Clinica e Investigacion en Ginecologia y Obstetricia最新文献_第9页

Fezolinetant: un nuevo tratamiento en estudio para la menopausia Fezolineant：更年期研究中的新疗法

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Clinica e Investigacion en Ginecologia y Obstetricia Pub Date : 2023-10-01 DOI: 10.1016/j.gine.2023.100888

P. Luque González , J.C. Mora Palma

{"title":"Fezolinetant: un nuevo tratamiento en estudio para la menopausia","authors":"P. Luque González , J.C. Mora Palma","doi":"10.1016/j.gine.2023.100888","DOIUrl":"https://doi.org/10.1016/j.gine.2023.100888","url":null,"abstract":"<div><p>Menopause is the physiological cessation of menstruation that can occur in women between 42 and 58 years of age with diverse symptoms. The most common clinic is vasomotor, which can greatly affect the quality of life of women. Traditionally, hormone replacement therapy has been used and is considered the most effective treatment. However, there are contraindications for which the use of non-hormonal therapy should be considered. Nowadays, these options are suboptimal in terms of effectiveness and tolerance, which is why research is being carried out on new treatments such as fezolinetant, a neurokinin 3 receptor antagonist.</p><p>To elucidate these investigations a bibliographic search has been carried out in the main databases. Although its safety and long-term effects remain to be established, fezolinetant looks promising in patients for whom hormonal therapy cannot be used. It decreases statistically significant the moderate or severe vasomotor symptoms from the first day of treatment when compared with placebo and with other non-hormonal treatments with a good tolerance profile and few side effects. However, this drug is still in phase III trials, so it needs to continue with its study.</p></div>","PeriodicalId":41294,"journal":{"name":"Clinica e Investigacion en Ginecologia y Obstetricia","volume":"50 4","pages":"Article 100888"},"PeriodicalIF":0.1,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49823596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metroplastia cervical histeroscópica en útero septo completo, septo cervical y tabique vaginal. Análisis de resultados clínicos y reproductivos en serie de casos de 2011 a 2021 宫腔镜下子宫全间隔、宫颈间隔和阴道间隔的宫颈大都市成形术。2011-2021年系列病例临床和生殖结果分析

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Clinica e Investigacion en Ginecologia y Obstetricia Pub Date : 2023-10-01 DOI: 10.1016/j.gine.2023.100884

I. Hinojal Toscano, M.A. Sánchez Oliver

{"title":"Metroplastia cervical histeroscópica en útero septo completo, septo cervical y tabique vaginal. Análisis de resultados clínicos y reproductivos en serie de casos de 2011 a 2021","authors":"I. Hinojal Toscano, M.A. Sánchez Oliver","doi":"10.1016/j.gine.2023.100884","DOIUrl":"https://doi.org/10.1016/j.gine.2023.100884","url":null,"abstract":"<div><h3>Background</h3><p>The septum uterus with cervical septum and vaginal septum is a rare entity only described in classifications that include complex Müllerian malformations such as the VCUAM (2005), ESHRE/ESGE (2013) and ASRM (2021) classifications. The objective of our work is to describe the results of hysteroscopic cervical metroplasty according to the Vercellini technique in our patients.</p></div><div><h3>Material and method</h3><p>This is a retrospective observational cohort study with a duration of 10years. Only patients with a diagnosis of a complete septum uterus, cervical septum, and vaginal septum with indication of cervical metroplasty according to the Vercellini technique between 2011 and 2021 were included.</p></div><div><h3>Results</h3><p>The results of five patients with indication of the technique were analyzed. Analyzing our result, we highlight a live newborn at term after performing the technique, which was followed up in the prematurity clinic without cervical modifications because of the resection of the cervical septum.</p></div><div><h3>Conclusion</h3><p>There is very little evidence available regarding the treatment of the uterus complete septum with cervical septum and vaginal septum due to its low prevalence and the heterogeneity of the diagnosis. Analyzing the results obtained, we consider the Vercellini intervention to be effective in removing the septum, which does not seem to be associated with major or minor complications. Based on the existing evidence, it could be useful to improve the reproductive prognosis of patients with this type of malformation; individualizing the need for a second hysteroscopic touch-up.</p></div>","PeriodicalId":41294,"journal":{"name":"Clinica e Investigacion en Ginecologia y Obstetricia","volume":"50 4","pages":"Article 100884"},"PeriodicalIF":0.1,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49823601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decúbito prono en el tercer trimestre del embarazo durante la era COVID-19: un abordaje transdisciplinar 新型冠状病毒时代妊娠晚期俯卧：跨学科方法

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Clinica e Investigacion en Ginecologia y Obstetricia Pub Date : 2023-10-01 DOI: 10.1016/j.gine.2023.100906

A. Fajardo-Campoverdi , A. Rodríguez , C. Chica-Meza

引用次数: 0

Importancia del papel de Haemophilus no ducreyi en el tracto genital femenino y su relación con la clínica 非杜克雷嗜血杆菌在女性生殖道中的作用及其与临床的关系

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Clinica e Investigacion en Ginecologia y Obstetricia Pub Date : 2023-10-01 DOI: 10.1016/j.gine.2023.100892

M. Neukirch , M. Ruiz del Pino , J.M. Navarro-Marí , J. Gutiérrez-Fernández , A. Rosales-Castillo

{"title":"Importancia del papel de Haemophilus no ducreyi en el tracto genital femenino y su relación con la clínica","authors":"M. Neukirch , M. Ruiz del Pino , J.M. Navarro-Marí , J. Gutiérrez-Fernández , A. Rosales-Castillo","doi":"10.1016/j.gine.2023.100892","DOIUrl":"https://doi.org/10.1016/j.gine.2023.100892","url":null,"abstract":"<div><h3>Background</h3><p>The isolation of new pathogens in clinical samples from the genital tract of subjects with suspected infection, such as <em>Haemophilus</em> no <em>ducreyi</em> (HND) species, is becoming more frequent. The objective of this work is to analyze the pathogenic role and the clinical importance of the isolation of these species in female genital tract.</p></div><div><h3>Patients and methods</h3><p>We carried out an observational, descriptive, and retrospective study from a Hospital in Granada (Spain). HND isolates in female genital samples between 2016 and 2019 from specialized care were studied. Clinical, epidemiological, and microbiological variables of clinical episodes of adult women and girls were analyzed.</p></div><div><h3>Results</h3><p>Forty-five (25 women and 20 girls) isolates of HND were found, corresponding to 1%; the most frequent specie was <em>Haemophilus influenzae</em> (64.4%). In women, leukorrhea and abdominal pain was frequent and in 72% there was a polymicrobial isolate. In girls, it was frequently in isolation, with the presence of vulvovaginal erythema, pathological discharge, and local itching. We highlight the high rate of resistance of <em>Haemophilus parainfluenzae</em> to azithromycin (72.7%) and cotrimoxazole (18.2%) in adult women, in contrast to resistance to azithromycin in girls (25%).</p></div><div><h3>Conclusions</h3><p><em>H. influenzae</em> and <em>H. parainfluenzae</em> should be considered as a possible etiological agent in cases of vaginitis and cervicitis in adult women, as well as in suspected pelvic inflammatory disease. In girls, <em>H.</em> <em>influenzae</em> represents one of the microbiological agents within the etiologies of vulvovaginal infections. We highlight the rate of resistance to azithromycin in <em>H.</em> <em>parainfluenzae</em> and to cotrimoxazole in both species.</p></div>","PeriodicalId":41294,"journal":{"name":"Clinica e Investigacion en Ginecologia y Obstetricia","volume":"50 4","pages":"Article 100892"},"PeriodicalIF":0.1,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49823644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Linfoma difuso de células B grandes primario de cérvix. A propósito de un caso 宫颈弥漫性原发性大B细胞淋巴瘤。关于一个案件

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Clinica e Investigacion en Ginecologia y Obstetricia Pub Date : 2023-10-01 DOI: 10.1016/j.gine.2023.100886

B. Pando Ruiz , I. Gonzalo García , L.M. Fernández Abad

{"title":"Linfoma difuso de células B grandes primario de cérvix. A propósito de un caso","authors":"B. Pando Ruiz , I. Gonzalo García , L.M. Fernández Abad","doi":"10.1016/j.gine.2023.100886","DOIUrl":"https://doi.org/10.1016/j.gine.2023.100886","url":null,"abstract":"<div><h3>Introduction</h3><p>Primary involvement of the female genital tract by non-Hodgkin lymphoma is very rare, so there is no consensus on treatment, and for this reason we present this clinical case and the treatment performed, as well as the prognosis of our patient.</p></div><div><h3>Clinical findings</h3><p>The patient presented is a 72-year-old woman who consulted for vaginal bleeding.</p></div><div><h3>Diagnosis</h3><p>Primary extranodal non-Hodgkin lymphoma of the cervix with immunophenotypeB of high cytological grade and high proliferative index was diagnosed.</p></div><div><h3>Therapeutic interventions and results</h3><p>The treatment of choice was chemotherapy only. This patient has presented a disease-free survival of 5years. It is currently being monitored by carrying out annual analytical controls.</p></div><div><h3>Conclusion</h3><p>The symptoms of this type of tumor are highly non-specific, as well as cytology is frequently negative, which is why it is necessary to resort to biopsy. Immunohistochemistry is essential for both diagnosis and prognosis. There are multiple imaging techniques used for both extension study and follow-up, highlighting the role of FDG-PET.</p><p>It currently seems that the most recommendable treatment is the R-CHOP chemotherapy regimen followed by radiotherapy.</p><p>The prognosis is generally good, with up to 80% survival at 5years.</p></div>","PeriodicalId":41294,"journal":{"name":"Clinica e Investigacion en Ginecologia y Obstetricia","volume":"50 4","pages":"Article 100886"},"PeriodicalIF":0.1,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49823594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biopsia guiada por ecografía para el diagnóstico de masas ováricas. Revisión sistemática 超声引导活检诊断卵巢肿块。系统回顾

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Clinica e Investigacion en Ginecologia y Obstetricia Pub Date : 2023-10-01 DOI: 10.1016/j.gine.2023.100889

J.A. García Mejido , R. García-Jiménez , I. Pelayo-Delgado , R. Neguillo-Moguel , L. Rodríguez-Cruz , J.A. Sainz-Bueno

{"title":"Biopsia guiada por ecografía para el diagnóstico de masas ováricas. Revisión sistemática","authors":"J.A. García Mejido , R. García-Jiménez , I. Pelayo-Delgado , R. Neguillo-Moguel , L. Rodríguez-Cruz , J.A. Sainz-Bueno","doi":"10.1016/j.gine.2023.100889","DOIUrl":"https://doi.org/10.1016/j.gine.2023.100889","url":null,"abstract":"<div><p>The definitive diagnosis of ovarian cancer requires histological confirmation. In certain situations, to avoid the morbidity of surgical resection, it is possible to perform an ultrasound-guided biopsy to obtain the pathological diagnosis. The aim of this systematic review was to assess the adequacy, reliability, accuracy, and safety profile of ultrasound-guided biopsy of ovarian masses. Following the PRISMA 2020 model, a bibliographic search was carried out in PubMed, Embase and Scopus, collecting a total of 10,245 articles, of which 24 were finally included. The studies mainly included patients with advanced inoperable tumors, poor performance status and other poor prognostic factors, with masses of solid content and irregular margins, generally accessible through the transvaginal route. In most of the articles, the patients had a previous history of malignancy or had inoperable tumors in advanced stages. Biopsiable ovarian masses were defined ultrasonographically as malignant or potentially malignant, mainly highlighting the presence of a solid or mixed component and irregular or heterogeneous margins. The most widely used technique in the included studies was core needle or tru-cut biopsy, presenting high values of adequacy, reliability, precision and performance, as well as a good safety profile with low complication rates. In conclusion, ultrasound-guided core needle biopsy of adnexal masses in patients eligible for neoadjuvant treatment is a technique with high adequacy, reliability, and precision rates, as well as a good safety profile.</p></div>","PeriodicalId":41294,"journal":{"name":"Clinica e Investigacion en Ginecologia y Obstetricia","volume":"50 4","pages":"Article 100889"},"PeriodicalIF":0.1,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49823597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fibrosarcoma primario de ovario. Reporte de una neoplasia inusual 卵巢原发性纤维肉瘤。异常肿瘤报告

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Clinica e Investigacion en Ginecologia y Obstetricia Pub Date : 2023-10-01 DOI: 10.1016/j.gine.2023.100891

R. Sarabia Ochoa , J.P. García de la Torre , A. Amezcua Recover

{"title":"Fibrosarcoma primario de ovario. Reporte de una neoplasia inusual","authors":"R. Sarabia Ochoa , J.P. García de la Torre , A. Amezcua Recover","doi":"10.1016/j.gine.2023.100891","DOIUrl":"https://doi.org/10.1016/j.gine.2023.100891","url":null,"abstract":"<div><h3>Introduction</h3><p>Ovarian fibrosarcoma is an extremely rare malignant ovarian stromal tumor, with few cases reported in the literature.</p></div><div><h3>Main symptoms and/or clinical findings</h3><p>A 56-year-old posmenopausal woman with scant vaginal bleeding of several days’ duration and pain in the right iliac fossa without fever or digestive symptoms. The gynecological examination was normal.</p></div><div><h3>Main diagnoses, therapeutic interventions and results</h3><p>Transvaginal ultrasound showed a homogeneous endometrium, a 2.4×1cm myoma, and a heterogeneous solid-cystic lesion with thick septa measuring 6.4×6.8cm in the left ovary. An intraoperative histological study was performed, which was reported as: solid neoplasm suspicious of malignancy. Hysterectomy plus double adnexectomy, omentectomy, and lymphadenectomy were performed. Histologically, the neoplasm was made up of spindle cells arranged in sheets and intertwined fascicles with a diffuse spike-like appearance, with moderate nuclear atypia, areas of necrosis and hemorrhage foci; 12 mitoses were identified for every 10 high-power fields. Immunohistochemically the cells were positive for inhibin, actin 1A4, vimentin, calretinin, CD56 and CD99. The proliferative rate with Ki-67 was 25%. The definitive diagnosis was: primary ovarian fibrosarcoma. One year later, the patient is free of the disease without any adjuvant treatment and continues to be followed up.</p></div><div><h3>Conclusion</h3><p>Ovarian fibrosarcoma is an exceptional malignancy with a poor prognosis. Currently, the treatments and prognostic factors for ovarian fibrosarcoma are still the subject of debate. This case highlights the important role of the intraoperative study and immunohistochemistry for its correct diagnosis.</p></div>","PeriodicalId":41294,"journal":{"name":"Clinica e Investigacion en Ginecologia y Obstetricia","volume":"50 4","pages":"Article 100891"},"PeriodicalIF":0.1,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49823598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Síndrome de ovario remanente. Revisión bibliográfica. Evidencia actual 残余卵巢综合征。文献回顾。当前证据

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Clinica e Investigacion en Ginecologia y Obstetricia Pub Date : 2023-10-01 DOI: 10.1016/j.gine.2023.100902

M. Arnáez de la Cruz, J. Gallardo Martínez

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Herlyn–Werner–Wünderlich syndrome: A case series Herlyn-Werner-Wünderlich综合征：一系列病例

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Clinica e Investigacion en Ginecologia y Obstetricia Pub Date : 2023-09-19 DOI: 10.1016/j.gine.2023.100912

M. Castillo Lara, L. De Pablo Zamora, E. Pozuelo Solis

引用次数: 0

Intervenciones dietéticas en el tratamiento del síndrome del ovario poliquístico. Una revisión bibliográfica 多囊卵巢综合征的饮食干预。文献综述

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Clinica e Investigacion en Ginecologia y Obstetricia Pub Date : 2023-08-28 DOI: 10.1016/j.gine.2023.100911

Jesús Javier Aguaviva Bascuñana , Nerea Olivares Sánchez

{"title":"Intervenciones dietéticas en el tratamiento del síndrome del ovario poliquístico. Una revisión bibliográfica","authors":"Jesús Javier Aguaviva Bascuñana , Nerea Olivares Sánchez","doi":"10.1016/j.gine.2023.100911","DOIUrl":"https://doi.org/10.1016/j.gine.2023.100911","url":null,"abstract":"<div><p>Polycystic ovary syndrome (PCOS) is a female endocrinopathy recognized as a heterogeneous disorder characterized by hyperandrogenism and ovulatory dysfunction that leads to fertility problems. In addition, patients usually present with associated symptoms such as insulin resistance, glucose intolerance, central obesity and/or metabolic syndrome that can induce an increased risk of cardiovascular disease. Since one of the main goals of PCOS is to reduce the metabolic consequences related to obesity, insulin resistance, and the metabolic syndrome, targeted dietary interventions may be effective in treating PCOS.</p><p>A bibliographic search has been carried out in different databases such as Web of Science, Pubmed and Google Scholar, establishing previously defined search criteria. Eleven have been chosen for full review and critical analysis. Among the different interventions that have been used, dietary strategies have been followed such as the dietary approaches to stop hypertension (DASH), modifications in carbohydrates, the inclusion of a certain food in the usual dietary pattern and/or lifestyle modifications. Of the results obtained, we highlight the improvements in body markers with a DASH diet, the benefits promoted by diets with modifications in carbohydrates, in insulin resistance and hormonal markers and favorable effects on clinical manifestations related to hyperandrogenism, fostered by soy consumption and lifestyle modifications.</p></div>","PeriodicalId":41294,"journal":{"name":"Clinica e Investigacion en Ginecologia y Obstetricia","volume":"51 1","pages":"Article 100911"},"PeriodicalIF":0.1,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49888474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0