International Journal of Cancer and Biomedical Research最新文献_第2页

TIP-1 is a Degradation Target of HPV-16 E6 TIP-1是hpv - 16e6的降解靶标

International Journal of Cancer and Biomedical Research Pub Date : 2023-06-01 DOI: 10.21608/jcbr.2023.186125.1289

M. Elsherbeny, Miranda Thomas, P. Massimi, L. Banks

引用次数: 0

Incense smoke inhalation affects spermatogenesis and sperm quality and impairs liver and kidney function in adult male rats 熏香烟雾吸入影响成年雄性大鼠的精子发生和精子质量，损害肝肾功能

International Journal of Cancer and Biomedical Research Pub Date : 2023-06-01 DOI: 10.21608/jcbr.2023.200215.1296

Tarek El Sewedy, N. Ismail, S. Ismail

{"title":"Incense smoke inhalation affects spermatogenesis and sperm quality and impairs liver and kidney function in adult male rats","authors":"Tarek El Sewedy, N. Ismail, S. Ismail","doi":"10.21608/jcbr.2023.200215.1296","DOIUrl":"https://doi.org/10.21608/jcbr.2023.200215.1296","url":null,"abstract":"Background : Despite the growing evidence indicating the association between inhalation of traditional incense smoke (IS) and the increased risk of numerous health issues, its possible effect on spermatogenesis is still confusing. Aim: The present study was designed to address the hypothesis that exposure to traditional IS may impact sperm quality and affect liver and kidney function. Material and Methods: Using a rat model, we evaluated the effects of IS exposure on semen quality by Computer-Assisted Semen Analysis (CASA) and blood samples were collected for the determination of random blood glucose, C-reactive protein (CRP), liver and kidney function parameters and testosterone levels. Results: Prolonged inhalation of IS caused a highly significant decrease in testosterone levels compared with the control group. Moreover, complete semen analysis indicated that sperm’s progressive motility, velocity, and vigor parameters were significantly decreased in IS-exposed groups compared with the unexposed group. Also, IS inhalation significantly increased the percentage of morphologically abnormal sperms. Biochemically, prolonged inhalation of IS caused a significant decrease in blood glucose while blood CRP, liver, and kidney function biomarkers were significantly elevated compared with the control group, reflecting potential toxicity. Conclusion: We concluded that excessive and prolonged IS inhalation may cause a remarkable deterioration in spermatogenesis, sperm quality as well as kidney and liver function.","PeriodicalId":428417,"journal":{"name":"International Journal of Cancer and Biomedical Research","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125072345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of pelvic lymph node dissection in endometrial carcinoma 子宫内膜癌盆腔淋巴结清扫的评价

International Journal of Cancer and Biomedical Research Pub Date : 2023-06-01 DOI: 10.21608/jcbr.2023.203411.1299

A. Elazab, M. Taher, Mohamed Salama, Nadhmi Rashad, Noha E Ezzat, I. Abdelrahman

{"title":"Evaluation of pelvic lymph node dissection in endometrial carcinoma","authors":"A. Elazab, M. Taher, Mohamed Salama, Nadhmi Rashad, Noha E Ezzat, I. Abdelrahman","doi":"10.21608/jcbr.2023.203411.1299","DOIUrl":"https://doi.org/10.21608/jcbr.2023.203411.1299","url":null,"abstract":"Background : Pelvic and para-aortic lymphadenectomy is suggested to provide prognostic and therapeutic benefits in endometrial carcinoma, particularly in high-risk and advanced tumors. Aim : Herein we compare the oncological and surgical outcomes in patients with and without pelvic lymphadenectomy performed. Patients and Methods: A retrospective study, included endometrial carcinoma patients who underwent hysterectomy at National Cancer Institute, Egypt from January 2013 to December 2017. We divided the patients into two groups according to the documented operative details, one group was subjected to pelvic lymphadenectomy (PLN), and one group had no lymphadenectomy done (No PLN). Results : 90 patients (60 patients had PLN, 30 patients had no PLN). The death rate was higher in the No PLN group compared to the PLN (36.7% vs 20%). The mean overall survival (OS), and disease-free survival (DFS) were nearly equal in both groups. Retroperitoneal nodal recurrence occurred in 6 patients in the PLN group out of 18 recurrences (33.3%) and in 5 patients in the no PLN group out of 11 recurrences (45.5%) with a p-value=0.869. The 5-year DFS in PLN and No PLN groups was 50% and 26.7% respectively, and the 5-year OS in PLN and No PLN groups was 70%, and 60 %, respectively but statistically not significant. Early postoperative complications occurred in 24 patients (40%) in the PLN group and 12 patients (40%) in the No PLN group. Conclusion: Excluding patients with low risk for nodal disease in endometrial carcinoma, pelvic lymphadenectomy may have a positive impact on survival or recurrence patterns.","PeriodicalId":428417,"journal":{"name":"International Journal of Cancer and Biomedical Research","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129293595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic implications of glutathione perioxiade2 (GPx2) and the stemness associated marker SOX2 in colonic carcinoma 谷胱甘肽周期化2 (GPx2)和干性相关标记物SOX2在结肠癌中的预后意义

International Journal of Cancer and Biomedical Research Pub Date : 2023-06-01 DOI: 10.21608/jcbr.2023.198226.1294

A. Eid, Radwa S. Awad, S. Darwish, F. Ibrahim

引用次数: 0

Epidemiology of Colorectal Cancer in Rural Population 农村结直肠癌流行病学研究

International Journal of Cancer and Biomedical Research Pub Date : 2023-06-01 DOI: 10.21608/jcbr.2023.188360.1291

S. Shaaban, Sarah Hamdy

引用次数: 0

Evaluation of the clinicopathological significance of E-Cadherin and Ki 67 immuno-expression in triple negative breast cancer E-Cadherin和Ki 67免疫表达在三阴性乳腺癌中的临床病理意义

International Journal of Cancer and Biomedical Research Pub Date : 2023-03-01 DOI: 10.21608/jcbr.2023.181487.1287

E. Esmail, Mohammed El-rashidy, H. Mashhour, Hend Abo-Safia

引用次数: 0

Effect of thyroglobulin level before ablative Radioactive Iodine on response and survival among patients with Differentiated Thyroid Carcinoma 放射碘消融前甲状腺球蛋白水平对分化型甲状腺癌疗效及生存的影响

International Journal of Cancer and Biomedical Research Pub Date : 2023-03-01 DOI: 10.21608/jcbr.2023.190589.1292

A. Abdelrahman

引用次数: 0

The prognostic significance of Minichromosome maintenance protein 2 (MCM2) and Trans-glutaminase 2 (TGM2) in Endometrial carcinoma: immunohistochemical and serological study 小染色体维持蛋白2 (MCM2)和反式谷氨酰胺酶2 (TGM2)在子宫内膜癌中的预后意义:免疫组织化学和血清学研究

International Journal of Cancer and Biomedical Research Pub Date : 2023-03-01 DOI: 10.21608/jcbr.2023.175146.1285

N. Heabah, Sara Zaghloul, Rasha A. Elkholy, Asmaa E. Bedeer

引用次数: 0

CRISPR-Cas9: what is beyond cancer immunotherapy? CRISPR-Cas9:癌症免疫治疗之外还有什么?

International Journal of Cancer and Biomedical Research Pub Date : 2023-03-01 DOI: 10.21608/jcbr.2022.152518.1270

Alyaa R. Elsergany, Omar Abualata

引用次数: 0

Immunohistochemical Study of 5-Methylthioadenosine Phosphorylase (MTAP) and Epithelial Membrane Antigen (EMA) in Differentiating Epithelioid Pleural Mesothelioma from Reactive Mesothelial Hyperplasia 5-甲基硫代腺苷磷酸化酶(MTAP)和上皮膜抗原(EMA)在鉴别上皮样胸膜间皮瘤和反应性间皮瘤中的免疫组化研究

International Journal of Cancer and Biomedical Research Pub Date : 2023-03-01 DOI: 10.21608/jcbr.2023.174100.1284

Nehal Hussien, M. Shareef, Y. Zamzam, A. Eid

引用次数: 0