CANADIAN THEATRE REVIEW最新文献

Loss of LBP triggers lipid metabolic disorder through H3K27 acetylation-mediated C/EBPβ- SCD activation in non-alcoholic fatty liver disease. 在非酒精性脂肪肝中，LBP 的缺失通过 H3K27 乙酰化介导的 C/EBPβ- SCD 激活引发脂质代谢紊乱。

IF 4.9 3区艺术学

CANADIAN THEATRE REVIEW Pub Date : 2024-01-18 DOI: 10.24272/j.issn.2095-8137.2023.022

Ya-Ling Zhu, Lei-Lei Meng, Jin-Hu Ma, Xin Yuan, Shu-Wen Chen, Xin-Rui Yi, Xin-Yu Li, Yi Wang, Yun-Shu Tang, Min Xue, Mei-Zi Zhu, Jin Peng, Xue-Jin Lu, Jian-Zhen Huang, Zi-Chen Song, Chong Wu, Ke-Zhong Zheng, Qing-Qing Dai, Fan Huang, Hao-Shu Fang

{"title":"Loss of LBP triggers lipid metabolic disorder through H3K27 acetylation-mediated C/EBPβ- SCD activation in non-alcoholic fatty liver disease.","authors":"Ya-Ling Zhu, Lei-Lei Meng, Jin-Hu Ma, Xin Yuan, Shu-Wen Chen, Xin-Rui Yi, Xin-Yu Li, Yi Wang, Yun-Shu Tang, Min Xue, Mei-Zi Zhu, Jin Peng, Xue-Jin Lu, Jian-Zhen Huang, Zi-Chen Song, Chong Wu, Ke-Zhong Zheng, Qing-Qing Dai, Fan Huang, Hao-Shu Fang","doi":"10.24272/j.issn.2095-8137.2023.022","DOIUrl":"10.24272/j.issn.2095-8137.2023.022","url":null,"abstract":"Non-alcoholic fatty liver disease (NAFLD) is associated with mutations in lipopolysaccharide-binding protein ( LBP), but the underlying epigenetic mechanisms remain understudied. Herein, LBP -/- rats with NAFLD were established and used to conduct integrative targeting-active enhancer histone H3 lysine 27 acetylation (H3K27ac) chromatin immunoprecipitation coupled with high-throughput and transcriptomic sequencing analysis to explore the potential epigenetic pathomechanisms of active enhancers of NAFLD exacerbation upon LBP deficiency. Notably, LBP -/- reduced the inflammatory response but markedly aggravated high-fat diet (HFD)-induced NAFLD in rats, with pronounced alterations in the histone acetylome and regulatory transcriptome. In total, 1 128 differential enhancer-target genes significantly enriched in cholesterol and fatty acid metabolism were identified between wild-type (WT) and LBP -/- NAFLD rats. Based on integrative analysis, CCAAT/enhancer-binding protein β (C/EBPβ) was identified as a pivotal transcription factor (TF) and contributor to dysregulated histone acetylome H3K27ac, and the lipid metabolism gene SCD was identified as a downstream effector exacerbating NAFLD. This study not only broadens our understanding of the essential role of LBP in the pathogenesis of NAFLD from an epigenetics perspective but also identifies key TF C/EBPβ and functional gene SCD as potential regulators and therapeutic targets.","PeriodicalId":42646,"journal":{"name":"CANADIAN THEATRE REVIEW","volume":"193 1","pages":"79-94"},"PeriodicalIF":4.9,"publicationDate":"2024-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10839665/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68882612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"艺术学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Casting Blackface in Canada: Unmasking the History of ‘White and Black’ Minstrel Shows 在加拿大铸造黑脸：揭开“白人和黑人”明斯特秀的历史

IF 0.3 3区艺术学

CANADIAN THEATRE REVIEW Pub Date : 2023-02-01 DOI: 10.3138/ctr.193.004

C. Thompson

{"title":"Casting Blackface in Canada: Unmasking the History of ‘White and Black’ Minstrel Shows","authors":"C. Thompson","doi":"10.3138/ctr.193.004","DOIUrl":"https://doi.org/10.3138/ctr.193.004","url":null,"abstract":"Abstract:Blackface minstrelsy was the dominant form of mass entertainment for over a century, from the 1840s through the 1940s. In Canada, there has been little scholarly research into the topic but for the work of Stephen Johnson and, in recent years, the works I have published on the subject. One of the reasons blackface has been understudied is the dearth of attention paid to histories of slavery. By exploring the history of casting blackface productions, both ‘white’ minstrelsy (white performers blackening up to imitate the song and dance of African-Americans) and ‘Black’ minstrelsy (Black performers in and out of blackface performing caricatures of themselves in front of majority-white audiences), we gain an understanding of how these shows were produced, and what audiences found appealing about them. Canada has produced its own blackface stars, like Colin ‘Cool’ Burgess (1840–1905) and Calixa Lavallée (1842–1891), both of whom toured the United States and Canada in the late nineteenth century and who not only performed in blackface but also produced songs, some of which are still known today, like “O Canada,” the Canadian national anthem, composed by Lavallée in 1880. Additionally, what the history of casting blackface in Canada shows is a long-standing desire among white audiences for depictions of the American Plantation South that often included the participation of local actors like playwright and writer Charles Wesley Handscomb (1867–1906), who moved to Winnipeg in 1879, who were often cast in touring minstrel productions to sing in blackface.","PeriodicalId":42646,"journal":{"name":"CANADIAN THEATRE REVIEW","volume":"193 1","pages":"16 - 20"},"PeriodicalIF":0.3,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48745583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"艺术学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Introduction: Casting Calls/Calls for Change 导言:选角要求/改变要求

IF 0.3 3区艺术学

CANADIAN THEATRE REVIEW Pub Date : 2023-02-01 DOI: 10.3138/ctr.193.001

Mariló Núñez, Jamie Robinson, Marlis Schweitzer, Yasmine Amirkhani, Liam Lockhart-Rush, Zoe Marin

引用次数: 1

Writers and Race: Why Playwrights of Colour Should Write Themselves into Their Plays 作家与种族：为什么有色人种剧作家应该把自己写进他们的戏剧中

IF 0.3 3区艺术学

CANADIAN THEATRE REVIEW Pub Date : 2023-02-01 DOI: 10.3138/ctr.193.012

Mariló Núñez

引用次数: 0

“The Biggest Mistake You Ever Made Was Thinking That Nobody Cared about Me”: The Representation of Black Lives in Our Fathers, Sons, Lovers and Little Brothers “你犯过的最大的错误是认为没有人关心我”:黑人生活在我们的父亲、儿子、情人和小兄弟中的表现