International Journal of Cancer and Biomedical Research最新文献

{"title":"The Effect of Implementing Peripherally Inserted Central Catheter Educational Program on Nurses' Knowledge, Practice, and Neonatal Outcomes: Thesis Abstract","authors":"Omnia Saltah, F. Abusaad","doi":"10.21608/JCBR.2021.59939.1137","DOIUrl":"https://doi.org/10.21608/JCBR.2021.59939.1137","url":null,"abstract":"IJCBR (jcbr.journals.ekb.eg) is published by Egyptian Society of Cancer Research (eacr.tanta.edu.eg) and sponsored by the Egyptian Knowledge Bank (www.ekb.eg) 1 The effect of implementing peripherally inserted central catheter educational program on nurses' knowledge, practice, and neonatal outcomes Omnia Saltah1 and Fawzia Abusaad2 University, Egypt Pediatric Nursing, Faculty of Nursing, Mansoura 1 Pediatric Nursing Department, Faculty of Nursing, Mansoura University, Egypt 2 Background: The peripherally inserted central catheters (PICCs) have become among the most common technologies employed in the intravenous therapy of neonates as they allow safe long-term intravascular access, comfort, and ease of transition to home therapy that contributed to the increased survival of those newborns. Aim: This study aimed to evaluate the effect of implementing peripherally inserted central catheter educational program on nurses' knowledge, practice, and neonatal outcomes. Materials and Methods: pretest-posttest quasi-experimental design was conducted on 45 neonatal nurses working at neonatal intensive care units affiliated to Mansoura University Children Hospital (MUCH) with a purposive sample of (20) neonates admitted to NICU throughout six months and need PICC line insertion was enrolled in the study. Tools of data collection: Data were collected by using three tools: Peripherally inserted central catheter insertion questionnaire sheet, PICC line insertion and care observational checklist and neonatal assessment sheet. Results: Majority of studied nurses had poor knowledge and more than half had competent skills about PICC before program implementation while after program implementation there was more than half had average knowledge and two third had competent practices as well as there is decrease in the prevalence of neonatal complication. Conclusion: There was appositive effect of the educational program on nurse’s knowledge and skills as well as neonatal. Recommendation: Continuing of nursing education and practices about PICC lines.","PeriodicalId":428417,"journal":{"name":"International Journal of Cancer and Biomedical Research","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127983171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Welcome note","authors":"N. Elmashad","doi":"10.21608/jcbr.2020.51793.1100","DOIUrl":"https://doi.org/10.21608/jcbr.2020.51793.1100","url":null,"abstract":"","PeriodicalId":428417,"journal":{"name":"International Journal of Cancer and Biomedical Research","volume":"24 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132731304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of TROP2, Cyclin D1 and FOXP3 in Bladder Carcinoma in Egyptian Patients: An Immunohistochemical Study","authors":"D. Al-Sharaky, Moshira Abdelwahed, H. Kassem, A. Abdelnaby","doi":"10.21203/rs.3.rs-91173/v1","DOIUrl":"https://doi.org/10.21203/rs.3.rs-91173/v1","url":null,"abstract":"\u0000 BackgroundIn Egypt, Urinary bladder carcinoma is a common malignancy accounting for 14.3% of total malignancies in both sexes with 3:1 male to female ratio. It comprises 88.3% of the total urinary system tumors. To reduce bladder cancer morbidity and mortality there is an urgent need to identify novel tumor marker which are specific enough for prognosis and can serve as effective anticancer targets .Therefore the purpose of this study is to evaluate the role of TROP2, CYCLIN D1, FOXP3 and their relationship with the established clinico-pathological parameters and overall survival of bladder cancer in Egyptian patientsMethodsUsing the standard immunohistochemical technique, TROP2, CYCLIN D1 and FOXP3 expression in 80 primary bladder carcinomas and 20 specimens as non neoplastic group were assessed. The bladder carcinoma cases included 50 cases with muscle invasive bladder cancer and 30 cases with non-muscle invasive bladder cancer ResultsOverexpression of both TROP2 and FOXP3 implied poor prognostic impact as significantly associated with muscle invasive bladder cancer, high grade, advanced stage, lymph node involvement and high mitotic count. Cyclin D1 displayed an inverse relation with both TROP2 and FOXP3 reflecting a favorable prognostic impact. Tumoral FOXP3 expression is directly correlated with peritumoral FOXP3+ lymphocytes expression. TROP2, CYCLIN D1, FOXP3 expression didn’t affect the overall survival of the studied sample.ConclusionsThe inverse relation between Cyclin D1 and TROP2 proposes consumption of Cyclin D1 by TROP2 as a ligand in the urinary bladder carcinogenesis. Strong diffuse overexpression of both TROP2, and FOXP3 could be promising potential biomarkers for identifying patients with poor prognostic factors in bladder cancer serving as potential targets for cancer therapy.","PeriodicalId":428417,"journal":{"name":"International Journal of Cancer and Biomedical Research","volume":"100 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123631216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"O6-MethylGuanine-DNA Methyltransferase (MGMT) Promoter Methylation Status Analysis in High-Grade Gliomas","authors":"Hodan Ibrahim, A. Matter, A. Abdel-Aziz, F. Badr, E. Abdelmoemen","doi":"10.21608/JCBR.2020.32135.1043","DOIUrl":"https://doi.org/10.21608/JCBR.2020.32135.1043","url":null,"abstract":"Background: The O6-methylguanine- DNA methyltransferase (MGMT) gene is frequently silenced by promoter hypermethylation in malignant gliomas and this has been pinpointed as an epigenetic mechanism reducing MGMT expression levels. The status of MGMT promoter hypermethylation and its relation to tumor progression in gliomas is under extensive study and previous studies have shown conflicting results on the significance of this epigenetic biomarker in relation to the tumor phenotype and clinical outcome. So, in our study, we assessed the role of the epigenetic biomarker; MGMT promoter methylation status, in high-grade glioma patients and correlated the results with the tumor phenotype and clinical outcome. Methods: The study included 40 high-grade glioma patients, assessed for MGMT promoter methylation status using methylation-specific PCR (MSP), and correlated the results with clinico-histopathological parameters and survival using appropriate statistical methodologies. Results: MGMT promoter methylation analysis revealed 65% of patients with the methylated promoter and 35% with unmethylated ones with no significant prognostic or predictive implications related to different treatment modalities (surgical, chemotherapy or radiation), recurrence rate, or overall survival. Conclusion: MGMT promoter methylation status role is not definitive in directing high-grade glioma patients’ clinical decision making. Further studies are needed for investigating its role as an epigenetic marker in high-grade gliomas in Egyptian patients.","PeriodicalId":428417,"journal":{"name":"International Journal of Cancer and Biomedical Research","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123128337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the prognostic significance of P53 and Proliferating cell nuclear antigen (PCNA) in laryngeal squamous cell carcinoma","authors":"Asmaa E. Bedeer, M. El-Rashidy, S. Elzayat, H. Elsherif","doi":"10.21608/jcbr.2020.31528.1042","DOIUrl":"https://doi.org/10.21608/jcbr.2020.31528.1042","url":null,"abstract":"","PeriodicalId":428417,"journal":{"name":"International Journal of Cancer and Biomedical Research","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114964157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adipocytokine, leptin, and resistin in combination with quantitative visceral adiposity as predictors of colorectal neoplasm: A case-control study","authors":"E. A. Shafik, D. Mohareb, H. Hetta, S. Khallaf, N. M. A. el-Rady, Zainab Gaber, Mohamed Zakaria Abu Rahma, W. Abbas, Haisam Atta","doi":"10.21608/jcbr.2020.28094.1029","DOIUrl":"https://doi.org/10.21608/jcbr.2020.28094.1029","url":null,"abstract":"Background: Substantial evidence has supported the association between adipocytokines and many types of cancers. However, the results in the setting of colorectal cancer (CRC) remains conflicting. Aim: This study aimed to evaluate the predictive power of adipocytokines (leptin and Rrsistin) levels and abdominal fat distribution in the diagnosis of colorectal cancer. Methods: Eighty participants were recruited then divided into three groups based on the endoscopic and histopathological investigation. The recruited individuals included 30 patients with colon cancer, 25 with colonic adenoma, and 25 controls. Serum adipocytokines (leptin and resistin) levels were measured, and the quantitative fat analysis was calculated based on an abdominal CT scan. Results: Multivariable logistic regression revealed that two predictors (leptin and resistin) of CRC development could be used. Visceral/superficial fat rate was the most significant predictor among the parameters of quantitative fat analysis. Also, psoas muscle and visceral fat volume showed significant differences among the study groups. Conclusion: Leptin and resistin can be used as a valuable independent predictor for the diagnosis of colorectal cancer. Also, the visceral/superficial fat rate was the most predictor.","PeriodicalId":428417,"journal":{"name":"International Journal of Cancer and Biomedical Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130368044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between the ACE (I/D) Gene Polymorphism and Hepatocellular Carcinoma Risk in Egyptian HCV Patients","authors":"N. Elabd, B. Montaser, Heba F. Khader, S. Gohar, K. Makboul, M. Elhamoly","doi":"10.21608/jcbr.2020.29926.1037","DOIUrl":"https://doi.org/10.21608/jcbr.2020.29926.1037","url":null,"abstract":"Abstract \u0000Background and Study Aims: Hepatocellular carcinoma (HCC) is one of the most fatal malignancies worldwide and is related to many risk factors. Chronic Hepatitis C virus (HCV) is associated with a 20–30-fold increased risk for HCC. Angiotensin-converting enzyme (ACE) is over expressed in many cancers and plays a major role in both angiogenesis and carcinogenesis. We aimed to elucidate the effect of the ACE I/D gene polymorphism in patients with HCV-related liver cirrhosis and HCC, as well as its relationship to clinical parameters. \u0000 \u0000Patients and Methods: The study included 120 patients, 60 cirrhotic and 60 HCC, and 60 healthy subjects (controls). Liver and renal function tests, alpha-fetoprotein, HCV antibodies and triphasic CT were assessed. Gene polymorphism was assessed by Nested PCR. \u0000 \u0000Results: We observed higher frequencies of DD (36.7%) and DI (51.7%) genotypes, along with the D allele (62.5%),in HCC compared to those of cirrhotic cases (10%, 40% and 30%, respectively; P< 0.001) and control subjects (6.7%, 38.3%, and 25.8%, respectively; P< 0.001). DD and DI genotypes increased the risk and predicted the occurrence of HCC by OR 25.932 [95% CI: 6.78 – 99.19] and OR 6.354 [95% CI: 2.39 – 16.89], respectively, compared to control subjects (OR 15.714 [95% CI: 4.63 – 53.30]) and cirrhotic cases (OR 5.536 [95% CI: 2.08 – 14.75]). The D allele conveys significant risk for HCC compared to control and cirrhotic groups with OR 4.785 [95% CI: 2.76 – 8.30] and OR 3.889 [95% CI: 2.27 – 6.66], respectively. Both the DD genotype and D allele are significantly correlated with larger tumor size (P<0.001) and metastasis (P<0.001). \u0000 \u0000Conclusion: The ACE I/D polymorphism (DD genotype and D allele) is significantly associated with HCC risk in HCV patients and is correlated with increased tumor growth and advanced stage","PeriodicalId":428417,"journal":{"name":"International Journal of Cancer and Biomedical Research","volume":"79 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115827541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paclitaxel as a possible continuation maintenance therapy in advanced non-small-cell lung cancer","authors":"S. Gohar, Amira Hegazy, S. Alhassanin, M. Shehata, N. Bary, Khaled Abd El Aziz","doi":"10.21608/jcbr.2020.29694.1036","DOIUrl":"https://doi.org/10.21608/jcbr.2020.29694.1036","url":null,"abstract":"Background: Understanding the molecular basis of lung cancer has led to the development of targeted agents with a significant clinical benefit. This benefit is confined to patients with specific molecular tumor characteristics. However, chemotherapy represents the backbone of treatment in fit patients and is associated with a significant overall survival prolongation and quality of life improvement. Aim: To evaluate the effect of a continuation maintenance therapy with paclitaxel in advanced NSCLC patients with weekly paclitaxel. Patients and Methods: The current study included patients with advanced non-small-cell lung cancer (NSCLC) (stage IIIB or IV) with performance status ≤ 2 who experienced good initial good response, or stable disease after receiving 4 cycles of paclitaxel carboplatin. Patients were randomized into 2 arms, the first arm received weekly paclitaxel (70 mg/m2) as continuation maintenance therapy for 3 weeks of 4 weeks cycle. The treatment was continued until disease progression or unacceptable toxicity (maintenance arm). The second arm was kept under observation (observation arm). Results: There was a better lung cancer symptoms scale in the maintenance arm. Both times to progression and overall survival for the maintenance arm was higher (P value 0.16 and 0.047, respectively). Treatment-related toxicities were significantly higher in the maintenance arm as compared to the observation arm (P value <0.001). Conclusion: Maintenance with paclitaxel can be a reasonable option in patients with NSCLC who experienced a complete or partial response after initial paclitaxel carboplatin combination.","PeriodicalId":428417,"journal":{"name":"International Journal of Cancer and Biomedical Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131322800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of balanitoside and gemcitabine on serum biochemistry during mouse lung carcinogenesis","authors":"E. Salim, Fouad A Abou-Zaid, Abeer A. Khamis, Sara S Abou-Eisha","doi":"10.21608/JCBR.2020.16116.1001","DOIUrl":"https://doi.org/10.21608/JCBR.2020.16116.1001","url":null,"abstract":"Gemcitabine is utilized as standard malignancy chemotherapy although its use is limited due to severe side effects. In the present study, we studied the impact of Balanitoside, extracted from Balanites aegyptiaca fruits on mouse serum biochemistry during chemically-inducted (Ure+ BHT) lung carcinogenesis, individually or combined with Gemcitabine chemotherapy. Our results reveal that elevated serum levels of alanine and aspartate transaminases caused by Ure+BHT injection was inhibited in mice treated with ethanolic extract of B. aegyptiaca, indicating its hepatoprotective actions either alone combined with gemcitabine. Also, the doses of B. aegyptiaca extract used here has enhanced the renal function parameters as it improved the changes by Ure+BHT occurred in serum urea, creatinine and uric acid levels. Moreover, the present data showed increased serum cholesterol, triglyceride and low-density lipoprotein (LDL) levels and a decrease in high-density lipoprotein (HDL) levels after carcinogen-treatment when compared with normal group, these were improved by B. aegyptiaca either alone or combined with gemcitabine. In conclusion, the B. aegyptiaca extract has significant modulatory effects and chemo-preventive properties against deranged serum biochemical levels in mouse lung carcinogenesis both alone or combined with gemcitabine. Thus, further investigations are warranted","PeriodicalId":428417,"journal":{"name":"International Journal of Cancer and Biomedical Research","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124167087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High expression of the checkpoint molecule PD-1 on regulatory and helper CD4+ T cells in metastatic breast cancer patients with poor prognosis","authors":"M. Esmail, M. Attia, Sameh Abd-Alaziz, S. El-Naggar, M. Salem","doi":"10.21608/jcbr.2020.22585.1010","DOIUrl":"https://doi.org/10.21608/jcbr.2020.22585.1010","url":null,"abstract":"Background: Recurrence and metastasis are common in patients of breast cancer even after chemotherapy and radiotherapy. This recurrence may occur due to the emergence of immunoregulatory T (Treg) cells and the immune checkpoint molecules such as programmed cell death protein 1 (PD-1) which are known to suppress anti-tumor immunity. Aim: The aim of this study is to investigate the numbers of Treg cells and the expression of PD-1 molecule on T cells in the peripheral blood of breast cancer patients at different stages (II, III, and IV) compared to healthy individuals. Materials and Methods: Blood samples were collected from early diagnosed metastatic cancer patients before surgery. Leucocytes were stained with different antibodies including CD4, CD25, CD127, and PD1, and then were analyzed by multiparametric flow cytometry. Results: The results showed that the relative and absolute numbers of Treg cells were significantly increased in breast cancer patients. Interestingly, we found a correlation between the numbers and cancer progression from stages II to III and IV, as compared with healthy individuals. Furthermore, significant increases in PD-1 expression were observed on Treg cells and CD4+ T cells in cancer patients as compared to healthy controls. This profile of PD-1 expression was also correlated with the poor prognosis of the patients. Conclusion: The results provide a better understanding of the immunomodulatory role of Treg cells and PD-1 expression in breast cancer patients who are the target for immunotherapy using checkpoint inhibitors.","PeriodicalId":428417,"journal":{"name":"International Journal of Cancer and Biomedical Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131189753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}