Brandon George Smith, Thomas Edmiston, Laura Hobbs, Michael Bath, Katharina Kohler, Saleyha Ahsan, Isla Kuhn, Tonny Luggya, Shobhana Nagraj, Sara Venturini, Cornelius Sendagire, Daphne Kabatoro, Almas Khattak, Charlotte Jane Whiffin, Peter John Hutchinson, Tom Bashford, Tariq Khan, Arthur Kwizera
{"title":"Mobile phone-based systems for community-led injury response and coordination: a scoping review protocol.","authors":"Brandon George Smith, Thomas Edmiston, Laura Hobbs, Michael Bath, Katharina Kohler, Saleyha Ahsan, Isla Kuhn, Tonny Luggya, Shobhana Nagraj, Sara Venturini, Cornelius Sendagire, Daphne Kabatoro, Almas Khattak, Charlotte Jane Whiffin, Peter John Hutchinson, Tom Bashford, Tariq Khan, Arthur Kwizera","doi":"10.1097/SP9.0000000000000040","DOIUrl":"10.1097/SP9.0000000000000040","url":null,"abstract":"<p><p>Traumatic injuries remain a leading cause of preventable death globally, and continue to burden global healthcare services, particularly in low-resource settings. Mobile phone-based community injury response and coordination (mCIRC) systems represent a promising solution in facilitating rapid identification of injured persons, and coordinating a community-led response as an alternative or adjunct to a formal emergency service. mCIRC systems may use technologies such as geolocation and push notifications to mobilize trained responders in the vicinity of the incident, ensuring timely intervention before professional medical services arrive. This scoping review aims to provide a comprehensive overview of the existing evidence on the effectiveness and implementation of mCIRC systems in response to trauma as well as other medical emergencies, such as out-of-hospital cardiac arrest. We will evaluate their deployment in both high- and low-resource settings. In particular, the review will assess how these systems improve health outcomes of patients, such as reducing mortality and morbidity, and the feasibility and uptake of such systems by the global community. Additionally, the review will explore the operational challenges and facilitators of implementing such systems, particularly in low- and middle-income countries where healthcare infrastructure is often limited. This review will offer a comprehensive insight into the role of mobile technologies in improving trauma care at the community level, highlighting possible avenues for future research in this domain.</p>","PeriodicalId":42077,"journal":{"name":"International Journal of Surgery Protocols","volume":"29 2","pages":"48-51"},"PeriodicalIF":1.1,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12373033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144972986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A randomized comparative study evaluating water-jet with CUSA for parenchymal dissection in living-donor liver procurement: WORLD trial.","authors":"Takeo Toshima, Shinji Itoh, Takashi Motomura, Kyohei Yugawa, Yuriko Tsutsui, Sunao Fujiyoshi, Mototsugu Shimokawa, Tomoharu Yoshizumi","doi":"10.1097/SP9.0000000000000048","DOIUrl":"10.1097/SP9.0000000000000048","url":null,"abstract":"<p><strong>Introduction: </strong>Water-Jet (WJ) dissection is an innovative technique for liver surgery that uses high-pressure saline jets to selectively dissect liver parenchyma while preserving vascular and biliary structures. Compared to the Cavitron Ultrasonic Surgical Aspirator (CUSA), WJ offers advantages such as reduced thermal damage, lower blood loss, and shorter operative times. These benefits are particularly important in living-donor liver transplantation (LDLT), where donor safety and rapid recovery are critical. This WORLD trial (\"W\"ater-Jet versus CUSA f\"o\"r Liver Pa\"r\"enchymal Transection in \"L\"iving \"D\"onor Liver Transplantation) aims to compare the efficacy and safety of WJ and CUSA in LDLT.</p><p><strong>Methods and analysis: </strong>This single-blind, randomized controlled trial will include 48 living liver donors, allocated in a 1:1 ratio to the WJ or CUSA group. Experienced surgeons will perform liver parenchymal transection using standardized protocols. The primary endpoint is transection speed (cm<sup>2</sup>/min), with secondary outcomes including operative time, blood loss, complication rates, length of postoperative hospital stays, and postoperative liver function tests. Statistical analysis will assess the non-inferiority of WJ using JMP and R software, with a one-sided α of 2.5% and 80% power.</p><p><strong>Ethics and dissemination: </strong>This study protocol was approved by the institutional review board of Kyushu University (No. 20232001). The study is registered in UMIN-CTR as UMIN000051662. Written informed consent will be obtained from all participants. The results will be published in a peer-reviewed journal and will be presented at medical meetings.</p>","PeriodicalId":42077,"journal":{"name":"International Journal of Surgery Protocols","volume":"29 3","pages":"82-87"},"PeriodicalIF":1.1,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12373076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144973160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xiaohe Lan, Yajing Huang, Yantong Lu, Yuqin Chen, Changjun Wang
{"title":"Evaluation of the efficacy of catgut implantation at acupoint in the treatment of musculoskeletal pain: a protocol for systematic review and meta-analysis based on randomized controlled clinical trials.","authors":"Xiaohe Lan, Yajing Huang, Yantong Lu, Yuqin Chen, Changjun Wang","doi":"10.1097/SP9.0000000000000044","DOIUrl":"10.1097/SP9.0000000000000044","url":null,"abstract":"<p><strong>Background and objectives: </strong>Musculoskeletal pain is one of the most common conditions in the general population, causing a variety of adverse effects. In addition to pharmacological treatments, the use of acupuncture has increased in recent decades and has shown satisfactory effects. However, the effect of catgut implantation at acupoint (CIA), a specific form of acupuncture, on the treatment of musculoskeletal pain has remained uncertain. Therefore, the aim of this study is to access whether CIA is effective and safe compared with other treatments for musculoskeletal pain.</p><p><strong>Methods: </strong>Nine electronic databases, including six English databases (e.g. Medline and Embase) and three Chinese databases (e.g. CNKI and Wanfang database) will be searched from the inception to 1 May 2024. Only randomized controlled trials evaluating the effect of CIA for musculoskeletal pain in adults will be included. Two reviewers will independently perform the literature screening, data extraction and quality assessment. Primary outcome is pain symptoms assessed by any pain scale (e.g. visual analogue scale). Pooled results will be calculated using a fixed-effects model if heterogeneity is not significant (<i>I<sup>2</sup></i> < 50%), otherwise, a random-effects model will be used. Several subgroup analyses and sensitivity analyses will be performed. All statistical analyses will be conducted using STATA 18.0.</p><p><strong>Results: </strong>A synthesis of the current evidence on the effect of CIA on the treatment of musculoskeletal pain will be published in a peer-reviewed journal.</p><p><strong>Conclusions: </strong>This study will provide high quality evidence of the effect of CIA on the treatment of musculoskeletal pain.</p>","PeriodicalId":42077,"journal":{"name":"International Journal of Surgery Protocols","volume":"29 2","pages":"52-56"},"PeriodicalIF":1.1,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12373096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144972889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
François Thuau, Guillaume Gadbled, Thomas Goronflot, Pierre Perrot, Alexandra Poinas, Ugo Lancien
{"title":"Free fat flap transfer in recurrent neurogenic thoracic outlet syndrome pain treatment: FIRST observational pilot study.","authors":"François Thuau, Guillaume Gadbled, Thomas Goronflot, Pierre Perrot, Alexandra Poinas, Ugo Lancien","doi":"10.1097/SP9.0000000000000045","DOIUrl":"10.1097/SP9.0000000000000045","url":null,"abstract":"<p><strong>Background: </strong>Neurogenic thoracic outlet syndrome (NTOS), characterized by brachial plexus compression, causes chronic pain and numbness in the upper extremities. Recurrences are common after surgical treatment, which typically includes an anterior scalenectomy and rib resection. Brachial plexus neurolysis and flap coverage can reduce scar fibrosis and prevent further recurrence. The latissimus dorsi flap is a common choice for this purpose. However, perforator fat flaps minimize donor site complications by avoiding muscle harvesting. Furthermore, a free flap transfer prevents new scars from developing in an already painful anatomical region. Given the lack of literature on this subject, we plan to use validated and recommended questionnaires to investigate the impact on pain and quality of life of brachial plexus wrapping with a free fat flap following neurolysis in cases of recurrent NTOS.</p><p><strong>Methods: </strong>FIRST is a single-center, prospective observational pilot study recruiting participants over 24 months. Eligible patients over the age of 18 are treated with brachial plexus neurolysis and a free perforator fat flap for recurrent NTOS. The study aims to enroll 20 patients and involves preoperative and postoperative assessments at a six-month follow-up. The primary outcome, measured using numerical scales, is pain reduction. Secondary outcomes include decreased painful body surface area, maximum and average pain levels, changes in quality of life, upper limb function, and anxiety-depressive symptoms, which are measured using various validated scales and questionnaires.</p><p><strong>Discussion: </strong>This study will provide insight into the efficacy of free perforator fat flaps in recurrent NTOS using standardized, validated assessments for neuropathic pain, including psychosocial aspects. By providing vascularization around the brachial plexus, fat flaps may reduce inflammation, fibrosis, and perineural scar adhesions, thereby alleviating pain. This technique also avoids extensive local dissection required for regional flaps and reduces donor site morbidity. Potential limitations include the technical complexity of free flap surgery.</p>","PeriodicalId":42077,"journal":{"name":"International Journal of Surgery Protocols","volume":"29 2","pages":"57-62"},"PeriodicalIF":1.1,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12373093/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144973030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sophie H Nelissen, Danny A Young-Afat, Joeke M Felderhof, Patrick I Ferdinandus, Femke van der Leij, Arjan J Witkamp, Annemiek Doeksen, Erik H Zonnevylle, Susanne van der Velde, Liesbeth M Veenendaal, Jan Maerten Smit, Desirée H J G van den Bongard, Henk J Coert, Liesbeth J Boersma, Wies Maarse
{"title":"Breast reconstruction and neoadjuvant radiotherapy (BRENAR) - study protocol for a multicenter, prospective, single-arm pilot study.","authors":"Sophie H Nelissen, Danny A Young-Afat, Joeke M Felderhof, Patrick I Ferdinandus, Femke van der Leij, Arjan J Witkamp, Annemiek Doeksen, Erik H Zonnevylle, Susanne van der Velde, Liesbeth M Veenendaal, Jan Maerten Smit, Desirée H J G van den Bongard, Henk J Coert, Liesbeth J Boersma, Wies Maarse","doi":"10.1097/SP9.0000000000000036","DOIUrl":"10.1097/SP9.0000000000000036","url":null,"abstract":"<p><strong>Background: </strong>Over the past decade, post-mastectomy radiotherapy (PMRT) is indicated more frequently in breast cancer treatment, especially in patients with involved axillary lymph nodes. However, PMRT is associated with high complication rates and less satisfactory cosmetic results when combined with immediate breast reconstructions. This has led to ongoing controversy regarding breast reconstruction and radiotherapy, often postponing the reconstruction until long after PMRT has been completed. Preoperative radiotherapy, also known as neoadjuvant radiotherapy (NART), is emerging as a safe and promising alternative with the potential to allow immediate reconstruction without the negative effects of radiotherapy on the reconstructed breast. However, data on the complication rates and patient-reported outcomes (PROs) after NART followed by mastectomy and breast reconstruction are still limited.</p><p><strong>Methods: </strong>This is a multicenter, prospective, single-arm pilot study including breast cancer patients requiring mastectomy and PMRT, who desire immediate breast reconstruction, either implant-based or autologous. The primary objective is to assess complications three months after the last planned reconstructive surgery. The secondary objectives are to evaluate patient-reported health-related quality of life (HR-QoL), patient- and physician-reported cosmetic results, and pathological response.</p><p><strong>Discussion: </strong>The primary outcome of this pilot study is to provide further evidence to determine whether NART is a viable alternative to PMRT in terms of complication rates when combined with immediate breast reconstruction. The secondary outcomes will enhance our understanding of patients' HR-QoL and cosmetic outcomes. If NART proves to be a safe alternative, this pilot study will lay the foundation for a national multicenter randomized controlled trial to evaluate long-term HR-QoL and oncological outcomes.</p>","PeriodicalId":42077,"journal":{"name":"International Journal of Surgery Protocols","volume":"29 2","pages":"18-25"},"PeriodicalIF":1.1,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12373098/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144972870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Protocol for reporting case reports and case series of fat embolism following non orthopedic procedures: a standardized approach.","authors":"Hossein Abdi, Javad Karimi Rozveh, Mohammad Azizmanesh, Maryam Rostami, Pouria Chaghamirzayi","doi":"10.1097/SP9.0000000000000038","DOIUrl":"10.1097/SP9.0000000000000038","url":null,"abstract":"<p><strong>Background: </strong>Fat embolism (FE), traditionally associated with orthopedic trauma, is increasingly recognized in non-orthopedic procedures such as fat grafting, liposuction, and organ transplantation. The variability in clinical presentation and diagnostic challenges in these contexts highlights the need for a standardized reporting framework.</p><p><strong>Methods: </strong>The protocol is based on findings from three systematic reviews and a comprehensive literature review, encompassing 187 cases of fat embolism in non-orthopedic settings. The proposed framework includes guidelines on patient demographics, procedural characteristics, symptom onset, clinical presentation, diagnostic methods, management strategies, and outcomes.</p><p><strong>Results: </strong>The proposed protocol aims to standardize the documentation of key factors in non-orthopedic fat embolism cases, facilitating improved case reporting and research. Key components include patient details, procedural descriptions, symptom timing, clinical signs, diagnostic approaches, and treatment protocols.</p><p><strong>Conclusion: </strong>A standardized reporting protocol for non-orthopedic fat embolism will enhance clinical recognition, improve management strategies, and contribute to better patient outcomes. Further validation through prospective studies is needed to refine and expand this framework.</p>","PeriodicalId":42077,"journal":{"name":"International Journal of Surgery Protocols","volume":"29 2","pages":"30-34"},"PeriodicalIF":1.1,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12373065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144972971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fahad M Iqbal, Alan Askari, Matthew J Lee, Marianne Hollyman, Roxanna Zakeri, Dimitri J Pournaras, Omar Al-Taan, Aruna Munasinghe, Aly Mohamed
{"title":"National Emergency Bariatric Surgical Audit (NEBSA): a protocol for a multi-center prospective study of unplanned interventions following emergency bariatric surgery.","authors":"Fahad M Iqbal, Alan Askari, Matthew J Lee, Marianne Hollyman, Roxanna Zakeri, Dimitri J Pournaras, Omar Al-Taan, Aruna Munasinghe, Aly Mohamed","doi":"10.1097/SP9.0000000000000037","DOIUrl":"10.1097/SP9.0000000000000037","url":null,"abstract":"<p><strong>Introduction: </strong>The advent of bariatric surgery as a widespread intervention is paralleled by comprehensive data capture in bariatric registries following elective surgery. However, significant challenges hinder tracking the incidence and nature of severe complications in the context of bariatric surgery. As the prevalence of bariatric procedures escalates, the establishment of a dedicated, prospective complication registry becomes imperative. Such an initiative would facilitate a nuanced understanding of bariatric surgical emergency (BSE) within the current healthcare milieu, enhance economic evaluations, elucidate long-term patient outcomes, and inform requisite adjustments in professional training. This study is designed to capture and assess the ramifications of emergency bariatric surgical practices within the United Kingdom.</p><p><strong>Methods and analysis: </strong>We propose a prospective, multi-center, audit of emergency bariatric surgical activity in all UK hospitals. Eligible participants are those who undergo any intervention or procedure (surgical or endoscopic) to diagnose or treat BSE. Primary outcome measures will include hospital length of stay, rates of complications (Clavien-Dindo), and 30-D mortality. Secondary outcomes will assess the broader impacts and patterns of care, including variations in practice and resource utilization across the nation, rates of outpatient follow-up, and the frequency of subsequent procedures (surgical or endoscopic) post-BSE. Additionally, the study will investigate potential predictors for patients' choice between state-funded and self-pay bariatric surgery options, considering factors such as ethnicity and previous engagement with NHS-specialized weight loss pathways.</p><p><strong>Ethics and dissemination: </strong>This study will be registered as clinical audit at each participating hospital. The protocol will be disseminated through the British Obesity and Metabolic Surgery Society network and using a targeted social media-based strategy in the UK.</p>","PeriodicalId":42077,"journal":{"name":"International Journal of Surgery Protocols","volume":"29 2","pages":"63-67"},"PeriodicalIF":1.1,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12373088/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144972970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Victor Oluwafemi Femi-Lawal, Victory B Effiom, Anayo James Michael, Achanga Bill-Smith Anyinkeng, Joy Nsa Ekpenyong, Ekene Nwajei, Shubh K Patel, Kevin R An, Kelechi E Okonta
{"title":"Valvular surgery for rheumatic heart disease in Africa: a scoping review protocol.","authors":"Victor Oluwafemi Femi-Lawal, Victory B Effiom, Anayo James Michael, Achanga Bill-Smith Anyinkeng, Joy Nsa Ekpenyong, Ekene Nwajei, Shubh K Patel, Kevin R An, Kelechi E Okonta","doi":"10.1097/SP9.0000000000000039","DOIUrl":"10.1097/SP9.0000000000000039","url":null,"abstract":"<p><strong>Background: </strong>Rheumatic heart disease (RHD) remains a major health challenge in Africa, where the prevalence is notably high. Valvular surgery is a crucial procedure for managing severe RHD. However, the current state and historical trend of research on this subject in African populations is not well understood. Understanding the scope, subject matter, and quality of the literature on this topic over time is essential to inform future research and clinical practice.</p><p><strong>Objective: </strong>This paper aims to assess the current published literature to evaluate vital outcomes such as surgical outcomes, survival rates, postoperative complications, long-term quality of life, morbidities, mortalities, and barriers to valve surgery for patients with RHD in Africa.</p><p><strong>Methods: </strong>This protocol adheres to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR). An extensive search will be conducted across different databases, including PubMed, Scopus, Web of Science, Cochrane Library, African Index Medicus, and African Journals Online. Studies will be identified through keyword searches and will be reviewed against predefined inclusion and exclusion criteria by two reviewers, with a third reviewer resolving any discrepancies. A narrative synthesis will be conducted to describe the findings.</p><p><strong>Conclusion: </strong>The findings from this scoping review will provide an understanding of the current literature on valvular surgery for RHD in African contexts. This will help guide future research directions in this field.</p>","PeriodicalId":42077,"journal":{"name":"International Journal of Surgery Protocols","volume":"29 2","pages":"26-29"},"PeriodicalIF":1.1,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12373035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144973245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lidiia Panaiotti, Aleksei Karachun, Anastasia Muravtseva, Aleksei Petrov
{"title":"Protocol for a phase II interventional trial investigating indocyanine green (ICG) fluorescence guided lymph node mapping for determination of bowel resection margins in colon cancer (ISCAPE).","authors":"Lidiia Panaiotti, Aleksei Karachun, Anastasia Muravtseva, Aleksei Petrov","doi":"10.1097/SP9.0000000000000041","DOIUrl":"10.1097/SP9.0000000000000041","url":null,"abstract":"<p><strong>Background: </strong>Optimal extent of lymph node dissection for colon cancer is debatable. Extensive lymphadenectomy may increase complication rate, while limited lymph node dissection may compromise oncological outcome. One of promising ways to find balance is to tailor extent of lymph node dissection to patient's individual anatomy using ICG lymphatic mapping.</p><p><strong>Methods: </strong>This is a single center interventional phase II trial with single group assignment aiming to determine if ICG lymphatic mapping sensitivity is sufficient to guide resection margins selection in colon cancer surgery. The trial's primary endpoint is proportion of pN+ patients in which affected lymph nodes are detected only within margins of ICG spread. Sample size of 101 patients was calculated using Buderer method <sup>[19]</sup> with a confidence level (1 - <i>α</i>) of 0.95 as a minimum of cases required to test accuracy of lCG lymphatic mapping for estimated sensitivity of 0.99 and precision of 0.03. The average of pN+ cases in our center (42%) was used as prevalence. Secondary endpoints are incidence of adverse events related to ICG lymphatic mapping, feasibility of ICG lymphatic mapping for colon cancer, incidence of lymph node metastases outside conventional resection margins (10 cm), colon cancer lymphatic spread patterns, proportion of operations which extent is affected by ICG lymphatic mapping. The trial is conducted among female or male patients, 18 years or older, with signed informed consent, and diagnosed primary colon cancer. Inclusion criteria include pathologically confirmed adenocarcinoma of the colon, T1-4aN0-2bM0-1b, clinical indications to colonic resection, ECOG - 0-2. Exclusion criteria consist of acute bowel obstruction, bleeding or perforation, adjacent organ invasion or peritoneal carcinomatosis, and contraindications to ICG administration. Eligible patients are allocated for colonic resection with intraoperative ICG mapping. During pathological examination, lymph nodes are assessed for presence of metastases and location in relation to tumor and fluorescence margins. The study began on 26 July 2022 and is conducted in and financed by N.N. Petrov NMRC of Oncology in Saint Petersburg, Russia, it is conducted in.</p><p><strong>Results: </strong>If after 101 ICG lymphatic mapping procedures, sensitivity of >96% is observed, this will provide rationale behind tailoring resection margins to fit ICG spread.</p><p><strong>Conclusions: </strong>ICG lymphangiography allows a surgeon to see locoregional lymphatics of a tumor site in real time and tailor colon and mesentery resection margins to meet oncological and functional needs. More data is needed to make this approach more widespread.</p>","PeriodicalId":42077,"journal":{"name":"International Journal of Surgery Protocols","volume":"29 2","pages":"40-47"},"PeriodicalIF":1.1,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12373104/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144972949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Veronica Ott, Anders Bech Jørgensen, Lennart Friis-Hansen, Birgitte Brandstrup
{"title":"Risk factors for anastomotic leakage after surgery for colorectal cancer: protocol for a scoping review.","authors":"Veronica Ott, Anders Bech Jørgensen, Lennart Friis-Hansen, Birgitte Brandstrup","doi":"10.1097/SP9.0000000000000043","DOIUrl":"10.1097/SP9.0000000000000043","url":null,"abstract":"<p><strong>Purpose: </strong>This planned scoping review aims to map the current knowledge on preoperative risk factors associated with anastomotic leakage following colorectal cancer surgery.</p><p><strong>Methods: </strong>The review will adhere to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Extensions for Scoping Reviews guidelines. The search will be conducted using MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials databases. Additionally, we will include grey literature sources. Only original studies examining a risk factor for anastomotic leakage will be included. Data will be charted based on trial characteristics, demographic data, population size, the investigated risk factors, and potential interventions.</p><p><strong>Results: </strong>The structured overview will be presented as a narrative summary with supplementary statistics.</p><p><strong>Conclusion: </strong>This protocol describes the methodology for a scoping review which aims to map primary research on preoperative risk factors for anastomotic leakage following colorectal surgery. By systematically collecting and presenting the existing evidence, this review seeks to identify key findings and highlight research gaps to guide clinicians and researchers.</p>","PeriodicalId":42077,"journal":{"name":"International Journal of Surgery Protocols","volume":"29 2","pages":"35-39"},"PeriodicalIF":1.1,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12373089/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144973239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}