Pakistan Heart Journal最新文献

{"title":"Modifiable Risk Factors in Diagnosed Cases of Acute ST Elevation Myocardial Infarction in Young Patients Presenting at Tertiary Care Hospital in Peshawar","authors":"S. Akbar, J. Ali, W. Sajjad, Noor Faraz, Rahid Ayaz, A. Iqbal","doi":"10.47144/phj.v56i1.2373","DOIUrl":"https://doi.org/10.47144/phj.v56i1.2373","url":null,"abstract":"Objectives: The objective of this study was to determine the frequency of modifiable risk factors in young patients diagnosed with acute ST elevation myocardial infarction (STEMI).\u0000Methodology: A cross-sectional study was conducted at the cardiology department of Lady Reading Hospital, Peshawar. A total of 236 patients presented with acute STEMI, between 18 to 50 years of age of either gender were included. All the included patients were subjected to detailed history and clinical examination and modifiable risk factors were observed.\u0000Results: Out of 236 patients, 42 (18%) patients were in age range 18-30 years and 194 (82%) patients were in age range 31-50 years. Mean age was 42±9.77 years, 156 (66%) patients were male. In total, 90 (38%) patients had sedentary lifestyle, 45 (19%) patients had positive history of atrial fibrillation. More over 92 (39%) patients were diabetic, 153 (65%) patients were hypertensive, 99 (42%) patients were smokers, 73 (31%) patients had dyslipidaemia, and 64 (27%) patients were obese.\u0000Conclusion: It has been observed that modifiable risk factors were prevalent in a vast majority of the young patients presenting with acute STEMI. Among these, sedentary lifestyle, smoking, obesity, and metabolic risk factors such as diabetes and dyslipidaemia need immediate attention.","PeriodicalId":42273,"journal":{"name":"Pakistan Heart Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45212420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between Intraoperative Direct and Transesophageal Echocardiographic Assessment of Right Ventricular Outflow Tract Pressure Gradient in Patients Undergoing Tetralogy of Fallot Repair","authors":"Fatima Amin, A. S. Shaikh, S. Bangash, A. Kamran, Nida Rafique, M. Rehman, Najma Patel","doi":"10.47144/phj.v56i1.2484","DOIUrl":"https://doi.org/10.47144/phj.v56i1.2484","url":null,"abstract":"Objectives: The objective of this study was to determine the correlation between intraoperative direct (needle) and transesophageal echocardiographic (TEE) assessment of right ventricular outflow tract (RVOT) pressure gradient in patients undergoing Tetralogy of Fallot (TOF) repair.\u0000Methodology: A total of 100 patients underwent for TOF repair were included. After completion of surgery and successful weaning from cardiopulmonary bypass, the TEE derived RVOT gradients were obtained from, the midesophageal ascending aortic short axis (AA Sax) view, upper esophageal aortic arch short axis (Arch Sax) view and trans-gastric RV outflow (TG RV outflow) view. Direct (needle) derived pressures from right ventricular (RV) and pulmonary artery (PA) were obtained by surgeon using a saline filled pressure transducer system. Correlation coefficient was computed between intraoperative direct and TEE assessment of RVOT gradient was evaluated.\u0000Results: In the sample of 100 patients, 41% were females and median age was 8 [5-11] years. The TEE derived RVOT gradients obtained in AA Sax, Arch Sax and TG RV outflow view were 26.46±6.98, 26.60±6.55, and 22.64±6.21 mmHg, respectively. Intraoperative RVOT pressure gradient was 19.05±8.9 mmHg. The correlation between intraoperative direct (needle) and TEE assessment of RVOT pressure gradient obtained in AA Sax, Arch Sax, and TG RV outflow view were 0.588 (p<0.001), 0.283 (p<0.001), and 0.383 (p<0.001), respectively.\u0000Conclusion: Intraoperative TEE assessment of RVOT pressure gradient showed a moderate correlation with the direct (needle) assessment. The ascending aorta short axis view was found to be the superior esophageal view.","PeriodicalId":42273,"journal":{"name":"Pakistan Heart Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46512358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Quantity and Duration of Junctional Rhythm during Successful Radiofrequency Ablation among Patients with Atrioventricular Nodal Re-Entry Tachycardia","authors":"U. Butt, I. Saleem, Hafiz Abdul Mannan Shahid, Waqar Hassan, M. A. Dar, Z. Akram","doi":"10.47144/phj.v56i1.2368","DOIUrl":"https://doi.org/10.47144/phj.v56i1.2368","url":null,"abstract":"Objectives: To evaluate the quantity and duration of junctional rhythm during radiofrequency ablation among atrioventricular nodal reentry tachycardia (AVRNT) patients.\u0000Methodology: A Cross sectional study was conducted at Punjab Institute of cardiology from May – July, 2022. Ablations of slow pathway were executed on 50 patients who fulfilled the inclusion criteria using ablation catheters of 4-mm tip. Power output was kept between 35- 40 Watt with a temperature control at 60 °C depending upon the occurrence of junctional rhythm. The target end points of radio frequency ablation (RFA) were inability to either induce or spontaneously demonstrate clinical tachycardia. Presence of more than one atrio-ventricular (AV) nodal echo beat was the criteria to continue further ablations as it was considered indicator residual slow pathway. Data was entered in SPSS software version 21.0 and were presented as mean ± SD were used.\u0000Results: The mean age of the patients was 36.50 ± 7.129 years. Ablation power was titrated between 35-40 watts (Mean 39.6 ± 1.37). The average amount of junctional beats in each patient was 57.34 ± 9.71 (73-38) with mean duration of junctional rhythm was 29.20 ± 3.47 sec. Successful ablation mean was 54.25 + 8.45 as compared to unsuccessful attempts of 44.32 ± 5.77 and was statistically significant (p<0.001).\u0000Conclusion: The study concluded that RFA had high success rate and a low recurrence rate with less complication. Junctional rhythm is a sensitive predictor of successful ablation and is a safe and effective way of permanent termination of AVNRT.","PeriodicalId":42273,"journal":{"name":"Pakistan Heart Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41863412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"12-Lead Electrocardiogram - A Valuable Tool in Temporary Cardiac Pacing Management","authors":"S. H. Naqvi","doi":"10.47144/phj.v56i1.2376","DOIUrl":"https://doi.org/10.47144/phj.v56i1.2376","url":null,"abstract":"Inadvertent malposition of pacing leads is a recognized complication of temporary cardiac pacing procedure, which can be fatal particularly if lead placement is in the left ventricular (LV) cavity because of the risk of thromboembolic events.1 Malposition leads can be either due to unrecognized congenital heart defects including atrial or ventricular septal defects, patent foramen ovale or due to iatrogenic perforation of interventricular septum but sometimes it may be due to faulty insertion via trans-arterial instead of trans-venous access.2\u0000 \u0000References\u0000\u0000Gupta S, Annamalaisamy R, Coupe M. Misplacement of temporary pacing wire into the left ventricle via an anomalous vein. Hellenic J Cardiol. 2010;51(2):175-7.\u0000Garg N, Moorthy N. Inadvertent temporary pacemaker lead placement in aortic sinus. Heart views: the official journal of the Gulf Heart Association. 2013;14(4):182.\u0000","PeriodicalId":42273,"journal":{"name":"Pakistan Heart Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42998600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute on Chronic Limb-Threatening Ischemia Associated with Septic Embolism in Patient with Infective Endocarditis","authors":"Nindya Sari Diajeng Laras Ati, Agus Subagjo, Rizal Muhammad, M. Aditya","doi":"10.47144/phj.v56i1.2408","DOIUrl":"https://doi.org/10.47144/phj.v56i1.2408","url":null,"abstract":"Septic embolism associated with infective endocarditis (IE) is the occlusion of a blood vessel caused by an infected thrombus traveling through the bloodstream resulting in ischemia and/or infarction. Septic embolism can result in ischemia and/or infarction due to vascular occlusion and infection, resulting in inflammation and possible abscess formation. Systemic embolization generally occurs in left-sided IE, causing stroke, blindness due to embolism or endophthalmitis, splenic or renal infarct, limb ischemia, or even acute myocardial infarction. Here, we report a case of acute on chronic limb-threatening ischemia due to septic embolism in patient with IE.","PeriodicalId":42273,"journal":{"name":"Pakistan Heart Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46869200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison between the Levels of N Terminal Pro-Brain Natriuretic Peptide and Troponin I to Predict Left Ventricular Ejection Fraction in Patients Presenting with First ST-Elevation Myocardial Infarction","authors":"K. Sheikh, A. Farooq, Abeer Sarfaraz, S. Sarfaraz, S. Athar, Aemon Zehra","doi":"10.47144/phj.v56i1.2328","DOIUrl":"https://doi.org/10.47144/phj.v56i1.2328","url":null,"abstract":"Objectives: To compare the levels of N Terminal- ProBrain natriuretic peptide (NT-proBNP) and Troponin I (Trop I) to predict left ventricular ejection fraction (LVEF) in patients presenting with first ST-elevation myocardial infarction (STEMI).\u0000Methodology: A cross-sectional study was carried out in Cardiology department of a tertiary care hospital from June to November 2021. A total of 150 patients who presented at emergency department with first STEMI and underwent primary percutaneous coronary intervention (PCI) were included. The patient’s second set of troponin I and NT-proBNP were collected during hospitalization. Echocardiography was done. Left ventricular function was assessed using modified Simpson’s method. For data analysis, SPSS 21 was used.\u0000Results: The mean age was 60.60±11.1 years. There were 76% males, 53% hypertensive, 44% diabetic, 14% smokers with the most prominent type of myocardial infarction being anterior wall myocardial infarction accounting for 76.7%. Mean Trop I was 12.2±6.81 ng/ml, 9.5±8.63 ng/ml and 3.0±5.41 ng/ml for LVEF≤40%, 41-49% and >50% respectively while NT-proBNP was 7136.4±7.97pmol/l, 2328.9±3498.6pmol/l and 441±283.6pmol/l for LVEF ≤40%, 41-49%, and >50% respectively. We found a significant mean difference for Trop I (p=0.000) and NT-proBNP (p=0.0001). There was an inverse significant relationship of left ventricular ejection fraction with Trop I (r=-0.290, p=0.000) and NT- proBNP (r=-0.388, p=0.000).\u0000Conclusion: In comparison to Troponin I, NT-proBNP serves as a better marker to predict LVEF in patients presenting with first STEMI.","PeriodicalId":42273,"journal":{"name":"Pakistan Heart Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43482678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Angiotensin Receptor and Neprlysin Inhibition (ARNI) in Patients of Heart Failure with Reduced Ejection Fraction (HFrEF) - a real-world study","authors":"M. Hafizullah, W. Aman, Hisar Afridi","doi":"10.47144/phj.v56i1.2454","DOIUrl":"https://doi.org/10.47144/phj.v56i1.2454","url":null,"abstract":"Objectives: This is a real world prospective study to evaluate the effects of Neprlysin Inhibition (ARNI) using sacubitril/valsartan in patients with heart failure with reduced ejection fraction (HFrEF).\u0000Methodology: This was an outpatient study on patients of HFrEF (EF<40%) and stable blood pressure after obtaining informed consent. Consecutive patients were enrolled and followed at 6 and 12 weeks. Detailed clinical and echocardiographic examinations were performed on all visits. Biochemistry evaluating ProBNP, renal profile, HbA1C and electrolytes were performed in 24 patients at baseline and follow-up.\u0000Results: We enrolled 80 patients, but 63 patients could be followed. Mean age was 53.54±13.32 years and 55% were males. After 12 weeks treatment improvement in NYHA functional class was seen in 66% and improvement by more than one grade in 31% (p<0.01). Pro-BNP reduced from 3552.71±1804.74 at the baseline to 723±930 on the second FU visit (p<0.002).  Structural improvement was seen in 33% of patients. Left ventricular (LV) end-diastolic diameter (EDD) reduced by 3.49 mm and LV end systolic diameter (ESD) by 3.97 mm (p<0.014). Fractional shortening (FS) increased by 2.07% and EF by 3.52 (p<0.01). Patients tolerated the drug well, but most could not tolerate the higher recommended dosage. Renal status, electrolytes, and HbA1C did not alter significantly.\u0000Conclusion: Treatment with sacubitril/valsartan in addition to the guideline directed medical therapy (GDMT) resulted in marked reduction in ProBNP, significant improvement in functional class and enhancement of cardiac pumping activity with reduction in LVEDD and LVESD and improvement in FS and EF.","PeriodicalId":42273,"journal":{"name":"Pakistan Heart Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42797937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can We Take Hyperuricemia as a Cardiovascular Risk?","authors":"T. Ashraf, Raffat Sultana","doi":"10.47144/phj.v56i1.2537","DOIUrl":"https://doi.org/10.47144/phj.v56i1.2537","url":null,"abstract":"Study conducted for Gouty arthritis at Pan Pakistan level in 2017 showed mean Uric Acid levels of 6.11±1.7mg/dl with frequency of hyperuricemia of 39% and having 27.9% male and 49.35 women respectively.1\u0000This type of arthritis results from monosodium urate crystal deposition in and around the joints affecting big toe around the joints of hands and feet. Gout has been shown to increase with age and associated with diabetes & hypertension.2,3 It has also been shown that hyperuricemia may be tied to increased risk of cardiovascular disease mortality.4\u0000Hyperuricemia has also shown to increase atherosclerosis by   systemic inflammation and oxidative stress. It also causes endothelial dysfunction and oxidation of lipoproteins with formation of atherosclerotic plaques.5\u0000Recent studies have shown hypertension, coronary artery disease, cardiovascular diseases, vascular dementia and preclampsia to be associated with high uric acid levels. The studies include Rotterdam (Serum Uric Acid Level and Myocardial infraction),2 PUMA study (Serum Uric Acid levels with cardiovascular events and deaths in hypertensive patients),6 PAMELA study (increased risk of cardiovascular deaths with increase of every 1mg /dl).4\u0000Three important co-relation i.e. Hyperuricemia, atherosclerosis and heart failure need bit of understanding. In one study elevated uric acid levels (75.5mg/dl) in 90% of adolescents with essential hypertension7 and lower uric acid levels in teens with either white coat or secondary hypertension.7 Secondly association between increased uric acid levels and coronary artery calcification has shown an independent risk factor for subclinical atherosclerosis in young adults.8 Similar association was also seen in atherosclerotic vulnerable carotid plaque.9 Thirdly in cardiovascular health study incidence of heart failure was 21% with Chronic hyperuricemia and 18% without.10\u0000For management of hyperuricemia (gout) multidisciplinary approach involving primary care physicians, rheumatologist and cardiologists might improve associated cardiovascular diseases other than primary pathology.\u0000Drugs like non-steroidal anti-inflammatory drug (NSAIDS), steroids & colchicine may improve Gout but improvement in cardiovascular comorbids are questionable.11,12\u0000Though different epidemiological studies have shown hyperuricemia as an independent risk factor for cardiovascular diseases and hypertension. Further studies are needed that my elucidate association of increased uric acid level with cardiovascular diseases. Multidisciplinary approach, awareness and counselling patient will hopefully prevent onset of heart disease and improve survival outcomes for gouty patients.\u0000References\u0000\u0000Raja S, Kumar A, Aahooja RD, Thakuria U, Ochani S, Shaukat F. Frequency of Hyperuricemia and its Risk Factors in the Adult Population. Cureus. 2019;11(3):e4198.\u0000Grassi D, Ferri L, Desideri G, Di Giosia P, Cheli P, Del Pinto R, et al. Chronic hyperuricemia, uric acid deposit and cardiovascular risk. Curr ","PeriodicalId":42273,"journal":{"name":"Pakistan Heart Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48610387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Coronary Artery Dominance In-terms of Presentation and In-hospital Outcomes of patients undergoing Primary PCI for Culprit Proximal Left Anterior Descending Artery","authors":"L. Rai, Rajesh Kumar, S. Raza, M. Batra, Zafar Iqbal Mandokhail, Haroon Ishaque, Muhammad Ishtiaq Ali, Abdul Basit, M. Siddiqui, Kubbra Rahooja, Maryam Samad, Fawad Farooq, Z. Rehman, T. Saghir, J. Sial","doi":"10.47144/phj.v56i1.2460","DOIUrl":"https://doi.org/10.47144/phj.v56i1.2460","url":null,"abstract":"Objectives: Objective of this study was to assess the difference in terms of presentation and in-hospital course between patients with right vs. left dominant arterial circulation undergoing “primary percutaneous coronary intervention (PCI)” for culprit proximal left anterior descending artery (LAD).\u0000Methodology: We included consecutive adult (≥18 years) patients diagnosed with STE-ACS undergoing primary PCI for culprit proximal LAD. Patients were categorized into right vs. left dominant circulation on left heart catheterization. Demographic, clinical characteristics, presentation, and hospital course were compared between the matched (propensity matched) and unmatched cohort of patients with right vs. left dominance.\u0000Results: We included 775 patients, out of which 81.3% (630) were males and mean age was 54.59 ± 11.3 years. On coronary angiogram left dominance was observed in 14.3% (111). Single vessel disease was higher with left compared to right dominant system, 53.2% vs. 43.5%, respectively. The rate of slow flow/no-reflow (15.4% vs. 7.2%; p=0.0.230), heart failure (9.3% vs. 6.3%; p=0.299), and in-hospital mortality (5.1% vs. 3.6%, p=0.493) were not different between right vs. left dominance, respectively. In the matched cohorts, the frequency of slow flow/no-reflow (15.3% vs. 7.2%; p=0.056), heart failure (6.3% vs. 6.3%; p>0.999), and mortality (5.4% vs. 3.6%, p=0.493) were not different between right vs. left dominance, respectively.\u0000Conclusion: No significant increase in complications and outcomes is witnessed among patients with left dominant arterial circulation undergoing primary PCI for culprit proximal LAD. However, careful handling of left main during intervention is warranted due lack of support from right system.","PeriodicalId":42273,"journal":{"name":"Pakistan Heart Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48943743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of High-sensitive C-Reactive Protein in predicting Severity of Coronary Artery Disease in Patients with Acute Coronary Syndromes","authors":"S. Kiani, Waheed Ashraf, M. Khan, A. Chaudhry, N. Azad, Waheed Ul Rehman, A. Zafar","doi":"10.47144/phj.v56i1.2468","DOIUrl":"https://doi.org/10.47144/phj.v56i1.2468","url":null,"abstract":"Objectives: We investigated the correlation between baseline C-reactive protein (Hs-CRP) levels and severity of coronary artery disease (CAD), measured in terms of Syntax Score (SScore), among patients presenting with acute coronary syndromes (ACS).\u0000Methodology: This cross-sectional study was conducted at the Armed Forces Institute of Cardiology (AFIC), Rawalpindi, from April 2022 to October 2022. Baseline Hs-CRP levels were obtained for all the patients. Patients were divided into three groups as per the SScore as low (≤ 22), intermediate (≥ 23), and high (≥ 33) burden of CAD.\u0000Results: Out of the 200 patients studied, 82.5% (165) were males, and mean age was 60.16±10.66 years. Diabetics were 50% (100) of the sample, 48.5% (97) were hypertensive, and smokers were 17.5% (35). Median Hs-CRP was 4.0 mg/L [2.0-12.5 mg/L], and median left ventricular ejection fraction (LVEF) was 45% [40-55%]. Median SScore was 23.5 [14.5-30.0], with 44.5% (89) categorized as low, 36.5% (73) as intermediate, and 19% (38) as high burden of CAD. The correlation between Hs-CRP and SScore was 0.236 (p=0.001) and -0.229 (p=0.001) with LVEF. A significant increase in Hs-CRP was observed in relation to the burden of CAD (p<0.001) with median of 2.0 mg/L [1.0-4.2 mg/L], 6.0 mg/L [3.1-15.7 mg/L], and 12.5 mg/L [5.8-20.7 mg/L] for low, intermediate, high burden of CAD, respectively.\u0000Conclusion: Admission Hs-CRP was found to be positively correlated with the burden of CAD and negatively correlated with LVEF in patients with ACS.","PeriodicalId":42273,"journal":{"name":"Pakistan Heart Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46631108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}