The Journal of The Korean Society for Transplantation最新文献_第4页

Changes in Insulin Sensitivity and Lipid Profile in Renal Transplant Recipients Converted from Cyclosporine or Standard Release Tacrolimus to Once-Daily Prolonged Release Tacrolimus 肾移植受者从环孢素或标准释放他克莫司转为每日一次缓释他克莫司后胰岛素敏感性和脂质谱的变化

The Journal of The Korean Society for Transplantation Pub Date : 2017-09-01 DOI: 10.4285/JKSTN.2017.31.3.126

J. Yang, Y. Kim, H. Shin, Y. Jung, H. Rim

{"title":"Changes in Insulin Sensitivity and Lipid Profile in Renal Transplant Recipients Converted from Cyclosporine or Standard Release Tacrolimus to Once-Daily Prolonged Release Tacrolimus","authors":"J. Yang, Y. Kim, H. Shin, Y. Jung, H. Rim","doi":"10.4285/JKSTN.2017.31.3.126","DOIUrl":"https://doi.org/10.4285/JKSTN.2017.31.3.126","url":null,"abstract":"Background: Tacrolimus (Tac) can cause impaired insulin release and dyslipidemia, and may affect the development of post-trans-plant diabetes mellitus. However, these effects on insulin sensitivity and lipid profile have not been compared in renal transplant recipients receiving traditional twice-daily tacrolimus (TacBID) or cyclosporine and those receiving once-daily prolonged release formulation of tacrolimus (TacOD). Methods: We conducted an observational prospective study of 15 stable non-diabetic renal transplant recipients to observe the changes in insulin sensitivity and lipid profiles for 1 year at a tertiary hospital. We evaluated the levels of hemoglobin A1c, total cholesterol, high density lipoprotein, low density lipoprotein, triglycerides, apolipoprotein A1, apolipoprotein B, serum creatinine, fasting plasma glucose, fasting insulin, homeostatic model assessment of  -cell (HOMA-  ) and HOMA-insulin resistance index at baseline and at 2 and 4 months. To analyze differences in parameters, we conducted a Wilcoxon rank sum test and general linear model (GLM)-repeated measures analysis of variance (ANOVA) in both groups (cyclosporine to TacOD conversion group/TacBID to TacOD conversion group). Results: At baseline, parameters did not differ between groups. GLM-repeated measures ANOVA revealed no change in insulin sensitivity or lipid profile after conversion at baseline or at 2 and 4 months. There were no complications after conversion from standard TacBID or cyclosporine to TacOD. Conclusions: There was no change in insulin sensitivity or lipid profile in renal transplant recipients. Any conversion from TacBID to TacOD should be performed in a controlled manner under Abbreviations: SBP, systolic blood pressure; DBP, diastolic blood pressure; GFR, glomerular filtration rate; LDL-C, low density lipoprotein cholesterol; HDL-C, density lipoprotein cholesterol; HbA1c, hemoglobin homeostasis of","PeriodicalId":420886,"journal":{"name":"The Journal of The Korean Society for Transplantation","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129156706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Late Onset Renal Vein Thrombosis after Kidney Transplantation 肾移植后迟发性肾静脉血栓

The Journal of The Korean Society for Transplantation Pub Date : 2017-06-01 DOI: 10.4285/JKSTN.2017.31.2.87

W. Park, S. Kang, K. Jin, S. Park, Seungyeup Han

引用次数: 0

Lessons Learned from Inappropriate Ligation of the Left Renal Vein for a Large Splenorenal Shunt in Living Donor Liver Transplantation 活体肝移植中大脾肾分流术左肾静脉结扎不当的经验教训

The Journal of The Korean Society for Transplantation Pub Date : 2017-06-01 DOI: 10.4285/JKSTN.2017.31.2.82

Y. Han

引用次数: 0

A Preliminary Study to Revise the Marginal Donor Criteria of KONOS in Deceased Donor Kidney Transplantation 修改已故供肾移植中KONOS边缘供者标准的初步研究

The Journal of The Korean Society for Transplantation Pub Date : 2017-06-01 DOI: 10.4285/JKSTN.2017.31.2.59

W. Huh

{"title":"A Preliminary Study to Revise the Marginal Donor Criteria of KONOS in Deceased Donor Kidney Transplantation","authors":"W. Huh","doi":"10.4285/JKSTN.2017.31.2.59","DOIUrl":"https://doi.org/10.4285/JKSTN.2017.31.2.59","url":null,"abstract":"Background: The Korean Network for Organ Sharing (KONOS), which was established in December 31st, 1999, is a nationwide system of deceased donor detection and distribution. From its inception, KONOS has defined marginal donors and used this definition for over 15 years. However, this definition should be reevaluated to determine if it requires revision. This study was conducted to confirm the feasibility of the main study for revision of the marginal donor definition in deceased donor kidney transplantation. Methods: This study is a retrospective meta-analysis of 786 patients who had deceased donor kidney transplant from six centers. After the data validation process, multivariable analysis was conducted to evaluate whether the marginal donor criteria of KONOS or UNOS expected adequately in terms of graft survival and delayed graft function (DGF). Results: Neither the KONOS or UNOS criteria affected graft survival. Expanded criteria for donors of UNOS was a risk factor for DGF. However, KONOS criteria did not affect DGF. Conclusions: Based on this preliminary study, there is a need to conduct a study to revise the marginal donor criteria of KONOS in deceased donor kidney transplantation. Such a study should have large scale and long-term follow-up data.","PeriodicalId":420886,"journal":{"name":"The Journal of The Korean Society for Transplantation","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129527553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case Treated with Extracorporeal Membrane Oxygenation for Disseminated Cytomegalovirus Infection after Liver Transplantation 体外膜氧合治疗肝移植术后弥散性巨细胞病毒感染1例

The Journal of The Korean Society for Transplantation Pub Date : 2017-06-01 DOI: 10.4285/JKSTN.2017.31.2.75

Jimyung Park, Yoon Hyun Lee, Y. Choi, Yeon Joo Lee, Dong Jung Kim, S. Jheon, Y. Cho

{"title":"A Case Treated with Extracorporeal Membrane Oxygenation for Disseminated Cytomegalovirus Infection after Liver Transplantation","authors":"Jimyung Park, Yoon Hyun Lee, Y. Choi, Yeon Joo Lee, Dong Jung Kim, S. Jheon, Y. Cho","doi":"10.4285/JKSTN.2017.31.2.75","DOIUrl":"https://doi.org/10.4285/JKSTN.2017.31.2.75","url":null,"abstract":"Cytomegalovirus (CMV) is a clinically important pathogen in immunocompromised patients, especially after organ transplantation. However, there have been several reports of severe CMV infections in immunocompetent patients. This report presents a case of an immunocompetent patient who presented with fulminant hepatitis requiring liver transplantation. Because CMV was detected upon histopathologic review of the explanted liver, it was later assumed that CMV may be the primary cause of hepatitis. However, at the time of transplantation, we did not suspect CMV hepatitis. Following transplantation and initiation of immunosuppression, the patient developed viral sepsis with a disseminated CMV infection. Respiratory failure because of CMV pneumonia worsened despite antiviral therapy, and venovenous extracorporeal membrane oxygenation (ECMO) was initiated. Although ECMO has been traditionally contraindicated in patients with sepsis, this patient recovered and was successfully weaned off ECMO. CMV should be included in the differential diagnosis of fulminant hepatitis, even in immunocompetent patients, especially when liver transplantation is considered.","PeriodicalId":420886,"journal":{"name":"The Journal of The Korean Society for Transplantation","volume":"78 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127718501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What Is Antibody-Mediated Rejection in Histologic Diagnosis in Liver Recipients? 抗体介导的排斥反应在肝脏受者的组织学诊断中的意义是什么?

The Journal of The Korean Society for Transplantation Pub Date : 2017-03-01 DOI: 10.4285/JKSTN.2017.31.1.1

K. Lee

{"title":"What Is Antibody-Mediated Rejection in Histologic Diagnosis in Liver Recipients?","authors":"K. Lee","doi":"10.4285/JKSTN.2017.31.1.1","DOIUrl":"https://doi.org/10.4285/JKSTN.2017.31.1.1","url":null,"abstract":"Antibody-mediated rejection (AMR) is a rare event in liver transplantation compared to other solid organs such as the kidney and heart because of the different immunologic reactions in the liver and it ability to compensate for damage. Although it is not easy to define the histological features that help diagnosis because of its rarity, a few histologic features such as portal eosinophilia with eosinophilic endothelialitis have been reported as useful for diagnosis of acute AMR in presensitized patients. C4d staining is not a good indicator of AMR in liver grafts because of its low sensitivity and specificity. AMR is an emerging cause of chronic graft failure, especially in high risk patients having preformed or de novo donor specific alloantibodies (DSA). Some histologic parameters including interface hepatitis, lobular inflammation, portal collagenation, portal venopathy, and sinusoidal fibrosis, have been suggested as chronic AMR to predict graft fibrosis and survival in DSA positive patients. In conclusion, recent studies have resulted in the histological diagnostic criteria of AMR becoming more specific; however, confirmation of AMR still requires strong clinical evidence for alloantibodies.","PeriodicalId":420886,"journal":{"name":"The Journal of The Korean Society for Transplantation","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116811003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influencing Factors Affecting Successful Organ Donation and Families' Consent to Donate after Drain Death 影响器官捐献成功的因素及引流死亡后家属捐献意愿的因素

The Journal of The Korean Society for Transplantation Pub Date : 2017-03-01 DOI: 10.4285/JKSTN.2017.31.1.43

Eun Woo Lee, Hye-Yeon Jang, S. Han, K. Han, S. Oh, Young-Nam Roh

{"title":"Influencing Factors Affecting Successful Organ Donation and Families' Consent to Donate after Drain Death","authors":"Eun Woo Lee, Hye-Yeon Jang, S. Han, K. Han, S. Oh, Young-Nam Roh","doi":"10.4285/JKSTN.2017.31.1.43","DOIUrl":"https://doi.org/10.4285/JKSTN.2017.31.1.43","url":null,"abstract":"Background: This study was conducted to identify the factors influencing successful organ donation and families’ consent to donate after brain death. Methods: Medical records and data regarding organ donation counseling with the families of 107 brain-dead potential donors between September 2012 and March 2016 at a single tertiary medical center were retrospectively reviewed. Results: The final consent rate was 57.9% (62/107), and successful donation was performed in 40.2% (43/107) of cases. Univariate and multivariate analyses revealed that the independent factors associated with successful organ donation were age <60 years (odds ratio [OR], 3.384; 95% confidence interval [CI], 1.350 to 8.484; P=0.009), systolic blood pressure ≥90 mmHg (OR, 6.261; 95% CI, 1.418 to 27.653; P=0.015), and serum sodium level ≥150 mEq (OR, 4.215; 95% CI, 1.655 to 10.733; P=0.003). Family’s consent to donate was significantly associated with head trauma (OR, 3.538; 95% CI, 1.104 to 11.334; P=0.033) and serum sodium level ≥150 mEq (OR, 3.392; 95% CI, 1.404 to 8.194; P=0.007). Conclusions: Successful organ donation was associated with patient age, systolic blood pressure and serum sodium level. Family’s consent to donate was associated with head trauma and serum sodium level.","PeriodicalId":420886,"journal":{"name":"The Journal of The Korean Society for Transplantation","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128750592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Development of Pre-discharge Group Education Program for Liver Transplant Patients 肝移植患者出院前团体教育方案的制定

The Journal of The Korean Society for Transplantation Pub Date : 2017-03-01 DOI: 10.4285/JKSTN.2017.31.1.34

J. Yun, Kyung-Choon Lim, J. Jeong, H. Ha, J. Hong, S. Lee, L. Kim, Yeon Hee Kim, Shin Hwang

引用次数: 5

Non-invasive Myocardial Strain Imaging to Evaluate Graft Failure in Cardiac Xenotransplantation 无创心肌应变显像评价异种心脏移植的移植物衰竭

The Journal of The Korean Society for Transplantation Pub Date : 2017-03-01 DOI: 10.4285/JKSTN.2017.31.1.25

H. Yang, H. Chee, J. Kim, W. Kim, J. Park, K. Shin, K. Park, S. Lee, Ka-hee Cho, W. Park, K. Oh, C. Ahn, I. Yun

{"title":"Non-invasive Myocardial Strain Imaging to Evaluate Graft Failure in Cardiac Xenotransplantation","authors":"H. Yang, H. Chee, J. Kim, W. Kim, J. Park, K. Shin, K. Park, S. Lee, Ka-hee Cho, W. Park, K. Oh, C. Ahn, I. Yun","doi":"10.4285/JKSTN.2017.31.1.25","DOIUrl":"https://doi.org/10.4285/JKSTN.2017.31.1.25","url":null,"abstract":"Background: The shortage of human hearts for allotransplantation makes xenotransplantation a possible option for controllable organ providers. To detect acute xenograft rejection, invasive biopsy seems inevitable; however, this occasionally results in poor incision wound healing or infection. To date, no method of noninvasive imaging for early detection of xenograft rejection has been established. We hypothesized that ultrasound speckle tracking would better detect xenograft failure than routine left ventricular ejection fractions (EF). Methods: From August 2013 to July 2015, a total of six cardiac heterotopic xenotransplants (  1, 3-galactosyltransferase gene-knockout porcine heart) into cynomolgus monkeys were monitored with echocardiography every 3 to 7 days. M-mode and two-dimensional (2D)-EF measurements and myocardial strain analyses were performed. Cardiac xenograft pathology was reviewed from the immediate postoperative biopsy, as well as the necropsy. Results: Myocardial speckle tracking analysis was feasible in all six cases. The longest survival was 43 days. Only one pathol-ogy-proven immunologic rejection occurred. Cardiac xenograft failure appeared as two types: a dilated pattern with decreased EF or a myocardial-thickening pattern with preserved EF. Both antibody-mediated rejection (n=1) and sepsis-induced myocardial dysfunction (n=2) revealed decreased radial or circumferential strains, but normal-range EF. Xenograft functional decline was significant with respect to radial or circumferential strain (P=0.028), but not to conventional M-mode or 2D-EFs (P=0.600, P=0.340, respectively). Conclusions: Radial and circumferential strains were significantly decreased in both types of xenograft failure, regardless of EF. Further studies are warranted to correlate the strain analysis and immunopathological","PeriodicalId":420886,"journal":{"name":"The Journal of The Korean Society for Transplantation","volume":"94 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125239133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Kidney Transplantation from Expanded Criteria Donor in Korea: It's Time to Have Our Own Criteria Based on Our Experiences 韩国扩大供体肾移植标准:是时候根据我们的经验制定我们自己的标准了

The Journal of The Korean Society for Transplantation Pub Date : 2017-03-01 DOI: 10.4285/JKSTN.2017.31.1.16

Shin-Seok Yang, J. Park

引用次数: 1