Pakistan Heart Journal最新文献

{"title":"The Role of Integrin Beta 3 Polymorphisms in Coronary Artery Disease: A Systematic Review and Meta-analysis","authors":"Sana Ashiq, K. Ashiq, M. Sabar","doi":"10.47144/phj.v56i1.2362","DOIUrl":"https://doi.org/10.47144/phj.v56i1.2362","url":null,"abstract":"Objectives: The literature on the role of integrin beta 3 (ITGB3) exonic variants in coronary artery disease (CAD) and lipid outcomes is scarce. However, the findings remained uncertain and still not clear. Therefore, the current study aims to determine the association of rs5918 polymorphism with coronary artery disease.\u0000Methodology: All the eligible literature published in the English language from February 3, 2005, up to December 19, 2021, were searched by using different electronic databases and extracted all the required information from the available literature. The statistical analysis was performed through the MetaGenyo program, and pooled odds ratios (ORs) were calculated to determine the association between rs5918 and CAD.\u0000Results: The final analysis includes four studies, and the overall rs5918 risk allele in all the tested genetic models as follow: allelic model: OR 0.80 CI 0.41-1.58; homozygote model: OR 1.66, 95% CI 0.20-2.16; recessive model: OR 0.71 CI 0.44-1.14; dominant model: OR 0.81 CI 0.22-3.03. In addition, the lipid outcomes, including lipoproteins, cholesterol, and triglycerides were associated with increased disease risk. The shapes of the funnel plots suggest no publication bias in our study.\u0000Conclusion: In conclusion, our final pooled analysis revealed a non-significant role of this exonic polymorphism in coronary artery disease that may exert its effect by modulating various lipid parameters. However, more studies are required with a larger cohort size that may give us conclusive results in the future.","PeriodicalId":42273,"journal":{"name":"Pakistan Heart Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47969853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular Imaging in Women with Heart Diseases, A local Clinical Practice Guidelines for Pakistani Population","authors":"S. Habib, Fateh Ali Tipoo Sultan, Saba Hussain, Lubna Baqai, S. Sohail","doi":"10.47144/phj.v56isupplement_1.2456","DOIUrl":"https://doi.org/10.47144/phj.v56isupplement_1.2456","url":null,"abstract":"This is the first time that a local preliminary document on gender differences in CVDs has been initiated in Pakistan. International forum has been highlighting significant gender and ethnicity in CVDs. So different countries from world took the initiative to develop their local guideline or clinical scientific statements on gender differences with different socio-cultural and educational background for their own countries. GRFW in collaboration with Scientific Council of Women with Heart Disease PCS Pakistan floated this idea to develop a local guideline in various aspects CVDs for our own women population. In this regard different topics were assigned to different groups including mostly female cardiologists, senior gynecologists/obstetricians and radiologist from all over Pakistan. Primary objectives of this write up on Cardiac Imaging in Women is to provide a local clinical practice guideline for the assessment and management of CVD that will improve and standardize the physicians’ decision making for Pakistani women population. In the setting of growing awareness of providing personalized precision medicine, addressing sex differences in CVD is a key goal.\u0000The intention is to inform cardiologists, non-cardiologist physicians’, general practitioners, and, obstetrician/gynecologists about the reasonable use and understanding of technologies to help in proper approach to their treating women with HDs and when to send them for cardiac specialist diagnostic center. As we could not find our own local data on cardiac imaging to report at present, most recommendations on cardiac imaging used has been taken from international literatures (which we have found feasible, readily available, and some cost effective approach in our money constraint society which can be followed in our population) and also which were published within the past decade were given priority. In this document, we discuss the role of using different cardiac imaging modalities, with a focus on diseases which are unique/or occur more in women. So, five women specific topics more commonly seen in our population were selected currently, which are (stable/unstable angina and ACS, MINOCA), non-ischemic CMP, HD during pregnancy, cardio-oncology, and connective tissue diseases (CTD). In these topics we have tried to used our own local incidences and prevalence of these diseases in our community/internationally on gender basis and have highlighted the availability/limitations of cardiac imaging in our society. The updated recommendations in women have been taken from international guidelines. Graphs and tables layout has been taken from abroad literatures and made some few changes according to its use in our population. You will find this a preliminary review document which will be simple to read, have updated approach in evaluating the diagnosis of HD in women easily. For current cost effectiveness issues for our population will be taken up by PCS to Health ministries of Pakistan for its ","PeriodicalId":42273,"journal":{"name":"Pakistan Heart Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43091913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Hypertension in Women. Pakistan Hypertension Clinical Practice Guidelines","authors":"Sumera Nasim, P. Sirichand, Nida Imran, Ayesha Zahide, Gulfareen Haider, A. Amna, N. Mohsin, A. Arain, A. Faruqui, Sohail Aziz, J. Sial, B. Mohydin, Shahbaz A Kureshi, N. Majeed, F. Memon, K. Soomro","doi":"10.47144/phj.v56isupplement_1.2455","DOIUrl":"https://doi.org/10.47144/phj.v56isupplement_1.2455","url":null,"abstract":"Hypertension has been recognized as a global health concern.  In developing countries, it is not addressed and described to the extent that the actual prevalence of the disease makes it necessary. In these countries, control of blood pressure (BP) remains suboptimal. Worldwide BP reduction is a serious issue, and the situation is more alarming situation in our country. Pakistan is one of them, more than 46% of the Pakistani population are hypertensive. In 2010, hypertension was the leading cause of death and disability worldwide, and a greater contributor to events in women. South Asia contributes 24% of world population and is undergoing a rapid epidemiological transition with significant rates of hypertension in different countries. The prevalence of hypertension in low socioeconomic population in Pakistan is 39% in women vs. 37% in men.\u0000There is no proper data regarding hypertension in women in Pakistan, except for a few populations based surveys conducted which showed the prevalence of hypertension. The pooled prevalence in Pakistani women is 24.76% vs. 24.9% for men for an age bracket of above 40 years. The occurrence is higher in urban compared to rural areas. General practitioners (GP) in Pakistan underdiagnose and undertreat high BP, especially in the elderly women. Only in 37% of patients, the treatment was initiated by a GP. 23% of this group received only sedatives alone or combination of sedatives and hypertension control medication. We lack published guidelines regarding hypertension.\u0000Hypertension still remains the major preventable cause of cardiovascular disease. Hypertension is a leading cause of mortality globally, and especially in our continent. The purpose of these guidelines is to highlight the neglected population (i.e., Women) of Pakistan, who are physically and hormonally different from men.  They have more complications as a result of hypertension. Early diagnosis and proper treatment and adherence to the treatment is therefore important.\u0000The task of developing guideline on hypertension is by Go Red Chairperson and Scientific Council Pakistan in collaboration with Pakistan cardiac society. This is first clinical practice guidelines for management of hypertension which is a need of our time with the objective to control the epidemic of hypertension in women.\u0000This scientific document on hypertension in women with local recommendation which are made local studies and randomized trials and south Asian studies. These educational tool help the health care providers GP and doctors because all see the women in theirs practice and using this guideline facilitate them for treatment because specially in elderly women usually received only sedative alone or in combination with antihypertensive medicines by GPS. Our efforts will encourage GPs and medical practitioners to practice these guidelines in their clinical judgment about risk and complications, as well as in the determination and implementation of preventive, diagnostic or the","PeriodicalId":42273,"journal":{"name":"Pakistan Heart Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41915555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FREQUENCY OF ISCHEMIC MITRAL REGURGITATION AFTER ACUTE ST- ELEVATION MYOCARDIAL INFARCTION AT A TERTIARY CARE CARDIAC CENTER","authors":"K. Khan, N. Khan, F. Qadir, Muhammad Tariq Farman, K. I. Bhatti, P. Akhtar","doi":"10.47144/phj.v55i4.2367","DOIUrl":"https://doi.org/10.47144/phj.v55i4.2367","url":null,"abstract":"Objectives: Among the common complications of coronary artery disease (CAD) is the ischemic mitral regurgitation (IMR). Identifying IMR and assessing its severity is pertinent owing to its significance in post- myocardial infarction (MI) risk stratification. It is associated with a higher risk of heart failure and mortality. This study aimed to determine the frequency of IMR after the first acute ST-elevation MI (STEMI) in the Pakistani population.\u0000Methodology: A cross-sectional observational study was conducted at NICVD, Karachi between January and July 2021. One hundred and ninety-five consecutive participants of first acute ST elevation MI who fulfilled the diagnostic criteria of IMR were included in the study. Demographic and clinical profile was recorded. All patients underwent echocardiography to grade the severity of IMR. Data was entered and analyzed using SPSS version 20.\u0000Results: Of 195 patients, 141 (72.3%) were males. 77 (39.5%) were diabetic, 92 (47.2%) were hypertensive, 18 (9.2%) had dyslipidemia and 58 (29.7%) used tobacco. IMR was observed in 74 (37.9%) with mild in 50 (67.6%), moderate in 18 (24.3%), and severe in 6 (8.1%) patients. IMR was statistically significantly associated with duration of symptoms, type of MI, diabetes mellitus, hypertension, and tobacco use.\u0000Conclusion: IMR was prevalent in more than one-third of patients presenting with acute ST elevation MI. Severity of IMR was moderate to severe in about one-third of the patients. IMR was found to be associated with duration of symptoms, type of MI, diabetes mellitus, hypertension, and tobacco use. Considering its prognostic role, assessment of IMR and its severity is necessary for appropriate management of patients.","PeriodicalId":42273,"journal":{"name":"Pakistan Heart Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45436645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COMPARISON OF CLINICAL AND ANGIOGRAPHIC CHARACTERISTICS OF DIABETIC AND NON-DIABETIC PATIENTS WITH ACUTE MYOCARDIAL INFARCTION","authors":"B. Ahmed, J. Shah, Rajesh Kumar, M. Batra, K. A. Shaikh, A. Ammar, Ambreen Nisar, Gulzar Ali, T. Saghir, N. Qamar","doi":"10.47144/phj.v55i4.2309","DOIUrl":"https://doi.org/10.47144/phj.v55i4.2309","url":null,"abstract":"Objectives: In this study, we evaluated the differences in clinical and angiographic profiles of ST-segment elevation myocardial infarction (STEMI) patients with and without diabetes mellitus (DM) at a tertiary care cardiac hospital in Karachi, Pakistan.\u0000Methodology: This descriptive cross-sectional study was conducted at a tertiary care cardiac hospital in Karachi, Pakistan. The study included consecutive adult patients (≥ 18 years of age) diagnosed with STEMI undergoing primary percutaneous coronary intervention (PCI). Diabetic and non-diabetic patients were compared for clinical and angiographic profiles.\u0000Results: The study sample consisted of 43.8% (218) diabetic patients. The mean age was 59.03 ± 9.69 years vs. 49.54 ± 11.53 years; p<0.001, proportion of females was 35.3% (77) vs. 14.6% (41); p<0.001, Killip class III or IV was (17) vs. 2.5% (7), and hypertension was 83% (181) vs. 56.8% (159); p<0.001 among the diabetic and non-diabetic group, respectively. The frequency of multi-vessel disease was 50.9% (111) vs. 39.6% (111), the significant left main disease was 5% (11) vs. 2.5% (7), and initial TIMI III flow was 19.3% (42) vs. 25.4% (71) in diabetic and non-diabetic patients, respectively.\u0000Conclusion: In conclusion, diabetes in STEMI setting is associated with complex coronary artery diseases, more hemodynamic instability at presentation, and the presence of multiple co-morbid conditions.","PeriodicalId":42273,"journal":{"name":"Pakistan Heart Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45620190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THIRTY-YEAR TREND OF NON-RHEUMATIC VALVULAR HEART DISEASE: A COMPARISON OF PAKISTAN WITH SOUTH ASIA AND GLOBAL SCENARIO","authors":"Bilal Ahmed, W. Hussain, Jamilul Hussain, Abdul Basit, Javeria Haider, A. Muhammad, Ahmed Raheem","doi":"10.47144/phj.v55i4.2452","DOIUrl":"https://doi.org/10.47144/phj.v55i4.2452","url":null,"abstract":"Objectives: This study aimed to evaluate the burden and trends of non-rheumatic valvular heart disease (VHD) in Pakistan compared to the South Asian (SA) and Global figures based on estimates of the Global Burden of Disease (GBD) study for the years 1990 to 2019.\u0000Methodology: Data for the estimated prevalence, deaths, and disability-adjusted life years (DALYs), along with age-standardized death rate (ASDR) due to non-rheumatic VHD in Pakistan, was extracted from the GBD study.\u0000Results: The prevalence of non-rheumatic VHD in Pakistan increased by 14.1% from 1990 to 2019, from 6.4 to 7.3/100,000. The ASDR per 100,000 population has shown a 12.9% increase between the years 1990 and 2019 (from 1.32 to 1.49) with an IRR of 1.102 [1.002-1.1983]. However, global and SA's decreased slightly with an IRR of 0.997 [0.971-1.024] and 0.996 [0.959-1.034]. The estimated number of deaths has shown a 1.1% increase from 0.6 to 0.6/100,000 from 1990 to 2019. Similarly, the estimated number of DALYs has shown an increased (17%) from 14.1 in 1990 to 16.5/100,000 in 2019. Interestingly, Sindh, Baluchistan, and Azad Jammu & Kashmir also had seen the most significant increase in DALYs over 30 years, accounting for 30.3%, 23.7%, and 23.9% respectively.\u0000Conclusion: Based on the analysis of GBD estimates, it can be concluded that, in Pakistan, the prevalence, deaths, and DALYs rate of non-rheumatic VHD per 100 thousand individuals increased substantially between 1990 and 2019. The age-standardized death rate also significantly increased over the past 30 years.","PeriodicalId":42273,"journal":{"name":"Pakistan Heart Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49221372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MECHANISM OF CAMEL MILK ON DIABETES COMPLICATIONS AND CARDIOVASCULAR DISORDERS","authors":"Taherah Mohammadabadi, Asif Ur Rehman, R. Jain","doi":"10.47144/phj.v55i4.2388","DOIUrl":"https://doi.org/10.47144/phj.v55i4.2388","url":null,"abstract":"Diabetes is a common metabolic disease that causes cardiovascular disease. Insulin and oral hypoglycemic drugs are the treatment for diabetes, but high percentage of patients cannot use allopathic drugs and rely on natural alternative healings. Camel milk with therapeutic properties, is a good source of vitamins C, minerals such as Mn, iron, Cu, Zn; and immunoglobulins compared to cow milk. Insulin of camel milk is a great substitute due to no coagulum formation in the stomach. Raw camel milk increases insulin secretion, reduces insulin resistance and affects signaling and glucose transport. It also decreases the complications due to diabetes like cardiovascular disorders, obesity, oxidative stress and promotes wound healing. There is high amount of unsaturated fatty acids in camel milk for heart health. Also, probiotic bacteria and hypocholesterolemia peptides reduce cholesterol absorption and hence better control of its blood level and cardiovascular issues. Therefore, camel milk is effective in preventing complications due to diabetes and cardiovascular disorders.","PeriodicalId":42273,"journal":{"name":"Pakistan Heart Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47261897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 AND NEGLECT OF CARDIOVASCULAR DISEASES TREATMENT","authors":"Sajjad Bahariniya, M. Ghanbari, Mohammad Ezati Asar, F. Madadizadeh","doi":"10.47144/phj.v55i4.2351","DOIUrl":"https://doi.org/10.47144/phj.v55i4.2351","url":null,"abstract":"Coronavirus was first reported as an acute respiratory syndrome in December 2019 in Wuhan, China. This infectious disease spreads rapidly in many countries , and humans worldwide, shows different symptoms of the disease. High fever, cough, and fatigue were the most common symptoms that patients with covid-19 showed.1 The COVID-19 pandemic has created unprecedented challenges for health care in many countries worldwide. In addition to patients, COVID-19 is very dangerous for health care staff at the frontline of fighting this disease. The large number of COVID-19 virus patients who need to be hospitalized puts a heavy burden on the health system of countries so the treatment of other diseases is seriously disrupted.2\u0000Cardiovascular disease is one of the most important diseases that has been neglected due to the focus of the Covid-19 pandemic and its special conditions, including completing the capacity of clinical departments and full-time participation of hospital staff.3 Among various diseases, cardiovascular diseases are the most common and the main cause of death in the world (Estimated 17.9 million death each year) and the most important factor of disability (Generally, about eleven percent of the total disease burden).4 Despite significant advances in the field of medicine, one-third of patients who suffer from a heart attack (myocardial infarction) still die, and two-thirds of those who never survive fully recover and are unable to lead normal lives.5\u0000There is a close relationship between COVID-19 and cardiovascular diseases so cardiovascular diseases are more common in patients with COVID-19, and these patients are at higher risk of death.6 Cardiovascular disease is associated with more severe symptoms of COVID-19 and higher mortality rates. COVID-19 can have primary cardiac involvement (arrhythmia, myocardial infarction, and myocarditis) and secondary cardiac involvement (myocardial damage/elevated biomarkers and heart failure). COVID-19 can have several effects on the cardiovascular system of patients. Acute cardiovascular complications can cause many challenges. For example, one of these challenges can be the need for a multidisciplinary heart and lung team to assess the condition of patients with severe symptoms.7,8\u0000Currently, the outbreak of COVID-19 disease has created unprecedented pressure on patients, physicians, and in general, the health care systems of the world and led to delays in the treatment of cardiovascular patients. Delay or neglect of treatment of cardiovascular patients is associated with inevitable complications and mortality. Because the living conditions of many of them are threatening and dangerous.9 Some early signs of cardiovascular disease (shortness of breath, chest pain) in patients may be confused with COVID-19 symptoms, and the patient may be misdiagnosed.10\u0000The COVID-19 pandemic has faced the world in a difficult position. Hospitals and health centers have been severely affected by treating patients with C","PeriodicalId":42273,"journal":{"name":"Pakistan Heart Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47313368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CONDITION LEADING TO PEDIATRIC CARDIOLOGY CONSULTATION IN TERTIARY CARE HOSPITAL PESHAWAR","authors":"H. Gul, I. Hussain, Haseen Dil, I. Ullah, Y. Rehman, Effat Hissamuddin, Muhammad Sohail Khan, Abdul Moeed, F. Gohar, FA Ali","doi":"10.47144/phj.v55i4.2323","DOIUrl":"https://doi.org/10.47144/phj.v55i4.2323","url":null,"abstract":"Objectives: This study was conducted to determine the basis for cardiology consultation and the rationale for different clinical conditions in the pediatric population.\u0000Methodology: This descriptive study was conducted in Pediatric Cardiology department, Peshawar institute of Cardiology from June 2021 to December 2021. A data of 817 patients was collected from monthly log of patients maintained by the consultation services, files of admitted patients, echocardiographic and laboratory reports. Patients enlisted through consecutive sampling irrespective of patients age, gender. Data collected was analyzed on IBM SPSS version 20. For numerical variables, mean/standard deviations were determined. For categorical variables, frequency and percentages were determined, and a p-value of 0.05 was deemed a significant difference.\u0000Results: Age at the time of consultation was 3.2 ± 11.7 years (range 1 day to 47 years). The most common basis for consultation were intercurrent illness in underlying congenital heart disease 288 (35.25%). A total of 551(67%) had Single consultation and 266(32.92%) had multiple consultation ranging from 2 to 4.\u0000Conclusion: Systematic approach should be followed to assess these patients in tertiary care hospital and all consultants must follow the curricula to get the required knowledge and gain expertise in these diseases to diagnose properly. None the less these data confirm the impression of increasing demands of the pediatric cardiologist, and thus may be useful in planning consultant services within the specialty.","PeriodicalId":42273,"journal":{"name":"Pakistan Heart Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42824688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IN-HOSPITAL MORTALITY AFTER INCOMPLETE PERCUTANEOUS REVASCULARIZATION IN PATIENTS WITH MULTIVESSEL CORONARY ARTERY DISEASE PRESENTING WITH ACUTE CORONARY SYNDROME","authors":"M. Iqbal, Shams Rehan, M. N. Khan, N. Soomro, Shakir Zada, Salman Abbas","doi":"10.47144/phj.v55i4.2308","DOIUrl":"https://doi.org/10.47144/phj.v55i4.2308","url":null,"abstract":"Objectives: Patients with significant multi-vessel coronary artery disease (CAD) are approximately one-half to two-thirds of patients presenting with acute coronary syndrome (ACS). Therefore, this study aimed to evaluate the in-hospital mortality of incomplete percutaneous revascularization in a patient with multi-vessel CAD presenting with ACS at a single tertiary care hospital in Karachi, Pakistan.\u0000Methodology: This descriptive study with 282 included consecutive patients from March 22, 2021, to September 21, 2021, fulfilling the inclusion criteria of aged between 18 and 75 years and of any gender, diagnosed with ACS, multi-vessel diseases, and undergone percutaneous revascularization of culprit artery only. Patients with pre-existing chronic kidney disease or cardiogenic shock at presentation were excluded. All patients were kept under observation during the hospital stay for up to one week, and in-hospital mortality was recorded.\u0000Results: Mean age was 55.7±10.8 years with 185 (65.6%) male patients. Types of ACS were noted as ST-elevation myocardial infarction (STEMI) in 109 (38.7%), 117 (41.5%) non-STEMI, while unstable angina was noted in 56 (19.9%) patients. Three-vessel disease was noted in 126 (44.7%), 108 (38.3%) were diabetics, 164 (58.2%) were hypertensive, and 128 (45.4%) were smokers. In-hospital mortality was documented in 22 (7.8%) patients.\u0000Conclusion: A significant proportion of in-hospital mortality was observed after incomplete percutaneous revascularization in ACS patients with multi-vessel CAD.","PeriodicalId":42273,"journal":{"name":"Pakistan Heart Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46480111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}