AIMS Allergy and Immunology最新文献_第3页

The gastrointestinal effects amongst Ehlers-Danlos syndrome, mast cell activation syndrome and postural orthostatic tachycardia syndrome ehers - danlos综合征、肥大细胞活化综合征和体位性心动过速综合征的胃肠道效应

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AIMS Allergy and Immunology Pub Date : 2022-01-01 DOI: 10.3934/allergy.2022004

Sammi Wong, Sara Hasan, Christina Parducci, B. Riley

引用次数: 1

Mast cells in severe respiratory virus infections: insights for treatment and vaccine administration 严重呼吸道病毒感染中的肥大细胞:治疗和疫苗管理的见解

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AIMS Allergy and Immunology Pub Date : 2022-01-01 DOI: 10.3934/allergy.2023001

A. Mamontov, A. Polevshchikov, Y. Desheva

{"title":"Mast cells in severe respiratory virus infections: insights for treatment and vaccine administration","authors":"A. Mamontov, A. Polevshchikov, Y. Desheva","doi":"10.3934/allergy.2023001","DOIUrl":"https://doi.org/10.3934/allergy.2023001","url":null,"abstract":"Mast cells (MCs) are a part of the innate immune system and express receptors for microbial and viral pathogens characteristic of this system. The pathological role of MCs has been demonstrated for a number of highly virulent viral infections. The role of MCs and their Fc receptors for IgE in the immediate-type hypersensitivity reactions and in immunocomplex reactions is well-known, although the role of MCs and their Fc receptors for IgG (FcγR) in immunocomplex processes is much less studied. Antibody-dependent enhancement syndrome (ADE) has been observed in a number of viral infections and is associated with greater secondary infection. ADE is enhanced by virus-specific antibodies, which are not involved in the virus penetration into the cell but are capable of forming immune complexes. The role of MCs in ADE is well-established for dengue infection, RSV infection and coronavirus (CoV) infection. The involvement of IgG-mediated mast cell responses in other human viral infections including Coronavirus disease 2019 (COVID-19) is poorly understood. Recently discovered mast cell activation disease is considered one of the causes of severe post-infectious complications in COVID-19. If the role of MCs in the pathogenesis of severe viral infections, including ADE in recurrent viral infection is clarified, these cells and the products they release may serve as promising targets for such therapeutic agents as histamine receptor blockers or membrane stabilizers to prevent possible complications.","PeriodicalId":40916,"journal":{"name":"AIMS Allergy and Immunology","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70184373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibody profiling reveals gender differences in response to SARS-COVID-2 infection 抗体谱分析揭示对SARS-COVID-2感染反应的性别差异

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AIMS Allergy and Immunology Pub Date : 2021-06-04 DOI: 10.1101/2021.06.01.21258175

L. Tsverava, N. Chitadze, G. Chanturia, M. Kekelidze, D. Dzneladze, P. Imnadze, A. Gamkrelidze, V. Lagani, Z. Khuchua, R. Solomonia

{"title":"Antibody profiling reveals gender differences in response to SARS-COVID-2 infection","authors":"L. Tsverava, N. Chitadze, G. Chanturia, M. Kekelidze, D. Dzneladze, P. Imnadze, A. Gamkrelidze, V. Lagani, Z. Khuchua, R. Solomonia","doi":"10.1101/2021.06.01.21258175","DOIUrl":"https://doi.org/10.1101/2021.06.01.21258175","url":null,"abstract":"The recent emergence of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to an ongoing global COVID-19 pandemic and public health crisis. Detailed study of human immune response to SARS-COVIS-2 infection is the important topic for a successful treatment of this disease. Our study was aimed to characterize immune response on the level of antibody profiling in convalescent plasma of patients in Georgia. Antibodies against the following SARS-COV-2 proteins were studied: nucleocapsid and various regions of Spike (S) protein: S1, S2 and Receptor binding domain (RBD). Convalescent plasma of patients 6-8 weeks after initial confirmation of SARS-COV-2 infection were tested. Nearly 80% out of 154 patients studied showed presence of antibodies against nucleocapsid protein. The antibody response to three fragments of S protein was significantly less and varied in the range of 20-30%. Significantly more females as compared to males were producing antibodies against S1 fragment, whereas the difference between genders by the antibodies against nucleocapsid protein and RBD was statistically significant only by one-tailed Fisher exact test. There were no differences between the males and females by antibodies against S2 fragment. Thus, immune response against some viral antigens are stronger in females and we suggest that it could be one of the factors of less female fatality after SARS-COVID-2 infection.","PeriodicalId":40916,"journal":{"name":"AIMS Allergy and Immunology","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2021-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41623523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Investigation of the factors potentially responsible for the significant different prevalence of COVID-19 between African-Africans and African-Americans 调查可能导致非洲裔非洲人和非洲裔美国人之间COVID-19患病率显著差异的因素

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AIMS Allergy and Immunology Pub Date : 2021-01-01 DOI: 10.3934/allergy.2021014

Canping Chen, W. Cao, Xiaosheng Wang

{"title":"Investigation of the factors potentially responsible for the significant different prevalence of COVID-19 between African-Africans and African-Americans","authors":"Canping Chen, W. Cao, Xiaosheng Wang","doi":"10.3934/allergy.2021014","DOIUrl":"https://doi.org/10.3934/allergy.2021014","url":null,"abstract":"Background The COVID-19 pandemic has resulted in more than 145 million cases and 3 million deaths as of April 23, 2021. Compared with the other continents, Africa had a relatively lower prevalence of COVID-19. However, the African-American population showed a higher COVID-19 susceptibility than the other U.S. populations. Methods To investigate the factors that are potentially responsible for the different susceptibility of COVID-19 between African-Africans and African-Americans, we collected the data of cumulative confirmed COVID-19 cases and deaths, temperature, humidity, wind speed, age distribution, incidences of age-related diseases, lung diseases, and HIV, and smoking rate in 40 African countries and 50 U.S. states and New York city. Results We found that old age, smoking, and age-related diseases (such as cardiovascular diseases, COPD, diabetes, hypertension, neoplasms, and stroke) were potential risk factors for COVID-19, while chronic kidney disease, tuberculosis, young age, and temperature were potential protective factors. Conclusions The significant differences in the age distribution, incidences of age-related diseases, lung diseases, and HIV, smoking rate, temperature, and humidity could be responsible for the markedly different prevalence of COVID-19 between African-Africans and African-Americans.","PeriodicalId":40916,"journal":{"name":"AIMS Allergy and Immunology","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70184117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The complex functions of microRNA-150 in allergy, autoimmunity and immune tolerance microRNA-150在变态反应、自身免疫和免疫耐受中的复杂功能

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AIMS Allergy and Immunology Pub Date : 2021-01-01 DOI: 10.3934/allergy.2021016

Katarzyna Nazimek

{"title":"The complex functions of microRNA-150 in allergy, autoimmunity and immune tolerance","authors":"Katarzyna Nazimek","doi":"10.3934/allergy.2021016","DOIUrl":"https://doi.org/10.3934/allergy.2021016","url":null,"abstract":"At present, special efforts are being made to develop the strategies allowing for activation of long-lasting antigen-specific immune tolerance in therapy of allergic and autoimmune diseases. Some of these therapeutic approaches are aimed at modulating cell functions at genetic level by using miRNA-based and miRNA-targeting treatments. Simultaneously, the crucial role of extracellular vesicles as natural miRNA conveyors is highlighted for induction of antigen-specific immune tolerance, especially that they appear to be easily manipulatable for therapeutic applications. Among other immune-related miRNAs, miR-150 is getting special attention as it is differently expressed by immune cells at various stages of their maturation and differentiation. In addition, miR-150 is involved in different signaling cascades orchestrating humoral and cell-mediated mechanisms of both innate and adaptive immune responses. Therefore, miR-150 is considered a master regulator of immunity in mammals. Currently, physiological miR-150-dependent regulatory circuits and causes of their malfunctioning that underlie the pathogenesis of allergic and autoimmune disorders are being unraveled. Thus, present review summarizes the current knowledge of the role of miR-150 in the pathogenesis and complications of these diseases. Furthermore, the involvement of miR-150 in regulation of immune responses to allergens and self-antigens and in induction of antigen-specific immune tolerance is discussed with the special emphasis on the therapeutic potential of this miRNA.","PeriodicalId":40916,"journal":{"name":"AIMS Allergy and Immunology","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70184185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of miRNAs in the inflammatory phase of skin wound healing mirna在皮肤伤口愈合炎症期的作用

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AIMS Allergy and Immunology Pub Date : 2021-01-01 DOI: 10.3934/allergy.2021020

Federica Serra, L. Aielli, E. Costantini

引用次数: 1

Tyk2-mediated homeostatic control by regulating the PGE2-PKA-IL-10 axis tyk2通过调节PGE2-PKA-IL-10轴介导的稳态控制

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AIMS Allergy and Immunology Pub Date : 2021-01-01 DOI: 10.3934/allergy.2021013

R. Muromoto, K. Oritani, T. Matsuda

引用次数: 4

The host immune responses to SARS-CoV-2 and therapeutic strategies in the treatment of COVID-19 cytokine storm 宿主对SARS-CoV-2的免疫应答及COVID-19细胞因子风暴治疗策略

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AIMS Allergy and Immunology Pub Date : 2021-01-01 DOI: 10.3934/allergy.2021018

Mansur Aliyu, Sayed-Hamidreza Mozhgani, Omid Kohandel Gargari, M. Yusuf, A. Saboor-Yaraghi

{"title":"The host immune responses to SARS-CoV-2 and therapeutic strategies in the treatment of COVID-19 cytokine storm","authors":"Mansur Aliyu, Sayed-Hamidreza Mozhgani, Omid Kohandel Gargari, M. Yusuf, A. Saboor-Yaraghi","doi":"10.3934/allergy.2021018","DOIUrl":"https://doi.org/10.3934/allergy.2021018","url":null,"abstract":"The ravaging pandemic caused by SAR-CoV-2, a member of β-coronaviruses, marks the end of the year 2019. Despite being identified and classified at the earliest stage, the virus records worldwide soaring transmissibility, morbidity, and mortality. Global data have shown the infection with SARS-CoV-2 to be severe among at least 15% of the infected; the aged and those with premorbid conditions like cancer, cardiovascular, and respiratory diseases. The highest prevalence and mortality are seen in the Americas, with African countries least affected. Severe respiratory distress and multiorgan failure are the usual findings in severe cases. A hyperinflammatory, fulminant, hypercytokinemia that is often further complicated by hypercoagulopathy and multiorgan failure has been reported extensively among severely infected patients. Scientists describe hyper-activated immune response mediated by macrophages secreting copious amounts of interleukin (IL)-6 forming the epicenter of cytokine storm (CS), thereby perpetuating signaling cascade through JAK/Kinase pathway that yields a hypercytokinemia. Researchers globally are exploring JAK/kinase inhibitors, immunomodulatory (immunosuppressive) therapy, cytokines, and cytokine receptor blockers for CS management. In which interestingly some of these agents possess antiviral activity. Here, we reviewed published studies with their respective outcome. However, a lot needs to be done to address the CS of COVID-19 to avert its fatal outcome.","PeriodicalId":40916,"journal":{"name":"AIMS Allergy and Immunology","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70184270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The mast cell/S1P axis is not linked to pre-lesional male skin remodeling in a mouse model of eczema. 在湿疹小鼠模型中，肥大细胞/S1P轴与病变前男性皮肤重塑无关。

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AIMS Allergy and Immunology Pub Date : 2021-01-01 Epub Date: 2021-05-28 DOI: 10.3934/allergy.2021012

Ross M Tanis, Piper A Wedman-Robida, Alena P Chumanevich, John W Fuseler, Carole A Oskeritzian

{"title":"The mast cell/S1P axis is not linked to pre-lesional male skin remodeling in a mouse model of eczema.","authors":"Ross M Tanis, Piper A Wedman-Robida, Alena P Chumanevich, John W Fuseler, Carole A Oskeritzian","doi":"10.3934/allergy.2021012","DOIUrl":"10.3934/allergy.2021012","url":null,"abstract":"<p><p>Atopic dermatitis (AD, eczema) is an inflammatory skin condition whose histopathology involves remodeling. Few preclinical AD studies are performed using male mice. The histopathological mechanisms underlying AD development were investigated here in male mice at a pre-lesional stage using a human AD-like mouse model. Hypodermal cellular infiltration without thickening of skin layers was observed after one epicutaneous exposure to antigen ovalbumin (OVA), compared to controls. In contrast to our previous report using female mice, OVA treatment did not activate skin mast cells (MC) or elevate sphingosine-1-phosphate (S1P) levels while increasing systemic but not local levels of CCL2, CCL3 and CCL5 chemokines. In contrast to the pathogenic AD mechanisms we recently uncovered in female, S1P-mediated skin MC activation with subsequent local chemokine production is not observed in male mice, supporting sex differences in pre-lesional stages of AD. We are proposing that differential involvement of the MC/S1P axis in early pathogenic skin changes contributes to the well documented yet still incompletely understood sex-dimorphic susceptibility to AD in humans.</p>","PeriodicalId":40916,"journal":{"name":"AIMS Allergy and Immunology","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602012/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54231495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A universal CAR-NK cell approach for HIV eradication 一种通用的CAR-NK细胞根除HIV的方法

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AIMS Allergy and Immunology Pub Date : 2021-01-01 DOI: 10.3934/allergy.2021015

Arosh S. Perera Molligoda Arachchige

引用次数: 4