Journal of Complementary Medicine Research最新文献

{"title":"Role of methylphenidate in cancer-related fatigue: A Systemic Review","authors":"Abdulrahman Alardan, H. Alkhudairi, Ghanim Almotiri, Saad Shamsy","doi":"10.5455/jcmr.2023.14.03.35","DOIUrl":"https://doi.org/10.5455/jcmr.2023.14.03.35","url":null,"abstract":"Introduction: Cancer-related fatigue (CRF) is a substantial medical issue that affects patients at all phases of their therapy and escalates with advanced cancer. To gather indications for the use of methylphenidate is objective of the study for the treatment of CRF, as well as to analyse the efficiency and safety of methylphenidate for the treatment of CRF so that we can tailor methylphenidate treatment to response patient only. Methods: To conduct the review of RCTs Systematic Reviews (PRISMA) statement was ideally chosen for Reporting Items. From inception through the first week of October 2021, A systematic search of the electronic databases PubMed, Embase, PSYCHInfo, and the Cochrane Library was done without any language restrictions. This helped to find all RCTs about the use of methylphenidate in patients with CRF. Search terms used were: methylphenidate, dexmethylphenidate, Ritalin, cancer, tumor, carcinoma, neoplasm, fatigue, asthenia, tiredness, CRF, and RCT. We also looked over a few journals' references to find more theoretically related papers. Results: A total of 267 citations were screened; among them, after a preliminary review 231 were excluded. 36 full-text articles assessed for eligibility; among them, 10 articles were met the inclusion criteria where all the selected articles were of good quality. Among 10 studies, 5 were identified in mixed tumor, 2 in prostate cancer, 1 in GI cancer, 1 in advanced cancer and 1 in Gynaecologic cancer. The characteristics of the studies changed broadly in terms of the treatment term and the population studied. Conclusion: To summarize up this study, cancer-related weakness could be critical clinical issue for cancer patients. Our findings suggest that methylphenidate may be useful in the treatment of CRF, but the evidence is inconclusive and has to be confirmed in a bigger study. All of the investigations, however, had tiny sample sizes. This counsel must be respected as provisional and temporary within the absence of considerable information from a single, expansive, well conducted randomized controlled trial. To support and propose new research topics and interventions, more study into biological factors affecting weariness is required.","PeriodicalId":41505,"journal":{"name":"Journal of Complementary Medicine Research","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80719023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial And Cytotoxic Effect of Selenium Nanoparticles Synthesized Using Clove and Cumin Formulation","authors":"Mufeetha M, R. S, T. Lakshmi","doi":"10.5455/jcmr.2023.14.03.17","DOIUrl":"https://doi.org/10.5455/jcmr.2023.14.03.17","url":null,"abstract":"Aim: The purpose of this study is to use clove and cumin extract to produce the selenium nanoparticles via green approach. Selenium nanoparticles synthesized using clove and cumin formulation nanotechnology explores a lot of interesting approaches in the field of biomedicine. Researchers have recently developed interest in biomolecule-mediated nanoparticle production because of its eco-friendly and non-toxic properties. Clova and cumin have long been used in traditional medicine to treat various illnesses. Materials And Method: Collection of clove and cumin extract then 1 g of clove and cumin, powder was dissolved in distilled water and boiled for 5–10 min at 60–70C. The solutions were then filtered using Whatman No. 1 filter paper. The filtered extract was collected, synthesis of seleniu","PeriodicalId":41505,"journal":{"name":"Journal of Complementary Medicine Research","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75916723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Economics And Pricing of Certain Segments of The Pharmaceutical Market","authors":"No author No author","doi":"10.5455/jcmr.2023.14.03.21","DOIUrl":"https://doi.org/10.5455/jcmr.2023.14.03.21","url":null,"abstract":"Pharmaceutical innovations over the past half century have made it possible to effectively treat and prevent a wide range of diseases. These achievements were so important for modern healthcare that equal access to them is considered one of the basic human rights. This article examines the economics and pricing in certain segments of the pharmaceutical market. The authors analyze various aspects affecting drug prices and price formation mechanisms in various segments of the pharmaceutical industry. The article considers the role of pharmaceutical companies, government regulators and consumers in determining the prices of medicines. The authors investigate the influence of factors such as research and development costs, production costs, patent protection, supply and demand, as well as political and regulatory measures on the formation of prices for pharmaceuticals. It is noted that although the demand for medicines is one of the driving forces of pharmaceutical spending, price increase is the main problem for health system managers, as drug prices increasingly seem unfair. The paper also analyzes various pricing strategies used by pharmaceutical companies, including differentiated pricing, cost pricing and pricing based on the value for a patient. The authors explore the advantages and limitations of each strategy and offer recommendations on the optimal choice of pricing strategy in different segments of the pharmaceutical market. The article ends with the main conclusions and offers recommendations for pharmaceutical companies and government regulators regarding effective pricing in certain segments of the pharmaceutical market, taking into account economic, political and social factors. The study has an important meaning for understanding the complexities and challenges associated with pricing in the pharmaceutical industry and helps to determine optimal pricing strategies for various market segments.","PeriodicalId":41505,"journal":{"name":"Journal of Complementary Medicine Research","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77325076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison Of Histomorphology, Angiogenesis and Proliferation in Kappa and Lambda Restricted Plasma Cell Myelomas with Its \u0000Effect on Prognosis","authors":"S. Priyadarshini, D. Basu, R. Kar, T. Dutta","doi":"10.5455/jcmr.2023.14.03.13","DOIUrl":"https://doi.org/10.5455/jcmr.2023.14.03.13","url":null,"abstract":"Aims Of the Study: To study the type of light chain restriction and correlate it with the morphological parameters, proliferation index, angiogenesis and clinical parameters. Materials And Methods: The study includes 46 cases of myeloma diagnosed over the period of five years. The histomorphological features like plasma cell morphology, percentage of plasma cells and pattern of infiltration were studied. Immunohistochemistry for kappa and lambda light chains was done. Angiogenesis was assessed by calculating the microvessel density (MVD) using anti CD34 immunohistochemistry. Proliferation was assessed immunohistochemically using Ki67 by comparing with anti CD38 which was used to highlight the plasma cells. Results: The cases with kappa light chain restriction had significantly less of poorly differentiated morphology (7.4% vs 36.8%; p=0.02) and diffuse pattern of infiltration (22% vs 63%; p=0.01) compared to lambda. The kappa group also had lower MVD (9.9 vs 16.5; p=0.02) and proliferation index (4.7 vs 94; p=0.04) compared to the lambda. Conclusion: Therefore, the type of light chain restriction is also a prognostic factor in plasma cell myeloma.","PeriodicalId":41505,"journal":{"name":"Journal of Complementary Medicine Research","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79205333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intelligent assistant to predict and control the home appliances in user environment through brain computer interface using hybrid deep learning model","authors":"Dr. G. Mohanraj, D. Nithyashri, Dr. V. Siva Brahmaiah, D. Shankar, Srithar S, Mr Azariya","doi":"10.5455/jcmr.2023.14.02.23","DOIUrl":"https://doi.org/10.5455/jcmr.2023.14.02.23","url":null,"abstract":"Brain Computer Interface (BCI) is the fast-growing research area that focuses on establishing the symbiotic relation between human brain and artificial intelligence. BCI enable the users to directly communicate with a computer by means of brain activity. Disability of a person due to medical issues such as spinal cord injury or cervical issues makes him/her to depend on caretakers for operating the home appliances. With the advancements in BCI technology, disabled people can control the home appliances through their brain activity without depending on caretaker. The existing models have accessibility challenges for the disabled people in two aspects Viz. accuracy and interaction time. The lack of high prediction accuracy as well as longer interaction time makes the existing models ineffective for the usage. To address the issues, hybridized deep learning model comprising Stacked Denoising Autoencoders and Extreme Machine learning is proposed and examined in this research. The proposed model acquires and preprocess the brain data of user and predicts the user intention with the improved accuracy. The proposed model is compared with different existing models investigated in the literature. The proposed approach achieves the maximum testing accuracy of 91.8% with 70% of training (10,500 Sample) and 30% of test validation (4,500 Sample) on the brain data of single user and takes interaction time of 0.48 seconds. The evaluation results of model validate the effectiveness of the proposed methodology.","PeriodicalId":41505,"journal":{"name":"Journal of Complementary Medicine Research","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76244109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Free Radical Scavenging Activity of Clove and Cumin Formulation Mediated Selenium Nanoparticl","authors":"Asmidha T, R. S, T. Lakshmi, S. G","doi":"10.5455/jcmr.2023.14.03.14","DOIUrl":"https://doi.org/10.5455/jcmr.2023.14.03.14","url":null,"abstract":"Background: Selenium nanoparticles (SeNPs) have the potential to be used for various applications.The green SeNPs (selenium nanoparticles) are formed by simple mixing Withania somnifera (W. somnifera) leaves extract and selenious acid (H2SeO3) solution. Nanoparticles have revolutionized for targeted drug delivery by minimizing the toxicity and side effects that commercially available drugs may have on patients. In this study we have chosen the clove and cumin because it protects from cholesterol, inflammatory damage and it has antioxidant property Aim: The aim of the study is to analyze the antioxidant activity of clove and cumin formulation mediated selenium nanoparticles. Materials & Methods: Cumin and Clove were powdered and stored in an air-sealed container. 1g of cumin and clove formulation was mixed with 100 ml of distilled water and boiled for 15 minutes and the formulation was filtered with Whatmann No.1 filter paper. 30mM sodium selenite was prepared in 50 ml of distilled water. 50 ml of sodium selenite solution and 50 ml of clove and cumin formulation was mixed and kept in a rotary shaker for 48 hours. UV spectroscopy reading based on color change was observed. Results: The antioxidant effect of selenium nanoparticles showed a higher percentage of inhibition at 50µg/ml in DPPH Assay and H2O2 Assay. The clove and cumin extract showed an increased percentage of inhibition with increasing concentration. Conclusion: The clove and cumin formulation mediated selenium nanoparticles acts as potent antioxidant agents. It also has the least side effects compared to commercial drugs.","PeriodicalId":41505,"journal":{"name":"Journal of Complementary Medicine Research","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77224260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Potential of Wild Salvia macilenta Boiss. of Oman as Nutraceuticals","authors":"S. Nadaf, Jamaleldin Sabahi, A. Lawati, Almandhar Mamari, F. Kindi, Abdulaziz Mawal, Houda Ruqaishi, Ahmed Ghafri, A. Farsi, N. Saady","doi":"10.5455/jcmr.2023.14.02.07","DOIUrl":"https://doi.org/10.5455/jcmr.2023.14.02.07","url":null,"abstract":"Background: Several plant extracts are now prescribed as nutraceuticals for human ailments in developed countries like China, France, Germany, the UK, USA including Oman. The objective of this study was to investigate on morphological characteristics, chlorophyll content of leaves, leaf chlorophyll, essential oil, and its chemical compounds to examine the possibility of isolating its incipient chemical compounds commercially in wild Salvia macilenta Boiss. Methods: Leaf samples of ten randomly selected Salvia plants were collected from two diversified wadi habitats. Edaphic features of the sites were recorded and their chemical contents, determined. Morphological characters were measured and chlorophyll contents, recorded. The essential oil (EO) was extracted and analyzed for chemical compounds. The data were statistically analyzed. Results: Al-Khoud plants had higher expressivity in all the morphological characters and chlorophyll contents than those of Halban. The EO yields of Salvia macilenta were 0.06 % (v/w) and 0.088 % (v/w) for the plant samples of Al-Khoud and Halban, respectively. The values of commonly occurring chemical contents of plants of two sites were found statistically similar (p<0.05). The top ten chemical compounds of plants contributed over 75% of the total and were common with seven chemical compounds. Of the ten top chemical compounds, alpha-Pinene, beta- Eudesmol, and Nerolidol contributed the highest in the same range from 61.13% (Al-Khoud) to 62.95% (Halban). These three compounds have the potential for use in both the pharmaceutical and perfumery industries. Conclusion: Wild Salvia plants can be exploited with Good Agriculture Practices for their medicinal and aromatic application.","PeriodicalId":41505,"journal":{"name":"Journal of Complementary Medicine Research","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91073837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in Euphorbia hirta Research: A 30-year Bibliometric Appraisal of the Present Realities","authors":"I. Elisha, J. Gotep, M. Makoshi, J. Usman, Blessing Shok, K. Oyebade, Z. Muhammad, Itodo Akogwu, K. Tondo, Hong Joseph, Edirin Akpojosevbe, B. Yakubu, Maryam Division, N. Vom, Plateau Stat","doi":"10.5455/jcmr.2023.14.01.16","DOIUrl":"https://doi.org/10.5455/jcmr.2023.14.01.16","url":null,"abstract":"Euphorbia hirta L.. is a common herb with global spread. Different parts of E. hirta are used in traditional medicine for the treatment of a variety of human and animal conditions, such as skin diseases, inflammation, digestive and respiratory disorders. This bibliometric study aimed to provide a panoramic view of the publication landscape in the last thirty years of Euphorbia hirta research. VOSviewer was used to analyze 603 documents retrieved from Scopus database during the period, 1992 to 2021. Dominant research themes in the last thirty years were centred on the application of crude extracts or isolated compounds from E. hirta against diabetes, oxidative stress, inflammation, tuberculosis, snake bite, gastro-intestinal disorders, respiratory infections, skin pathologies, bacterial, fungal and viral infections. Current paradigm shift in E. hirta research are targeted at improving the efficacy of phytomolecules against resistant bacterial pathogens and cancer cells via green synthesis of nanoparticles and the application of in silico technologies in predicting the activities of nano-phytomolecules against SARS-CoV-2 and the dengue virus. This study recommends further research in the determination of the bioavailability of molecules in in vivo models. Researchers should carry out more preclinical investigations with the aim of establishing the pharmacokinetic and pharmacodynamic properties of phytocompounds instead of relying solely on in silico predictions.","PeriodicalId":41505,"journal":{"name":"Journal of Complementary Medicine Research","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84820115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review Of Physiological Responses to Eight-Week Basketball Trainings","authors":"Abdullah Demirli, Emre Yamaner, Eda elik, A. Moghanlou","doi":"10.5455/jcmr.2023.14.03.25","DOIUrl":"https://doi.org/10.5455/jcmr.2023.14.03.25","url":null,"abstract":"<jats:p />","PeriodicalId":41505,"journal":{"name":"Journal of Complementary Medicine Research","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81888852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Convolutional Neural Network for Cancer Disease Diagnosis – A Deep Learning based Approach","authors":"S. Sivanantham, D. M, A. Velmurugan, Dr. T. Deepa, Akshaya V","doi":"10.5455/jcmr.2023.14.01.14","DOIUrl":"https://doi.org/10.5455/jcmr.2023.14.01.14","url":null,"abstract":"Human are vulnerable to the terrible disease named cancer, which is a major factor in the high mortality rate. There are currently lesser DLTs (Deep learning techniques) or MLTs (machine learning techniques) for identifying cancer, despite advances in cancer treatment approaches. The proposed work performs a comparative study which compares the some significant DLTs like RFs (Random Forests), LSTMs (Long Short Term Memories), CNNs (Convolutional Neural Networks) and BPNNs (Back Propagation Neural Networks). These techniques are used here in this work for classification problem. The techniques are made to classify the medical records into benignand cancerous. Three pathological datasets are used to evaluate the above said techniques. CNNs provide the best performance of 0.97 accuracy and it is even good at its values of precisions, recalls and F1 scores.","PeriodicalId":41505,"journal":{"name":"Journal of Complementary Medicine Research","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86473163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}