Case Reports in Immunology最新文献_第8页

Concomitant Transverse Myelitis and Acute Axonal Sensory-Motor Neuropathy in an Elderly Patient. 老年患者并发横贯脊髓炎和急性轴突感觉-运动神经病变。

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Case Reports in Immunology Pub Date : 2017-01-01 Epub Date: 2017-07-13 DOI: 10.1155/2017/7289474

L M Oliveira, R G Cury, L H Castro, R Nitrini

引用次数: 9

Pure Cold-Induced Cholinergic Urticaria in a Pediatric Patient 纯冷致胆碱能性荨麻疹的儿科患者

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Case Reports in Immunology Pub Date : 2016-11-29 DOI: 10.1155/2016/7425601

Tina Abraham, David P McGarry, J. Frith, Jason Casselman, H. Tcheurekdjian, R. Hostoffer

引用次数: 3

Differential Impairment of Interferon-γ Responses in Two Cases of Pulmonary Nontuberculous Mycobacterial Disease 两例肺非结核分枝杆菌病中干扰素-γ反应的差异损害

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Case Reports in Immunology Pub Date : 2016-11-16 DOI: 10.1155/2016/9165641

W. Rae, Yifang Gao, E. Eren, R. Döffinger, B. Marshall, Anthony P. Williams

引用次数: 3

Tranexamic Acid: An Exceedingly Rare Cause of Anaphylaxis during Anaesthesia 氨甲环酸:在麻醉期间过敏性反应的一个极其罕见的原因

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Case Reports in Immunology Pub Date : 2016-10-31 DOI: 10.1155/2016/7828351

R. Bansal, A. Nicholas, Amolak S. Bansal

引用次数: 15

Giant Condyloma Acuminata in Indonesian Females with SLE under Immunosuppressant and Steroid Therapy 免疫抑制剂和类固醇治疗下印尼女性SLE患者的巨大尖锐湿疣

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Case Reports in Immunology Pub Date : 2016-10-24 DOI: 10.1155/2016/4710979

A. Rachman, Nabila Hasan

{"title":"Giant Condyloma Acuminata in Indonesian Females with SLE under Immunosuppressant and Steroid Therapy","authors":"A. Rachman, Nabila Hasan","doi":"10.1155/2016/4710979","DOIUrl":"https://doi.org/10.1155/2016/4710979","url":null,"abstract":"Introduction. Immunosuppressant and steroid therapy in systemic lupus erythematosus (SLE) increases the risk of human papillomavirus (HPV) infections, one of which is giant condyloma acuminata (GCA). To our knowledge, there is no report evaluating the correlation between immunosuppressive and steroid therapy in patients with SLE and the prevalence of GCA. Case Report. A 42-year-old female was diagnosed with SLE a year ago and has been treated with steroids and immunosuppressive drugs. In the last few months she presented GCA involving the genital area recurring almost every two months. Type 6 and 11 HPVs were identified in vulva, vagina, and cervix. Methods. PubMed, EBSCO, and Cochrane Library literature were searched from inception to July 2015. Authors screened all titles and abstracts and read full text article, and two case-control studies were found relevant. Results. SLE patients in both studies were under immunosuppressive and steroid therapy. Condyloma acuminata was diagnosed at 108 months (latest) and 1 month (earliest) after SLE. Type 6, 11, 16, 42, and oncogenic group of HPV were identified. Conclusions. GCA is a type of HPV infection seldom observed in SLE patients. Therefore, their correlation is still unclear. Period of time since SLE was diagnosed and GCA varies from months to years. A more thorough physical and laboratory examination leading to HPV and other infectious disease is recommended.","PeriodicalId":42865,"journal":{"name":"Case Reports in Immunology","volume":"125 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2016-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87291109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Successful Use of Tocilizumab in a Patient with Coexisting Rheumatoid Arthritis and Ulcerative Colitis Tocilizumab在并发类风湿关节炎和溃疡性结肠炎患者中的成功应用

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Case Reports in Immunology Pub Date : 2016-10-12 DOI: 10.1155/2016/7562123

M. Szeto, M. Yalçın, Abdul Latif Khan, A. Piotrowicz

{"title":"Successful Use of Tocilizumab in a Patient with Coexisting Rheumatoid Arthritis and Ulcerative Colitis","authors":"M. Szeto, M. Yalçın, Abdul Latif Khan, A. Piotrowicz","doi":"10.1155/2016/7562123","DOIUrl":"https://doi.org/10.1155/2016/7562123","url":null,"abstract":"Tocilizumab is an interleukin-6 receptor inhibitor licensed for moderate to severe rheumatoid arthritis (RA). We report a case of Tocilizumab monotherapy for severe active RA in a patient with coexisting ulcerative colitis (UC). The patient was intolerant to multiple disease-modifying drugs, so Tocilizumab monotherapy was commenced. We found clinical improvement in both RA and UC. There was no major adverse event after 2 years. Manufacturer advised caution in using Tocilizumab in patient with gastrointestinal ulceration due to an increased risk of bowel perforation. However, alternative treatments such as glucocorticoid and nonsteroidal anti-inflammatory drugs may carry a higher bowel perforation risk. The presence of gastrointestinal ulceration therefore should not constitute an absolute contraindication for Tocilizumab therapy. Future studies of registry data will inform clinician of the Tocilizumab-related risk of gastrointestinal toxicity in “real-life” settings. Contrary to previous case report, we found Tocilizumab therapy to have a positive effect on UC. Laboratory studies supported a role for interleukin-6 in the pathophysiology of UC. Further clinical trial to evaluate the therapeutic role of Tocilizumab in UC would be warranted.","PeriodicalId":42865,"journal":{"name":"Case Reports in Immunology","volume":"8 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2016-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82866422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Early Diagnosis and Hematopoietic Stem Cell Transplantation for IL10R Deficiency Leading to Very Early-Onset Inflammatory Bowel Disease Are Essential in Familial Cases 家族性病例中，对于IL10R缺乏导致的早发性炎症性肠病的早期诊断和造血干细胞移植至关重要

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Case Reports in Immunology Pub Date : 2016-09-06 DOI: 10.1155/2016/5459029

N. Karaca, G. Aksu, Ezgi Ulusoy, S. Aksoylar, Salih Gozmen, F. Genel, S. Akarcan, N. Gulez, T. Hirschmugl, S. Kansoy, K. Boztug, N. Kutukculer

{"title":"Early Diagnosis and Hematopoietic Stem Cell Transplantation for IL10R Deficiency Leading to Very Early-Onset Inflammatory Bowel Disease Are Essential in Familial Cases","authors":"N. Karaca, G. Aksu, Ezgi Ulusoy, S. Aksoylar, Salih Gozmen, F. Genel, S. Akarcan, N. Gulez, T. Hirschmugl, S. Kansoy, K. Boztug, N. Kutukculer","doi":"10.1155/2016/5459029","DOIUrl":"https://doi.org/10.1155/2016/5459029","url":null,"abstract":"Alterations of immune homeostasis in the gut may result in development of inflammatory bowel disease. A five-month-old girl was referred for recurrent respiratory and genitourinary tract infections, sepsis in neonatal period, chronic diarrhea, perianal abscess, rectovaginal fistula, and hyperemic skin lesions. She was born to second-degree consanguineous, healthy parents. Her elder siblings were lost at 4 months of age due to sepsis and 1 year of age due to inflammatory bowel disease, respectively. Absolute neutrophil and lymphocyte counts, immunoglobulin levels, and lymphocyte subsets were normal ruling out severe congenital neutropenia and classic severe combined immunodeficiencies. Quantitative determination of oxidative burst was normal, excluding chronic granulomatous disease. Colonoscopy revealed granulation, ulceration, and pseudopolyps, compatible with colitis. Very early-onset colitis and perianal disease leading to fistula formation suggested probability of inherited deficiencies of IL-10 or IL-10 receptor. A mutation at position c.G477A in exon of the IL10RB gene, resulting in a stop codon at position p.W159X, was identified. The patient underwent myeloablative hematopoietic stem cell transplantation from full matched father at 11 months of age. Perianal lesions, chronic diarrhea, and recurrent infections resolved after transplantation. IL-10/IL-10R deficiencies must be considered in patients with early-onset enterocolitis.","PeriodicalId":42865,"journal":{"name":"Case Reports in Immunology","volume":"11 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2016-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87122391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Mycetoma Caused by Acremonium Species in a Patient with Chronic Granulomatous Disease 慢性肉芽肿患者由顶孢菌所致足菌肿1例

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Case Reports in Immunology Pub Date : 2016-02-28 DOI: 10.1155/2016/3209493

R. Antrobus, G. Wong, Julie Jones, A. Huissoon

引用次数: 3

Successful Use of Plasma Exchange in the Treatment of Corticosteroid-Refractory Eosinophilic Granulomatosis with Polyangiitis Associated with Gastrointestinal Manifestations 血浆置换成功治疗皮质类固醇难治性嗜酸性肉芽肿病伴胃肠道表现的多血管炎

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Case Reports in Immunology Pub Date : 2016-02-17 DOI: 10.1155/2016/8341751

Kohei Tsujimoto, M. Yagita, M. Taniguchi, M. Fujita

引用次数: 3

Autoimmune Lymphoproliferative Syndrome: A Rare Cause of Disappearing HDL Syndrome. 自身免疫淋巴增生性综合征:消失的HDL综合征的罕见原因。

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Case Reports in Immunology Pub Date : 2016-01-01 Epub Date: 2016-08-08 DOI: 10.1155/2016/7945953

Swetha Sriram, Avni Y Joshi, Vilmarie Rodriguez, Seema Kumar

{"title":"Autoimmune Lymphoproliferative Syndrome: A Rare Cause of Disappearing HDL Syndrome.","authors":"Swetha Sriram, Avni Y Joshi, Vilmarie Rodriguez, Seema Kumar","doi":"10.1155/2016/7945953","DOIUrl":"https://doi.org/10.1155/2016/7945953","url":null,"abstract":"<p><p>The term disappearing HDL syndrome refers to development of severe high density lipoprotein cholesterol (HDL-C) deficiency in noncritically ill patients with previously normal HDL-C and triglyceride levels. Autoimmune lymphoproliferative syndrome (ALPS) is a disorder of the immune system due to an inability to regulate lymphocyte homeostasis resulting in lymphadenopathy and hepatosplenomegaly. We describe a 17-year-old boy who was evaluated in the lipid clinic for history of undetectable or low HDL-C and low density lipoprotein cholesterol (LDL-C) levels. Past medical history was significant for ALPS IA diagnosed at 10 years of age when he presented with bilateral cervical adenopathy. He was known to have a missense mutation in one allele of the FAS protein extracellular domain consistent with ALPS type 1A. HDL-C and LDL-C levels had been undetectable on multiple occasions, though lipids had not been measured prior to the diagnosis of ALPS. He had been receiving sirolimus for immunosuppression. The HDL-C and LDL-C levels correlated with disease activity and improved to normal levels during times when the activity of ALPS was controlled. This case highlights the importance of considering ALPS as a cause of low HDL-C and LDL-C levels in a child with evidence of lymphoproliferation. </p>","PeriodicalId":42865,"journal":{"name":"Case Reports in Immunology","volume":"2016 ","pages":"7945953"},"PeriodicalIF":1.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/7945953","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34350937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5