Cardiovascular Innovations and Applications最新文献_第8页

Intracoronary Electrocardiography-guided Strategy for the Treatment of Coronary Bifurcation Lesions 冠状动脉内心电图引导下治疗冠状动脉分叉病变的策略

4区医学

Cardiovascular Innovations and Applications Pub Date : 2023-01-01 DOI: 10.15212/cvia.2023.0055

Dobrin Vassilev, Niya Mileva, Panayot Panayotov, Krasimir Kostov, Kenan Yumerov, Nikolay Petkov, Carlos Collet, Gianluca Rigatelli, Robert J. Gil, Thach Nguyen

{"title":"Intracoronary Electrocardiography-guided Strategy for the Treatment of Coronary Bifurcation Lesions","authors":"Dobrin Vassilev, Niya Mileva, Panayot Panayotov, Krasimir Kostov, Kenan Yumerov, Nikolay Petkov, Carlos Collet, Gianluca Rigatelli, Robert J. Gil, Thach Nguyen","doi":"10.15212/cvia.2023.0055","DOIUrl":"https://doi.org/10.15212/cvia.2023.0055","url":null,"abstract":"Introduction: Revascularization of bifurcation lesions remains an interventional challenge. Intracoronary electrocardiograms can predict the functional significance of side branch stenosis after bifurcation stenting. Aim: This study was aimed at evaluating the effects of an intracoronary ECG electrocardiography (icECG)-guided revascularization strategy, compared with the currently accepted standard of care, on the clinical outcomes of patients after coronary bifurcation stenting. Methods: Patients with coronary bifurcation lesions who underwent percutaneous revascularization were enrolled in a prospective all-comers’ registry. Clinical outcomes were compared between patients who underwent icECG-guided revascularization versus the current standard of care (SOC), provisional stenting. Results: A total of 768 patients were included in the analysis: 349 were treated with an icECG-guided strategy, and 419 received SOC. The overall all-cause death rate was 23.2%, and the cardiovascular death rate was 15.9%. Patients with icECG guidance had significantly lower all-cause mortality (20.3% vs. 25.5% for icECG vs. SOC, log-rank P = 0.006) and cardiovascular mortality (12.6% vs. 18.6% for icECG vs. SOC, log-rank P = 0.004). The decrease in mortality was most pronounced in patients with no increase or a moderate increase in troponin post-PCI, or with higher-than-normal baseline troponin concentrations. Conclusion: An icECG-guided strategy for coronary bifurcation PCI led to lower patient mortality than the provisional stenting strategy.","PeriodicalId":41559,"journal":{"name":"Cardiovascular Innovations and Applications","volume":"126 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136259078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inappropriate Activation of TLR4/NF-κB is a Cause of Heart Failure TLR4/NF-κB的不适当激活是心力衰竭的原因之一

IF 0.5 4区医学

Cardiovascular Innovations and Applications Pub Date : 2022-12-15 DOI: 10.15212/cvia.2022.0020

Jiedong Zhou, Hui Lin, Tingting Lv, Jinjin Hao, Hanlin Zhang, Shimin Sun, Juntao Yang, J. Chi, Hangyuan Guo

{"title":"Inappropriate Activation of TLR4/NF-κB is a Cause of Heart Failure","authors":"Jiedong Zhou, Hui Lin, Tingting Lv, Jinjin Hao, Hanlin Zhang, Shimin Sun, Juntao Yang, J. Chi, Hangyuan Guo","doi":"10.15212/cvia.2022.0020","DOIUrl":"https://doi.org/10.15212/cvia.2022.0020","url":null,"abstract":"\u0000Significance: Heart failure, a disease with extremely high incidence, is closely associated with inflammation and oxidative stress. The Toll-like receptor 4 (TLR4)/nuclear factor kappa-B (NF-κB) pathway plays an important role in the occurrence and development of heart failure.\u0000\u0000Recent advances: Previous studies have shown that TLR4/NF-κB causes heart failure by inducing oxidative stress and inflammation; damaging the endothelia; promoting fibrosis; and inducing myocardial hypertrophy, apoptosis, pyroptosis, and autophagy.\u0000\u0000Critical issues: Understanding the pathogenesis of heart failure is essential for the treatment of this disease. In this review, we outline the mechanisms underlying TLR4/NF-κB pathway-mediated heart failure and discuss drugs that alleviate heart failure by regulating the TLR4/NF-κB pathway.\u0000\u0000Future directions: During TLR4/NF-κB overactivation, interventions targeting specific receptor antagonists may effectively alleviate heart failure, thus providing a basis for the development of new anti-heart failure drugs.","PeriodicalId":41559,"journal":{"name":"Cardiovascular Innovations and Applications","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42803145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to: Staged Revascularization for Chronic Total Occlusion in the Non-IRA in Patients with ST-segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention: An Updated Systematic Review and Meta-analysis st段抬高型心肌梗死接受初级经皮冠状动脉介入治疗的非ira慢性全闭塞患者的分期血运重建术:一项最新的系统评价和荟萃分析

IF 0.5 4区医学

Cardiovascular Innovations and Applications Pub Date : 2022-12-15 DOI: 10.15212/cvia.2022.0022

Yu Geng, Yintang Wang, Lianfeng Liu, Guobin Miao, Ou Zhang, Yajun Xue, Ping Zhang

{"title":"Corrigendum to: Staged Revascularization for Chronic Total Occlusion in the Non-IRA in Patients with ST-segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention: An Updated Systematic Review and Meta-analysis","authors":"Yu Geng, Yintang Wang, Lianfeng Liu, Guobin Miao, Ou Zhang, Yajun Xue, Ping Zhang","doi":"10.15212/cvia.2022.0022","DOIUrl":"https://doi.org/10.15212/cvia.2022.0022","url":null,"abstract":"Objectives: Meta-analysis was performed to evaluate the effect of staged revascularization with concomitant chronic total occlusion (CTO) in the non-infarct-associated artery (non-IRA) in patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (p-PCI). Methods: Various electronic databases were searched for studies published from inception to June, 2021. The primary endpoint was all-cause death, and the secondary endpoint was a composite of major adverse cardiac events (MACEs). Odds ratios (ORs) were pooled with 95% confidence intervals (CIs) for dichotomous data. Results: Seven studies involving 1540 participants were included in the final analysis. Pooled analyses revealed that patients with successful staged revascularization for CTO in non-IRA with STEMI treated with p-PCI had overall lower all-cause death (OR, 0.46; 95% CI, 0.23–0.95), cardiac death (OR, 0.43; 95% CI, 0.20–0.91), MACEs (OR, 0.47; 95% CI, 0.32–0.69) and heart failure (OR, 0.57; 95% CI, 0.37–0.89) compared with the occluded CTO group. No significant differences were observed between groups regarding myocardial infarction and re-peated revascularization. Conclusions: Successful revascularization of CTO in the non-IRA was associated with better outcomes in patients with STEMI treated with p-PCI.","PeriodicalId":41559,"journal":{"name":"Cardiovascular Innovations and Applications","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48490238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The 33rd Great Wall International Congress of Cardiology Asian Heart Society Congress 2022 2022年第33届长城国际心脏病学大会亚洲心脏学会大会

IF 0.5 4区医学

Cardiovascular Innovations and Applications Pub Date : 2022-10-01 DOI: 10.15212/cvia.2022.0015

引用次数: 0

In Memoriam: C. Richard Conti, MD (1934 ‐ 2022), Founding Editor-in-Chief of Cardiovascular Innovations and Applications 纪念：C.Richard Conti，医学博士（1934‐2022），《心血管创新与应用》创始主编

IF 0.5 4区医学

Cardiovascular Innovations and Applications Pub Date : 2022-09-01 DOI: 10.15212/cvia.2022.0008

引用次数: 0

Common Statistical Methods and Reporting of Results in Medical Research 医学研究中常见的统计方法和结果报告

IF 0.5 4区医学

Cardiovascular Innovations and Applications Pub Date : 2022-05-01 DOI: 10.15212/cvia.2022.0001

G. Feng, Guoyou Qin, Tao Zhang, Zheng Chen, Yang Zhao

引用次数: 0

The Clinical Value of Syntax Scores in Predicting Coronary Artery Disease Outcomes 句法评分在预测冠状动脉疾病预后中的临床价值

IF 0.5 4区医学

Cardiovascular Innovations and Applications Pub Date : 2022-01-01 DOI: 10.15212/cvia.2022.0002

Lutfu Askin

引用次数: 3

Termination of Recurrent Atrial Fibrillation by Superior Vena Cava Isolation: A Case Report 上腔静脉隔离终止复发性心房颤动1例报告

IF 0.5 4区医学

Cardiovascular Innovations and Applications Pub Date : 2022-01-01 DOI: 10.15212/cvia.2022.0017

Dechun Yin

引用次数: 1

Nomogram for Predicting the Severity of Coronary Artery Disease in Young Adults ≤45 Years of Age with Acute Coronary Syndrome 预测≤45岁急性冠脉综合征青壮年冠状动脉病变严重程度的Nomogram

IF 0.5 4区医学

Cardiovascular Innovations and Applications Pub Date : 2022-01-01 DOI: 10.15212/cvia.2022.0016

Wenbin Zhang

{"title":"Nomogram for Predicting the Severity of Coronary Artery Disease in Young Adults ≤45 Years of Age with Acute Coronary Syndrome","authors":"Wenbin Zhang","doi":"10.15212/cvia.2022.0016","DOIUrl":"https://doi.org/10.15212/cvia.2022.0016","url":null,"abstract":"Background: A non-invasive predictive model has not been established to identify the severity of coronary lesions inyoung adults with acute coronary syndrome (ACS).Methods: In this retrospective study, 1088 young adults (≤45 years of age) first diagnosed with ACS who underwentcoronary angiography were enrolled and randomized 7:3 into training or testing datasets. To build the nomogram, wedetermined optimal predictors of coronary lesion severity with the Least Absolute Shrinkage and Selection Operatorand Random Forest algorithm. The predictive accuracy of the nomogram was assessed with calibration plots, and performancewas assessed with the receiver operating characteristic curve, decision curve analysis and the clinical impact curve.Results: Seven predictors were identified and integrated into the nomogram: age, hypertension, diabetes, body massindex, low-density lipoprotein cholesterol, mean platelet volume and C-reactive protein. Receiver operating characteristicanalyses demonstrated the nomogram’s good discriminatory performance in predicting severe coronary arterydisease in young patients with ACS in the training (area under the curve 0.683, 95% confidence interval [0.645–0.721])and testing (area under the curve 0.670, 95% confidence interval [0.611–0.729]) datasets. The nomogram was also well-calibrated in both the training (P = 0.961) and testing (P = 0.302) datasets. Decision curve analysis and the clinicalimpact curve indicated the model’s good clinical utility.Conclusion: A simple and practical nomogram for predicting coronary artery disease severity in young adults ≤45 yearsof age with ACS was established and validated.","PeriodicalId":41559,"journal":{"name":"Cardiovascular Innovations and Applications","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67305659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A Case of Premature Ventricular Complexes from the Proximal Left Bundle Branch Successfully Ablated from the Right Coronary Cusp 右冠状动脉尖成功消融左束支近端早心室复合体1例

IF 0.5 4区医学

Cardiovascular Innovations and Applications Pub Date : 2022-01-01 DOI: 10.15212/cvia.2022.0006

Jianhua Fan

引用次数: 0