Istanbul Medical Journal最新文献

{"title":"Investigation of the Prognostic Values of the Shock Index and Modified Shock Index in Predicting the Clinical Outcomes in Elderly Hospitalized Patients with Coronavirus Disease-2019","authors":"S. Yeşiltaş, Saadet Öztop, M. Günay, I. Sümer, S. Akbaş, S. Yılmaz, Ö. Pasin, K. Karaaslan","doi":"10.4274/imj.galenos.2023.44380","DOIUrl":"https://doi.org/10.4274/imj.galenos.2023.44380","url":null,"abstract":"Introduction: Advanced age is an independent risk factor for increased mortality in coronavirus disease-2019 (COVID-19). However, the best method for estimating mortality in elderly patients with COVID-19 is still under debate. We performed this study to assess the shock index (SI) and the modified shock index (MSI) for the abovementioned problem. Methods: A retrospective study was conducted including elderly cases (>= 65 years) confirmed with COVID-19 who admitted to a tertiary university hospital between March-December 2020. The SI and MSI at the time of the emergency department visits were used to evaluate the intensive care unit admission, ventilator support, septic shock, and 30-day mortality in all patients. The receiver operating characteristic and area under the curve (AUC) were used to measure the overall ability of SI and MSI to predict clinical outcomes. Results: We recruited 334 consecutive COVID-19 patients with a mean age of 75.2 +/- 7.3 and an almost equal gender distribution [170 males (50.9%)]. In deceased and surviving patients, the SI was 0.66 +/- 0.16 and 0.6 +/- 0.1 (p=0.014), while the MSI was 0.95 +/- 0.22 and 1.09 +/- 0.34 (p=0.003), respectively. In predicting mortality, the AUC of the SI and MSI were 0.590 [95% confidence interval (CI): 0.535 to 0.643] and 0.608 (95% CI: 0.553 to 0.660), respectively. Conclusion: Increased SIs and MSIs are associated with 30-day mortality. SI and MSI can benefit the triage of elderly patients hospitalized for COVID-19. However, it was found that there is no single cut-off value of SI or MSI with optimum accuracy for predicting COVID-19-related clinical outcomes.","PeriodicalId":42584,"journal":{"name":"Istanbul Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48627348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Trigger Point Dry Needling on Neck Pain, Sleep, and Depression in Patients with Fibromyalgia","authors":"E. Demirhan, S. Atar, Rasim Akgün, Begüm Siret Özfırat, Ö. Kuru","doi":"10.4274/imj.galenos.2023.66502","DOIUrl":"https://doi.org/10.4274/imj.galenos.2023.66502","url":null,"abstract":", PSQI, HADS, and FIQ scores (for all parameters; p<0.001). Conclusion: For better management of patients with FMS patients, MTrPs should not be ignored. DN treatment should also be among the treatment options as an effective treatment.","PeriodicalId":42584,"journal":{"name":"Istanbul Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45574606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Interest of Healthcare Employees in Distance Training in the Coronavirus Disease-2019 Pandemic Process","authors":"Arzu Kaplanoğlu, G. Şengöz, F. Pehlivanoğlu, Öznur Yıldırım, Yeşim Kanıpek","doi":"10.4274/imj.galenos.2023.92624","DOIUrl":"https://doi.org/10.4274/imj.galenos.2023.92624","url":null,"abstract":"Introduction: In-service healthcare personnel training is an ongoing process. However, emerging unknowns require momentary planning. The Coronavirus disease-2019 (COVID-19) pandemic has made distance training (DT) compulsory for healthcare employees (HE). Thus, it is important to learn about their interest levels. This study investigates the interest of HE in DT during the pandemic process. Methods: The research population consisted of 3,442 personnel registered to take the \"HE COVID-19\" training at research and training hospital in 2020. The population of the study consisted of all personnel employed at research and training hospital and registered for the training. The study was planned retrospectively for reaching all personnel whose training registrations were made between 17.03.2020 and 15.04.2020. This study was used the data of the personnel who completed the \"HE COVID-19 Training\" within the scope of the announcements that were made as DT as reported on the Hospital Training System. Results: The total training completion rate of the participants was found to be 90%. When the interests of the HE in the DT in the process of the COVID-19 pandemic were compared, no statistically significant difference could be observed in the participation rates of the specialist doctors, resident doctors, and nurses (p=0.094). The rate of the resident doctors to complete the training until the second announcement was significantly lower compared to the specialist doctors and nurses (specialist doctor vs. resident doctor p=0.044;nurse vs. resident doctor p<0.001). The rates of completing the training after two announcements were significantly higher among the resident doctors than the specialist doctors and nurses and among the specialist doctors than the nurses (respectively p=0.018, p<0.001, p=0.018). Conclusion: Continuous training must ensure that HE are adequately prepared to deal with public health emergencies such as the COVID-19 pandemic. DT should be prioritized in the Emergency Action Plan.","PeriodicalId":42584,"journal":{"name":"Istanbul Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45575388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Idiopathic Thrombocytopenic Purpura and Cardiovascular Disease: Is Elevated Triglycerides to High-density Lipoprotein Cholesterol Ratio a Marker?","authors":"A. Işık, Esra Turan Erkek, Müjgan Kaya Tuna","doi":"10.4274/imj.galenos.2023.23682","DOIUrl":"https://doi.org/10.4274/imj.galenos.2023.23682","url":null,"abstract":"","PeriodicalId":42584,"journal":{"name":"Istanbul Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43137191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recommendation Versus Current Status: Retrospective Analysis of Age to Circumcise in a District Hospital","authors":"Muhammer Ergenç, T. Uprak","doi":"10.4274/imj.galenos.2022.47786","DOIUrl":"https://doi.org/10.4274/imj.galenos.2022.47786","url":null,"abstract":"","PeriodicalId":42584,"journal":{"name":"Istanbul Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42771304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain metastases and immune checkpoint inhibitors in non-small cell lung cancer: a systematic review and meta-analysis.","authors":"Haizhu Chen, Yu Feng, Yu Zhou, Yunxia Tao, Le Tang, Yuankai Shi","doi":"10.1007/s00262-022-03224-2","DOIUrl":"10.1007/s00262-022-03224-2","url":null,"abstract":"<p><strong>Background: </strong>The use of immune checkpoint inhibitors (ICIs) for brain metastases (BMs) from non-small cell lung cancer (NSCLC) remains debatable. This study aimed to explore the efficacy of ICIs for NSCLC with BMs. We also evaluated the effect of BMs on outcomes of ICIs.</p><p><strong>Methods: </strong>A systematic search of PubMed, Embase, Web of Science, and Cochrane databases was conducted to identify studies where the efficacy of ICIs against BMs from NSCLC, or the association between BMs and outcomes of ICIs were evaluated. Outcomes included intracranial objective response rate (icORR), intracranial disease control rate (icDCR), systemic ORR and DCR.</p><p><strong>Results: </strong>Overall, 33 studies were included in this meta-analysis. The pooled icORR was 13% (95%CI 6-23%) and icDCR was 50% (95%CI 40-63%) for programmed cell death-ligand 1 (PD-L1) unselected patients with any BMs. For active BMs, pooled icORR was 15% (95%CI 6-28%) and icDCR was 47% (95% CI 36-57%). For PD-L1 ≥ 50% patients with any BMs, pooled icORR and icDCR were 68% (95%CI 57-80%) and 82% (95%CI 73-92%), respectively. Additionally, pooled systemic ORR and DCR for any BMs were 22% (95%CI 15-30%) and 41% (95%CI 18-67%), respectively. Patients with BMs had inferior progression-free survival (HR 1.19, 95%CI 1.07-1.33, P = 0.0016) and overall survival (HR 1.14, 95%CI 1.03-1.25, P = 0.011) when applying ICIs compared to those without BMs. However, no significant difference in systemic ORR between patients with and without BMs was observed (OR 0.94, 95%CI 0.72-1.20, P = 0.629).</p><p><strong>Conclusion: </strong>ICIs may be clinically active in NSCLC patients with BMs. More effective treatments for BMs from NSCLC are needed.</p>","PeriodicalId":42584,"journal":{"name":"Istanbul Medical Journal","volume":"21 1","pages":"3071-3085"},"PeriodicalIF":5.8,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10992555/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90905133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Sensitive Skin Syndrome and Accompanied Diseases Among Women Doctors: A Nationwide Study","authors":"Vildan Manav, Müge Göre Karaali","doi":"10.4274/imj.galenos.2022.48264","DOIUrl":"https://doi.org/10.4274/imj.galenos.2022.48264","url":null,"abstract":"","PeriodicalId":42584,"journal":{"name":"Istanbul Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45825604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time to Castration Resistance as a Predictor of Response to Docetaxel in Metastatic Castration Resistance in Prostate Cancer","authors":"İlkay Gültürk, Gülçin Şahingöz Erdal, Gülru Birce Sönmezoz, Mustafa YILMAZ, S. Tacar, A. Özmen, D. Tataroğlu Özyükseler, Özgecan Dulgar, I. Çil, D. Tural","doi":"10.4274/imj.galenos.2022.56804","DOIUrl":"https://doi.org/10.4274/imj.galenos.2022.56804","url":null,"abstract":"","PeriodicalId":42584,"journal":{"name":"Istanbul Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44632910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Usage of Cardiovascular Magnetic Resonance Imaging: Single-Center Experience in the New Era of Cardiovascular Imaging","authors":"Özge Özden, H. Tokdil, K. Ohtaroğlu Tokdil, C. Sevgican, Gülsüm Bingöl","doi":"10.4274/imj.galenos.2022.90757","DOIUrl":"https://doi.org/10.4274/imj.galenos.2022.90757","url":null,"abstract":"","PeriodicalId":42584,"journal":{"name":"Istanbul Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42395415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum Adiponectin Related to Neovascularization Process in Diabetic Retinopathy","authors":"Mehtap Gökçe Margunato, H. Aral, Özen Ayrancı Osmanbaşoğlu, H. Güngel, E. Altunoğlu, M. Usta, Ş. Köse, E. Serin, Savaş Karataş","doi":"10.4274/imj.galenos.2022.22804","DOIUrl":"https://doi.org/10.4274/imj.galenos.2022.22804","url":null,"abstract":"","PeriodicalId":42584,"journal":{"name":"Istanbul Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47054828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}