Osmangazi Journal of Medicine最新文献

{"title":"Otolog Hematopoetik Kök Hücre Nakli Yapılan Hastalarda Komorbidite İndekslerinin Sağkalım İle İlişkisinin Değerlendirilmesi","authors":"Fatih Yaman, Vildan Ozkocaman, Fahir Özkalemkaş, Sedat Çelikçi","doi":"10.20515/OTD.861236","DOIUrl":"https://doi.org/10.20515/OTD.861236","url":null,"abstract":"Bu calismanin amaci hematopoetik kok hucre nakli yapilan hastalarda komorbidite indekslerinin sagkalimi ongormede prediktif degerlerini saptamakti. Agustos 2009–Mart 2014 tarihleri arasinda otolog hematopoetik kok hucre nakli (OHKHN) yapilan hematolojik maligniteli 110 hastanin verileri retrospektif olarak incelendi. Komorbidite indeksleri ve sagkalim sureleri arasindaki iliski Kaplan-Meier testi kullanilarak incelendi. OHKHN yapilan 110 hastanin 58’ini (%53) kadin, 52’sini (%47) erkek hastalar olusturmaktaydi. Hastalarin ortanca yasi 54 (22-72)’tu. OHKHN yapilan hastalarin 84’u (%76) Multipl miyelom (MM), 18’i (%17) Non-hodgkin lenfoma (NHL), 8’i (%7) Hodgkin lenfoma (HL) taniliydi. 2 yillik takiplerinde hastalarin 57’si (%52) nuks olmustu, 53’u (%48) remisyondaydi, 40’i (%36) hayatini kaybetmisti. Hayatta olan 70 (%64) hasta vardi. En sik komorbiditeler pulmoner hastaliklar (%33), psikiyatrik hastaliklar (%29) ve enfeksiyon hastaliklariydi (%20). Hematopoietic Cell Transplantation Comorbidity Index (HCT-CI), Flexible Hematopoietic Cell Transplantation Comorbidity Index (Flexible HCT-CI) ve Charlson Comorbidity Index (CCI) skoru ile progresyonsuz sagkalim ve genel sagkalim arasindaki iliski incelendiginde istatistiksel anlamli bir iliski bulunamadi (p>0.05). Yapilan calismalarda genel sagkalimi en iyi ongoren komorbidite skoru HCT-CI olmakla birlikte bizim calismamizda daha sik 65 yas alti, perfomans durumu iyi olan, komorbid hastaligi az olan hastalara nakil yapilmasi nedeni ile HCT-CI komorbidite skorunun bu grup hastalarda kullanimi ve sagkalimi ongormedeki etkisi kisitlidir. Komorbidite indekslerindeki parametre sayilari arttikca sagkalimi ongormedeki duyarliliklari artmaktadir. Nakil oncesi rutin kullanima girmeleriyle birlikte bu konuyla ilgili tecrubelerimiz artacaktir.","PeriodicalId":409672,"journal":{"name":"Osmangazi Journal of Medicine","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130863575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topikal Atorvastatinin Random Paternli Cilt Fleplerinin Yaşayabilirliğine Etkisi ,Deneysel Çalışma","authors":"B. Can, O. Özturan, Meltem Oral, Sadi Bener","doi":"10.20515/OTD.858659","DOIUrl":"https://doi.org/10.20515/OTD.858659","url":null,"abstract":"Random fleplerin yasayabilirliginin arttirilmasi plastik cerrahide,suregelen arastirmalara konu olmustur. Bir cok ajan denenmis ancak cogu klinik kullanima girememistir. Atorvastatinler lipid dusurucu olarak kullanilmaktadir. Ayrica , sistemik uygulama ile flep yasayabilirligini , arttirdiklari deneysel olarak gosterilmistir. Bu calismada atorvastatinin , topikal uygulama ile flep yasayabilirligine etkisi arastirilmistir. 180-230 gram agirliginda wibstor albino tipi , 20 erkek rat kontrol ve deney grubu olarak ayrilmistir. Her bir grupta , Mc Farlane flebi eleve edilmis , deney grubunda flep uzerine, hazirlanan atorvastatin krem uygulanirken;kontrol grubu herhangi bir tedavi almamistir. Islemden 7 gun sonra flep saglikli ve nekrotik doku gecis zonundan 4 mm’ lik kesitler halinde doku ornekleri alinarak ,hematoksilen eozin ile boyanmis ve isik mikroskobu altinda lenfosit hucre yogunlugu, notrofil hucre yogunlugu , kapiller dansite ve granulasyon dokusu dansitesi acisindan incelenmistir. Fleplerdeki nekroz alanlari sasaki kagidi metodu ile isaretlenmis, isaretleme AUTOCAT 2012 programina aktarilarak fleplerdeki nekroz oranlari bulunmustur. Histolojik parametlerin ve fleplerdeki nekroz oranlarinin karsilastirilmasi icin Mann Whitney U testi kullanilmistir (p<0,05) Calismaya gore deney grubunda notrofil hucre yogunlugu ve kapiller dansite artmis, granulasyon dokusu dansitesi ve lenfosit hucre yogunlugu ise degismemistir. Flep nekroz oraninin atorvastatin uygulanan grupta azaldigi gosterilmistir. Flep nekroz orani kontrol grubunda 32,1% iken deney grubunda 14,17% olarak bulunmustur .Ek calismalara ihtiyac olmakla birlikte , atorvastatin topikal olarak kullanim ile flep yasayabilirligini arttirmaktadir.","PeriodicalId":409672,"journal":{"name":"Osmangazi Journal of Medicine","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126935214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medium Rotator Manşet Yırtıklarının Artroskopik Onarımı Sonrası Yeniden Yırtılmanın Öngörülebilirliği, Retrospektif bir Çalışma","authors":"Vedat Biçici, Emre Nalbant, İzzet Bi̇ngöl","doi":"10.20515/OTD.895350","DOIUrl":"https://doi.org/10.20515/OTD.895350","url":null,"abstract":"Omuz eklemi stabilizatorlerinden olan rotator manset (RM)' in yirtiklari omuz patolojilerinin en onemli nedenlerinden biridir. Konservatif tedaviden fayda goremeyen hastalara genellikle cerrahi tedavi gerekmektedir ve genelde artroskopik tamir tercih edilir. RM onarimi sonrasi yeniden yirtilma en sik karsilasilan komplikasyonlardandir. Calismamizin amaci; rotator manset yeniden yirtilmanin preoperatif kas atrofisi ile olan iliskisini incelemek ve yeniden yirtilma olusumunu tahmin etmenin mumkun olup olmadigini degerlendirmektir. Medium (1-3 cm) boyutunda tam kat rotator manset yirtiklari nedeni ile artroskopik tamir yapilan, en az 1 yillik takipte olan 87 hasta degerlendirildi. Hastalarin yas, cinsiyet, etkilenen taraf, diabetes mellitus, hipertansiyon, hiperlipidemi ve sigara kullanimi gibi demografik verileri toplandi. Tamir yontemi (tek sira ve cift sira) kaydedildi. Preoperatif ve son kontrolde Constant Murley Shoulder Score ve Oxford Shoulder Score kullanildi. Postoperatif 1. yilda rotator mansette iyilesme ve yeniden yirtilma acisindan Ultrasonografi (USG) ile degerlendirildi. Hastalarin, preoperatif cekilen Manyetik Rezonans (MR) goruntulerinden modifiye tanjant derecelendirme yontemi ile supraspinatus (SS) atrofileri siniflandirildi. USG' de 19 (21,8%) hastada yeniden yirtilma, 68 'inde (78,2%) iyilesme saptandi. Hastalarin preoperatif cekilen MR' larinda; 48 (55,2%) hasta 1. derece, 29 (33,3%) hasta 2. derece ve 10 (11,5%) hasta 3. derece SS kas atrofisi oldugu saptandi. Preoperatif MR' da yeniden yirtilma olanlarin saglam olanlara gore dereceleri daha yuksek saptandi (p<0.001). Hastalarin preoperatif MR derecesine gore yeniden yirtilma acisindan istatistiksel olarak anlamli farklilik vardi (p<0.001). MRI 3. derece olanlarin tamaminda tekrar yirtilma yasanirken 2. derece olanlarin % 24,1' inde, 1. derece olanlarin ise % 4,2' sinde yeniden yirtilma olusmustur. En cok yirtilma orani 3. derece, en az 1. derece olgularda gorulmustur. Rotator manset yeniden yirtilma acisindan; SS kas atrofisinin risk faktoru oldugunu, derecesi arttikca olma ihtimalinin arttigini ve preoperatif tahmin edilebilecegini soyleyebiliriz. Bu durum hastaya en uygun tedavinin belirlenmesinde ve postoperatif donemde prognozu belirlemek acisindan yol gosterici olacagi kanaatindeyiz.","PeriodicalId":409672,"journal":{"name":"Osmangazi Journal of Medicine","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129794313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 Pandemisi Nedeniyle Evlerinde Sosyal İzolasyon Yaşayan ve Daha Önceden Fibromyalji Sendromu Tanısı Almış Bireylere Uygulanan Tele-Rehabilitasyonun Etkinliğinin Araştırılması","authors":"Yıldız Akbaba, Fulya Demirhan, Nurettin Taşteki̇n","doi":"10.20515/OTD.860027","DOIUrl":"https://doi.org/10.20515/OTD.860027","url":null,"abstract":"It was aimed to investigate the effect of Tele-rehabilitation application on the symptoms of the disease in patients with fibromyalgia. The cases were randomized into three groups as strengthening (n=20), stretching-relaxation (n=20) and control (n=20). The study was terminated with 55 people. In all cases; Fibromyalgia Impact Inquiry Scale (FIQ), Visual Analogue Scale (VAS), Quality of Life Scale (SF-36), Beck Depression Inventory (BDI), Pittsburgh Sleep Quality Index (PSQI) and Positive-Negative Affect Scale (PANAS), 5 The Sit-to-Go Test (5-TSBS), Timed Up and Go Test (TUG) and V-Sit-Reach Test (VSR) were used. There was no statistically significant difference in terms of demographic and clinical characteristics of the groups (p>0,05). The intragroup assessment showed that in strengthening group, FIQ score (p=0,01), PSQI score (p=0,01), VAS score (p=0,00), PANAS positive-negative (p=0,01), 5-TSBS, TUG, VSR (p=0,01) scores and all sub-scores of the SF-36 scale were found to be significantly different. In the stretching-relaxation group, PSQI (p=0,01), SF-36 Physical function (p=0,01), SF-36 Role Restriction (p=0,03), SF-36 Vitality (p=0,01) and SF-36 Mental Health (p=0,01) sub-scores were found to be statistically significant. In comparison between groups, BDI (p=0,03), VSR (p=0,006) and SF-36 Pain (p=0,04), Vitality (p=0,00) and Mental Health (p=0,01) sub-scores were found to be statistically significant. Tele-rehabilitation applications with different exercise contents applied in patients with fibromyalgia positively affect the health status, pain, sleep quality, depression, mood, physical performance and quality of life results. In terms of quality of life and depression in the group given muscle strengthening exercises compared to the other groups; In the group that was given stretching-relaxation exercise, more improvement was observed in terms of flexibility. In cases where access to the clinic is difficult, Tele-rehabilitation application can be preferred as a useful and safe treatment option.","PeriodicalId":409672,"journal":{"name":"Osmangazi Journal of Medicine","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122559726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Yeni Koronavirüs Hastalığının (Covid-19) Klinik, Laboratuvar ve Radyolojik Sonuçlarının İncelenmesi","authors":"M. Kaya, M. Demirkol","doi":"10.20515/OTD.867956","DOIUrl":"https://doi.org/10.20515/OTD.867956","url":null,"abstract":"Covid-19, which emerged in China in December 2019 and spread to the whole world in a short time, has been a serious public health problem threatening humanity. In this study, we aimed to reveal demographic, clinical, laboratory and radiological features of patients diagnosed with Covid-19. The study is a retrospective cross-sectional study consisting of patients who were hospitalized in health institutions in Bolu, Turkey between 11.03.2020 and 19.04.2020 with a definitive or probable diagnosis of Covid-19. The number of patients in the study was 262. The mean age of the patients participating in the study was 57.39 ± 19.85, the youngest patient was 19 and the oldest was 94 years old. Of the patients, 40.1% was between the ages of 18-50, 59.9% were over 50 years old. 55.3% of the patients were women and 44.7% were men. Most common symptoms were fever (75.6%), cough (71.8%) and dyspnea (46.9%). Elevated CRP (in 71.3%), elevated LDH (in 56.9%), elevated D-DIMER (in 56.4%) and lymphopenia (in 30.5) were most detected laboratory abnormalities. The result of the real-time reverse-transcription polymerase chain reaction (RT-PCR) test was positive in 35.5% of 262 patients. 88.5% of the patients had chest CT findings compatible with Covid-19. Additionally, 24% had both positive RT-PCR results and CT findings compatible with Covid-19. Expected findings were found to be in older patients more than younger ones. We suggest that clinical features, laboratory abnormalities and radiological findings can be used to provide an early diagnosis and treatment of Covid-19.","PeriodicalId":409672,"journal":{"name":"Osmangazi Journal of Medicine","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121855414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ailesel HDR Sendromu olgu sunumu","authors":"Birgul Kirel, İlhan Hazer, C. Aydın","doi":"10.20515/OTD.785745","DOIUrl":"https://doi.org/10.20515/OTD.785745","url":null,"abstract":"","PeriodicalId":409672,"journal":{"name":"Osmangazi Journal of Medicine","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132141315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glioblastome Multiforme 'de Güncel Durum ve Uzun Yaşam","authors":"Faruk Altinel, Mehmet Nur Altinors","doi":"10.20515/OTD.828338","DOIUrl":"https://doi.org/10.20515/OTD.828338","url":null,"abstract":"Glioblastome Multiforme (GBM) ozellikle orta ve ileri yas grubunda sik gorulen, en kotu huylu primer beyin tumorudur. Cerrahi rezeksiyon, radyoterapi ve kemoterapiyi iceren uclu tedaviye ragmen sag kalim suresi ortalama bir yil civarindadir. Bu taniyi almis, uc yil veya daha uzun sure yasamda kalmis hastalarin uzun yasadigi dusunulur. GBM hastalarinin cok dusuk bir yuzdesi bu gruba girer. Uzun yasadigi gozlenen GBM'li olgularda histopatolojik taninin tekrar gozden gecirilmesi gerekir. Uzun yasamla iliskili faktorler kesin olarak bilinmemektedir. Genc yas, Karnofsky skoru yuksekligi ve Metil Guanin MetilTransferaz(MGMT) metilasyonunun GBM'li hastalarda daha iyi bir prognoz ve daha uzun sag kalimla iliskili oldugu one surulmustur.","PeriodicalId":409672,"journal":{"name":"Osmangazi Journal of Medicine","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129679241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SLAP Lezyonlarının MRG ve Artroskopik karşılaştırması","authors":"Cüneyd Günay, M. Kavak","doi":"10.20515/OTD.864773","DOIUrl":"https://doi.org/10.20515/OTD.864773","url":null,"abstract":"Superior labrum anterior-posterior (SLAP) yirtiklari ortopedi hastalarinda omuz agrisi kaynaklarindandir. Manyetik rezonans goruntuleme (MRG) bu hastalarda teshis icin gereklidir. Bu calismanin amaci SLAP lezyonlarinin MRG ve artroskopi degerlendirmeleri arasindaki uyumu gostermektir. Calisma Nisan 2019- Mayis 2020 tarihleri arasinda varolan omuz patolojisi icin omuz artroskopi cerrahisine giden yas ortalamsi 50.40 (aralik: 19-74 yas) olan, 32 kadin ve 20 erkek iceren toplam 52 hastadan olusmaktadir. 34 hastada (%65) sag, 18’ nde (%35) sol omuz etkilenmisti. Hastalarda ameliyat oncesi teshis; rotator kaf sendromu (n:34), impingement sendromu (n:7), donuk omuz (n:2) ve bankart lezyonu (n:9) idi. MRG yapildiktan sonra omuz artroskopisi yapildi. Sadece artroskopik degerlendirmede SLAP tip siniflamasi tespit edildi ve 13 Tip 1 (%33), 23 Tip 2 (%58), bir Tip 3 (%3), bir Tip 4 (%3) ve 1 Tip 5 (%3) lezyon mevcut idi. Oniki hastada hem MRG hemde artroskopi de SLAP lezyonlari saptandi. MRG de SLAP lezyon olmasina ragmen 3 hastada artroskopik olarak lezyon saptanmadi. 10 hastada hem artroskopi hem de MRG de SLAP lezyonu yoktu. 27 hastada MRG de lezyon yok iken, artroskopi de lezyon saptandi. SLAP lezyonlarinin teshisinde, MRG %31 duyarlilik, %77 ozgulluk, %80 pozitif ongorme degeri ve %27 negatif ongorme degeri gosterdi. MRG’ nin dogrulugu %42 olarak bulundu. MRG ve artroskopi arasinda anlasmanin guvenilirligi (Fleiss kappa) 0.048 (p=0.596) olarak bulundu. MRG diger omuz patolojilerini teshis etmekte yararli bir arac olmasina ragmen, altin standart olan omuz artroskopisine kiyasla SLAP lezyonlarini tespit etmekte yeterli degildir.","PeriodicalId":409672,"journal":{"name":"Osmangazi Journal of Medicine","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124072311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatrik Olguda EDTA’ya Bağlı Psödotrombositopeni","authors":"M. Çiçek, M. Aktaş, N. Topal","doi":"10.20515/otd.830994","DOIUrl":"https://doi.org/10.20515/otd.830994","url":null,"abstract":"","PeriodicalId":409672,"journal":{"name":"Osmangazi Journal of Medicine","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125501762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Çocukluk Çağı Alerjik Hastalıklarında Tamamlayıcı ve Alternatif Tıp Kullanımının Araştırılması","authors":"Şükrü Çekiç, Yakup Canıtez, Fatih Çi̇çek, Yasin Karalı, Zuhal Karali, Nihat Sapan","doi":"10.20515/otd.816414","DOIUrl":"https://doi.org/10.20515/otd.816414","url":null,"abstract":"","PeriodicalId":409672,"journal":{"name":"Osmangazi Journal of Medicine","volume":"38 5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124849513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}