Universa Medicina最新文献

{"title":"Neuroprotective effect of South Sulawesi propolis on neurogenesis in primary cultures of rat cerebral cortical neurons","authors":"Nurhadi Ibrahim, T. Andraini, Amirah Yusnidar, Putu Indah Paramita Adi Putri, I. R. Sianipar","doi":"10.18051/univmed.2023.v42.137-149","DOIUrl":"https://doi.org/10.18051/univmed.2023.v42.137-149","url":null,"abstract":"BackgroundNeurodegenerative diseases have a significant risk factor, namely aging, which is associated with increased neuronal dysfunction and death. Propolis has been widely used as medicine due to its various benefits. This research study investigated the effect of propolis from the stingless bee (Tetragonula sapiens) from South Sulawesi, Indonesia, on neurogenesis in primary cultures of embryonic cerebral cortex of Wistar rats at 17-18 days of gestation.\u0000Methods This research was an experimental study involving 4 female pregnant Wistar rats, which were terminated and the cerebral cortex of the embryos collected and grown as primary cultures. The cultures were divided into 3 groups, i.e. control, vehicle, and propolis extract group. The research began with 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) to obtain the optimal dose among propolis doses of 0.5 μg/mL, 1 μg/mL, 5 μg/mL, 10 μg/mL, 25 μg/mL, and 100 μg/mL. The study was continued by using the best dose in immunostaining examination using microtubule-associated protein 2 (MAP2) primary antibody and qRT-PCR examination of brain-derived neurotrophic factor (BDNF) mRNA expression. One Way ANOVA and Kruskal-Wallis test were used to analyse the data.\u0000ResultsThe results showed that the propolis doses of 0.5 μg/mL and 1 μg/mL significantly increase cell viability compared to the other doses (p=0.011) and stimulate dendritic growth. The propolis dose group of 1 μg/mL induces a significantly higher expression of BDNF mRNA than the control group (p=0.031).\u0000ConclusionOur findings indicate that stingless bee propolis has neuroprotective effects against BDNF mRNA in rats. It is shown that propolis can be a candidate inhibitor in neurodegenerative diseases.","PeriodicalId":42578,"journal":{"name":"Universa Medicina","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46636499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Repurposing of fluoxetine for antibacterial activities in catheter-associated urinary tract biofilm infections: an in vitro analysis","authors":"M. Poyil, Rameesha Shafqat, M. A. Alfaki","doi":"10.18051/univmed.2023.v42.128-136","DOIUrl":"https://doi.org/10.18051/univmed.2023.v42.128-136","url":null,"abstract":"BackgroundUrinary tract infections are often initiated by indwelling catheters and bring about serious consequences, especially when they are caused by multidrug-resistant bacterial pathogens. The biofilms of uropathogens such as Enterococcus faecalis and Escherichia coli pose serious challenges. Therefore the scientific world is trying to experiment with alternative drugs to replace conventional antibiotics as the latter are more prone to cause the development of antibacterial resistance. Here, we evaluate the repurposing of the antidepressant fluoxetine as an antibacterial agent against the mentioned pathogens.\u0000MethodsTo repurpose fluoxetine for its antibacterial activity against Enterococcus faecalis and Escherichia coli, the agar diffusion method was used. The minimal inhibitory concentration was found by the microdilution method. The drug was also analyzed as a coating on catheters to evaluate its efficiency against biofilm formation by pathogens.\u0000Results The drug fluoxetine showed potential antibacterial and anti-biofilm activities. Its minimum inhibitory concentration was found to be 18.75 µg/mL and 37.5 µg/mL against Enterococcus faecalis and Escherichia coli respectively. The antibiofilm activity on polystyrene surfaces was also remarkable as it reduced the formation of Enterococcus faecalis and Escherichia coli biofilms by 70% and 74%, after being treated with 1x MICs and 2x MICs respectively.\u0000Conclusions Fluoxetine - one of the drugs of choice in treating depression, when repurposed, has shown considerable antibacterial and antibiofilm effects against two of the major catheter-associated urinary tract infection-causing bacteria - viz. Enterococcus faecalis and Escherichia coli. Therefore, further studies are needed to understand its applicability as an antibacterial agent.","PeriodicalId":42578,"journal":{"name":"Universa Medicina","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45930611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre-emptive versus preventive analgesia for postoperative pain: a systematic review and meta-analysis","authors":"Aida Rosita Tantri, Riyadh Firdaus, Hansen Angkasa, Ahmad Pasha Natanegara, Muhammad A. I. Maulana","doi":"10.18051/univmed.2023.v42.227-239","DOIUrl":"https://doi.org/10.18051/univmed.2023.v42.227-239","url":null,"abstract":"BackgroundPostoperative pain is a type of nociceptive pain that originates from tissue damage due to trauma caused by surgery. Pre-emptive analgesia is treatment that starts before surgery, to prevent or reduce the establishment of sensitization of dorsal horn neurons caused by tissue injury, the sensitized neurons being supposed to amplify postoperative pain. Pre-emptive analgesia consists of administering analgesic medication before tissue injury, that is, before the reception, transmission, modulation, and nociception of the aggressive stimulus, aiming to prevent hyperalgesia. This review aims to compare the efficacy of pre-emptive analgesia and preventive analgesia in postoperative pain. MethodsArticle searching was done on five databases (PubMed, ProQuest, Scopus, ScienceDirect, ClinicalKey). Hand-searching was also done to find additional articles. We have only included double-blind, randomized, controlled trials (RCT). A total of fifteen articles were included and all were RCT studies comparing pre-emptive analgesia with preventive analgesia. The quality of the included studies was evaluated with Cochrane risk-of-bias assessment tools. Quantitative analysis was performed by Review Manager 5.4. ResultsFifteen studies comprising 830 subjects were included in this study. Our analysis revealed that pre-emptive analgesia significantly improved visual analog scale (VAS)/numeric rating scale (NRS)/verbal rating scale (VRS) 4 hours postoperatively [mean difference (MD) = -0.25, 95% CI: [- 0.49, -0.02]; I2 = 94%]. Unfortunately, pain scoring at 6, 12 and 24 hours after surgery did not differ significantly between pre-emptive and preventive analgesia. Duration of analgesia was comparable between the two groups. Time to rescue analgesics was similar between the two groups, but the pre-emptive group was associated with less analgesic consumption postoperatively than the preventive group. ConclusionPre-emptive analgesia provided better pain relief than preventive analgesia during the short term. Time to rescue analgesics is comparable between both groups, but pre-emptive analgesia is associated with lower amounts of rescue analgesics postoperatively.","PeriodicalId":42578,"journal":{"name":"Universa Medicina","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136286951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum microRNA-126 expression as a biomarker of diabetic retinopathy","authors":"N. M. A. Surasmiati, N. M. A. Suryathi, Ari Andayani","doi":"10.18051/univmed.2023.v42.121-127","DOIUrl":"https://doi.org/10.18051/univmed.2023.v42.121-127","url":null,"abstract":"BackgroundDiabetic retinopathy (DR) is a microvascular complication of diabetes mellitus (DM). Diabetic retinopathy causes permanent blindness in the productive age group and has a multifactorial pathogenesis. MicroRNA-126 (miRNA-126) regulates the expression of the vascular endothelial growth factor (VEGF) gene at the post-transcriptional level, VEGF being an important angiogenic protein regulating inflammation in DR development. This study aimed to determine serum miRNA-126 expression as a biomarker in DM patients with DR.\u0000MethodsThis was a cross-sectional study involving 4 healthy persons and 21 type 2 DM patients. Subjects consisted of 4 groups: i) healthy controls, ii) DM patients without diabetic retinopathy (NDR), iii) DM patients with non-proliferative DR (NPDR) and iv) DM patients with proliferative DR (PDR). Venous blood was collected from subjects for miRNA-126 examination by real-time polymerase chain reaction (PCR). MiRNA-126 in each group was analyzed using the One Way Anova test and p<0.05 was considered to be statistically significant.\u0000ResultsMean miRNA-126 expression was significantly decreased in PDR (1.86±1.03) and NPDR (1.01±0.43 ) groups when compared to healthy control (2.44±1.29) and NDR groups (2.15± 0.48) (p=0.027). MiRNA-126 values of less than 1.81 can differentiate NDR from the control group (sensitivity 83%, specificity 75%) and miRNA-126 of less than 1.56 can be used to predict NPDR when compared to the control group (sensitivity 86%, specificity 75%).\u0000ConclusionSerum miRNA-126 is a potential biomarker for screening of NPDR and NDR in type 2 DM patients, and could be considered a non-invasive diagnostic parameter.","PeriodicalId":42578,"journal":{"name":"Universa Medicina","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43984069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre-emptive versus Preventive Analgesia for Postoperative Pain: A Systematic Review and Meta-Analysis","authors":"A. Tantri, Riyadh Firdaus, H. Angkasa, A. P. Natanegara, M. A. I. Maulana","doi":"10.37766/inplasy2023.6.0005","DOIUrl":"https://doi.org/10.37766/inplasy2023.6.0005","url":null,"abstract":"BackgroundPostoperative pain is a type of nociceptive pain that originates from tissue damage due to trauma caused by surgery. Pre-emptive analgesia is treatment that starts before surgery, to prevent or reduce the establishment of sensitization of dorsal horn neurons caused by tissue injury, the sensitized neurons being supposed to amplify postoperative pain. Pre-emptive analgesia consists of administering analgesic medication before tissue injury, that is, before the reception, transmission, modulation, and nociception of the aggressive stimulus, aiming to prevent hyperalgesia. This review aims to compare the efficacy of pre-emptive analgesia and preventive analgesia in postoperative pain.\u0000MethodsArticle searching was done on five databases (PubMed, ProQuest, Scopus, ScienceDirect, ClinicalKey). Hand-searching was also done to find additional articles. We have only included double-blind, randomized, controlled trials (RCT). A total of fifteen articles were included and all were RCT studies comparing pre-emptive analgesia with preventive analgesia. The quality of the included studies was evaluated with Cochrane risk-of-bias assessment tools. Quantitative analysis was performed by Review Manager 5.4.\u0000ResultsFifteen studies comprising 830 subjects were included in this study. Our analysis revealed that pre-emptive analgesia significantly improved visual analog scale (VAS)/numeric rating scale (NRS)/verbal rating scale (VRS) 4 hours postoperatively [mean difference (MD) = -0.25, 95% CI: [- 0.49, -0.02]; I2 = 94%]. Unfortunately, pain scoring at 6, 12 and 24 hours after surgery did not differ significantly between pre-emptive and preventive analgesia. Duration of analgesia was comparable between the two groups. Time to rescue analgesics was similar between the two groups, but the pre-emptive group was associated with less analgesic consumption postoperatively than the preventive group.\u0000ConclusionPre-emptive analgesia provided better pain relief than preventive analgesia during the short term. Time to rescue analgesics is comparable between both groups, but pre-emptive analgesia is associated with lower amounts of rescue analgesics postoperatively.","PeriodicalId":42578,"journal":{"name":"Universa Medicina","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43376986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research trends in brain imaging of mild cognitive impairment in 25 years: a bibliometric analysis","authors":"Daniella Satyasari, Agnes Tineke Waney Rorong","doi":"10.18051/univmed.2023.v42.214-226","DOIUrl":"https://doi.org/10.18051/univmed.2023.v42.214-226","url":null,"abstract":"Mild cognitive impairment (MCI) is a condition that is experienced by most elderly in the world. Although there has been a huge rise in research on developing brain imaging tests that can identify and evaluate MCI early on, a bibliometric analysis of this issue is still lacking. The purpose of this review is to determine the pattern and growth of research trends related to MCI and brain imaging using bibliometric analysis, based on Scopus data from 1996 to 2021. The data was converted to Comma Separated Values (CSV) and exported to VOSviewer to bibliometrically analyze the origin by country, keywords, frequently cited articles, author, and journals. Over a 25-year period, 5081 articles were discovered, with the number rising, particularly in the past four years, and significantly in 2022 when 561 articles (11.04%) were found. The Journal of Alzheimer's Disease (19.22%) and Neuroimage Clinical (10.22%) published the largest number of articles on this subject. The United States (24.31%) led all other countries in the number of publications, followed by China (14.84%) and UK (6.5%). The most cited article was by Petersen RC in 1999 (41 citations) about MCI and its clinical characterization. The keywords that appeared the most frequently were mild cognitive impairment (984 occurrences) associated with biomarkers, brain scanning procedures, brain part, age, and human subject. The most frequently cited authors were Petersen RC (1365 citations) and Jack CR (1103 citations). Neuroimage (4164 citations), and Neurology (3268 citations) are the most repeatedly cited journals. This bibliometric study displays the trend in the last 25 years for MCI and brain imaging.","PeriodicalId":42578,"journal":{"name":"Universa Medicina","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46605391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"More than just a name: \"nonalcoholic fatty liver disease (NAFLD)\" versus \"metabolic associated fatty liver disease (MAFLD)\"","authors":"Kathryn Effendi","doi":"10.18051/univmed.2023.v42.119-120","DOIUrl":"https://doi.org/10.18051/univmed.2023.v42.119-120","url":null,"abstract":"The term nonalcoholic fatty liver disease (NAFLD","PeriodicalId":42578,"journal":{"name":"Universa Medicina","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48911067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of spinal anesthesia with sufentanil on length of stages I and II of labor in singleton pregnant women: a randomized controlled trial","authors":"Mina Yadollahi, K. Sadegi, M. Afshari, Batool Shahraki Mojahed","doi":"10.18051/univmed.2023.v42.94-100","DOIUrl":"https://doi.org/10.18051/univmed.2023.v42.94-100","url":null,"abstract":"BackgroundLabor pain is one of the most painful experiences in a women's life. One of the methods of pain relief is spinal anesthesia. The purpose of this study was to evaluate the effect of spinal anesthesia with sufentanil on the length of the first and second stages of labor in singleton pregnant women.\u0000MethodsA randomized clinical trial was conducted involving 56 women who had to be at least 37 weeks pregnant with a singleton pregnancy and 20 to 35 years of age, as well as seeking a spontaneous natural delivery. They were randomized into an intervention group (spinal anesthesia with sufentanil) of 28 subjects and a control group (no spinal anesthesia) of 28 subjects. Statistical analysis was performed using SPSS software program 20.0.\u0000ResultsMean duration of stage I of labor was 152.32 ± 92.01 and 187.68 ± 121.01 minutes in the intervention and control groups, respectively (p=0.34), whereas mean duration of stage II of labor in the 2 groups was 15.96 ± 14.26 and 26.43 ± 20.90 minutes, respectively (p=0.06). Twenty five percent of women in the intervention group and 35.71% of women in the control group experienced a long stage I, whereas 21.43% of women in the intervention group and 35.71% of women in the control group experienced a long stage II (p>0.05).\u0000ConclusionThis study suggests that spinal anesthesia with sufentanil does not increase the duration of labor stages. It is recommended that more studies be performed in the future using larger sample sizes to allow for the drawing of solid conclusions.","PeriodicalId":42578,"journal":{"name":"Universa Medicina","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43802647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatoprotective activity of Averrhoa bilimbi L. fruit extract on carbon tetrachloride-induced acute liver faiure in Wistar rats","authors":"Rachellicya Ristioni Sihaloho, Chodijah Chodijah, Titiek Sumarawati, Joko Wahyu Wibowo, S. Zulaikhah, A. Putra, N. Hidayah, S. S. Ghaissani, Mohammad Ariq Nazar","doi":"10.18051/univmed.2023.v42.61-69","DOIUrl":"https://doi.org/10.18051/univmed.2023.v42.61-69","url":null,"abstract":"Background Acute liver failure (ALF) is a state of rapid and progressive deterioration of liver function. Continuous exposure to chemicals and viruses can increase reactive oxygen species (ROS) which leads to prolonged inflammation due to the production of tumor necrosis factor-alpha (TNF-á) thus inhibiting the production of platelet-derived growth factor (PDGF). The objective of this study was to evaluate the effect of administration of Averrhoa bilimbi L. fruit extract on PDGF levels and TNF-á levels in carbon tetrachloride (CCl4)-induced ALF rats.\u0000MethodsThis study used a post-test-only control group design involving 20 Wistar rats. They were randomized into 4 groups, namely sham, control, T1, and T2. Group T1 was exposed to CCl4 with the administration of A. bilimbi fruit extract at a dose of 500mg/kgBW, while, group T2 was exposed to CCl4 and given A. bilimbi fruit extract of 750 mg/kgBW. On the 15th day, the serum was analyzed to determine the levels of PDGF and TNF-á using ELISA.\u0000ResultsThe highest mean PDGF level in the control group was 146.60±15.36 pg/mL, while the highest mean TNF-á level in group T1 was 40.11±4.44 pg/mL. The One-way ANOVA test showed that there were significant differences in TNF-á (p=0.002) and PDGF (p=0.000) levels between the study groups.\u0000ConclusionThe administration of A.bilimbi L. fruit extract affected PDGF and TNF-á levels in CCl4-induced ALF rats. The present study revealed that A. bilimbi fruits have significant hepatoprotective activity in experimental Wistar rats.","PeriodicalId":42578,"journal":{"name":"Universa Medicina","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45086633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of aerobic and resistance exercises on body composition and quality of life in overweight and obese women: a randomized control trial","authors":"G. Cicek, Rabia Hurrem OZDURAK SINGIN","doi":"10.18051/univmed.2023.v42.70-83","DOIUrl":"https://doi.org/10.18051/univmed.2023.v42.70-83","url":null,"abstract":"BackgroundObesity has become a major health issue in the world and directly reduces the quality of life. The aim of this study was to compare the effect of aerobic and resistance exercises on body composition and quality of life (QoL) in overweight and obese women.\u0000Method An experimental study involving 90 overweight/obese women aged between 20-45 years participated in the study voluntarily and were randomized into control (n=30), aerobic exercise (AE) (n=30), and resistance exercise (RE) (n=30) groups. Either AE or RE groups performed exercise for 60 minutes per day for 10 weeks, whereas the control group did not perform any exercise. The body composition and QoL of the women were measured before and after the exercise.\u0000ResultsBody weight, BMI, fat mass, and waist and hip circumferences decreased significantly in both AE and RE groups after the exercise intervention compared to the control group (p<0.05). In addition, quality of life sub-dimensions including physical health, psychological health, social relationship, and environment sub-dimensions improved significantly in the AE and RE groups compared to the control group (p<0.001). Post hoc Tukey test showed that AE was as effective as RE for improving body composition parameters and QoL sub dimension compared to control group.\u0000ConclusionThis study demonstrated that both AE and RE were effective in improving body composition and thereby increasing the QoL in overweight and obese women. Both AE and RE programs are effective and should be considered within any multicomponent therapy program in overweight and obese women.","PeriodicalId":42578,"journal":{"name":"Universa Medicina","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49639219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}