International Journal of Cancer and Biomedical Research最新文献

{"title":"Carbon Nanostructures as promising Targeted Drug Delivery systems of Anticancer Agents","authors":"Mahmoud Elsayed","doi":"10.21608/jcbr.2024.250410.1323","DOIUrl":"https://doi.org/10.21608/jcbr.2024.250410.1323","url":null,"abstract":"Nanotechnology has opened new paths for cancer treatment, with carbon nanostructures (CNSs) becoming drug delivery vehicles. This review examines fullerenes, carbon nanotubes (CNTs), graphene, and their derivatives as effective drug delivery vehicles for anticancer therapies. Their high surface area, ease of functionalization, exceptional thermal and electrical conductivity, and ability to cross biological barriers make them ideal candidates for improving anticancer drug specificity, bioavailability, and therapeutic efficacy while minimizing systemic toxicity. The biocompatibility and changeable surfaces of CNSs provide targeted delivery to treat cancer cell heterogeneity. This precision targeting reduces chemotherapy side effects. Adding ligands, antibodies, and peptides to CNSs makes them more selective for cancer cells, letting the therapeutic payload go to the tumor site. Because they absorb a lot of light, graphene-based nanostructures can be used in photothermal therapy and photoacoustic imaging to treat and keep an eye on cancers without cutting them open. CNSs in multimodal cancer treatment techniques, such as radio-chemotherapy, may improve cancer treatment. After clinical research and biocompatibility improvements, CNSs could transform cancer treatment with more precise, efficient, and less toxic choices. Thus, using carbon nanostructures in cancer treatment marks a breakthrough in nanomedicine and a new age of focused and effective cancer treatments .","PeriodicalId":428417,"journal":{"name":"International Journal of Cancer and Biomedical Research","volume":" March","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140092604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tramadol and/or Ketamine Repurposing as Potential Anticancer Drugs in Metastatic Castration-Resistant Prostate Cancer Cell Lines","authors":"Neveen Hussein, mohammad Ahmad, Khaled Ali","doi":"10.21608/jcbr.2024.255088.1327","DOIUrl":"https://doi.org/10.21608/jcbr.2024.255088.1327","url":null,"abstract":"Prostate cancer (PCa) progression to androgen independence is the main cause of death. Although all metastatic patients initially responded to anti-androgen therapy, most of them failed hormonal treatments in less than 2 years. Tramadol is an opioid agonist with the central effect of treating pain. Ketamine is a flexible medication that has a wide range of clinical uses. This in vitro study evaluated the repurposing of tramadol and/or ketamine as potential anticancer drugs. Moreover, the impact of these drugs on cell death pathways was assessed. PC-3 and DU145 cell lines were treated with tramadol and/or ketamine. Apoptosis, autophagy, necroptosis, parthanatos, endoplasmic reticulum stress, the Raf/MEK/ERK pathway, and epithelial-mesenchymal transition-related genes were determined by real-time PCR. Current data showed upregulation of most gene expression in PC-3 cells treated with TRA and/or KET compared to untreated cancer cells, except for N-cadherin, which was insignificantly downregulated by KET. On the other hand, gene expressions in DU145 showed an insignificant difference in all treated cells compared to each other or untreated cancer cells, except for significant up-regulation of ATG3, Beclin1, and ATF6 by KET (P = 0.047, 0.035, and 0.042, respectively), IRE1 by TRA (P = 0.023) and N-cadherin by the combined drug (P = 0.014) compared to untreated cells. PC-3 cells were significantly more susceptible to tramadol and/or ketamine than DU145 cells. ROS-induced cell death pathways could be the mechanism by which tramadol and ketamine exert their anticancer effects against metastatic PCa. Targeting cell death pathways is an ideal strategy for developing new anticancer therapies .","PeriodicalId":428417,"journal":{"name":"International Journal of Cancer and Biomedical Research","volume":"502 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140274376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights into the Clinico-Epidemiological Aspects of Non-Epithelial Ovarian Tumor Emphasizing Diagnosis and Tailored Surgical Approach; a Single Institutional Retrospective Study","authors":"Ahmad Abdelrahman, Asmaa Eldmaty, Ahmed Elshahat, Shih Min Hsia, Rasha Abdellatif","doi":"10.21608/jcbr.2024.265911.1337","DOIUrl":"https://doi.org/10.21608/jcbr.2024.265911.1337","url":null,"abstract":"Background: Ovarian cancers account for approximately 27% of all female tumors, with non-epithelial ovarian cell carcinoma being rare at around 10% of overall ovarian cancer cases. The aim of this study is to recognize the prognostic factors Reporting survival outcome in the form of OAS, DFS, and PFS. Aim and Objectives: The aim of the study is: Defining the lines of treatment have been uses and recognize the prognostic factors Reporting survival outcome in the form of OAS, PFS, and DFS. Patients and Methods: This study included fifty-six patients, who had recruited in the period between January 2005 and December 2020 with the following criteria: Proven non-epithelial ovarian carcinoma, all stages, age greater than 18 years. All statistical analyses will be performed using a software tool (SPSS) (statistical package for social sciences) version 26. Quantitative data will be summarized as medians & minimum-maximum values (range) or mean & standard deviation, while qualitative data as percentages. The results will be considered significant if the p-value was < 0.05. Results: all 56 patients (100%) underwent surgery: 96.4% had upfront early debulking, and 3.6% had interval debulking post-neoadjuvant chemotherapy. Fertility Sparing Surgery was performed in 50%, optimal debulking in 41.4%. Surgical debulking left no residual disease in 78.6% (44 patients); 12 patients had residual disease (R1 or R2). Chemotherapy was administered to 55.4% of patients, with 67.7% receiving the BEP regimen and 9 patients receiving other regimens. Pathological responses in 12 patients with residual disease 75% achieved complete response. After a median follow-up of 61 months (20 to 200 months), the study found a median (OAS) of 66 months (22-201 months). The 5-year OAS rate was 94.6% for 53 patients. Median (PFS) was 66 months (15-201 months), with a 5-year PFS rate of 85.7% for 48 patients. Among 44 completely treated patients, (DFS) was 83 months (range: 24-201 months), with a 5-year DFS rate of 93.2% for 41 patients. (Supplementary table is available). Conclusion: According to the data presented in this study, by univariate analysis; performance status, stage, type of surgery, and tumor residual after debulking surgery were significant prognostic factors for survival .","PeriodicalId":428417,"journal":{"name":"International Journal of Cancer and Biomedical Research","volume":"38 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140086383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlating DNMT1, PCNA, and RB1 genes as new prognostic biomarkers","authors":"Rady El-Araby, Marwa Mona, Mariam Zaghloul, Maha Morsi, Mosaad Ibrahim, Wafaa Radwan, Amr Rezk, Mohamed Shaheen, Walid Abusheir, Yasmine Elhusseny, Reham Othman, Hany X Elghobary","doi":"10.21608/jcbr.2024.252496.1325","DOIUrl":"https://doi.org/10.21608/jcbr.2024.252496.1325","url":null,"abstract":"Background: Hepatocellular carcinoma (HCC) can be successfully treated, and long-term survival rates can be significantly improved if diagnosed early enough","PeriodicalId":428417,"journal":{"name":"International Journal of Cancer and Biomedical Research","volume":"87 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140086949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitogen-Activated Protein Kinase 2 Relevance for the in-vitro Chemo-Sensitivity and Clinical Response in Children with Acute Lymphoblastic Leukemia in Mansoura University Hospitals","authors":"M. Mortada, Asmaa El-Rakhawy, Ahmad Darwish, Nabil Adeb, G. Dahab","doi":"10.21608/jcbr.2023.218437.1306","DOIUrl":"https://doi.org/10.21608/jcbr.2023.218437.1306","url":null,"abstract":"Background : Identification of different prognostic biomarker of pediatric acute lymphoblastic leukemia (ALL) permits more characterization of patient subgroups and helps the risk-adapted treatment strategies. Aim : Our study assessed the role of Mitogen-Activated Protein Kinase (ERK1/2) as a prognostic biomarker of pediatric ALL in MUH patients. Another aim is to detect the relevance of ERK1/2 for the in-vitro leukemic cells response to chemotherapeutic agents (Vincristine, L-asparaginase Dexamethasone and Doxorubicin). Material and Methods : ERK1/2 was measured in the bone marrow aspirates of 26 children with newly diagnosed ALL by ELISA technique. The MTT in vitro chemo-sensitivity assay was used to detect in-vitro leukemic cells response. Results: At diagnosis, the pERK 1/2 and tERK 1/2 are significantly higher in the HR gp than SR gp (p-value =0.000 & 0.003 respectively). While the pERK/tERK 1/2 ratio at diagnosis was significantly higher than that post induction in the patients of our study (p-value= 0.03) . A significant association was detected between in vitro chemo-sensitivity to vincristine, l-asparaginase, dexamethasone & doxorubicin and complete remission after induction therapy, respectively). Conclusion : Our results indicated that ERK1/2 could be considered as an independent predictor of complete remission. Besides, a significant positive correlation was detected between ERK 1/2 and in vitro leukemic cells response to the four chemotherapeutic agents at diagnosis.","PeriodicalId":428417,"journal":{"name":"International Journal of Cancer and Biomedical Research","volume":"44 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139390185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NRF-2 and KEAP-1 Expression in Pancreatic Cancer Patients: A clinicopathological study","authors":"M. Fawzy, Heba Sheta, H. Elkalla, W. Yusuf","doi":"10.21608/jcbr.2023.230174.1312","DOIUrl":"https://doi.org/10.21608/jcbr.2023.230174.1312","url":null,"abstract":"Background : Pancreatic cancer is one of the main causes of death in many nations. A delayed diagnosis would be detrimental because it has a bad prognosis and has poor specific symptoms and indicators. Additionally, it demonstrates a significant level of chemotherapeutic treatment resistance. Oxidative stress has a key role in the aetiology of pancreatic cancer. The transcription factor NRF2 controls how the body responds to oxidative stress since it interacts with Keap1, causing it to be targeted for ubiquitylation and proteasomal destruction. In cancer biology, Nrf2 has a double-edged sword depending on the stage of carcinogenesis. Aim : The study aimed to investigate the expression of Keap1 and Nrf2 in pancreatic cancer cells and to compare the findings to other clinicopathological parameters. Materials and Methods : A retrospective study was done on 45 pancreatic carcinoma patients. Immunohistochemical staining for Nrf2 and Keap1 was done and correlated with clinicopathological parameters. Results : Significant statistical associations were found between NRF2 expression with duodenal and pancreatic infiltration. A significant relation was seen between Keap1 expression and duodenal infiltration as well as between NRF2 expression and Keap1 expression in tumor cells. Conclusion : Nrf2 and Keap1 may play important roles in pancreatic carcinogenesis.","PeriodicalId":428417,"journal":{"name":"International Journal of Cancer and Biomedical Research","volume":"632 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139024566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of PI3KCA immunohistochemical expression and tumor infiltrating lymphocytes (CD4 and CD8) in invasive breast carcinoma and their relation to molecular subtypes","authors":"M. Eldeib, Safinaz Elshorbagy, Asmaa E. Bedeer, N. Heabah","doi":"10.21608/jcbr.2023.240668.1317","DOIUrl":"https://doi.org/10.21608/jcbr.2023.240668.1317","url":null,"abstract":"","PeriodicalId":428417,"journal":{"name":"International Journal of Cancer and Biomedical Research","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139017160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Utility of Trichorhinophalangeal Syndrome Type 1 (TRPS1) immunostain in breast carcinoma compared to GATA3","authors":"Nadia Elafify, H. Alshenawy, Heba Harras, Duaa S. Helal","doi":"10.21608/jcbr.2023.200224.1297","DOIUrl":"https://doi.org/10.21608/jcbr.2023.200224.1297","url":null,"abstract":"Background : Female breast cancer (BC) has become the most diagnosed cancer and the fifth cause of cancer mortality worldwide. Metastatic breast cancer is a main differential diagnosis for any suspected metastatic carcinoma in women due to its high incidence. It’s essential to identify a specific and sensitive marker to diagnose primary breast cancer. TRPS1 is a nuclear transcription factor, belonging to the GATA family with a transcriptional repressor function. The aim of the present study was to assess the diagnostic value of TRPS1 in the detection of BC cases compared to the routinely used GATA3 immunostain. Material and Methods: Seventy BC specimens and 80 specimens of non-breast carcinomas known to exhibit morphological similarity to metastatic breast cancer or show GATA3 positivity were evaluated for immunohistochemical expression of TRPS1 and GATA3. Results: TRPS1 and GATA3 were positive in 92.9% and 80% of studied BC specimens with a specificity of 96.3% and 80%, respectively. TRPS1 was found to be more sensitive and specific than GATA3 in the detection of BC. Conclusions: TRPS1 can be considered as a diagnostic marker of BC since it is more sensitive and specific than GATA3 . The double combination of TRPS1 and GATA3 provided higher sensitivity and specificity in detection of BC.","PeriodicalId":428417,"journal":{"name":"International Journal of Cancer and Biomedical Research","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123992024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of serum carbonic anhydrase IX in Egyptian patients with cirrhosis and/ or hepatocellular carcinoma.","authors":"Heba M. Abd El Latif, I. El-Elaimy, O. Hendy, Naglaa Meghawry, A. Zied","doi":"10.21608/jcbr.2023.206235.1303","DOIUrl":"https://doi.org/10.21608/jcbr.2023.206235.1303","url":null,"abstract":"Introduction : Hepatocellular carcinoma (HCC) is the commonest type of primary liver cancers, and most patients are diagnosed in advanced or terminal stages with poor prognosis. Furthermore, cirrhosis, a chronic liver disease characterized by fibrosis and impaired liver function, is a major risk factor for the development of HCC. Therefore, it is crucial to establish new clinical markers for early HCC diagnosis and staging. Aim: Our study aimed to evaluate carbonic anhydrase IX (CA9) as an early serum biomarker for HCC diagnosis within cirrhotic Egyptian patients. Material and methods: Fifty-eight cirrhotic patients and sixty HCC patients as well as fifty-eight healthy control subjects were selected for the current study. Routine liver tests, CBC, C-reactive protein, alpha-fetoprotein (AFP), and serum CA9 were done for all the patients included. Results: Serum CA9 and AFP levels increased significantly in HCC and cirrhotic patients compared to controls. CA9 increased with the development of hepatic disease through the direct proportion of CA9 with BCLC staging, child classification, ascites, and encephalopathy in the HCC cohort and the direct proportion with child classification and ascites in the cirrhotic cohort. Our findings showed that CA9 has higher accuracy than AFP to differentiate between HCC (at cutoff value>85 pg/mL) or cirrhotic patients (at cutoff value>54.7 pg/mL) and control with greater sensitivity and specificity than AFP. On the other hand, CA9 showed lower sensitivity and specificity than AFP in discrimination between cirrhosis and HCC only 51.67% and 46.55%, respectively. Conclusions: CA9 could be used as a biomarker for early HCC diagnosis and there is a strong relationship between CA9 level and HCC´s worse prognosis suggesting its potential role in HCC development and disease progression.","PeriodicalId":428417,"journal":{"name":"International Journal of Cancer and Biomedical Research","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127907957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Schistosomicidal and immunological properties of Grape seed extract during murine Schistosoma mansoni infection","authors":"Alshimaa M. Elmalawany, H. Mahmoud, A. Mohamed","doi":"10.21608/jcbr.2023.184278.1288","DOIUrl":"https://doi.org/10.21608/jcbr.2023.184278.1288","url":null,"abstract":"","PeriodicalId":428417,"journal":{"name":"International Journal of Cancer and Biomedical Research","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122647142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}