Journal of Complementary Medicine Research最新文献

{"title":"A Review on Unleashing the Potentials of Natural Products in Managing Dengue","authors":"S. Abidin, S. Makpol, N. Ahmad, N. Muhamad, W. Yap","doi":"10.5455/jcmr.2023.14.02.11","DOIUrl":"https://doi.org/10.5455/jcmr.2023.14.02.11","url":null,"abstract":"Background/Aims: Dengue virus (DENV) spreads widely in many tropical and sub-tropical countries by Aedes sp. In recent decades, dengue has been alarmingly on the rise and affects approximately half of the world population. The current dengue treatments are still mainly supportive without any approved vaccines or effective anti-dengue drugs. This leads to an urgency to seek alternative solutions in reducing dengue morbidity and mortality. Methods: A total of 94 articles describing in vitro and in vivo studies were screened and selected through curated databases. The selected articles underpinned the potentials of natural products as alternative anti-dengue compounds. Results: Those compounds have been employed as larvicide, mosquitocide, mosquito repellents, agents in sticky traps and non-specific interventions for dengue. In this review, their direct and indirect effects on dengue virus replication and dengue diseases were deliberated. Inteestingly, the majority of them demonstrated remarkable anti-inflammatory effects on dengue diseases. Several phytochemical contents such as luteolin, coumarins and geraniin were shown to inhibit DENV replication in vitro. Conclusion: Natural product-based anti-dengue agents are believed to be less costly, easy to derive, biologically effective and less toxic. This review, therefore, aims to provide current updates and insights on the benefits of natural products in preventing, managing and treating dengue.","PeriodicalId":41505,"journal":{"name":"Journal of Complementary Medicine Research","volume":"7 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75979863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti Inflammatory activity of AgNps synthesized using flower formulation (Rosa andJasminum","authors":"R. Bharath, A. Arthanari, S. Rajeshkumar","doi":"10.5455/jcmr.2023.14.01.25","DOIUrl":"https://doi.org/10.5455/jcmr.2023.14.01.25","url":null,"abstract":"Introduction: In recent years, there has been a resurgence in the use of traditional medicinal herbs, and as a result, pharmaceutical companies are investing heavily in developing natural medications derived from plants. Nanoparticles act in a number of potential ways and fields. Chemical synthesis of nanoparticles is no longer advantageous compared to plant-based synthesis. The current study uses a green method to create silver nanoparticles (AgNPs) utilizing flower extract. Materials and methods: The anti-inflammatory activity for gel was tested by the following convention proposed by Muzushima and Kabayashi with specific alterations. 0.05 mL of Rosa and jasminum jel of various fixations. Result: Using rosa and jasminum extract in the manufacture of silver nanoparticles, the nanoparticles showed remarkable antioxidant and anti-inflammatory activity. It was discovered that the cytotoxic effect was less harmful, demonstrating biocompatibility. Rosa jasminum extract of AgNps showed good anti-inflammatory efficacy in the EA and BSA assays. Conclusion: From our study we concluded that Silver nanoparticles were created using rosa and jasminum extract, and the nanoparticles displayed impressive anti-inflammatory.","PeriodicalId":41505,"journal":{"name":"Journal of Complementary Medicine Research","volume":"32 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74465172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does Single Intra-Articular Plasma-Rich Plasma (PRP) Injection for Temporomandibular Joint (TMJ) Internal Derangement Relieve Joint Pain?","authors":"B. Jamal","doi":"10.5455/jcmr.2023.14.02.15","DOIUrl":"https://doi.org/10.5455/jcmr.2023.14.02.15","url":null,"abstract":"Introduction: The temporomandibular disorder (TMD) is a common pathological entity and is found in 31% of the adult population. Different minimally invasive techniques, such as the injection of diverse substances into the joint, arthrocentesis have exhibited good clinical results and such modalities would be considered either for severe TMDs or after the failure of conservative treatments. Several studies endorsed intra-articular injections of platelet- rich plasma (PRP) as an effective procedure to decrease TMD tenderness. The primary aim of this study is to assess the effectiveness of a single PRP injection in terms of reducing pain, and improving mandibular motion in patients affected by internal derangement of the TMJ. Materials & Methods: The study consisted of 10 patients who reported to the oral and maxillofacial surgery clinic with painful dysfunction of the temporomandibular joint who received a single injection of PRP in the TMJ. Variables measured including pain score and mouth opening were assessed preoperatively and postoperativel. SPSS 24.0 was used for data management and statistical analysis. The level of significance was set at 0.05 for all statistical tests using chi-square. Results:The group of 10 patients consisted of 9 women and 1 man. The age of the participants ranged from 27 to 75 years, and a median age of 45.5. Upon the follow up visit within 1-3 months: 7/10 patients showed a significant reduction of the pain intensity (more than 50% reduction of pain intensity), 2/10 patients showed a partial resolution of the symptoms with minimal reduction of pain and one patient showed no improvement in either pain or mouth opening and subsequently underwent arthrocentesis. The PRP injections were successful in decreasing pain intensity scores to below 5 in most cases. A Chi-squared test was performed to test for an association between the PRP injections and pain intensity score and the outcome supports the conclusion that there is a strong correlation between the PRP injection and pain and that it is statistically significant. Conclusions:TMD symptoms and movement limitations disrupt everyday life and in cases with severe illness, studies showed that the conservative treatment measures lead to insignificant or low improvement in quality of life. For this reason, a fast acting and effective method of reducing pain and movement limitations is essential and our study findings support the role of PRP injections. It exhibited a very strong negative relationship, which indicates that the PRP injection and pain scores are inversely related.","PeriodicalId":41505,"journal":{"name":"Journal of Complementary Medicine Research","volume":"31 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73654153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Upper Extremity Function in Chronic Stroke Patients: Exploration of the Impact of Multimodal Mental Practice Approach","authors":"M. Alqahtani","doi":"10.5455/jcmr.2023.14.03.33","DOIUrl":"https://doi.org/10.5455/jcmr.2023.14.03.33","url":null,"abstract":"Objective: The present study aims to explore the impact of a multimodal mental practice approach on enhancing upper extremity function in chronic stroke patients. Specifically, we seek to investigate the potential benefits of incorporating MMP into the existing rehabilitation protocols for stroke survivors and assess its effectiveness in improving motor outcomes. Methods: The study utilized a randomized controlled trial design with chronic stroke patients who experienced upper extremity impairments. The participants were provided multimodal physical practice, multimodal mental practice, and blended multimodal practice regimen for three months. Results: The ANOVA analysis revealed a significant difference among the groups for the MMPG measure, indicating that the Blended Multimodal Practice Group (BMPG) performed significantly better compared to the Multimodal Physical Practice Group (MPPG) and the Multimodal Mental Practice Group (MMPG). Conclusion: The findings of this study suggest that incorporating multimodal mental practice approaches into stroke rehabilitation programs can enhance upper extremity function in chronic stroke patients.","PeriodicalId":41505,"journal":{"name":"Journal of Complementary Medicine Research","volume":"28 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86769187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture at Bi'nao increases the recovery of hypophasis in patients with incomplete recovered Bell’s palsy: a randomized controlled clinical trial and task-state fMRI study","authors":"Zhidan Liu, Chuang Zhao, Xiaoyan Li, Chunlan Chen, Zunyuan Li, Wenge Huo, Jiang-bo He","doi":"10.5455/jcmr.2023.14.02.37","DOIUrl":"https://doi.org/10.5455/jcmr.2023.14.02.37","url":null,"abstract":"Objectives: To evaluate the efficiency of acupuncture at the acupoint of Bi’nao for hypophasis and the mechanisms responsible for effect in the cerebral cortex. Methods: Participants with hypophasis were selected from patients with incompletely recovered Bell’s palsy and randomly allocated into Bi’nao group, Sham Bi’nao group and healthy control group with 33 participants per group. Acupuncture therapy was applied at the real or sham Bi’nao acupoint to compare efficiency. Clinical effects were evaluated by the House-Brackman Scale (HBS), Eye Crack Width Measurement (ECWM) scale and Eyelid Strength Assessment (ESA) before and after therapy. Regions of the brain cortex that were stimulated by acupuncture were detected by task-state functional magnetic resonance imaging. Results: HBS and ESA scores in the Bi’nao group were lower than in the other two groups (P<0.05) while ECWM scores were higher (P<0.05). The cingulate cortex and cerebellum were activated during acupuncture stimulation in the Bi’nao group when compared to both the Sham Bi’nao group and the healthy control group (P<0.05). Conclusion: Acupuncture at the acupoint Bi’nao increased the recovery of hypophasis in patients with incomplete recovered Bell’s palsy. The underlying mechanism might be associated with the activation of the cingulate cortex and cerebellum.","PeriodicalId":41505,"journal":{"name":"Journal of Complementary Medicine Research","volume":"16 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81792954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurological Consequences of Arvi","authors":"Khyadi Khabrieva, Soltanat Utegenova, A. Polyakov, Zalina Dogaeva, Timur Rustamovich\u0000Imamutdinov, Alexander Markov","doi":"10.5455/jcmr.2023.14.03.06","DOIUrl":"https://doi.org/10.5455/jcmr.2023.14.03.06","url":null,"abstract":"This work includes consideration of neurological consequences of acute respiratory viral infection (ARVI), such as meningitis, encephalitis, headache, sleep disorders and mental disorders. The authors are based on existing studies showing that ARVI can cause inflammatory processes in the nervous system and lead to long-term health consequences. The article also discusses methods of diagnosis and treatment of neurological manifestations of ARVI. The research results may be useful for doctors treating patients with acute respiratory viral infections, as well as for people who want to understand the possible consequences of this disease. In addition, the authors note that the neurological consequences of ARVI can be especially dangerous for certain groups of patients, such as children, the elderly and people with concomitant diseases. Therefore, it is important to pay attention to the neurological symptoms of ARVI and to carry out timely diagnosis and treatment. The paper also notes that possible causes of neurological manifestations of ARVI may be not only viruses, but also immune mechanisms, as well as other factors such as stress and lack of physical activity during the disease. In general, the article provides an overview of the neurological consequences of ARVI, indicating their severity and the need for additional research in this area. This information can be useful both for doctors and for the general public, helping to understand the importance of prevention and timely treatment of acute respiratory viral infections.","PeriodicalId":41505,"journal":{"name":"Journal of Complementary Medicine Research","volume":"116 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80685430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polymeric nanoparticle of Ebastine: Formulation, Characterization and in vitro Evaluation","authors":"H. Ali, N. Rajab","doi":"10.5455/jcmr.2023.14.01.03","DOIUrl":"https://doi.org/10.5455/jcmr.2023.14.01.03","url":null,"abstract":"The main aim of this research work was the development and evaluation of polymeric nanoparticle for the bioavailability improvement of Ebastine (EBT) to treat allergic condition. EBT is a piperidine derivative that binds preferentially to peripheral H1 receptors and is a long-acting, non-sedating second-generation histamine receptor antagonist. It is practically insoluble in water (class II, according to BCS). This work aims to formulate and adjust Ebastine polymeric nanoparticles to improve the EBT solubility as well as dissolution rate. For the synthesis of PNPs, the solvent evaporation technique was used, and three different types of stabilizer that used (HPMC E5, Soluplus, tween 80). The particle size analysis indicated that the optimized formula EBT 9 had a reduced nanoparticulate size of 42 nm, with a 90 percent increase in in-vitro dissolution profile compared to 17 percent for the comparison Ebastine powder in 0.1 N HCl media (pH 1.2). As a result, polymeric nanoparticles formulation of weakly water soluble EBS greatly improved the drug's dissolving rate and increased its solubility.","PeriodicalId":41505,"journal":{"name":"Journal of Complementary Medicine Research","volume":"16 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82348736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic Activity of Moringa Oleifera and Thyme Vulgaris Essential Oil Against Streptococcus Mutans: An Observational Study","authors":"Sadhana Karunakaran, P. Sinduja, R. Priyadharshini, P. Ganesh","doi":"10.5455/jcmr.2023.14.01.29","DOIUrl":"https://doi.org/10.5455/jcmr.2023.14.01.29","url":null,"abstract":"Background: Dental caries still remain a highly prevalent disease among all age groups especially children. It is caused due to repetitive and/or prolonged demineralization of tooth enamel caused by exposure to low pH from organic acids produced by acidogenic oral bacteria during fermentation of dietary carbohydrates. Streptococcus mutans is a facultative anaerobic , gram positive cocci commonly found in the human oral cavity which plays an important role in causing dental caries. Moringa oleifera Lam. (drumstick tree) is a Moringaceae family member which possesses a variety of advantageous biological properties, such as immunomodulatory, anticancer, antiulcer and antimicrobial properties. Thymus vulgaris is a pleasant smelling perennial shrub which has a direct influence on many bacteria species. The use of combinations of these two EOs and their components are thus a new approach to increase the antimicrobial efficacy of EOs , taking advantage of their synergistic and additive effects. Materials and methods: The broth microdilution method was used to determine the minimum inhibitory concentration(MIC) of the essential oils. The MIC of Moringa, Thyme and combination of the both essential oils against S.mutans which were used in the assay were assessed at a different concentration level. Results: The antimicrobial activity of M.oleifera, T.vulgaris and combination of both the essential oils was proven with the MIC value of 2.5%v/v, 0.03906% and 0.03906% respectively. Conclusion: The combination of Moringa oleifera and Thymus vulgaris essential oil can be used as a good antimicrobial agent to treat various Streptococci borne oral infections. Further incorporation of this oil into the drug formulations is also recommended to treat S.mutans borne oral as well as systemic infections.","PeriodicalId":41505,"journal":{"name":"Journal of Complementary Medicine Research","volume":"45 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84664221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficiency of life style change in IBS in Alqunfudah governate and its villages","authors":"N. Qusty, Anas Sarhan, Hassan Alsuhabi, Ali A Alsyed, Abdullah A Alrashdi, Mohammed A. Alessa, Haitham H Alzubaidi, Musleh Alzubaidi, Majed S. Almutairi, Ebrahem R Alsohabi, M. Taha","doi":"10.5455/jcmr.2023.14.03.31","DOIUrl":"https://doi.org/10.5455/jcmr.2023.14.03.31","url":null,"abstract":"Background: Irritable bowel syndrome (IBS) is the commonest functional gastrointestinal disorder with worldwide prevalence 11.2%, IBS characterized by recurrent colicky or cramping abdominal pain and altered bowel habit. Methods: A cross sectional study was conducted among AL Qunfudhah population with total 1003 of participants who were asked to complete questionnaires. Results: 28.9% were affected with IBS, this study shows higher predominance in females than males, The most common symptoms among our participants were bloating 37.1%, abdominal pain 26.8% and constipation 20.4%.24.4% were suffering from constipation or diarrhea in the morning and these symptoms affected by spicy food and fried food. Conclusion: Based on our findings, the predominance of IBS among females was higher. Bloating and abdominal pain were the commonest symptoms. Anxiety and depression affect IBS symptoms significantly. Our study emphasizes the correlation between certain foods and IBS symptoms. High fiber diet and low carbohydrate diet will improve the IBS symptoms.","PeriodicalId":41505,"journal":{"name":"Journal of Complementary Medicine Research","volume":"4 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88440166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arterial Embolization; A Lifesaving Solution in Placenta Accreta spectrum Post Hysterectomy: A Case Report","authors":"Samera F. AlBasri","doi":"10.5455/jcmr.2023.14.01.12","DOIUrl":"https://doi.org/10.5455/jcmr.2023.14.01.12","url":null,"abstract":"Case Summary: A 25-year-old woman who was referred to our hospital at 38 week’s gestation from another hospital as a case of placenta previa with possible accreta. She underwent cesarean hysterectomy and encountered sever postpartum hemorrhage that required massive transfusion of blood products and arterial embolization which was done and saved her life without further morbidity. Conclusion: With increased prevalence of placenta accreta spectrum, arterial embolization facility should be an integral part of treatment protocol to save maternal life.","PeriodicalId":41505,"journal":{"name":"Journal of Complementary Medicine Research","volume":"51 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84615427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}