{"title":"A Rare Case of a Primary Cardiac Tumor Presenting as Fatal Ventricular Tachycardia","authors":"Xu-Dong Guo","doi":"10.15212/cvia.2022.0014","DOIUrl":"https://doi.org/10.15212/cvia.2022.0014","url":null,"abstract":"Primary cardiac tumors are extremely uncommon. Here, we report the case of a patient with a primary left ventricularinterstitial tumor presenting with hemodynamically unstable ventricular tachycardia. In response to hemodynamicallyunstable ventricular tachycardia, an implantable cardioverter-defibrillator was inserted. One month after defibrillatorimplantation, the patient developed episodes of high ventricular tachycardia that could not be effectively terminatedby catheter radiofrequency ablation, thus further confirming that the ventricular tachycardia was induced by the leftventricular interstitial tumor. The patient is doing well on medical therapy to date.","PeriodicalId":41559,"journal":{"name":"Cardiovascular Innovations and Applications","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67305533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Neutrophil/Lymphocyte Ratio is Associated with Different Stages of Development of Coronary Artery Disease","authors":"Jianlin Du","doi":"10.15212/cvia.2022.0018","DOIUrl":"https://doi.org/10.15212/cvia.2022.0018","url":null,"abstract":"Introduction: Inflammation plays a role in coronary artery disease (CAD). The neutrophil/lymphocyte ratio (NLR),monocyte/lymphocyte ratio (MLR) and platelet/lymphocyte ratio (PLR) are blood parameters associated with inflammation.We aimed to perform a systematic comparison and study the predictive values of these inflammatory parameterswith respect to CAD stage.Method: A total of 513 patients who had undergone coronary angiography (CAG) were retrospectively analyzed.Clinical status, lipid profiles, CAG scans and hematological parameters were collected. NLR, MLR and PLR were calculated. All patients were classified into a normal coronary group (n = 133), coronary atherosclerosis (CA) group (n = 149), chronic coronary syndrome (CCS) group (n = 175) or acute myocardial infarction (AMI) group (n = 56). NLR, MLR and PLR were compared among groups.Results: NLR and MLR were higher in the CCS and AMI groups. PLR was higher in the AMI group. The AMI grouphad higher NLR, PLR and MLR than the CCS group. Logistic regression analysis revealed that NLR (OR:1.227, 95%CI: 1.016–1.482. P < 0.05) had a strong significant correlation with CAD. Area under the ROC curve of NLR was 0.580(95% CI = 0.516–0.644) in predicting CCS and 0.727 (95% CI = 0.642–0.811) in predicting AMI.Conclusion: NLR may be associated with the occurrence and progression of CAD, and may serve as a marker of inflammation.","PeriodicalId":41559,"journal":{"name":"Cardiovascular Innovations and Applications","volume":"13 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67305858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dapagliflozin in Heart Failure with Reduced Ejection Fraction: A Real-World Study","authors":"Yanzhou Zhang","doi":"10.15212/cvia.2022.0005","DOIUrl":"https://doi.org/10.15212/cvia.2022.0005","url":null,"abstract":"Aims: We aimed to observe the improvements in cardiac function indexes and the occurrence of adverse events in patients with heart failure with reduced ejection fraction (HFrEF) after dapagliflozin administration in a real-world setting.Methods: We retrospectively enrolled 201 patients with HFrEF who were treated at a tertiary hospital in Zhengzhou and started to take dapagliflozin (10 mg/d) from March 2020 to June 2021. Their New York Heart Association (NYHA) functional class, cardiac ultrasound indexes, laboratory indexes, and vital signs between baseline and the last follow-up visit were compared, and their adverse events during the follow-up period were recorded.Results: The follow-up period was 173 (67–210) days. The cardiac function indexes of patients at follow-up, compared with baseline, indicated significant improvement (proportion of NYHA functional class I and II: 40.8% vs. 56.2%; left ventricular ejection fraction: 28.4 ± 5.3% vs. 34.7 ± 5.9%; left ventricular end-diastolic diameter: 70.1 ± 6.4 mm vs. 64.7 ± 5.6 mm; N-terminal pro-B-type natriuretic peptide: 5421.9 ± 2864.4 pg/mL vs. 2842.8 ± 1703.4 pg/mL at baseline vs. at follow-up; all P < 0.05). The rates of hypotension, deterioration of renal function, and genital infection during the follow-up period were 6.5%, 4.0%, and 3.5%, respectively.Conclusions: We believe that dapagliflozin is safe and effective in patients with HFrEF in the real world.","PeriodicalId":41559,"journal":{"name":"Cardiovascular Innovations and Applications","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67304968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Novel Robotic Control System Mimics Doctor’s Operation to Assist Percutaneous Coronary Intervention","authors":"Ping Zhang","doi":"10.15212/cvia.2022.0003","DOIUrl":"https://doi.org/10.15212/cvia.2022.0003","url":null,"abstract":"Objectives: The use of current robotic systems to assist in percutaneous coronary intervention (PCI) fundamentallydiffers from performing conventional PCI. To overcome this problem, we developed a novel master-slave roboticcontrol system to assist in PCI, and evaluated its safety and feasibility in the delivery and manipulation of coronaryguidewires in vitro and in vivo.Methods: The novel robotic assist PCI system is composed of three parts: 1) a master actuator, which imitates thetraditional torque used by surgeons in conventional PCI, 2) a slave actuator, including a guidewire delivery system andforce monitoring equipment, and 3) a local area network based communication system.Results: The experiment was performed in six pigs. Both robotic and manual control completed the operation with no device- or procedure-associated complications. An experienced interventional cardiologist who was a first-time userof the novel robotic PCI system was able to advance the guidewire into a distal branch of a coronary artery within asimilar time to that required with the manual procedure.Conclusion: This early in vivo experiment with the novel robotic assisted PCI control system demonstrated that its feasibility, safety, and procedural effectiveness are comparable to those of manual operation. The novel robotic-assisted PCI control system required significantly less time to learn than other currently available systems.","PeriodicalId":41559,"journal":{"name":"Cardiovascular Innovations and Applications","volume":"93 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67305341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hypertensive-Like Reaction: A Definition for Normotensive Individuals with Symptoms Associated with Elevated Blood Pressure","authors":"Yifang Guo","doi":"10.15212/cvia.2022.0004","DOIUrl":"https://doi.org/10.15212/cvia.2022.0004","url":null,"abstract":"<jats:p> </jats:p>","PeriodicalId":41559,"journal":{"name":"Cardiovascular Innovations and Applications","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67305417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Application Potential of Probiotics in Acute Myocardial Infarction","authors":"Hui Jiang","doi":"10.15212/cvia.2022.0019","DOIUrl":"https://doi.org/10.15212/cvia.2022.0019","url":null,"abstract":"Myocardial infarction (MI) is associated with high rates of death and disability, and is the main cause of death due tocardiovascular disease and the most frequent cause of death in the developed world. Recent studies have shown that, in addition to traditional risk factors, such as hypertension, diabetes, hyperlipidemia, obesity, smoking and the environment, the gut microbiota plays an important role in MI development and progression. The discovery of an enteric-cardioid axis provides a new route to examine the complex mechanism of MI and has become a research hotspot in recent years. Experiments have suggested that probiotics decrease ischemia/reperfusion injury and inflammation, regulate lipid metabolism and decrease the myocardial infarction area. In this review, we discuss the relationship between probiotics and MI as well as potential underlying mechanisms, to provide new ideas for the prevention and treatment of MI.","PeriodicalId":41559,"journal":{"name":"Cardiovascular Innovations and Applications","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67305487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Role of Epicardial Adipose Tissue in Triggering and Maintaining Atrial Fibrillation","authors":"Ye Tian","doi":"10.15212/cvia.2022.0012","DOIUrl":"https://doi.org/10.15212/cvia.2022.0012","url":null,"abstract":"Atrial fibrillation is the most common arrhythmia leading to cardiogenic stroke. Without membranous sructure betweenepicardial adipose tissue and atrial myocardium, epicardial adipose tissue directly covers the surface of the atrial myocardium.The formation of an epicardial adipose tissue inflammatory microenvironment, fibrosis, infiltration by epicardialadipose tissue, autonomic dysfunction and oxidative stress are important mechanisms that trigger and maintainatrial fibrillation. Those mechanisms are reviewed herein.","PeriodicalId":41559,"journal":{"name":"Cardiovascular Innovations and Applications","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67305726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mechanisms of Myocardial Stunning in Stress-Induced Cardiomyopathy*","authors":"Dechun Yin","doi":"10.15212/cvia.2022.0010","DOIUrl":"https://doi.org/10.15212/cvia.2022.0010","url":null,"abstract":"Stress-induced cardiomyopathy, in contrast to acute myocardial infarction, is a type of acute heart failure characterizedby reversible left ventricular dysfunction. Cardiac imaging primarily reveals left ventricle myocardial stunning, 81.7%of which is apical type. Emotional or psychological stress usually precedes the onset of stress-induced cardiomyopathy,which is increasingly being recognized as a unique neurogenic myocardial stunning disease. To distinguish betweenacute myocardial infarction and acute viral or auto-immune myocarditis, this review summarizes specific mechanismsof myocardial stunning in stress-induced cardiomyopathy, such as calcium disorders, metabolic alterations, anatomicaland histological variations in different parts of the left ventricle, and microvascular dysfunction.","PeriodicalId":41559,"journal":{"name":"Cardiovascular Innovations and Applications","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67305454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Role of Sleep Deprivation in Arrhythmias","authors":"Dechun Yin","doi":"10.15212/cvia.2022.0013","DOIUrl":"https://doi.org/10.15212/cvia.2022.0013","url":null,"abstract":"Sleep is essential to the normal psychological and physiological activities of the human body. Increasing evidenceindicates that sleep deprivation is associated with the occurrence, development, and poor treatment effects of variousarrhythmias. Sleep deprivation affects not only the peripheral nervous system but also the central nervous system,which regulates the occurrence of arrhythmias. In addition, sleep deprivation is associated with apoptotic pathways,mitochondrial energy metabolism disorders, and immune system dysfunction. Although studies increasingly suggestthat pathological sleep patterns are associated with various atrial and ventricular arrhythmias, further research is neededto identify specific mechanisms and recommend therapeutic interventions. This review summarizes the findings ofsleep deprivation in animal experiments and clinical studies, current challenges, and future research directions in thefield of arrhythmias.","PeriodicalId":41559,"journal":{"name":"Cardiovascular Innovations and Applications","volume":"221 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67305897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effects of Loading-Dose Statins Combined with PCSK9 Inhibitor Pre-Treatment before Primary Percutaneous Coronary Intervention on the Short-Term Prognosis in Patients with ST-Segment Elevation Myocardial Infarction","authors":"J. An","doi":"10.15212/cvia.2022.0011","DOIUrl":"https://doi.org/10.15212/cvia.2022.0011","url":null,"abstract":"Objective: This study was aimed at investigating the effects of preoperative treatment with a loading dose of statinscombined with a PCSK9 inhibitor on coronary blood perfusion and short-term cardiovascular adverse events in patientswith ST-segment elevation myocardial infarction (STEMI).Method: Sixty-five patients with STEMI who had visited the Shanxi Cardiovascular Disease Hospital between May2018 and May 2021 were enrolled in the study. The enrolled patients had no history of oral statins or antiplatelet therapy.The patients were divided into a combined treatment group (loading dose of statins combined with PCSK9 inhibitors, 35patients) and a routine treatment group (loading dose of statins only, 30 patients). The primary endpoints were thrombolysisin myocardial infarction (TIMI) blood flow grading, corrected TIMI frame count (CTFC), and TIMI myocardial perfusiongrading (TMPG), immediately after and 30 days after the operation. The secondary endpoint was a composite endpoint ofcardiovascular death, nonfatal myocardial infarction, and target vessel revascularization 30 days after the operation.Results: The combined treatment group had significantly lower CTFC (14.09 ± 8.42 vs 26 ± 12.42, P = 0.04) and betterTMPG (2.74 ± 0.61 vs 2.5 ± 0.73, P = 0.04) than the routine treatment group immediately after the operation. Similarly,the combined treatment group had a significantly lower CTFC (16.29 ± 7.39 vs 26.23 ± 11.53, P = 0.04) and significantlybetter TMPG (2.94 ± 0.24 vs 2.76 ± 0.43, P = 0.01) than the routine treatment group 1 month after the operation.Conclusion: Preoperative treatment with a loading dose of high-intensity statins combined with PCSK9 inhibitorsincreased coronary blood flow and myocardial perfusion after emergency thrombus aspiration in patients withSTEMI. However, the treatment did not significantly decrease the incidence of cardiovascular death, nonfatal myocardialinfarction, or target vessel revascularization.","PeriodicalId":41559,"journal":{"name":"Cardiovascular Innovations and Applications","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67305590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}