{"title":"Erratum: Hydatid Cysts of Parotid Glands- Diagnosis, Treatment and Recurrences: Retraction.","authors":"","doi":"10.1097/SP9.0000000000000071","DOIUrl":"10.1097/SP9.0000000000000071","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.29337/ijsp.154.].</p>","PeriodicalId":42077,"journal":{"name":"International Journal of Surgery Protocols","volume":"30 3","pages":"44"},"PeriodicalIF":0.6,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13485842/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148798946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Saad Arsalan Wasti, Areesha Wasti, Haris Bin Khalid, Beenish Sabir, Saif-Ur Rehman, Aiema Hamid, Eman Shafquat, Muhammad Usman Iqbal, Fatima Hajj
{"title":"Ginger as a low-cost option for postoperative nausea and vomiting prevention after laparoscopic surgery in low- and middle-income countries: a systematic review and meta-analysis protocol.","authors":"Saad Arsalan Wasti, Areesha Wasti, Haris Bin Khalid, Beenish Sabir, Saif-Ur Rehman, Aiema Hamid, Eman Shafquat, Muhammad Usman Iqbal, Fatima Hajj","doi":"10.1097/SP9.0000000000000066","DOIUrl":"10.1097/SP9.0000000000000066","url":null,"abstract":"<p><strong>Background: </strong>Postoperative nausea and vomiting (PONV) is a common complication following laparoscopic surgery and remains a significant source of patient discomfort and healthcare burden. Although pharmacologic prophylaxis is widely used, PONV incidence remains considerable, particularly in low- and middle-income countries (LMICs), where resource constraints may limit access to newer antiemetics. Ginger (<i>Zingiber officinale</i>), a widely available and inexpensive herbal remedy, has demonstrated potential antiemetic effects in clinical trials. However, evidence remains inconsistent, and no focused synthesis has evaluated its role specifically in laparoscopic procedures in LMICs. This protocol outlines a systematic review and meta-analysis to assess the efficacy and safety of ginger versus placebo for preventing PONV after laparoscopic surgery in LMICs.</p><p><strong>Methods: </strong>PubMed, Embase, Scopus, Web of Science, Cochrane Library, and ClinicalTrials.gov will be searched through February 2026 to identify randomized controlled trials comparing ginger with placebo in adults undergoing laparoscopic procedures in LMICs. Gray literature, including Google Scholar and citation tracking, will also be searched. Study selection, data extraction, and risk-of-bias assessment will be conducted independently by two reviewers using the Cochrane Risk of Bias 2 tool. Primary outcomes will include PONV incidence. Secondary outcomes will include nausea and vomiting severity, rescue antiemetic use, and adverse events. Random-effects meta-analysis will be performed using risk ratios or mean differences with 95% confidence intervals. Pre-specified subgroup and sensitivity analyses will be conducted, and evidence certainty will be assessed using GRADE.</p><p><strong>Results: </strong>This review aims to provide a focused synthesis of randomized evidence evaluating ginger for PONV prevention after laparoscopic surgery in LMICs. The findings are expected to clarify its comparative efficacy and safety profile relative to placebo.</p><p><strong>Conclusion: </strong>The findings of this systematic review and meta-analysis are expected to inform perioperative care strategies in resource-limited settings and clarify the potential role of ginger as a low-cost option for PONV prevention.</p>","PeriodicalId":42077,"journal":{"name":"International Journal of Surgery Protocols","volume":"30 3","pages":"38-43"},"PeriodicalIF":0.6,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13485918/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148798996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kai-Li Qu, Jing-Wen Fu, Tao He, Min-Juan Zhang, Yan Huo, Zhi-Hong Lu
{"title":"Effect of transcutaneous electrical acupoint stimulation on major complications after cerebral endovascular procedures (ASSET): study protocol for a randomized controlled trial.","authors":"Kai-Li Qu, Jing-Wen Fu, Tao He, Min-Juan Zhang, Yan Huo, Zhi-Hong Lu","doi":"10.1097/SP9.0000000000000065","DOIUrl":"10.1097/SP9.0000000000000065","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effect of transcutaneous electrical acupoint stimulation (TEAS) administered during surgery on major morbidity after cerebral endovascular procedures.</p><p><strong>Methods: </strong>A single-center randomized controlled trial was conducted in Xijing hospital. 158 participants scheduled for cerebral endovascular procedures are randomly assigned to the TEAS group and the control group in a 1:1 ratio, receiving TEAS and no stimulation, respectively. The primary outcome is the incidence of in-hospital major complications after surgery. The secondary outcomes include the VAS score of pain and the QoR-40 score at 1 day and 3 days after surgery, the incidence of major complications and mortality by 30 days and 90 days after surgery, and the length of postoperative hospital stay.</p><p><strong>Ethics and dissemination: </strong>This study protocol was approved by the Ethics Review Committee of Xijing hospital. All participants are required to provide written informed consent. This study will be published on completion in peer-reviewed publications.</p><p><strong>Conclusion: </strong>The results of this study will provide evidence of TEAS as a standardized perioperative adjunctive therapy for patients undergoing cerebral endovascular procedures.</p><p><strong>Trials registration number: </strong>NCT05413460.</p>","PeriodicalId":42077,"journal":{"name":"International Journal of Surgery Protocols","volume":"30 2","pages":"14-19"},"PeriodicalIF":0.6,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13186140/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147983796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Florine I de Haes, Marit van Barreveld, Niek H Sperna Weiland, Wouter Hehenkamp, Marianne Dougle, Anne C van der Eijk, Oliver Findl, Monique Chambon, Frenk van Harreveld, Dorien A Salentijn
{"title":"Multicenter study protocol on clinical, environmental, and economic outcomes of hybrid versus disposable surgical trays (project rEUsable).","authors":"Florine I de Haes, Marit van Barreveld, Niek H Sperna Weiland, Wouter Hehenkamp, Marianne Dougle, Anne C van der Eijk, Oliver Findl, Monique Chambon, Frenk van Harreveld, Dorien A Salentijn","doi":"10.1097/SP9.0000000000000064","DOIUrl":"10.1097/SP9.0000000000000064","url":null,"abstract":"<p><p>Climate change threatens global health, while health care contributes significantly to emissions and waste. In the Netherlands, the sector produces 7% of national CO₂ emissions and 4% of waste. Operating rooms account for 20%-30% of hospital waste, mainly from disposable surgical trays. Reusable trays could reduce this impact, but adoption is hindered by financial and behavioral barriers. A system-wide switch could lower costs through scale effects, yet evidence on environmental and financial feasibility remains limited. This multicenter study compares the environmental impact and costs of hybrid (including <i>reusable</i> drapes and gowns) versus disposable procedure trays using Life Cycle Assessment and Health Technology Assessment (HTA). Environmental impact across 17 categories will be monetized, integrating sustainability into economic evaluation to inform health policy decisions. Results will be reported from an EU perspective. Data from three Dutch hospitals will be collected on tray use, costs, and acceptance among health care professionals. The study analyses 3 × 150 surgical cases to assess sustainability, economic feasibility, and implementability. Key deliverables include developing sustainable procedure trays and a piloted method to integrate environmental aspects into HTA, supporting sustainable health care innovation. The project will also produce an EU policy brief to guide hospitals in adopting reusable trays, highlighting environmental and economic benefits. Finally, it will provide insights into promoting acceptance and adoption of reusables to advance sustainable clinical practices.</p>","PeriodicalId":42077,"journal":{"name":"International Journal of Surgery Protocols","volume":"30 1","pages":"7-13"},"PeriodicalIF":0.6,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12944117/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147327515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yuhang Liu, Xinyi Zhang, Han Zou, Yongping Xu, Jiebin Xie
{"title":"Perioperative and oncologic outcomes of the indocyanine green-guided lymphadenectomy versus non-indocyanine green-guided lymphadenectomy for gastric cancer: a protocol for systematic review and meta-analysis.","authors":"Yuhang Liu, Xinyi Zhang, Han Zou, Yongping Xu, Jiebin Xie","doi":"10.1097/SP9.0000000000000063","DOIUrl":"10.1097/SP9.0000000000000063","url":null,"abstract":"<p><strong>Backgrounds: </strong>Gastric cancer (GC) has a high global incidence and high mortality rate, with lymph node (LN) metastasis worsening prognosis. Indocyanine green (ICG)-guided lymphadenectomy has improved surgical precision over laparoscopic methods, but the safety of its clinical application in the field of GC still needs to be further evaluated. This meta-analysis compared ICG guided and conventional dissection in patients with GC, assessing surgical and survival outcomes to provide clearer clinical guidance.</p><p><strong>Methods: </strong>This study is registered in PROSPERO. We conducted a literature search of the Embase, Pubmed, and Cochrane databases from the time of library construction to July 2025. Long-term survival metrics, intraoperative metrics, short-term adverse event metrics, and postoperative recovery metrics were compared between ICG-guided lymphadenectomy and non-ICG-guided lymphadenectomy. The meta-analysis summarized the odds ratios, weighted mean differences, and 95% confidence intervals.</p><p><strong>Results: </strong>Evidence on the therapeutic effect of ICG-guided LN dissection on GC will be published in a peer-reviewed journal.</p><p><strong>Conclusion: </strong>This study will provide high quality evidence of the effect of ICG on the treatment of GC.</p>","PeriodicalId":42077,"journal":{"name":"International Journal of Surgery Protocols","volume":"30 1","pages":"1-6"},"PeriodicalIF":0.6,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12944132/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147327518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oliver Didzun, Adriana C Panayi, Iman Ghanad, Sophie Osenegg, Laura Siegwart, Emre Gazyakan, Felix Vollbach, Ulrich Kneser, Amir K Bigdeli
{"title":"Comparison of outcomes of arterial end-to-side versus end-to-end anastomosis in autologous deep inferior epigastric perforator (DIEP) flap breast reconstruction: DIEP-ES study protocol.","authors":"Oliver Didzun, Adriana C Panayi, Iman Ghanad, Sophie Osenegg, Laura Siegwart, Emre Gazyakan, Felix Vollbach, Ulrich Kneser, Amir K Bigdeli","doi":"10.1097/SP9.0000000000000035","DOIUrl":"10.1097/SP9.0000000000000035","url":null,"abstract":"<p><strong>Background: </strong>End-to-end anastomosis to the internal mammary artery (IMA) is the current standard anastomosis technique for women undergoing autologous breast reconstruction with deep inferior epigastric perforator (DIEP) flap. This approach fails to preserve the length of the IMA, compromising its availability for cardiac surgery use in women who develop coronary heart disease. A viable alternative may be end-to-side anastomosis, but data on its feasibility is currently lacking.</p><p><strong>Methods: </strong>This pilot study will involve 60 patients at a single-center institute over approximately 24 months. Inclusion criteria are female sex, age >18 years, history of breast cancer, and eligibility for unilateral autologous DIEP breast reconstruction. Exclusion criteria include patients with a legal guardian, inability to consent, and history of blood clotting disorders or hypercoagulability. Data will be collected at 2 weeks, 6 weeks, 6 months, and 1-year post-surgery. The primary outcome is \"major complication\" of the recipient site, including anastomotic insufficiency, arterial thrombosis, hematoma, reoperation, or flap loss. Secondary outcomes are abdominal perfusion and major donor site complications, such as wound healing disorders. Patient satisfaction will be assessed using the SF-36 and BREAST-Q (reconstructive module) questionnaires.</p><p><strong>Study status: </strong>The DIEP-ES study has begun enrolment in February 2023. As this is an ongoing trial, no results have been gathered yet. The results will be reported upon completion of the study. We anticipate that the primary and secondary outcomes of the end-to-side approach will be comparable to the accepted standard of care, i.e., end-to-end anastomoses.</p><p><strong>Conclusions: </strong>End-to-side anastomosis may be a safe alternative for DIEP breast reconstruction, especially for patients at risk for coronary heart disease. This pilot study aims to evaluate the feasibility and safety of the end-to-side anastomosis technique in DIEP-flap breast reconstruction. The preliminary findings will inform the design of future multicentric trials to confirm the efficacy of this approach.</p>","PeriodicalId":42077,"journal":{"name":"International Journal of Surgery Protocols","volume":"29 1","pages":"1-7"},"PeriodicalIF":1.1,"publicationDate":"2025-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052231/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144973163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluation of the effect of virtual reality hypnosis on pain through attentional diversion during prostate biopsies under local anesthesia (HYPNOSURG-VR): a study protocol.","authors":"Maximilien Delay, Assilah Bouzit, Joris Giai, Jean-Alexandre Long, Jean-Luc Descotes, Gaëlle Fiard, Clement Sarrazin","doi":"10.1097/SP9.0000000000000062","DOIUrl":"10.1097/SP9.0000000000000062","url":null,"abstract":"<p><strong>Background: </strong>Prostate cancer is the second most commonly diagnosed cancer in men worldwide. Prostate biopsies are essential for diagnosis but often induce significant pain and anxiety despite local anesthesia. Virtual reality (VR) has emerged as a promising non-pharmacological tool for pain management during medical procedures. This study aims to assess the effect of virtual reality hypnosis (VRH) as an adjunct to standard local anesthesia during prostate biopsies.</p><p><strong>Methods: </strong>This single-center, prospective, randomized, controlled, parallel-group, single-blind trial will compare standard prostate biopsies under local anesthesia with and without VRH. A total of 130 patients will be randomized in a 1:1 ratio to receive either standard care with local anesthesia alone or standard care plus VRH. The VRH will be initiated 15 minutes pre-procedure and continue throughout. The primary outcome is the maximum pain assessed using a 0-10 Numerical Pain Rating Scale immediately post-procedure by a blinded assessor. Secondary outcomes include post-procedure pain, anxiety, physiological stress response, immersion level, patient satisfaction, procedural success, additional analgesia needs, procedure duration, and adverse events. Follow-up will occur at 1 month.</p><p><strong>Discussion: </strong>This trial will provide high-quality evidence regarding VRH effectiveness as a non-pharmacological adjunct for pain management during prostate biopsies. By targeting both anticipatory anxiety and procedural pain, this approach may significantly improve patient comfort. If effective, this technique could transform the standard of care for prostate biopsies and potentially extend to other invasive urological procedures.</p>","PeriodicalId":42077,"journal":{"name":"International Journal of Surgery Protocols","volume":"29 4","pages":"142-148"},"PeriodicalIF":1.1,"publicationDate":"2025-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12668589/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145662331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N Hariharan, T S Rao, S J Rajappa, C K Naidu, B Rayani, S Kodandapani, V Koppula, D Gudipudi
{"title":"From exclusion to inclusion: Analysis of patterns of follow-up in breast cancer.","authors":"N Hariharan, T S Rao, S J Rajappa, C K Naidu, B Rayani, S Kodandapani, V Koppula, D Gudipudi","doi":"10.1097/SP9.0000000000000061","DOIUrl":"10.1097/SP9.0000000000000061","url":null,"abstract":"<p><strong>Introduction: </strong>Follow-up data in breast cancer is essential and forms the basis for survival metrics and key statistical measures related to morbidity and mortality. Standard practice classifies any woman who does not engage in reviews/follow-up as \"lost to follow-up (LTFU),\" effectively excluding her from further analysis and disregarding her data. This study aims to evaluate patterns and predictors of LTFU among women with non-metastatic breast cancer.</p><p><strong>Design: </strong>This is a single-center prospective cohort study involving women diagnosed with non-metastatic breast cancer between 2017 and 2018. The study will follow a three-phase approach. In Phase I, 5-year follow-up data will be collected retrospectively through hospital records and electronic medical records (EMRs) up to 2024. In Phase II, patients identified as LTFU will be contacted using phone, SMS, or email to assess health status and update follow-up data. Informed consent will be obtained during outreach. In Phase III, patients who respond will be asked about reasons for missed follow-up visits, including barriers related to logistics, finance, awareness, or physician advice. Data will be analyzed using descriptive statistics, logistic regression, and thematic analysis.</p><p><strong>Objectives: </strong>To determine the proportion of patients who are lost-to-follow-up at 5 years, identify factors associated with LTFU, and explore patient-reported barriers to follow-up in a public sector cancer care setting.</p><p><strong>Discussion: </strong>This study uses a mixed-methods approach, combining quantitative tracking with qualitative insights, with the aim of understanding patient retention and long-term oncology care. This study will provide real-world evidence on follow-up adherence and its determinants in a high-volume, resource-constrained oncology setting. The study is registered with ClinicalTrials.gov (Trial identifier: NCT06927102).</p>","PeriodicalId":42077,"journal":{"name":"International Journal of Surgery Protocols","volume":"29 4","pages":"156-160"},"PeriodicalIF":1.1,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12668582/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145662399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prepectoral direct-to-implant breast reconstruction using a novel acellular dermal matrix: framework for a cohort study.","authors":"Yousef Tanas, Sarya Swed, Aldona Spiegel","doi":"10.1097/SP9.0000000000000059","DOIUrl":"10.1097/SP9.0000000000000059","url":null,"abstract":"<p><strong>Background: </strong>Capsular contracture remains a significant complication in implant-based breast reconstruction, particularly in the context of prepectoral direct-to-implant (DTI) techniques. The advent of acellular dermal matrices (ADMs) has enabled broader adoption of prepectoral reconstruction by enhancing implant support and tissue integration. FlexHD Pliable PRE is a novel ADM designed specifically for prepectoral breast reconstruction, featuring fenestrations and conformable architecture to optimize pocket support and aesthetic outcomes. However, clinical data evaluating capsular contracture rates and associated risk factors with this product remain limited.</p><p><strong>Objective: </strong>To determine the incidence of capsular contracture and identify associated risk factors in patients undergoing prepectoral DTI breast reconstruction using FlexHD Pliable PRE.</p><p><strong>Methods: </strong>This retrospective cohort study includes all consecutive patients who underwent prepectoral DTI breast reconstruction with FlexHD Pliable PRE between February 2017 and June 2024. Exclusion criteria include subpectoral placement, autologous reconstruction, and follow-up under 12 months. Patient demographics, procedural details, and postoperative outcomes (including capsular contracture, implant malposition, infection, implant loss, and other potential complications) will be collected. Capsular contracture will be defined as Baker grade III/IV. Univariate analysis and multivariable logistic regression will identify independent predictors of contracture.</p>","PeriodicalId":42077,"journal":{"name":"International Journal of Surgery Protocols","volume":"29 4","pages":"161-166"},"PeriodicalIF":1.1,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12668585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145662339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Remimazolam in elderly patients undergoing EBUS-TBNA: protocol for a randomized clinical trial.","authors":"Yeqin Liu, Yuqin Chen, Longxiang Ma, Furong Zhang, Maiqiao Yang, Liang He","doi":"10.1097/SP9.0000000000000058","DOIUrl":"10.1097/SP9.0000000000000058","url":null,"abstract":"<p><strong>Background: </strong>Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) remains the diagnostic benchmark for mediastinal staging, though geriatric patients require optimized anesthesia due to compromised pharmacokinetics and elevated perioperative risks.</p><p><strong>Methods: </strong>A prospective, double-blinded, randomized controlled clinical trial is conducted at a tertiary hospital. Sixty eligible patients aged over 70 years who underwent EBUS-TBNA under general anesthesia were enrolled. Participants were randomized 1:1 to receive either propofol (Group P, <i>n</i> = 30) or remimazolam besylate (Group R, <i>n</i> = 30) with protocolized perioperative management. Primary outcome assessed anesthesia emergence quality. Secondary outcomes encompassed serial hemodynamics, cumulative vasoactive drug requirements, recovery metrics (time/quality), 24-hour QoR-40 scores, and perioperative complications.</p><p><strong>Discussion: </strong>This randomized trial compared remimazolam and propofol for EBUS-TBNA anesthesia in elderly patients. Remimazolam demonstrated accelerated Steward recovery and enhanced hemodynamic stability, whereas propofol exhibited risks of adipose tissue deposition and hypotension. These pharmacodynamic profiles inform anesthetic optimization in geriatric cohorts, necessitating multicenter validation of age-adjusted protocols.</p>","PeriodicalId":42077,"journal":{"name":"International Journal of Surgery Protocols","volume":"29 4","pages":"149-155"},"PeriodicalIF":1.1,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12668587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145662324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}