":"Eurasian Journal of Pulmonology","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70723182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does the benefit from pulmonary rehabilitation differ between phenotypes in chronic obstructive pulmonary disease?","authors":"M. Buyukşirin, G. Polat, H. Sahin, A. Ayrancı, G. Karadeniz, F. Güldaval, S. Susam, F. Üçsular, C. Anar, Onur Süneçlı","doi":"10.4103/ejop.ejop_26_20","DOIUrl":"https://doi.org/10.4103/ejop.ejop_26_20","url":null,"abstract":"INTRODUCTION: Chronic obstructive pulmonary disease (COPD) is a disease caused by airway and/or parenchymal pathology. Therefore, some patients inevitably have chronic bronchitis and some patients have emphysema. The current thinking is that exercise affects these two major phenotypes differently. In this study, we investigated the benefits of pulmonary rehabilitation (PR) in chronic bronchitis- and emphysema-predominant COPD patients. METHODS: Retrospective data of chronic bronchitis- and emphysema-predominant COPD patients who completed an outpatient 8-week PR program between the years 2013 and 2017 in the PR unit of our hospital were examined. Demographic data (age, sex, body mass index, smoking history, long-term oxygen therapy, noninvasive ventilation, emergency admissions, and number of hospitalizations) were recorded. The patients were divided into two groups: chronic bronchitis predominant and emphysema predominant. Patients were assigned to the emphysema-predominant group based on radiology results. Patients were assigned to the chronic bronchitis-predominant group according to clinical description. The two groups were compared using the recorded data cited above. RESULTS: Of the 146 patients, 85 (58.2%) were assigned to the emphysema-predominant group and 61 (41.8%) were assigned to the chronic bronchitis-predominant group. There was no difference between the two groups in age and gender. Pulmonary function test (PFT) parameters (forced expiratory volume in 1 s and diffusing capacity of the lungs for carbon monoxide (DLCO)), arterial blood gas values (pO2, PCO2, and SpO2), 6 min of walking time, and quality of life scores were significantly improved after PR. However, there was no difference between the emphysema- and chronic bronchitis-predominant groups in terms of the improvements after PR. CONCLUSION: In this study, it was observed that the improvement due to PR seen in COPD patients was independent of phenotype. Therefore, all COPD patients should be encouraged to participate in PR programs regardless of their phenotypes.","PeriodicalId":42933,"journal":{"name":"Eurasian Journal of Pulmonology","volume":"23 1","pages":"32 - 40"},"PeriodicalIF":0.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44916020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How was the management of patients scheduled for surgical biopsy through a multidisciplinary approach to the diagnosis of interstitial lung diseases? Was a pathological diagnosis alone enough?","authors":"M. Ağca, Reyhan Yıldız, B. Gundogus, S. Bekir, Fatma Ozbaki, A. Kosif, Mine Cankurtaran, C. Akman, Ayçım Şen, A. Hazar, T. Sevim, Dilek Ernam","doi":"10.4103/ejop.ejop_67_20","DOIUrl":"https://doi.org/10.4103/ejop.ejop_67_20","url":null,"abstract":"OBJECTIVE: The present study examines the clinical and radiological findings and pathological diagnoses of patients undergoing surgical biopsy with an multidisciplinary team (MDT) decision and investigates whether final diagnoses change on the reevaluated of pathological diagnoses at MDT meetings. MATERIALS AND METHODS: A total of 416 patients were discussed at MDT meetings held at the University of Health Sciences Istanbul Sureyyapasa Chest Diseases and Thoracic, Surgery Training and Research Hospital January between January 2016 and May 2019, with surgical biopsy decisions made for 50 (12%) patients. RESULTS: Among the 50 patients, 26 (52%) were female, with a mean age of 53 ± 12 years. The most common locations of the surgical biopsy were the right lung (n = 27, 54%), lower lobe (n = 38, 76%) and single lobe (n = 35, 70%). A definitive pathological diagnosis was established in 41 (82%) patients following the biopsy. The most common diagnoses were usual interstitial pneumonia (UIP; n = 19, 38%), sarcoidosis (n = 11, 22%), unclassifiable fibrosis (n = 9, 18%), (non-specific interstitial pneumonia; n = 5, 10%), (hypersensitivity pneumonitis; n = 2, 4%) and others (n = 4, 8%), respectively. Diagnoses of 13 (26%) such patients were revised. The revision was most common in the unclassifiable fibrosis and UIP subgroups. The radiological appearance was classified based on the high-resolution computed tomography parameters for idiopathic pulmonary fibrosis (IPF). The final diagnosis was IPF in eight of 14 patients with “probable” diagnoses, all four patients with “indeterminate” diagnoses and three of the 28 patients with “alternative” diagnoses. CONCLUSION: Diagnosing interstitial lung diseases is difficult, and while surgical biopsy provides the most definitive diagnosis, it is not enough by itself. IPF may vary in radiology. Patients diagnosed with UIP and unclassifiable fibrosis after biopsy should be reevaluated, and the final diagnosis should be established through a multidisciplinary approach.","PeriodicalId":42933,"journal":{"name":"Eurasian Journal of Pulmonology","volume":"23 1","pages":"41 - 49"},"PeriodicalIF":0.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47888815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of clinical and radiological findings in COVID-19 pneumonia","authors":"M. Doğan, S. Icten, B. Baysal, Y. Çağ","doi":"10.4103/ejop.ejop_42_21","DOIUrl":"https://doi.org/10.4103/ejop.ejop_42_21","url":null,"abstract":"BACKGROUND AND AIM: We aimed to examine the demographic, clinical, and imaging characteristics of patients with COVID???19 pneumonia and also to identify the factors affecting mortality. MATERIALS AND METHODS: This study was designed as a retrospective single???center observational study. A total of 126patients with COVID???19 pneumonia who were polymerase chain reaction confirmed and underwent thorax computer tomography(CT) were analyzed. The patients' demographic and clinical data were obtained from the electronic medical record. Thorax CT findings were re???evaluated retrospectively by thoracic radiologists according to the severe acute respiratory syndrome coronavirus 2 pneumonia guidelines of the Radiological Society of North America. The extent of lesions was evaluated by CT lobe score, which was the sum of individual lobe scores(0-5 point) of the lungs. RESULTS: The mean age of the patients was 60.4 +/- 18.6years and 54%(n=68) were male. The most common symptoms included cough, fever, and shortness of breath. The average time interval between the onset of symptoms and thorax CT acquisition was 6.6 +/- 8.3days. The most common radiological findings included ground???glass opacity(98.4%), consolidation(72.2%), and vascular enlargement(69.8%), respectively. The deceased patients had more common consolidation, vascular enlargement, and high lobe scores in thorax CT as compared to survivors. According to logistic regression analysis age(P=0.003), lobe score(P=0.001), numbers of comorbidities(P=0.017), symptoms duration(P=0.034), and vascular enlargement(P=0.045) were independent risk factors on 30???day mortality. CONCLUSION: This study indicated that age, symptoms duration, the number of comorbidities, lobe score, and vascular enlargement in thorax CT are associated with the prognosis of COVID???19 pneumonia","PeriodicalId":42933,"journal":{"name":"Eurasian Journal of Pulmonology","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70722902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The importance of pulmonary rehabilitation in lung transplantation","authors":"M. Arumugam, R. Ramanathan, J. Thacker, S. Rajagopala, Pitchaimani Govindharaj","doi":"10.4103/ejop.ejop_29_20","DOIUrl":"https://doi.org/10.4103/ejop.ejop_29_20","url":null,"abstract":"Lung transplantation is now the standard of care for nonreversible end-stage lung disease and leads to dramatic improvements in pulmonary function, quality of life, and survival. Pretransplant pulmonary rehabilitation (PR) can optimize potential recipients and widen or open a “transplant window” period. Given the potential for long wait times in our country, ongoing PR is crucial to ensure recipient fitness. Postoperative rehabilitation is an integral part of care of the recipient and may extend beyond hospital discharge. We present the case of a 42-year-old female who underwent bilateral lung transplantation for advanced interstitial lung disease and discuss the challenges and our approach to PR in this setting.","PeriodicalId":42933,"journal":{"name":"Eurasian Journal of Pulmonology","volume":"23 1","pages":"67 - 71"},"PeriodicalIF":0.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45007271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can hematological parameters guide the differentiation between sarcoidosis and tuberculous lymphadenitis?","authors":"B. Kerget, Y. Aydın, Sevilay Özmen, D. Afşin, E. Uçar, L. Sağlam","doi":"10.4103/ejop.ejop_6_20","DOIUrl":"https://doi.org/10.4103/ejop.ejop_6_20","url":null,"abstract":"BACKGROUND: Tuberculosis (TB) and sarcoidosis, which are considered two different ends of the same disease spectrum, usually cannot be differentially diagnosed based on laboratory tests and radiological imaging. Clinical, histopathological, and bacteriological examinations as well as response to treatment can guide diagnosis. The aim of this study was to examine correlations between hematological parameters and disease in patients who were diagnosed with sarcoidosis, TB, or reactive lymphadenopathy (LAP) after mediastinoscopy. MATERIALS AND METHODS: The study included a total of 223 patients diagnosed with either reactive LAP (n = 65), sarcoidosis (n = 83), or TB (n = 75) after mediastinoscopy between September 2012 and May 2017. The patient groups were retrospectively evaluated in terms of demographic characteristics, complete blood count parameters, erythrocyte sedimentation rate, and radiological findings. RESULTS: Sedimentation rate and platelet count were significantly higher in TB patients compared with sarcoidosis (P = 0.001, P = 0.011) and reactive LAP patients (P = 0.001, P = 0.001). Lymphocyte count was significantly higher in patients with reactive LAP than in patients with TB and sarcoidosis (P = 0.001, P = 0.001). Platelet/lymphocyte ratio (PLR) was significantly higher in TB patients compared to those with sarcoidosis and reactive LAP (P = 0.001, P = 0.001) and in sarcoidosis patients compared to reactive LAP patients (P = 0.001). Neutrophil/lymphocyte ratio (NLR) values in the TB and sarcoidosis groups were significantly higher than that of the reactive LAP group (P = 0.001, P = 0.012). Stage 2 sarcoidosis patients were found to have significantly higher PLR, NLR, and platelet count compared to Stage 1 patients (P = 0.001, P = 0.01, P = 0.009). CONCLUSION: PLR and NLR can be used to discriminate patients with sarcoidosis and TB from patients with reactive LAP. In addition, PLR may also serve as a guiding parameter in the differentiation between tuberculous LAP and sarcoidosis.","PeriodicalId":42933,"journal":{"name":"Eurasian Journal of Pulmonology","volume":"23 1","pages":"19 - 24"},"PeriodicalIF":0.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47191508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}