AIMS Allergy and Immunology最新文献

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Contributions of immune cell populations in the maintenance, progression, and therapeutic modalities of glioma. 免疫细胞群在胶质瘤的维持、发展和治疗模式中的贡献。

IF 0.7

AIMS Allergy and Immunology Pub Date : 2018-01-01 Epub Date: 2018-03-21 DOI: 10.3934/allergy.2018.1.24

Michael D Caponegro, Jeremy Tetsuo Miyauchi, Stella E Tsirka

{"title":"Contributions of immune cell populations in the maintenance, progression, and therapeutic modalities of glioma.","authors":"Michael D Caponegro, Jeremy Tetsuo Miyauchi, Stella E Tsirka","doi":"10.3934/allergy.2018.1.24","DOIUrl":"10.3934/allergy.2018.1.24","url":null,"abstract":"Immunotherapies are becoming a promising strategy for malignant disease. Selectively directing host immune responses to target cancerous tissue is a milestone of human health care. The roles of the innate and adaptive immune systems in both cancer progression and elimination are now being realized. Defining the immune cell environment and identifying the contributions of each sub-population of these cells has lead to an understanding of the immunotherapeutic processes, and demonstrated the potential of the immune system to drive cancer shrinkage and sustained immunity against disease. Poorly treated diseases, such as high-grade glioma, suffer from lack of therapeutic efficacy and rapid progression. Immunotherapeutic success in other solid malignancies, such as melanoma, now provides the principals for which this treatment paradigm can be adapted for primary brain cancers. The central nervous system is complex, and relative contributions of immune sub-populations to high grade glioma progression are not fully characterized. Here, we summarize recent research in both animal and humans which add to the knowledge base of how innate and adaptive immune cells contribute to glioma progression, and outline work which has demonstrated their potential to elicit anti-tumorigenic responses. Additionally, we highlight Neuropilin 1, a cell surface receptor protein, describe its signaling functions in the context of immunity, and point to its potential to slow glioma progression.","PeriodicalId":40916,"journal":{"name":"AIMS Allergy and Immunology","volume":"2 1","pages":"24-44"},"PeriodicalIF":0.7,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7480949/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38368709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

"Toll-free" pathways for production of type I interferons. 生产I型干扰素的“免费”途径。

IF 0.7

AIMS Allergy and Immunology Pub Date : 2017-01-01 Epub Date: 2017-11-06 DOI: 10.3934/Allergy.2017.3.143

Ling Wang, Shunbin Ning

{"title":"\"Toll-free\" pathways for production of type I interferons.","authors":"Ling Wang, Shunbin Ning","doi":"10.3934/Allergy.2017.3.143","DOIUrl":"https://doi.org/10.3934/Allergy.2017.3.143","url":null,"abstract":"Pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) are recognized by different cellular pathogen recognition receptors (PRRs), which are expressed on cell membrane or in the cytoplasm of cells of the innate immune system. Nucleic acids derived from pathogens or from certain cellular conditions represent a large category of PAMPs/DAMPs that trigger production of type I interferons (IFN-I) in addition to pro-inflammatory cytokines, by specifically binding to intracellular Toll-like receptors or cytosolic receptors. These cytosolic receptors, which are not related to TLRs and we call them \"Toll-free\" receptors, include the RNA-sensing RIG-I like receptors (RLRs), the DNA-sensing HIN200 family, and cGAS, amongst others. Viruses have evolved myriad strategies to evoke both host cellular and viral factors to evade IFN-I-mediated innate immune responses, to facilitate their infection, replication, and establishment of latency. This review outlines these \"Toll-free\" innate immune pathways and recent updates on their regulation, with focus on cellular and viral factors with enzyme activities.","PeriodicalId":40916,"journal":{"name":"AIMS Allergy and Immunology","volume":"1 3","pages":"143-163"},"PeriodicalIF":0.7,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710802/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35217407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

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