World Journal of Clinical & Medical Images最新文献

{"title":"Persistent trigeminal artery: rare cause of ischemic stroke in young people","authors":"","doi":"10.33140/wjcmi.01.01.16","DOIUrl":"https://doi.org/10.33140/wjcmi.01.01.16","url":null,"abstract":"A young girl, 17-years-old, history of drug addiction, followed for thrombophilia with a right hemiplegia due to a left superficial sylvian infarction for 6 months, hospitalized for etiological exploration. Cerebral magnetic resonance imaging showed a sequela of left frontal ischemia due to occlusion of the superficial branches of the left middle cerebral artery (Figure. 1), with the presence of an artery connecting the basilar trunk and the left internal carotid artery, also called the persistent trigeminal artery (Figure. 2).","PeriodicalId":408468,"journal":{"name":"World Journal of Clinical & Medical Images","volume":"262 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122903210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functionality and Clinical Effects of Anti-Cov2 Vaccines (Aka Mrna) And Integration on Mitochondrial DNA","authors":"","doi":"10.33140/wjcmi.01.01.01","DOIUrl":"https://doi.org/10.33140/wjcmi.01.01.01","url":null,"abstract":"1. This issue would require many pages, but it is briefly described here for easier understanding 2. The writer refers to the Molecular Biology Experts and to reading the copious literature on the proteins/ enzymes found in mRNA vaccines using the BLASTP approach (Appendix 1) 3. The reference literature, apart from being written in English, is also worded in an extremely technical style 4. They are given a specific functional sequence, aimed at the incorporation and expression of vaccine mRNA into the genome of the mitochondria (mtDNA) 5. The vaccine mRNA does not refer to the segment relating to the Spike protein, but to the entire viral genome 6. Therefore, the Ribosomes are not the final destination of the vaccine mRNA; instead, the Mitochondria are actually the seat of a DNA, accommodating the SARS-Cov2 genome in the same way as it does in the nuclear genome. 7. Both the Mitochondria and Ribosomes are located in the Ergastoplasm and are separated from the cytosol by an oxidation/reduction barrier 'in mV' (= one thousand times) three times higher than that of the cytosol. 8. Article from Science: Oxidized Redox State of Glutothiane in the Endoplasmic reticulum - 11 September 1992 volume 257, page 1496:15026 9. Thus only an mRNA that exits from both the nuclear and mitochondrial genomes has the enzyme support that allows it to reach the ribosomes, overcoming the resistance of the oxidation/reduction barrier 10. If this were not the case, RNA viruses would not lengthen the pathway, integrating before the genome and then reaching the ribosomes again as mRNA (it must be said that, in an RNA virus, the genomic RNA is the same as the RNA coming out of the nucleus), but would immediately aim to reach the ribosomes, as RNA vaccines are said to do. 11. Nano technologies are said to be the architects of this miraculous and rapid rush to the ribosomes of vaccine mRNA 12. These nano-technologies are nothing more than a sequence of proteins/enzymes - undeclared - which are now described here in their function in the main patterns 13. a) ryanodine receptorby managing the Ca++ ion flux channels, it first depolarises the mitochondrial membrane, which is the first step for mRNA entry and then it lowers the oxidative/reductive level of the ergastoplasm, activating an osmotic \"Δ\" (= delta-difference) around the mitochondria, releasing the protonated ions (=H + ) present in the virtual space of the two sheets forming the mitochondrial membrane into the area. 14. b) ABC transporter - ATP - binding protein By binding to ATP, it allows vaccine RNA to enter the mitochondria 15. c) Epical complex lysine methyltran spherase By providing mobility for the entering mRNA, it allows to reach the stretch of mitochondrial DNA most suitable for integration 16. d) DDLS - Typ - integrase/transpasase It simultaneously does the work performed before by reverse transcriptase and integrase, and then inserts a viral genome RNA, similar to the genomic RNA in RNA viruses, into the mito","PeriodicalId":408468,"journal":{"name":"World Journal of Clinical & Medical Images","volume":"75 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134259685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blind Spots in Neuroradiology: Editorial","authors":"","doi":"10.33140/wjcmi.01.01.04","DOIUrl":"https://doi.org/10.33140/wjcmi.01.01.04","url":null,"abstract":"There are blind spots in the eye and blind spots in the brain and these spots can make inexperienced radiologist with untrained eye miss some important findings, not because he/she can see them and do not understand them, but because they are hidden/or better to say our brains neglect to see them. Our brains and eyes focus on the important details or what the brain thinks it’s important. Some of the findings might small in size or do not appear on certain windows therefore; these findings need an examiner who has an eye for details in order to find these pathologies.","PeriodicalId":408468,"journal":{"name":"World Journal of Clinical & Medical Images","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130808352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Klippel-Trenaunay Syndrome Complicated with Scrotal Lymphedema: A Rare Entity Not to be Ignored","authors":"","doi":"10.33140/wjcmi.01.01.09","DOIUrl":"https://doi.org/10.33140/wjcmi.01.01.09","url":null,"abstract":"Klippel-Trenaunay syndrome is an extremely rare congenital angiodysplasia of undetermined aetiology, characterised by venous and lymphatic malformations, bone and soft tissue hypertrophy [1]. Its management is multidisciplinary. In some cases, surgery can improve the quality of life of patients. We report the case of a 59-year-old Moroccan patient, known to have Klippel-Trendaunay syndrome for 20 years, who consulted us for scrotal lymphedema that had been evolving for 3 years. The patient had never travelled abroad, particularly to filarial endemic countries. The clinical examination revealed a large, enlarged scrotum with local haemangiomas [Figure 1] and haemangiomas of the lower limbs. The biological work-up revealed no abnormalities and no imaging was performed.","PeriodicalId":408468,"journal":{"name":"World Journal of Clinical & Medical Images","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115014463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design of a plasmonic refractive index sensor based on the amplifier system with two plasmonic waveguides and four cavities with different dimensions and coordinates","authors":"","doi":"10.33140/wjcmi.01.01.15","DOIUrl":"https://doi.org/10.33140/wjcmi.01.01.15","url":null,"abstract":"In this research, we design a plasmonic refractive index sensor based on metal insulated metal waveguide (MIM) and examine it numerically. To design the structure of this sensor, we use five cavities with different dimensions and coordinates and two plasmonic waveguides. The resonant wavelengths and refractive index of the resonators are investigated and simulated by the finite difference time domain (FDTD) method. Due to the fact that the sensors and conduction characteristics of plasmonic waves are affected by the structure parameters, by changing the refractive index and changing the dimensions of the cavities, we can weaken or strengthen the passage coefficient in the resonant modes. As a result, we obtain the sensitivity coefficient, the competency digit (FOM) and the sensor quality coefficient. These plasmonic sensors with a simple frame and high optical resolution can be used to measure the refractive index in the medical, chemical and food industries, and due to the special correct distribution of resonances, they are highly sensitive to changes in the refractive index of the environment.","PeriodicalId":408468,"journal":{"name":"World Journal of Clinical & Medical Images","volume":"154 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114793947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence of Cryptogenic Stroke in Covid-19 Patients","authors":"","doi":"10.33140/wjcmi.01.01.012","DOIUrl":"https://doi.org/10.33140/wjcmi.01.01.012","url":null,"abstract":"Introduction The risk of ischemic stroke during COVID-19 is approximately 5% reported by WHO. Hemorrhagic strokes are less common compared to ischemic ones, but few cases have been reported. The strokes are called a cryptogenic strokes which means an unknown origin. Diagnostic investigations were incomplete in patients with COVID-19 leading to a high rate of cryptogenic stroke. Materials and Methods It is a prospective observational study conducted at a single centered hospital in Hanamkonda the data was collected from January 2020 to April 2020 and all Parameters were expressed as Mean ± Standard Deviation (SD). Data analysis was performed using MS Excel and Graphpad Prism (9.0 version). A One-Way ANOVA (Analysis of variance) followed by Dunnett’s Multiple Comparison test was done to assess the significant difference between visit 1and visit 3 cryptogenic parameters. A p-value <0.0001 was considered significant. Results There were significant changes observed from visit 1 to visit 3 in evaluating the parameters and treatment of coagulation and inflammation. Conclusion The risk of cryptogenic stroke in COVID-19 infected patients was assessed by considering parameters such as TLC, CRP, LDH, RBS, FERRITIN, D-DIMER, IL-6 and it can be concluded that the evaluation of the above parameters is to be evaluated in every patient irrespective of comorbidities, age, and anti-coagulants, anti-diabeticandanti-inflammatoryagentswillplayasubstantialroleinthe management of cryptogenic stroke in COVID-19.","PeriodicalId":408468,"journal":{"name":"World Journal of Clinical &amp; Medical Images","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131771454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medical and psychological assistance to adolescents with type I diabetes mellitus","authors":"","doi":"10.33140/wjcmi.01.01.03","DOIUrl":"https://doi.org/10.33140/wjcmi.01.01.03","url":null,"abstract":"the present study is due to the widespread prevalence of diabetes mellitus in children and insufficient knowledge of a number of its clinical and psychological aspects. Children and adolescents with newly diagnosed DM need individual psychological and pedagogical support, psychotherapeutic assistance is shown to this contingent of patients, which contributes to the creation of partnership relations between the psychologist and the patient, timely psychodiagnostics and psychocorrection of disorders of the anxiety-depressive and phobic spectrum of the neurotic level is necessary for more effective and comprehensive treatment. In connection with the emerging progress in pharmacotherapy, the issues of an integrated approach to the treatment and organization of psychosocial rehabilitation, social adaptation and correction of anxiety-phobic and depressive symptoms in children and adolescents are becoming as urgent as possible.","PeriodicalId":408468,"journal":{"name":"World Journal of Clinical &amp; Medical Images","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134058881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unusual Cause of Bumpy Head in Neonates: Calcified Cephalhematoma","authors":"","doi":"10.33140/wjcmi.01.01.06","DOIUrl":"https://doi.org/10.33140/wjcmi.01.01.06","url":null,"abstract":"Cephalhematomas, which are usually a complication of assisted delivery, might get calcified in a minority of newborns, resulting in a hard palpable skull swelling. This is a matter of concern for both the parents and the clinician as it might lead to osseous deformities and craniosynostosis, apart from the cosmetic deformity. Hence, its identification in the early stages might help in appropriate management of the child. We present a case of a 1 month old child with hard scalp swelling which gave an appearance of double skull on radiological examination. As the child did not have any neurological deficit, follow up was preferred as the management plan. We also discuss the complications and other management plans of this condition.","PeriodicalId":408468,"journal":{"name":"World Journal of Clinical &amp; Medical Images","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128411422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glycation injury effects on aging and possible ways of prevention","authors":"","doi":"10.33140/wjcmi.01.01.14","DOIUrl":"https://doi.org/10.33140/wjcmi.01.01.14","url":null,"abstract":"Glycation is both a physiological and pathological process that mainly affects proteins, nucleic acids, and lipids. Advanced glycation end product (AGE) formation begins with the non-enzymatic glycation of free amino groups by sugars and aldehydes which leads to a succession of rearrangements of intermediate compounds and ultimately to irreversibly bound products known as AGEs. Recent studies have revealed the contributing roles of AGEs in the development of various aging-related conditions, such as diabetes, heart disease, and cancer. Controlling the blood sugar level is a natural method to inhibit glycation in diabetes. It is also seen from animal studies that exercise reduces the concentration of AGEs and highly reactive intermediates of AGE.","PeriodicalId":408468,"journal":{"name":"World Journal of Clinical &amp; Medical Images","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114590023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biostatistical and mathematical analysis on liver disease during COVID-19 pandemic","authors":"","doi":"10.33140/wjcmi.01.01.17","DOIUrl":"https://doi.org/10.33140/wjcmi.01.01.17","url":null,"abstract":"The liver is the body's biggest organ and is involved in metabolic processes. The liver is involved in both metabolism and dehydration. It helps in the detoxification of harmful chemicals as well as the growth of microorganisms. For systemic removal and preservation of organisms and other creatures, the liver is the most essential organ. As a result, liver injury has significant ramifications. Liver disease is regarded as a serious health issue. Overuse of several medicines, which are occasionally prescribed as part of treatment, can cause organ damage. Hepatotoxicity is caused by other chemical agents, such as those employed in labs (thioacetamide, alcohol, etc.) and industry, as well as natural compounds (such as microcystin). Many over-the-counter medicines aren't prescribed to help people with liver disease, and they can actually harm the liver. As a result, plant-based treatments are utilised to treat liver illness. As a result, several human herbal treatments have been evaluated in experimental animal models for antioxidant and hepatoprotective liver function. Acanthus ilicifolius was used as Traditional Chinese medicine (TCM) and Traditional Indian medicine (TIM). The plants showed many clinical properties. Still, the neurological related functions and disorders are not well explored in this plant. Complex interplay of positive and negative emotions orchestrated by intricately associated neuronal circuits, neurotransmitters coupled with endocrinal in- fluence holds responsible for human behavior, considered as the root of human civilization, is currently facing existential crisis during COVID-19 pandemic. In the present study, an attempt was made to identify the interaction between A. ilicifolius natural compounds and Echinacoside as reference compounds were to study the neurotransmitters functions through biomathematical and computational method. Initially, in silico molecular docking was performed to identify the potent natural compounds against neurological disease. The results show among 8 natural compounds, 26.27-Di(nor)- cholest-5,7,23-trien-22-ol, 3-methoxymethoxy, Cholest-5-en-3-ol (3, Beta.)-, carbonochloridate, Cholesterol and Echinacoside exhibited maximum interaction with all the target proteins. Especially, Echinacoside exhibited the maximum interaction with (Serotonin) 5- hydroxytryptamine receptor 2A (-17.077), Sodium-dependent serotonin transporter (-15.810) and (Histamine) Histamine H2 receptor (-17.556). These two neurotransmitters act as a major concern related to the mental disorders and neurological functions. The natural compounds may potent inhibitor for neurological disorders.","PeriodicalId":408468,"journal":{"name":"World Journal of Clinical &amp; Medical Images","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123899659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}